Viewing negative mentions of gene expression of Il4 (R. norvegicus) in T cells

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Piccinni et al. (2002)IL-4T cellMore important, a higher proportion of C. albicans-specific T cell clones was generated from lesional mucosa of patients with RVC than from normal mucosa, all of which produced IFN-gamma but not IL-4.
Yamaguchi et al. (1998)IL-4T cellsReverse transcriptase polymerase chain reaction (RT-PCR) analysis revealed that CD45RC- CD4+ T cells harvested from hepatic allografts pretreated with PVG.r1 blood expressed interleukin-4 (IL-4) and interleukin-10 (IL-10), but not interleukin-2 (IL-2) or interferon-gamma (IFN-gamma).
Yamaguchi et al. (1998)IL-4T cellsIn contrast, CD45RC- CD8+ T cells from hepatic allografts pretreated with PVG.r1 blood expressed IL-4, IL-10, and IFN-lambda, but not IL-2.
Fukushima et al. (2003)IL-4T cellsBN T cells contained interleukin (IL)-4 and IFN-gamma, while Lewis T cells expressed no IL-4.
Engler et al. (2010)IL-4T cellIn addition, upon T cell receptor stimulation with anti-CD3, isolated splenocytes of DSP-4 treated animals produced significantly less interferon (IFN)-gamma but not IL-2 and IL-4.
Williams et al. (1991)IL4T cellsIn the absence of IL4 and IL1 (and in the presence of costimulators that are not yet defined) the T cells that are preferentially expanded belong to the IL2-producing subset.
Ben-Sasson et al. (2000)IL-4T cellsNaive CD4(+) T cells differ from memory cells by their heightened expression of the disialoceramide recognized by antibody 3G11. 3G11(bright) cells respond well to immobilized anti-CD3 / anti-CD28 and to their cognate antigens but produce little or no IFN-gamma or IL-4 "acutely" and undergo cell death even in the presence of IL-2.
Nishijima et al. (1997)IL-4T cellalpha s1-Casein-specific CD8+ T cell clones expressed the interleukin (IL)-4 receptor, although they did not secrete detectable IL-4.
Ando et al. (2001)IL-4T cellsSemiquantitative RT-PCR for cytokine gene expression showed that gammadelta T cells from the kidneys expressed TGF-beta, but not IL-4, IL-10, or IFN-gamma.
Brugnolo et al. (1999)IL-4T cellsStreptokinase-specific T cells from all subjects showed intracellular expression of IFN-gamma with poor or no IL-4, whereas Der p 1-specific T cells exhibited IFN-gamma but low or no IL-4 expression in nonatopics, and remarkable IL-4 expression in atopic donors.
Maestrelli et al. (1997)IL-4T-cellIn vitro studies using the technique of cloning lymphocytes demonstrated that a great proportion of T-cell clones derived from bronchial mucosa of subjects with TDI-induced asthma produced IL-5 and interferon-gamma, but not IL-4, upon in vitro stimulation.
Sanders et al. (1987)interleukin 4T cellsThe proportion of conjugates was increased two- to threefold when antigen-pulsed trinitrophenyl-specific B cells, but not T cells, were pre-exposed to interleukin 4.
Noble et al. (2001)IL-4T cellsHere we show that CD4 T cells can become biased towards type 1 or type 2 phenotypes during their initial activation in the absence of IL-4 or IL-12.
Ruschpler and Stiehl (2002)IL4T cellSurprisingly, IL4 was not differential expressed and could be associated with another special T cell subset in this disease.
Komata et al. (2003)interleukin-4T cellsWhen CD44low CD4+ T cells were activated with immobilized anti-CD3 antibody and interleukin-2, they proliferated and produced interferon-gamma but not interleukin-4.
Seder et al. (1993)IL-4T cellsNaive CD4+ T cells produce interleukin 2 (IL-2) but little IL-4 or interferon gamma (IFN-gamma).
Yudoh et al. (2000)IL-4T cellsThere was a reciprocal relationship between the frequency of Thl cells and CD4+ T cells producing IL-10 but not IL-2 and IL-4 in the peripheral blood of RA patients.
Yudoh et al. (2000)IL-4T cellCONCLUSION: In RA, reduced expression of the CD4+ T cell subset producing IL-10 but not IL-2 and IL-4 may be responsible for the dominance of Th1 over Th2 cells at sites of inflamed synovium and in the peripheral blood.
