Viewing affirmative mentions of gene expression of IFNG (B. taurus) in T cells

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Weynants et al. (1998)IFN-gammaT-cellsMoreover, this method could be used to estimate the number of T-cells specifically producing IFN-gamma.
Ishikawa et al. (1994)IFN-gammaT cellIFN-gamma production was apparently suppressed by treatment of the PBMC with MoAb to bovine pan-T cell.
Suomalainen et al. (1993)IFN-gammaT-cellsOur results indicate that the maturation of IFN-gamma producing T-cells is delayed in CMA, which could lead to a disturbance in the regulation of T-cell function.
Kubota et al. (1999)IFN-gammaT cellsThis finding may indicate the presence of drug-specific IFN-gamma producing T cells in patients with an anaphylactic shock reaction to medication.
Sato et al. (1997)IFN gammaT cellsTh1 type T cells, which produce IFN gamma, and extrathymic T cells may play an important role in immunological control system of liver regeneration after PHx on the basis of the cellular immunity restricted by MHC class I and II molecules.
Nagata et al. (2010)Interferon-gammaT-cellsIt has been also indicated that blood cells from calves infected with Mycobacterium avium subsp. paratuberculosis (Map) produce a large amount of IL-10 after stimulation with Map antigen, and it leads to suppression of Interferon-gamma (IFN-gamma) production in T-cells.
Chernyshov (2009)interferon-gammaT cellsB7-2/CD28 costimulatory pathway in children with atopic dermatitis and its connection with immunoglobulin E, intracellular interleukin-4 and interferon-gamma production by T cells during a 1-month follow-up.
PĂ©rez-Ilzarbe et al. (2009)interferon-gammaT cellsProduction of interferon-gamma was inhibited by cocultured media with MSCs while MSCs also induced a significant inhibition of cell cycle in T cells.
Pasquali et al. (2006)interferon-gammaT lymphocytesHowever, when rBoIL-12 was subcutaneously administered daily from 2 days before infection to 2 days after infection, a consistent increase of T lymphocytes and an higher expression of interferon-gamma (IFN-gamma) was detected.
Van Kleef et al. (2002)interferon-gammaT-cellsLow molecular weight proteins of Cowdria ruminantium (Welgevonden isolate) induce bovine CD4+-enriched T-cells to proliferate and produce interferon-gamma.
Sathiyaseelan et al. (2002)IFN-gammaT cellsWhen intracytoplasmic staining for interferon-gamma (IFN-gamma) was also used here to assess activation through CD3, a small proportion of gammadelta T cells (approximately 14%) produced IFN-gamma during the first 4 h of culture and by 72 h of culture that number had doubled.
Sathiyaseelan et al. (2002)IFN-gammaT cellsBy comparison, a much larger proportion of CD4 and CD8 T cells stimulated with anti-CD3 mAb divided and although the percentage of CD4 and CD8 T cells that produced IFN-gamma at 4 h was similar to that of gammadelta T cells, by 72 h the majority of CD4 and CD8 T cells were IFN-gamma(+).
Asano et al. (1998)interferon-gammaT cellAs compared with mice treated with saline, TWH extract administered orally at doses of more than 400 microg kg(-1) once a day for 14 days inhibited the ability of inguinal lymph node cells to produce T cell cytokines interleukin-2 and interferon-gamma when the cells were obtained from mice 21 days after immunization and cultured in vitro with C II.
Osterlund and Suomalainen (2002)interferon-gammaT cellsLow frequency of CD4+, but not CD8+, T cells expressing interferon-gamma is related to cow's milk allergy in infancy.
Kakumu et al. (1988)IFN-gammaT cellsThe normal expression of IFN-gamma receptors on T cells from CAH may provide a reasonable basis for IFN-gamma therapy to type B CAH.
Bel'ski? et al. (2004)interferon-gammaT-cell[Ehrlich tumor cells stimulate T-cell production of interferon-gamma and are resistant to autocrine nitric oxide].
Bel'ski? et al. (2004)interferon-gammaT-cellEhrlich tumor cells released factors which activated T-cell production of interferon-gamma and triggered a mechanism of nitric oxide (NO) production instead of interferon-gamma.
