Viewing negative mentions of regulation of IL2 (H. sapiens) in T cells

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Gulino et al. (1990)IL-2 geneT cellsPhorbol ester and calcium ionophore did not modulate the expression of the transfected IL-2 gene in NIH-3T3 and HeLa cells, while these agents increased its expression in transfected BFS lymphoma T cells.
Gmünder et al. (1990)IL-2 mRNAT cellAs in cultures of splenic T cells, GSH depletion had no substantial effect on the induction of IL-2 mRNA and TCGF production in several mitogenically stimulated T cell clones.
Shimizu et al. (1988)interleukin-2T cellsIn contrast, surfactant had no effect on pokeweed-mitogen (PWM, T cell-dependent B lymphocyte mitogen)-induced DNA synthesis or on interleukin-2 (IL-2) receptor expression on T cells activated with PHA, Con A or PWM.
Creemers et al. (1986)IL-2T cellsWe conclude that a defect in IL-2 production is associated with human T-cell lymphotropic virus III infection, but that the expression of the IL-2 receptor on T cells is not greatly affected.
Kucharz et al. (1988)IL-2T-cellsLithium did not influence the expression of IL-2 receptors on T-cells.
Kucharz and Sierakowski (1990)interleukin 2T cellsIsoniazid did not affect the expression of interleukin 2-receptors on the surface of T cells, except a slight decrease in cells exposed to high levels of the drug.
Sugimura et al. (1989)interleukin 2T lymphocytesA cytokine, lymphocyte blastogenesis inhibitory factor (LBIF), arrests mitogen-stimulated T lymphocytes at early G1 phase with no influence on interleukin 2 production and interleukin 2 receptor light chain expression.
Kogkopoulou et al. (2006)IL-2T cellsIn contrast, IL-2 levels were not affected significantly when strong stimulation was provided to T cells.
Batten et al. (1999)IL-2T cellsIn contrast, addition of B7-1 transfectants to T cells/PAEC had no effect either on T cell proliferation, IL-2 production, or CsA resistance.
Stünkel et al. (1991)IL-2T cellCIP alone had no influence on the basal release of IL-2 by NOB-1 cells, a T cell line that responds to IL-1 with an increase in IL-2 synthesis, but, in combination with recombinant IL-1, CIP significantly enhanced the release of IL-2 by these cells.
Commes et al. (1986)IL-2T cellThe fact that IL-2 production was not affected in MM, in spite of an imbalance of some T cell subsets, is of major interest.
Sidell et al. (1984)IL-2T-cellRA treatment of thymus cells did not affect IL-2 production nor IL-2-dependent T-cell blast growth.
June et al. (1989)IL-2 geneT-cellIn contrast, IL-2 gene expression and T-cell proliferation induced by CD28 MoAb plus PMA were unaffected by cyclosporine.
Lipkowitz et al. (1984)IL 2T lymphocytesIn contrast, proliferation of T lymphocytes committed to proliferate was not affected by IL 2 receptor blockade with the anti-Tac antibody.
Chandy et al. (1984)IL-2T lymphocyteThe expression of the IL-2 receptor (Tac) during T lymphocyte activation was not altered by K channel blockers, whereas the production of interleukin 2 (IL-2) was reduced to the level in unstimulated T lymphocytes.
Lewis et al. (1993)IL-2T cellsTherefore, PDE inhibitors do not affect synthesis of IL-2 mRNA in this model of activated T cells.
Upham et al. (1997)IL-2T cellDespite inhibiting proliferation, alveolar macrophages had little or no effect on T cell calcium flux, the characteristic changes in CD3, CD2, CD28 and interleukin-2 (IL-2) receptor expression which accompany normal T cell activation, and IL-2 and interferon gamma secretion.
Kelleher et al. (1988)IL-2T cellsWe conclude that PMA can stimulate IL-2 secretion independent of the translocation of PKC activity, and suggest that there is an alternative mechanism of action for phorbol esters in activated T cells.
Lindstein et al. (1989)IL-2T cellThis pathway does not directly affect the steady-state messenger RNA level, transcription, or messenger RNA half-life of other T cell activation genes, including c-myc, c-fos, IL-2 receptor, and the 4F2HC surface antigen.