Jirapongsananuruk and Leung (1997)IL-4T cellsThe majority of T cells in early allergic reactions are T helper type 2 (TH2)-like producing IL-4, IL-5, IL-13 but not IFN-gamma.
de Souza et al. (2005)IL-4T cellEctopic expression of TIM-1 during T cell differentiation results in a significant increase in the number of cells producing IL-4 but not IFN-gamma.
Kemeny et al. (1999)IL-4T cellsHowever, not all CD8(+) T cells are alike and subsets that make IFN-gamma but not IL-4 (Tc1), IL-4 but not IFN-gamma (Tc2) as well as those that make both (Tc0) have been described.
Munder et al. (2009)IL-4T cellsL. major-specific CD4(+) T cells rendered hyporesponsive by L-arginine deprivation can be partially rescued by addition of exogenous L-arginine to produce IL-4 and IL-10, but not to produce IFN-gamma.
Quayle et al. (1993)IL-4T-cellIn the mycobacterial antigen-specific group, all CD4+ alpha beta T-cell clones produced IFN-gamma at high levels, while the production of IL-4 was generally absent or low (< 1 ng/ml), consistent with a Th1-like profile.
Spinozzi et al. (1997)IL-4T lymphocytesHowever, despite high expression of this molecule, cloned allergen-specific cord CD4+ T lymphocytes were unable to produce IFN-gamma and/or IL-4.
Cheng et al. (2005)IL-4T cellsThere was no significant difference on the frequencies of IL-4-producing peripheral T cells between the two groups.
Mizuki et al. (1998)IL-4T cellOne case expressed CD8alphaalpha dim and IL-4 mRNA, while the other two cases expressed no IL-4 mRNA and showed CD8alphaalpha bright phenotype, features not found in normal T cell populations.
Strehlau et al. (1996)IL-4T-cellIL-2, the principal T-cell growth factor and IL-4 were not detectable in any biopsy at the time of histologically apparent rejection.
Castigli et al. (1993)IL-4T cellsNorthern blot analysis of total RNA derived from the patient's T cells revealed a weak or absent expression of mRNA coding for IL-2, IL-3, IL-4, and IL-5.
Visvanathan and McNeil (1999)IL-4T cellsThe proliferating T cells produced IFN-gamma but not IL-4, indicating a bias toward a type 1 immune response.
Aklilu et al. (2004)IL-4T cellsExpanded T cells produced interferon-gamma, but not IL-4.
Barnaba et al. (1994)IL-4T cellHowever, all of the CD4+CD56+ T cell clones produced IFN-gamma but not IL-4 and IL-5 (Th1-like cell clones).
Satoguina et al. (2002)IL-4T cellsHere we show that in the chronic helminth infection onchocerciasis (river blindness), where patients have relatively little sign of dermatitis despite the presence of millions of small worms in the skin, T cells can be obtained which bear characteristics of Tr1 cells, producing no IL-2 or IL-4 but substantial amounts of IL-10, variable amounts of IL-5, and some IFN-gamma.
Leblond et al. (1997)IL-4T cellsReverse transcription-polymerase chain reaction assays showed similar amounts of interferon-gamma transcripts in the two subsets; tumor necrosis factor-alpha, IL-4, and IL-10 transcripts were detected in CD4+CD7- T cells but not in their CD4+CD7+ counterparts.
Kabashima et al. (1998)interleukin-4T cellsHowever, CD4-positive T cells did not stain for interleukin-4 (IL-4).
Fujihashi et al. (1993)IL-4T cellsFreshly isolated CD4+CD8- IEL T cells contain Th2-type cells, e.g. high numbers of IL-5 secreting (spot forming) cells (SFC) followed by IL-4 and IL-6, while DP T cells have IL-5 and IL-6 producing cells, but not IL-4.
Geha et al. (1991)IL-4T cellsNorthern blot analysis of total RNA derived from the patient's T cells revealed a weak or absent expression of mRNA coding for IL-2, IL-3, IL-4, and IL-5.
Melgar et al. (2003)IL-4T cellsT cells of UC patients did not express IL-4 or IL-5.
Matyszak et al. (2000)IL-4T cellsFurthermore, multiple restimulation of T cells with these DC gave rise to a subpopulation of T regulatory cells (Tr1) which were negative for IFN-gamma and IL-4 but were IL-10 positive.
Tzianabos et al. (1999)IL-4T cellsCytokine mRNA analysis showed that T cells from PS A-treated animals produced transcript for IL-2, IFN-gamma, and IL-10, but not for IL-4.
Roncarolo and Bacchetta (1992)IL-4T cellHost-reactive CD4+ and CD8+ T cell clones were normal in their capacity to produce IL-2, IFN-gamma, GM-CSF and IL-5, but they failed completely to synthesize IL-4.