Otsubo et al. (1988)interferon-gammaT cellsIn order to investigate the cellular interactions among thyrocytes, T cells and monocytes in thyroid glands from patients with Graves' disease, we determined alterations of HLA-DR antigen expression on thyrocytes and T cells, and the production of interferon-gamma during coculture of thyrocytes, T cells and monocytes obtained from patients with Graves' disease.
Otsubo et al. (1988)interferon-gammaT cellsIn culture supernatants, interferon-gamma was detected in 4 of 14 cocultures of thyrocytes and T cells, in 5 of 10 cocultures of thyrocytes, T cells and monocytes, but not in any cultures of thyrocytes alone, T cells alone and T cells and monocytes.
Otsubo et al. (1988)interferon-gammaT cellsThese results suggest that HLA-DR antigen positive thyrocytes are able to induce the HLA-DR antigen expression of T cells in the presence of monocytes, and the activated T cells are capable of producing interferon-gamma which acts on thyrocytes to induce and maintain the expression of HLA-DR antigens.
Collins et al. (1998)IFNgT cellsAnalysis of the T cell subsets by flow cytometry showed that CD4+ T cells comprised the largest contributors to IFNg production.
Collins et al. (1998)IFNgT cellsThe WC1 + gd T cells did not appear to contribute to the production of IFNg.
Marth et al. (2004)interferon-gammaT cellsBACKGROUND: Epithelial ovarian cancer prognosis is improved by the presence of intratumoral CD3 + T cells, which are known to produce interferon-gamma.
Marth et al. (2004)interferon-gammaT-lymphocytesWe therefore speculated that interferon-gamma expression in ovarian cancer-infiltrating T-lymphocytes might cause better prognosis.
Hagiwara et al. (2008)IFN-gammaT cellsThese results suggest that the CD8-positive T cells in colostrum play a role as producers of IFN-gamma.
Bassey and Collins (1997)IFN-gammaT lymphocytesThese data for cattle are similar to observations made for other animal species, where CD4+ cells are the major type of T lymphocytes producing IFN-gamma.
Bassey and Collins (1997)IFN-gammaT cellsThey further suggest that whatever the role gammadelta+ T cells may play in paratuberculosis, it is not likely to be mediated by IFN-gamma production.
Vesosky et al. (2004)Gamma interferonT cellsGamma interferon production by bovine gamma delta T cells following stimulation with mycobacterial mycolylarabinogalactan peptidoglycan.
Vesosky et al. (2004)gamma interferonT cellsThis study investigated the ability of bovine gamma delta T cells to expand and produce gamma interferon (IFN-gamma) in response to stimulation with mycobacterial products.
Naiman et al. (2001)IFN-gammaT cellsTwo-color immunofluorescence revealed that one-third of the IFN-gamma-producing cells were gammadelta T cells, with the remaining cells being CD4(+) T cells.
Weynants et al. (1998)gamma-interferonT-lymphocytesQuantitative assessment by flow cytometry of T-lymphocytes producing antigen-specific gamma-interferon in Brucella immune cattle.
Campbell et al. (1998)IFN gammaT cellThus by controlling T cell IFN gamma production, the parasite induces a "window" of cytokine expression which promotes its own growth, but avoids potential inhibitory effects of the cytokine.
Baldwin et al. (2002)IFN-gammaT cellsActivation of bovine peripheral blood gammadelta T cells for cell division and IFN-gamma production.
Baldwin et al. (2002)IFN-gammaT cellsBovine peripheral blood gammadelta T cells have been evaluated for effector function (IFN-gamma production) and clonal expansion in a variety of systems including following activation by mitogens, IL-12, and stimulation, through the T cell receptor (TCR) with anti-CD3 monoclonal antibody (mAb), a cell-bound molecule and a soluble antigenic extract.
Baldwin et al. (2002)IFN-gammaT cellsIt was found that bovine gammadelta T cells produced IFN-gamma and clonally expanded when stimulated through the TCR/CD3 complex by a cell-associated autologous molecule on monocyte, by bacterial components following in vivo sensitization of gammadelta T cells with a leptospira vaccine or by anti-CD3 mAb.
Baldwin et al. (2002)IFN-gammaT cellsIn several systems the amount of IFN-gamma produced per cell by gammadelta T cells was less than that produced by CD4 T cells in the same cultures.