Dumont et al. (1988)IL-2T-cellAddition of the H-22.10 mAb at the initiation of such stimulated T-cell cultures was found to prevent the augmentation of TAP but not to affect the emergence of IL-2 receptors or the increase of Pgp-1 expression.
Luger et al. (1986)IL 2T lymphocytesIn contrast, in vitro IL 2 production by T lymphocytes was not altered in septic patients.
Lahat et al. (1989)IL-2T-cellPA-negative CF patients, however, also had functional T-cell defects and inhibitory sera, but these sera did not affect IL-2 pathways.
Chouaib et al. (1985)IL 2T cellIn contrast to its effect on peripheral blood lymphocytes, PGE2 had no effect on transferrin receptor expression or cell proliferation by IL 2-dependent T cell clones and IL 2-independent T cell lines.
Li and Pauza (2009)IL2T cellIn contrast, rosiglitazone did not affect Erk activation but the IL2 signaling pathway, which accounts for rosiglitazone suppression of IL2-dependent, Vdelta2 T cell proliferation without affecting TCR-dependent functions.
Makedonas et al. (2010)IL-2T cellsIn our data set, however, the contribution of IL-2 from naïve CD8+ T cells in response to SEB stimulation is minimal compared to the antigen-experienced cells (not shown), and does not change the relationship we observe between IL-2 and perforin.
Powell et al. (1999)IL-2T cellTo better define the cellular events that lead to the induction of anergy, we used the immunosuppressive agent rapamycin, which blocks T cell proliferation in late G1 phase but does not affect costimulation-dependent IL-2 production.
Hooi et al. (2004)IL-2T-cellIn the present study, we have determined the comparative effects of two chemically distinct and endobronchially detectable QSSM, N-(3-oxododecanoyl)-L-homoserine lactone (3-oxo-C12-HSL) and 2-heptyl-3-hydroxy-4 (1H)-quinolone or the Pseudomonas quinolone signal (PQS), on human leukocytes exposed to a series of stimuli designed to detect differential immunological activity in vitro. 3-Oxo-C12-HSL and PQS displayed differential effects on the release of interleukin-2 (IL-2) when human T cells were activated via the T-cell receptor and CD28 (a costimulatory molecule). 3-Oxo-C12-HSL inhibited cell proliferation and IL-2 release; PQS inhibited cell proliferation without affecting IL-2 release.
Saito et al. (1990)interleukin-2T cellPregnancy zone protein inhibits production of interleukin-2 but does not affect interleukin-2 receptor expression on T cell activation.
Turka et al. (1991)IL-2T cellEarly events in T cell activation, as assessed by steady-state mRNA levels of c-myc, IL-2, c-myb, histone, and cdc2 kinase, as well as surface IL-2 receptor expression, were unaffected.
Canonica et al. (1985)IL-2T-cellThe experiments reported herein suggest that in general the T cell proliferation in AMLR is not completely dependent on the presence of IL-2 in the cultures and that aged subjects are probably defective in the production of other factor(s) presumably involved in AMLR proliferation, since the addition of exogenous IL-2 does not produce T-cell proliferation comparable to normal young subjects.
Gerosa et al. (1986)Interleukin-2T-cellInterleukin-2 production in response to phytohemagglutinin is not necessarily dependent upon the T3-mediated pathway of T-cell activation.
Craddock et al. (2007)IL-2T cellThere was no significant difference in the production of IL-2 by patient and control T cells stimulated with plate-bound anti-CD3 at concentrations of 0 µg/ml, 0.01 µg/ml, 0.1 µg/ml and 1 µg/ml (figure 4A), demonstrating that insufficient IL-2 production is not responsible for lower T cell proliferative responses observed in schizophrenia patients.
Inaba and Geiger (2006)IL-2T cellsThus, refractory T cells are able to suppress naive T-cell proliferative responses in part by blocking both IL-2 production and the mitogenic but not anti-apoptotic effects of IL-2.
Seder et al. (1995)IL-2T cellsAddition of IL-2 or IL-15 to short-term in vitro cultures of either PBMCs or CD4+ T cells had little effect on IL-2, IL-4, or IFN-gamma production.