Ballow et al. (1996)IL-4T cellsAlthough interleukin (IL)-2, IL-4, and IL-6 could not be detected by ELISA in the T-cell-derived supernatants, RA probably generates a cytokine/interleukin from T cells which modulates B-cell Ig secretion.
Coronel et al. (2001)IL-4T-cellT-cell cytokines (IL-2, IL-4, IL-10) were not produced in culture conditions in which T cells were nevertheless present.
Ovigne et al. (2001)interleukin-4T cellsThe majority of epidermal CD8+ T cells in chronic plaque psoriasis are activated Tc1 cells producing interferon-gamma and no interleukin-4, a small proportion of which express NK-T receptors.
Ovigne et al. (2001)interleukin-4T-cellAll the TCL and 37/39 CD8+ T-cell clones produced interferon-gamma but no or minimal interleukin-4 or interleukin-10.
van der Burg et al. (2003)IL-4T cellExamination of the cytokines produced by these Th-cells showed that a majority of the proliferative p53-specific T cell cultures produced none of the key cytokines (IFNgamma, TNFalpha, IL-4, IL-5 or IL-10), indicating that these p53-specific Th-responses are not polarized.
Kim et al. (2010)IL-4T cellsThe "converted" Foxp3(+) T cells that were derived from Th2 memory cells down-regulated GATA-3 and IRF4 and produced little IL-4, IL-5, and IL-13.
Till et al. (1997)IL-4T-cellAddition of exogenous recombinant IFN-gamma or IL-12, cytokines known to inhibit Th2-type responses, significantly inhibited allergen-driven production of both IL-13 and IL-5, but not T-cell proliferation, whereas exogenous IL-4 did not significantly affect production of IL-13 or IL-5.
Ward et al. (2006)IL-4T cellsDC-primed T cells secreted IFN-gamma (Th1); however, no detectable IL-4 (Th2) was noted.
Streeter et al. (2004)IL-4T-cellWhen stimulated with alloantigen, both CD4(+) CD134(+) T-cell subsets responded by secreting interferon-gamma and interleukin (IL)-10, and neither T-cell subset produced detectable levels of IL-2 or IL-4.
Feske et al. (1996)IL-4T cellsFurthermore both childrens' T cells were unable to produce the cytokines IL-2, interferon-gamma (IFN-gamma), IL-4 and tumor necrosis factor-alpha (TNF-alpha).
Corrigan et al. (1995)IL-4T-LCComparing the asthmatics with the controls, elevated percentages of CD4 T-LC expressed mRNA encoding IL-5, IL-4, and GM-CSF (P < 0.02) but not IL-3, IL-2, or IFN-gamma.
Takahashi et al. (1992)IL-4T lymphocytesThese inhibitory effects of anti-CD4 and anti-CD8 mAbs occur on normal T lymphocytes, since they also were observed with CD4+ and CD8+ T-cell blasts, and are specific for IL-2 responses, since IL-4 responses of CD4- and CD8-transfected HT-2 cells were not affected by the anti-CD4 and anti-CD8 mAbs.
Carding et al. (1989)IL 4T cellsMost importantly, we have shown by in situ hybridization analysis that the majority of individual CD4+ T cells produce only IL 2 or IL 4 mRNA, and not both, after primary activation in vitro.
Karenko et al. (2001)interleukin-4T cellsChromosomally clonal T cells in the skin, blood, or lymph nodes of two Sezary syndrome patients express CD45RA, CD45RO, CDw150, and interleukin-4, but no interleukin-2 or interferon-gamma.
Rosenbaum et al. (1995)IL-4T-cellRESULTS: Using Wilcoxon rank sum analysis, mRNA for interleukin (IL)-1 alpha or IL-8 was significantly more abundant in corneas from patients with pseudophakic bullous keratopathy relative to either comparison group. mRNA for the T-cell marker, CD4, and for T-cell derived cytokines, IL-2, IL-4, and interferon gamma, could not be detected in any corneal sample.
Plana et al. (2000)interleukin 4T lymphocytesAt baseline, there was an important increase in cells producing interferon-gamma (IFNgamma) with no significant abnormalities in T lymphocytes producing interleukin 2 (IL-2), tumour necrosis factor alpha and interleukin 4.
Ito et al. (2009)interleukin 4T cellsFOXP3-positive CD4+ T cells from patients, as well as those from controls, showed little capability to synthesize interferon gamma and interleukin 4.