Van Kleef et al. (2002)IFN-gammaT-cellProteins of molecular weights 13-18kDa induced the CD4+-enriched T-cell cultures, derived from each of the animals, to proliferate and produce IFN-gamma.
Kobayashi et al. (2004)IFN-gammaT cellsThe reduced IFN-gamma production was observed only in V(alpha)24 NKT cells and not conventional CD4 T cells, but was normal in patients with remitting disease, suggesting that non-remitting sarcoidosis involves an insufficient IFN-gamma production of V(alpha)24 NKT cells which is well correlated with disease activity.
Walravens et al. (2002)IFN-gammaT-cellAnalysis of the antigen-specific IFN-gamma producing T-cell subsets in cattle experimentally infected with Mycobacterium bovis.
Walravens et al. (2002)IFN-gammaT-cellsTwo colour immunofluorescence staining of intracellular IFN-gamma and bovine cell surface molecules showed that both CD4+ and CD8+, but not WC1+, T-cells produced IFN-gamma following stimulation with PPD, live or killed BCG.
Walravens et al. (2002)IFN-gammaT-cellsMagnetic positive selection of T-cells from infected animals showed that CD4+ T-cells produced specific IFN-gamma only in the presence of antigen presenting cells (APCs).
Walravens et al. (2002)IFN-gammaT-cellsIn vitro depletion of the CD4+ T-cells, but not the depletion of CD8+ or WC1+ T-cells, resulted in abrogation of the specific IFN-gamma production showing the key role of this cell population for the specific IFN-gamma production.
Shimojo et al. (1996)interferon-gammaT cellsDiminished interferon-gamma (IFN-gamma) production by bacterial antigen-specific T cells in atopic patients.
Shimojo et al. (1996)IFN-gammaT cellsActivation of PPD-specific TCL from patients with calcium ionophore A23187 plus phorbol myristate acetate resulted in much higher IFN-gamma production than in TCL established from healthy controls, indicating that the low production of IFN-gamma by PPD-specific T cells from atopic patients is not due to an intrinsic T cell defect but to some regulatory mechanisms.
Platt et al. (2006)interferon-gammaT-cellSpecific T-cell responses were evaluated by comparing CD25 upregulation and intracellular interferon-gamma expression by 5-color flow cytometry.
Lutje et al. (1995)IFN-gammaT-cellAs parameters of T-cell-mediated immunity, we measured T-cell proliferation and IFN-gamma production.
Van Rhijn et al. (2007)IFN-gammaT cellsThe gammadelta T cells could not be induced to produce IFN-gamma, TNF-alpha, and IL-10, and they did not express costimulatory molecules, IL-2 receptor, and MHC Class II molecules.
Lara-Villoslada et al. (2004)interferon-gammaT cellsCytokine production by spleen derived T cells showed a Th2 response with high levels of interleukin-4 production and low levels of interferon-gamma in cow milk-sensitized mice.
Goff et al. (1998)interferon-gammaT cellsIn addition, we used RT-PCR to assess the contribution of gammadelta T cells as a source of interferon-gamma (IFN-gamma), the induction signal for iNOS.
Bethune et al. (2009)interferon-gammaT-cellAt saturating levels of interferon-gamma, activated T-cell media does not further increase transepithelial peptide flux, indicating the primacy of interferon-gamma as an effector of increased epithelial permeability during inflammation.
Akashi and Mizuno (2000)interferon-gammaT cellsIn the primary infection of EBV, T cells infected with the episomal form of EBV sometimes produce a high amount of interferon-gamma that may lead to the occurrence of hemophagocytic lymphohistiocytosis.
Amills et al. (2002)interferon-gammaT cellsThe role of T-helper (Th) responses in the subclinical progression of bovine leukemia virus (BLV) infection was explored by determining the contribution of CD4+ T cells to the expression of mRNAs encoding interferon-gamma (IFN-gamma), interleukin-2 (IL-2), interleukin-4 (IL-4), and interleukin-10 (IL-10) in BLV-infected cattle.
Amills et al. (2002)IFN-gammaT cellsIn contrast, Con A stimulated PBMCs and CD4+ T cells did not differ significantly in expression of IFN-gamma, IL-2, IL-10, or IL-4 mRNAs among the BLV infection groups.