Tovar et al. (2002)IL-2T-lymphocytesThe biochemical deficiency did not affect production nor mRNA expression of IL-2 from T-lymphocytes stimulated in vitro with PHA compared with the control group.
Nishi et al. (1997)IL-2T lymphocytesEffects of lyso-PC on T lymphocytes appear to be selective and specific, since lyso-PC also increases interleukin (IL)-2 receptor expression but does not affect mRNA levels for IL-2 or IL-4.
Tamma et al. (1996)IL-2T cellL-cycloserine also inhibited T cell mitogen responses without affecting IL-2 production.
Habicht et al. (1995)interleukin-2T cellAttempts at improving primary T cell activation revealed that exogenous cytokines, including interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and interleukin-2 (IL-2), were not effective.
Tomai et al. (1992)IL-2T cellFixation of APC by paraformaldehyde (PF) treatment impaired their ability to induce optimal T cell proliferation in response to pep M5 without significantly affecting interleukin (IL-2) production.
Grove et al. (1995)IL-2T cellFor splenocytes and LNL from flight (FLT) animals, IL-2 production decreased in response to the T cell receptor-independent mitogen 12-O-tetradecanoylphorbol-13-acetate plus ionomycin, but was not affected by stimulation with the T cell receptor-dependent mitogens Concanavalin A or phytohemagglutinin.
Asano et al. (2001)IL-2T cellsRXM also had no effect on IL-2 and IFN-gamma secretion by T cells prepared from both healthy and allergic rhinitis donors.
Bayley et al. (2003)IL-2T cellIn contrast to the results reported in mouse T cell clones and single human T cells, we found no evidence for the monoallelic expression of the IL-2, IL-3, and IL-13 genes.
Kashiwakura et al. (1999)IL-2T cellsAntisense oligodeoxynucleotide of Txk specifically inhibited IFN-gamma production of normal peripheral blood lymphocytes, antigen-specific Th1 clones, and Th0 clones; IL-2 and IL-4 production by the T cells was unaffected.
Craddock et al. (2007)IL-2T cellsLower proliferative responses in patient T cells is not a result of lower IL-2 production or lower expression of the IL-2 receptor CD25
Uchiyama et al. (1984)IL-2T cellsIL-2 receptors on ATL cells, unlike normal activated T cells, were not modulated (down-regulated) by anti-Tac antibody.
Munakata et al. (1999)IL-2T-cellRESULTS: Terfenadine inhibited T-cell proliferation and IL-4 and IL-5 production under each costimulatory condition tested, whereas it had no effect on IL-2 and IFN-gamma production.
Hathcock et al. (1994)interleukin 2T cellExpression of B7-2 on these B cell populations was significantly higher than expression of B7-1 at all times assayed after stimulation; (c) blocking of B7-2 costimulatory activity inhibited TCR-dependent T cell proliferation and cytokine production, without affecting early consequences of TCR signaling such as induction of CD69 or interleukin 2 receptor alpha (IL-2R alpha); and (d) expression of B7-1 and of B7-2 can be regulated by a variety of stimuli.
Sakata-Kaneko et al. (1998)IL-2T cellsWe found that lyso-PC increased IFN-gamma production and CD40L expression in CD4+ T cells stimulated with anti-CD3 Ab and recombinant CD80 molecules, whereas lyso-PC did not affect IL-2 and IL-4 production.
Gidlund et al. (1992)IL-2T cellThe suppression of the specific T cell response was reversed by the addition of anti-CD3, did not affect the proliferative response to IL-2, and was independent of the amount of antigen.
Leenaerts et al. (1992)IL-2T cellsMoreover, in PBMC-stimulated cultures exogenous IL-6 and IL-1 or antisera to these lymphokines did not significantly alter proliferative responses, cytotoxicity, IL-2 levels in the supernatant, or IL-2R expression on responder T cells.
June et al. (1989)lymphokineT cellsFurthermore, these studies suggest that lymphokine production in T cells is not controlled by an "on/off" switch, but rather, that CD28 regulates a distinct intracellular pathway which modulates the level of IL-2 production on a per cell basis.
Fabricius and Stahn (1980)TCGFT-cellsThe continuously growing T-cells are unable to produce TCGF and depend strictly on external supply of the growth factor.
