Viewing affirmative mentions of regulation of IL2 (H. sapiens) in T cells

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Gerber et al. (1989)interleukin-2T lymphocytesThe influence of interleukin-2, feeder cells, and timing of irradiation on the radiosensitivity of human T lymphocytes assessed by the colony-forming assay.
Inouye et al. (1980)TCGFT cellIn an effort to increase the potency of T cell growth factor (TCGF), several variables were examined for their effects on the production of TCGF.
Meuer et al. (1982)IL 2T cellThe human T cell subset(s) responsible for production of interleukin 2 (IL 2) was investigated in the present study.
Williams et al. (1996)IL-2T cellIL-2 production by the human T cell line Jurkat is dependent on a fall in mRNA for c-myc and a rise in mRNA for c-fos.
Arya et al. (1984)TCGF mRNAT lymphocytesTCGF is produced by a subset of T lymphocytes, and this production is regulated at the TCGF mRNA level.
DeFreitas et al. (1986)interleukin 2T cellsRegulation of interleukin 2 receptors on T cells from multiple sclerosis patients.
Gulino et al. (1990)IL-2T cellsInterleukin-2 (IL-2) gene expression is tightly controlled and generally limited to antigenic stimulation of T cells.
Pelassy et al. (1991)interleukin-2T cellEffects of the serine analogues isoserine and serinol on interleukin-2 synthesis and phospholipid metabolism in a human T cell line Jurkat.
Tsudo et al. (1983)TCGF receptorT cellsThese results indicate that regulation of Tac antigen-TCGF receptor is different between normal and malignant T cells, suggesting that failure of down-regulation of Tac antigen on leukemic cells by anti-Tac antibody may play an important role in the malignant proliferation of ATL cells.
Walther et al. (1999)interleukin-2T lymphocytesRecent work with the random positioning machine, a new instrument to simulate conditions similar to microgravity, indicate that there are direct gravitational effects on the genetic expression of interleukin-2 and of its receptor in T lymphocytes.
Wacholtz et al. (1991)IL2T cellsCharacterization of the 3',5'-cyclic adenosine monophosphate-mediated regulation of IL2 production by T cells and Jurkat cells.
Wacholtz et al. (1991)IL2T cellsThus, these observations indicate that IL2 production by both peripheral T cells and Jurkat cells can be modulated by cAMP-elevating agents.
Fujita et al. (1986)interleukin-2T lymphocytesRegulation of human interleukin-2 gene: functional DNA sequences in the 5' flanking region for the gene expression in activated T lymphocytes.
Yang et al. (1994)IL-2T-lymphocyteTaken together, these results suggest that triptolide inhibits T-lymphocyte proliferation mainly by affecting IL-2 receptor expression rather than IL-2 production.
Müller-Quernheim et al. (1986)IL 2T cellsThe sarcoid lung T cells, however, did not express the IL 2 gene constitutively; when placed in culture with no stimulation and evaluated after 24 hr, they demonstrated down regulation of the amounts of IL 2 mRNA transcripts, despite the fact that they were capable of re-expressing the IL 2 gene and releasing more IL 2 in response to added activation signals.
Liu and Rosenberg (2003)IL-2T-cellHere they report that this growth of IL-2 transductants depended on restimulation of the T-cell receptor complex and appeared to be regulated at the transcriptional level of the transduced IL-2 gene.
Hemler et al. (1984)interleukin 2T cellsAntigenic stimulation regulates the level of expression of interleukin 2 receptor on human T cells.
Holán et al. (1994)interleukin-2T cellEffects of direct current on T cell activity: modulation of interleukin-2 production.
Matesanz et al. (2000)IL-2 geneT lymphocytesTherefore, we investigated the regulation of allelic expression of the IL-2 gene in non-genetically manipulated human T lymphocytes by following natural allelic polymorphisms.
Matesanz et al. (2000)IL-2T cellsThis allowed the study by single-cell PCR of the regulation of the human IL-2 allelic expression in heterozygous CD4(+) T cells, which was found to be tightly controlled monoallelically.