Werfel et al. (1996)interferon-gammaT cellsThe notion that the majority of allergen-specific, skin-infiltrating T cells are capable of producing interferon-gamma further supports the concept that interferon-gamma expression has major pathogenetic relevance for the chronic phase of atopic dermatitis.
Mwangi et al. (1998)IFN-gammaT-cellStrong expression of IFN-gamma, tumor necrosis factor alpha (TNF-alpha), TNF-beta, and IL-2 receptor alpha-chain mRNA was detected in T-cell lines 48 h after antigen stimulation.
Gaddum et al. (2003)IFN-gammaT cellsBRSV protein recognition by CD8+ T cells was analysed using cytotoxic T lymphocyte (CTL) assays or by the production of interferon-gamma (IFN-gamma) following restimulation with BRSV proteins.
Olsen and Storset (2001)IFN-gammaT-cellIn contrast, APC/T-cell contact was necessary to induce the IFN-gamma production in infected animals, suggesting that both innate and adaptive IFN-gamma production in response to MPP14 could occur.
Klevar et al. (2007)IFN-gammaT cellsA whole blood flow cytometric assay showed that CD4+ T cells were the major IFN-gamma producing cells, but in the early stages of the infection both NK cells and CD8+ T cells contributed to IFN-gamma production.
Kohyama et al. (1998)IFN-gammaT cellThe CD8+ T cell clone 5F1 produces interleukin 10 (IL-10) and interferon gamma(IFN-gamma) in response to stimulation with a peptide corresponding to region 142-149 of bovine alpha(s1)-casein (p142-149).
Kohyama et al. (1998)IFN-gammaT cellNinety analog peptides derived from p142-149 with single amino acid substitutions of putative T cell receptor contact residues were prepared to examine whether production of IL-10 and IFN-gamma by 5F1 can be altered by stimulation with these peptides.
Kohyama et al. (1998)IFN-gammaT cellsOur results clearly demonstrate that the signaling pathway required for IL-10 production in CD8+ T cells differs from that required for IFN-gamma production.
Voyich et al. (2001)IFN-gammaT-cellsIn conclusion, systemic immunization of cattle with parasite antigen results in priming of bovine T-cells that are antigen specific and can produce an anamnestic IFN-gamma response to subsequent stimulation with antigens of T. foetus.
Sopp and Howard (2001)IFN gammaT cellsIFN gamma and IL-4 production by CD4, CD8 and WC1 gamma delta TCR(+) T cells from cattle lymph nodes and blood.
Sopp and Howard (2001)IFN gammaT cellsThe synthesis of IFN gamma and IL-4 by CD4, CD8 and WC1 gamma delta TCR(+) T cell sub-populations, and T cells stained with activation/memory-sub-set markers has been examined by flow cytometric analysis.
Simutis et al. (2007)IFN-gammaT cellsIFN-gamma production by-infected cultures containing added gammadelta T cells was not enhanced compared to that of infected macrophages alone.
Simutis et al. (2007)IFN-gammaT cellsIn contrast, addition of PPD-stimulated CD4+ T cells obtained at PID 60 to M. paratuberculosis-infected macrophages resulted in significantly increased IFN-gamma production compared to cultures without added T cells or cultures containing unstimulated CD4+ T cells or unstimulated or antigen-stimulated gammadelta T cells.
Simutis et al. (2007)IFN-gammaT cellsHowever, the increased production of IFN-gamma by co-cultures containing PPD-stimulated CD4+ T cells did not result in increased bacterial killing or increased production of nitrites compared to cultures without added T cells.
Simutis et al. (2007)IFN-gammaT cellsTaken together, the data suggest that (1) gammadelta T cells do not produce significant IFN-gamma and do not significantly increase NO production from M. paratuberculosis-infected macrophages in vitro, (2) the production of significant IFN-gamma by antigen-stimulated CD4+ T cells from infected calves is insufficient to enhance mycobacterial killing or nitrite production by infected macrophages, and (3) macrophages may have an impaired NO response following intracellular M. paratuberculosis infection, even in the presence of significant concentrations of IFN-gamma.
Stich et al. (1999)IFN-gammaT cellTo identify potentially protective "universal" T helper (Th) cell antigens, fractions of homogenized B. bovis merozoites were tested for the ability to stimulate proliferation of oligoclonal CD4+, IFN-gamma-producing T cell lines derived from four immune animals previously shown to differ in major histocompatibility complex class II expression.