Shi et al. (1992)lymphokineT cellAntisense oligonucleotides corresponding to c-myc block the constitutive expression of c-Myc protein in T cell hybridomas and interfere with all aspects of activation-induced apoptosis without affecting lymphokine production in these cells.
Schwartz et al. (1992)IL-2T-cellThe levels of expression of cell surface molecules involved in T-cell functions (CD4, CD3, CD28, CD29, IL-2 receptor) were not modified in cell populations expressing Nef.
Lewis et al. (1988)interleukin 2T-cellIn murine helper (CD4+) T-cell clones IL-4 production appears to be regulated independently of interferon gamma and interleukin 2.
Kelley et al. (2001)IL-2T cellsNor did it alter the percentage T cells producing IL-2, interferon gamma, and percentage of monocytes producing TNFalpha.
Balaji and Nayak (1997)IL-2T cellsIn this report, we show that 5-Fluorouracil increases the Interleukin-1 expression upto 2.66 folds without significantly affecting the levels of surface expression of p55 IL-2 receptor on human Peripheral blood mononuclear cells, CD4 and CD8 T cells.
Damle and Doyle (1989)IL-2T cellsWhen examined for their effects on cytokine production, CD3-dependent production of IL-2 and IFN-gamma was affected by neither cytokine, whereas IL-4 strongly inhibited the production of IFN-gamma by IL-2-stimulated T cells.
Shenker et al. (1990)interleukin-2T cellsFirst, ISF failed to alter either the synthesis of interleukin-2 (IL-2) or the expression of IL-2 receptors on T cells.
Tsuyuguchi (1990)IL-2T cellThis depressed T cell response was due to depressed interleukin-2 (IL-2) production and not due to depressed IL-2 responsiveness.
Nagy et al. (1994)IL-2T cellsMoreover, concurrent treatment of partially purified T cells (> 90% CD3+) with PHA and rIL-12 selectively enhanced IFN-gamma mRNA stability and protein production, while IL-2 protein and mRNA levels were unaffected.
Wojtulewicz-Kurkus et al. (1978)lymphokineT cellsA significant impairment of skin reactivity and the lowering of the number of T cells were found, while no definite changes of lymphokine production were detected.
Miglio et al. (2005)IL-2T cellD-(-)-2-Amino-5-phosphonopentanoic acid (D-AP5), and (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine [(+)-MK 801], competitive and non-competitive NMDA receptor antagonists, respectively, inhibited PHA-induced T cell proliferation, whereas they did not affect IL-2 (10 U/ml)-induced proliferation of PHA blasts.
Witsch et al. (2002)IL-2T cellsOn coculture of "naive"CD4(+) T cells with mature DC in the presence of superantigen, ICOS was highly up-regulated on T cells, but played only a secondary role in the CD28-dominated release of TNF-alpha and IFN-gamma, and did not participate in the induction of IL-2.
Gertsch et al. (2003)Interleukin-2T cellsInterleukin-2 (IL-2), and-6 (IL-6) mRNAs levels were not influenced markedly by curcumin in stimulated PBMCs, but significantly reduced in stimulated Jurkat T cells.
González et al. (1994)IL-2T cellsWe conclude that in patients with laryngeal carcinoma there is a phenotypic alteration of the T cells that is variable according to tumor stage, without functional alterations in blastogenic capacity or IL-2 production.
Rogers et al. (1997)IL-2T cellsWhen peptide was administered i.v. without adjuvant, 50% of the Ag-specific cells expressed IL-2, but the peak of expression occurred before IL-2 receptor alpha-chain up-regulation, and only a minority of the Ag-specific T cells underwent blast transformation.
Kaufmann and Berke (1983)IL 2T cellUnfractionated Con A supernatants, containing IL 2 and other factors known to influence T cell responsiveness, or IL 2-containing media of stimulated hybridomas affect neither the growth nor the lytic activity of the hybridomas.
Putheti et al. (2010)IL-2T cellstreated resting memory CD4+ T cells (Fig 3A), it is not totally unexpected that addition of IL-2 to cultures of resting memory CD4+CD25?