Hopkins and Failla (1999)interleukin-2 geneT lymphocytesTranscriptional regulation of interleukin-2 gene expression is impaired by copper deficiency in Jurkat human T lymphocytes.
Prasad et al. (2002)IL-2T-cellsWe used a human Th(0) malignant lymphoblastoid cell line, HUT-78, to study the effect of zinc on IL-2 production in PHA/PMA activated T-cells.
Kabouridis and Tsoukas (1990)interleukin 2T lymphocytesRegulation of expression of interleukin 2 receptors upon triggering of the TCR-CD3 complex on human T lymphocytes.
Povlsen et al. (1989)IL-2T-lymphocytesThe effect of in vitro administration of Cyclosporin A (CsA) during mitogen, antigen and alloantigen activation of human T-lymphocytes on high affinity interleukin-2 (IL-2) receptor expression and -turnover and IL-2 production was investigated.
Essery et al. (1988)IL-2T cellsIn order to determine if modulation of IL-2 receptors is able to induce or abrogate unresponsiveness, the T cells were treated with anti-Tac antibody alone or together with tolerizing concentrations of antigen.
June et al. (1989)IL-2T cellsInterleukin-2 (IL-2) gene regulation was investigated in primary cultures of highly purified human peripheral blood CD28+ T cells.
Fraser et al. (1991)IL-2T cellProduction of interleukin-2 (IL-2) can be regulated by signal transduction pathways distinct from those induced by the T cell antigen receptor.
Shibuya and Taniguchi (1989)IL-2T-cellsRegulated expression of interleukin-2 (IL-2) gene constitutes an essential part in the clonal proliferation of activated T lymphocytes (T-cells).
Hughes and Pober (1996)IL-2T cellsWe conclude that IL-2 transcriptional regulation differs in tumor cell lines compared with normal T cells and that different costimulatory signals converge on the same cis-elements in the IL-2 promoter.
Tadmori et al. (1986)IL 2T lymphocyteDown regulation of IL 2 mRNA by antibody to the 50-kd protein associated with E receptors on human T lymphocyte.
Tadmori et al. (1986)IL 2T cellWe used a human IL 2 cDNA clone to investigate the effect of antibody 9.6 and cyclosporin A (CsA) on the regulation of IL 2 mRNA levels in the cloned human leukemic T cell line Jurkat, J32.
June et al. (1989)IL-2T cellsThe regulation of IL-2 gene expression during T cell activation and proliferation has been investigated in primary cultures of purified human peripheral blood T cells.
Debatin et al. (1989)IL-2T cellsThe finding of abundant IL-2 receptors on malignant T cells in adult T cell leukemia suggested a deregulation of the IL-2/IL-2 receptor system and was assumed to account for aberrant growth in malignant disorders of T cells.
Krönke et al. (1985)interleukin-2T-cellDeregulation of interleukin-2 receptor gene expression in HTLV-I-induced adult T-cell leukemia.
Holländer et al. (1998)IL-2T cellsWith the use of fluorescent in situ hybridization and single-cell polymerase chain reaction in cells with different IL-2 alleles, IL-2 expression in mature thymocytes and T cells was found to be tightly controlled by monoallelic expression.
Kazakova et al. (1991)interleukin-2T-lymphocytesThe influence of some immunomodulation peptides SKD, R and L on the interleukin-2 (IL-2) synthesis in T-lymphocytes and possibility of their specific interaction with nucleotide sequences of IL-2 gene were studied.
Lillehoj and Shevach (1985)IL-2T cellWe have studied the mechanism by which cyclosporin A (CsA), dexamethasone (DEX), and ouabain (OUA) inhibit T cell proliferation by measuring the effects of these agents on 1) interleukin-2 (IL-2) production, 2) acquisition of IL-2 responsiveness, 3) the induction of IL-2 receptor expression, and 4) the specific interaction of IL-2 with its receptor.
Becker et al. (1995)IL-2 geneT cellsHere we present evidence for a mechanism of negative IL-2 gene regulation in anergic T cells.
Jordan et al. (1989)interleukin-2T cells1,25-Dihydroxyvitamin-D3 regulation of interleukin-2 and interleukin-2 receptor levels and gene expression in human T cells.