Splitter and Everlith (1989)IFN-gammaT-cellIFN-gamma at 1 U/ml in combination with B. abortus produced a 32% decrease in T-cell response, while IFN-gamma at 100 U/ml added to B. abortus-treated cultures produced an 82% reduction in T-cell response.
Brown et al. (1993)IFN-gammaT cellTwo Bb-1-specific T cell clones produced the Th1 pattern of cytokines: IL-2, IFN-gamma, TNF-beta and TNF-alpha, but not IL-4.
Liang et al. (2008)IFN-gammaT cellsDepletion studies showed that CD4+ T cells were responsible for IFN-gamma production.
Sopp et al. (2006)IFN-gamma-expressingT cellsSignificant numbers of IFN-gamma-expressing CD4+ T cells were detected following culture of heparinized blood from M. bovis-infected animals, but not from BCG vaccinates, with purified protein derived from M. bovis (PPD-B) or live mycobacteria.
Maley et al. (2006)IFN-gammaT cellsTissue destruction by the parasite may have occurred; in addition, there may have been a T helper 1 (Th-1) immune response to the neospora infection at the materno-fetal interface, resulting in infiltrations of CD4T cells, gammadelta T cells and NK cells and the subsequent production of IFN-gamma.
Chernyshov (2009)IFN-gammaT cellsLymphocyte subsets (B7-2 on B cells, CD28(+) on T cells, IL-4 and IFN-gamma producing T helper cells), total and specific IgE, and IgG4 at days 1 and 30 were also studied.
Mwangi et al. (2002)interferon gammaT cellReverse transcription polymerase chain reaction (RT-PCR) analysis of cytokine expression by T cell lines derived from this population revealed strong expression of interferon gamma (IFN-gamma), interferon alpha (IFN-alpha), tumour necrosis factor alpha (TNF-alpha), tumour necrosis factor beta (TNF-beta), interleukin-2 receptor alpha (IL-2Ralpha) transcripts, and weak expression of IL-2 and IL-4.
Mwangi et al. (2002)IFN-gammaT cellsRT-PCR analysis of cytokine expression by T cell lines which were dominated by gammadelta T cells revealed expression of IFN-gamma, TNF-alpha, TNF-beta, IL-2Ralpha transcripts.
Uzzo et al. (1999)IFN-gammaT cellsGangliosides prepared from RCC supernatants, as well as the purified bovine gangliosides G(m1) and G(d1a), suppressed NFkappaB binding activity in T cells and reduced expression of the cytokines IL-2 and IFN-gamma.
Totsuka et al. (1998)IFN-gammaT cellsEnhancement of antigen-specific IFN-gamma production from CD8(+) T cells by a single amino acid-substituted peptide derived from bovine alphas1-casein.
Morris et al. (2009)IFNGT-lymphocytesThe effects of decreased lymphocyte numbers are evident in Fig. 4 where IFNG, which is mainly produced by T-lymphocytes and NK cells, is downregulated in SNEB animals.
Billman-Jacobe et al. (1990)gamma-IFNT cellT cell epitopes were mapped by measuring the ability of recombinant antigens to stimulate gamma interferon (gamma-IFN) production in a whole blood culture system. gamma-IFN production was measured using a sandwich enzyme immunoassay specific for bovine gamma-IFN.
Osterlund et al. (2003)IFN-gammaT cellsPreviously, the production of the cytokines TNF-alpha and IFN-gamma in T cells from children with CMA has been shown to be decreased, and the production of IL-4 has been shown to be increased when compared to healthy children.
Brown et al. (2001)IFN-gammaT lymphocytesAcquired immunity against the hemoprotozoan parasite Babesia bovis is believed to depend on activation of antigen-specific CD4(+) T lymphocytes and IFN-gamma production.
Brown et al. (2001)IFN-gammaT cellFurthermore, Bbo20-specific CD4(+) T cell clones proliferated in response to several B. bovis strains and produced IFN-gamma.
Brown et al. (1998)interferon-gamma-producingT-cellThe progress made towards identification of the immunogenic proteins and epitopes that stimulate anamnestic CD4+ type-1 (interferon-gamma-producing) T-cell responses in cattle immune to challenge with Babesia bovis or B. bigemina is the subject of the present review.