Kowalczyk et al. (1986)lymphokineT cellsThis regulatory effect of cancer patients' monocytes on lymphokine production was independent of the initial potential of T cells to produce TIF.
Schmitt et al. (1995)interleukin-2T-lymphocyteMitogen-induced T-lymphocyte proliferation and interleukin-2 receptor expression were not altered significantly.
Attali et al. (1992)interleukin 2 mRNAT cellWhile charybdotoxin has no effect on interleukin 2 mRNA induction, clofilium potently inhibits interleukin 2 mRNA expression upon mitogen-induced T cell activation.
Brown et al. (1988)IL-2T cellsAlthough IL-4 stimulation of T cells is independent of IL-2, IL-4 plus PMA treatment of resting T cells does cause enhanced expression of IL-2R and prepares cells to proliferate to IL-2 alone.
Higuchi and Fujii (2009)IL-2T-cellsHow does the Tax1 PBM play a role in persistent HTLV-1 infection in vivo without affecting the IL-2-dependent immortalization of primary T-cells?
Maecker (2003)IL-2T cellAs such, essentially no effect was observed on CD8 (CD3+CD4-) T cell IL-2 production (panels D and H).
Hu et al. (1999)IL-2T cellsRESULTS: The supernatant of the cultured non-immunological cells of decidua can inhibit the immunological function of T cells, natural killer cells and B cells to different extents, their maximum inhibiting ratio were 22.7%, 52.3% and 14.8% respectively, but there is no significant effect on the IL-2 secretion by lymphocytes.
Böhler et al. (2008)Il-2T-lymphocytesIn contrast Tabebuia exerted no effects on cytokine expression (Il-2 and TNF-alpha) by PMA/Ionomycin stimulated T-lymphocytes.
Dawson et al. (2008)IL-2T cellsMore interestingly, while we have also observed increased activation and proliferation by human T cells upon culture with RAR agonists, no significant changes in the production of IL-2 (another type 1 cytokine) were observed post RAR agonist treatment in our hands (data not shown).
Hutchcroft et al. (1995)IL-2T cellsIn addition, we have found that wortmannin, a potent inhibitor of PI3 kinase, does not interfere with the induction of IL-2 after stimulation of Jurkat T cells with anti-CD28 monoclonal antibody and PMA.
Loza et al. (2010)IL-2T cellTotal T cell numbers did not significantly change in PBL from both control and asthmatic subjects in cultures with IL-2 (Figure 3A).
Ting et al. (1992)IL-2T cellCulturing CD3-AK cells in GSH did not change the distribution of T cell subsets, did not affect the cells' ability to produce lymphokine (IL-2), and did not induce suppressor cells.
Zhang et al. (2004)IL-2T cellsIn this study, we show that adenosine suppressed IL-2-dependent proliferation of CTLL-2 T cells by inhibiting STAT5a/b tyrosine phosphorylation that is associated with IL-2R signaling without affecting IL-2-induced phosphorylation of Jak1 or Jak3.
von Freeden et al. (1991)IL-2T cellsNeonatal and adult T cells showed no difference in the expression of the 55-kD alpha and 75-kD beta chains of the IL-2 receptor.
Godar and Lucas (2005)IL-2T cellsDuring UVA1-triggered immediate apoptosis of Jurkat T cells, IFN-gamma levels increased in a dose-dependent manner at 4 h, but returned to baseline levels at 24 h post-exposure, whereas, there was no significant change in IL-2 at 4 or 24 h.
Tanaka et al. (1995)IL-2T cellConcerning T cell surface molecule gene expression in our modified MLC, IL-2 receptor gene expression was not altered so much in allo BMT patients, however, CD28 and CTLA-4 gene expression were elevated in patients with graft failure and severe acute GVHD.
Wang et al. (1999)IL-2T lymphocytesThe antagonists based on the neurotensin-VIP hybrid molecule did not affect the inhibitory effect of VIP/PACAP on IL-2 and IL-10 production, confirming that astrocytes and T lymphocytes express different receptors.
Zheng et al. (2004)IL-2T cellsThe proliferating CD4(+)CD25(+) T cells produce no detectable IL-2, suggesting that 4-1BB costimulation of these cells does not involve IL-2 production.