McGuire et al. (1993)interleukin-2T-cellInfluence of human T-cell leukemia virus type I tax and rex on interleukin-2 gene expression.
Baker et al. (1978)TCGFT cellTherefore, the forces affecting TCGF production may modulate the amplitude of a T cell-mediated cytolytic response.
Roth and Dröge (1987)TCGFT-cellRegulation of T-cell activation and T-cell growth factor (TCGF) production by hydrogen peroxide.
Minakuchi et al. (1990)IL-2T cellThe capacity of PGE2 to inhibit human T cell responses was examined by investigating its effect on mitogen-induced IL-2 production and proliferation of highly purified CD4+ T cells.
Deenick et al. (2003)IL-2T cellStochastic model of T cell proliferation: a calculus revealing IL-2 regulation of precursor frequencies, cell cycle time, and survival.
Aihara et al. (1999)IL-2T cellsEffects of isoproterenol on IL-2 and cAMP production in peripheral T cells from asthmatic and non-asthmatic subjects sensitive to Candida.
Kucharz and Sierakowski (1990)interleukin 2T cellsThe effect of isoniazid on interleukin 2 production and interleukin 2-receptor expression by phytohemagglutinin-stimulated human T cells was investigated.
Goto et al. (2008)interleukin-2T-cellDifferent effects of all-trans-retinoic acid on phorbol ester-stimulated and phytohemagglutinin-stimulated interleukin-2 expression in human T-cell lymphoma HUT-78 cells.
Goto et al. (2008)IL-2T-lymphocytesThese results suggest that ATRA affects the production of IL-2 by T-lymphocytes in a stimulus-dependent manner.
Lardone et al. (2006)IL-2T cellsThese findings indicate that endogenous melatonin synthesized by human T cells would contribute to regulation of its own IL-2 production, acting as an intracrine, autocrine, and/or paracrine substance.
Mouzaki et al. (1993)IL-2T cellsIn the present study, analysis of the interleukin-2 (IL-2) gene activation shows that naive human helper T cells (cord blood CD4+ T cells, adult CD4+CD45RO- T cells) regulate IL-2 transcription by a mechanism involving both a silencer and an activator acting on the purine-rich IL-2 promoter elements (NF-AT binding sites).
Bárcena et al. (1991)IL-2T cellsBoth IL-2 and IL-4 responsiveness are developmentally regulated in human thymocytes, since IL-2 and IL-4 responses decline with increasing thymocyte differentiation, double-positive T cells displaying far less proliferation than immature thymocytes.
Landewé et al. (1996)interleukin-2T cellsTo investigate the regulation of interleukin-2 (IL-2) responsiveness of T cells, a human CD4+ T-cell clone with constitutive expression of IL-2 receptors was stimulated with recombinant IL-2 (rIL-2) in the presence or absence of immobilized anti-CD3 monoclonal antibodies (alpha CD3imm MoAb).
Arya and Gallo (1984)T-cell growth factorT-cellThus, the production of T-cell growth factor was regulated at the level of its mRNA.
Sieg et al. (2001)IL-2T cellsStrikingly, IFN-gamma and IL-2 are differentially regulated in T cells of HIV-infected patients such that the numbers of CD69(+) cells or IFN-gamma-positive cells that make IL-2 are proportionally decreased in CD4(+) T cells from HIV-infected patients.
Himes et al. (2000)IL-2 promoterT cellsThe alteration of HMGI(Y) levels affects IL-2 promoter activity not only in Jurkat T cells but also in PBL.
Puri et al. (1995)IL-2T cellTo understand the mechanism of inhibition of T cell proliferation, we have investigated the regulation of IL-2 production and its receptor expression on a human CD4+ T lymphoid cell line (H9) transfected with HIV-1 tat gene.
Lowenthal et al. (1985)IL 2T lymphocyteAntigenic stimulation regulates the expression of IL 2 receptors in a cytolytic T lymphocyte clone.
Lafont et al. (1998)interleukin-2T cellsIt has been shown that stimulation of lymphoid cells causes the activation of the extracellular signal-regulated-2 (ERK-2) which activates nuclear factor of activated T cells (NF-AT), a transcription factor involved in the regulation of interleukin-2 (1L2) gene transcription.
Ballow et al. (1997)IL-2T cellsCONCLUSION: These studies suggest that RA can augment IL-2 mRNA production by T cells with a possible paracrine effect on IL-2R-alpha expression.
Li et al. (1992)IL-2T cellsIn view of the importance of the IL-2 receptors in the expression of antiallograft immunity and the currently existing controversy regarding the effect of CsA on the induction of IL-2 receptors, we explored the effect of cyclosporine on the induction of interleukin-2 receptor alpha and beta in normal human T cells.
Li et al. (1992)IL-2T cellsThe effect of CsA on the induction of IL-2 receptors was examined at the levels of mRNA expression (with the aid of the polymerase chain reaction), protein (by SDS-PAGE analysis of chemically crosslinked 125I-IL-2 membrane protein complexes and by FACS), and function (by Scatchard analysis of 125I-IL-2 binding to T cells).
Zlotnik et al. (1983)IL 2T cellThe production of IL 2 by the T cell hybridomas is known to be dependent on the expression of Ia antigens by the antigen-presenting cells.
Kashiwado et al. (1989)IL-2T lymphocyteThe above findings suggest that normal M phi and EC secrete an identical or closely related inhibitor of IL-2 synthesis and IL-2 response, and this inhibitor regulates these IL-2-related functions by a suppressive action on the T lymphocyte.
Smith et al. (1992)IL-2T cellModulation of human T cell functions by surface sulphydryl groups: differential effects on IL-2 production and responsiveness.
Mary et al. (1987)interleukin 2T cellsRegulation of interleukin 2 synthesis by cAMP in human T cells.
Geiselhart et al. (1997)IL-2T-cellThese results suggest that p-BQ inhibits T-cell mitogenesis by blocking a thiol-dependent event that controls IL-2 production but not other T-cell activation events.
Alfaro-Bustamante et al. (1997)interleukin-2T lymphocytesEffect of phorbol myristate acetate (PMA) and ionophore A23187 on interleukin-2 levels and proliferation of activated T lymphocytes from patients with lepromatous leprosy.
Terao and Fukase (1991)interleukin-2T cellEffects of hyperlipaemic serum on interleukin-2 (IL-2) production, IL-2 receptor expression, and T cell proliferation induced by IL-2 in cynomolgus monkeys.
Bhayani and Falcoff (1985)interleukin 2T-cellT-cell surface antigens defined by monoclonal antibodies, involved in the induction of human interferon-gamma and interleukin 2.
Kashiwado et al. (1987)IL-2T lymphocyteThe observed inhibition of both IL-2 synthesis and IL-2 response suggests that the target of the inhibition was the T lymphocyte.
Larsen et al. (1988)interleukin 2T lymphocytesModulation of high-affinity interleukin 2 receptors on activated human T lymphocytes by activators of protein kinase C.
Whisler et al. (1996)IL-2T cellsThe resting and stimulated levels of NF kappa B were reduced in T cells from certain elderly individuals; however, alterations of NF kappa B did not correlate with changes in IL-2 expression.
Paliogianni and Boumpas (1996)IL-2T cellsThese results suggest that cAMP regulates IL-2 production in human T cells by a transcriptional mechanism which involves discrete transactivating pathways for IL-2-promoter activation.
Schluesener et al. (1990)interleukin-2T cellThe cytokines have identical effects inhibiting activation of most T line cells and the activation-dependent changes in interleukin-2 (IL-2) receptor and T cell receptor expression.
Filion et al. (1995)IL-2T cellsAltogether, these results suggest that the tolerance of GpIIb-IIIa autoreactive T cells from healthy individuals could involve post-transcriptional regulation of IL-2 expression.
Gerber et al. (1985)IL-2T lymphocyteIn order to explain the mechanism of enhancing effect of irradiation on IL-2 production, assumption that radio-induced free radicals could act as a signal for mitogenesis and/or increase lipid peroxidation of T lymphocyte membrane phospholipids was made.
Li et al. (1991)interleukin 2T cellsDifferential regulation of transforming growth factor beta and interleukin 2 genes in human T cells: demonstration by usage of novel competitor DNA constructs in the quantitative polymerase chain reaction.
Li et al. (1991)interleukin 2T cellThe regulation of mRNA encoding transforming growth factor beta (TGF-beta) and interleukin 2 (IL-2) in normal human T cells was explored using novel competitor DNA constructs in the quantitative polymerase chain reaction and accessory cell-independent T cell activation models.
Marcoulatos et al. (1996)IL-2 geneNFATSeveral transcription factors regulate IL-2 gene expression, including the nuclear factor of activated T cells (NFAT).
Bartik et al. (1994)IL-2T cellsIn the present study, experiments were performed to determine how costimulatory signals modulate the inhibitory effects of cAMP-elevating agents on proliferation and interleukin 2 (IL-2) secretion by anti-CD3 mAb-stimulated T cells.
Aussel et al. (1990)interleukin-2T lymphocytesRegulation of interleukin-2 production and phosphatidylserine synthesis in Jurkat T lymphocytes by K+ channel antagonists.
Auberger et al. (1989)IL2T-lymphocyteOur results imply that a chymotryptic-type serine protease plays an active role in the regulation of IL2 synthesis and thus in the whole process of T-lymphocyte activation.
Tenbrock and Tsokos (2004)interleukin 2T cellsTranscriptional regulation of interleukin 2 in SLE T cells.
Tenbrock and Tsokos (2004)IL-2T cellsThis article will review the defective transcription regulation of IL-2 in SLE T cells, which is the result of decreased expression of the enhancers NF-kappa B and AP1 and the increased expression of the transcriptional repressor CREM.
Lotz et al. (1986)IL 2T cellIn contradistinction, IFN-gamma secretion is exclusively of T cell origin, is absolutely dependent on the prior elaboration of IL 1 and IL 2, and is maximal 8 days after EBV infection.
Lieberman and Tsokos (2010)IL-2T cellsTranscription factors regulating IL-2 production behave aberrantly in SLE T cells.
Roth and Dröge (1991)interleukin 2T lymphocytesRegulation of interleukin 2 production, interleukin 2 mRNA expression and intracellular glutathione levels in ex vivo derived T lymphocytes by lactate.
Marcoulatos et al. (1998)IL-2 geneNFATSeveral transcription factors regulate IL-2 gene expression, including the nuclear factor of activated T cells (NFAT).
Hooi et al. (2004)interleukin-2T-cellIn the present study, we have determined the comparative effects of two chemically distinct and endobronchially detectable QSSM, N-(3-oxododecanoyl)-L-homoserine lactone (3-oxo-C12-HSL) and 2-heptyl-3-hydroxy-4 (1H)-quinolone or the Pseudomonas quinolone signal (PQS), on human leukocytes exposed to a series of stimuli designed to detect differential immunological activity in vitro. 3-Oxo-C12-HSL and PQS displayed differential effects on the release of interleukin-2 (IL-2) when human T cells were activated via the T-cell receptor and CD28 (a costimulatory molecule). 3-Oxo-C12-HSL inhibited cell proliferation and IL-2 release; PQS inhibited cell proliferation without affecting IL-2 release.
Krönke et al. (1987)IL-2T-cellThus, IL-2 receptor gene regulation controls IL-2 receptor expression at the cell surface and is intimately linked to the control of T-cell proliferation.
Rossi et al. (1988)IL2T-cellIn normal controls, we demonstrated that IL2 secretion per T-cell from BM was 5.4-fold greater than that from normal PB, suggesting a very efficient role of accessory cells controlling IL2 production in normal BM.
Kabuki et al. (1990)IL2T cellsSaibokuto-pretreated adherent cells failed to present Df antigen to non-adherent responding T cells for induction of their IL2 responsiveness.
Kabuki et al. (1990)IL2T cellSaibokuto-pretreated adherent cells failed to present Df antigen to non-adherent responding T cell for induction of their IL2 responsiveness.
Kabuki et al. (1990)IL2T cellSaibokuto-pretreated adherent cells failed to present Df antigen to non-adherent responding T cell for induction of their IL2 responsiveness.