Viewing affirmative mentions of binding of IL2 (H. sapiens) in B cells

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Lagoo et al. (1990)IL-2B cellsWe report that sustained increase of intracellular calcium ion concentration and protein kinase C (PKC) activation maintained throughout the G1 phase of cell cycle do not provide sufficient signals to cause S-phase entry in rabbit B cells, and that additional signals transduced by IL-2 and IL-2 receptor interaction are essential for G1 to S transition.
Petersen et al. (1987)interleukin-2B-lymphocytesBinding, uptake and degradation of human recombinant interleukin-2 (125 ala) in activated human T- and B-lymphocytes and in monocyte-macrophages.
Nakagawa et al. (1988)IL-2B cellsIL-2 and BCGF may preferentially interact with different subpopulations of B cells.
Ceuppens and Stevens (1986)interleukin 2B cellsImmunoglobulin production in cultures of pokeweed mitogen stimulated human peripheral blood mononuclear cells requires interaction of interleukin 2 with the B cells.
Boyd et al. (1985)IL 2B cellThese studies suggest that the initial stages of B cell proliferation involves a sequential interaction of BCGF and IL 2 with their respective receptors.
Goldstein and Kim (1993)IL-2B cellsAfter the binding of IL-2, IL-4, or IL-6 to their respective receptors on activated human B cells, a multistep cascade of intracellular events is initiated that results in the secretion of Ig.
Mingari et al. (1984)IL-2B cellsRecently, however, a monoclonal antibody reacting with the IL-2 receptor molecules expressed by activated T cells (anti-Tac) was shown to react also with certain B tumour cells; in addition, murine B cells proliferate in response to pure human IL-2.
Panayotides et al. (1986)IL-2B-cellHere, in five of 11 B-cell leukemia/lymphoma cases, we identified cells which not only express the IL-2 receptor, but also respond to IL-2 stimulation, as shown by a marked increase of 3H-thymidine incorporation and by differentiation of lymphoma cells.
Wörmann et al. (1987)IL-2B cellWe conclude that IL-2 has essentially no proliferative effect on B cell precursor ALL, despite the presence of high affinity IL-2 receptors and the presence of the IL-2 binding cell surface molecules similar to those on activated T cells.
Wörmann et al. (1987)IL-2B cellCross-linking of 125I-labeled IL-2 to TPA activated B cell precursor ALL revealed the 55 kD Tac/CD25 protein and an additional protein of 75 kD.
Tsudo et al. (1984)IL-2B cellsImmunoaffinity-purified interleukin 2 (IL-2) induced the proliferation of SAC-activated B cells, and the proliferation was completely inhibited by anti-Tac antibody, which blocked the membrane binding and action of IL-2.
Touw et al. (1987)interleukin 2B cellThe proliferative response of B cell chronic lymphocytic leukemia to interleukin 2: functional characterization of the interleukin 2 membrane receptors.
Nakagawa et al. (1988)IL-2B cellsThe interaction of IL-2 or BCGF with normal activated B cells may induce both similar and different intracellular events.
Tanaka et al. (1988)interleukin 2B cellsNovel receptor-mediated internalization of interleukin 2 in B cells.
Stamatopoulos et al. (2009)IL2B cellsVPA inhibited the proliferation of CpG/IL2-stimulated CLL B cells and modulated many cell cycle messenger RNAs.
Tsilivakos et al. (1994)interleukin 2B-cellCharacterization of interleukin 2 receptors on B-cell chronic lymphocytic leukemia cells.
Dugas et al. (1986)interleukin 2B cellBoth Verapamil and PTC inhibited the B cell proliferation induced by costimulation with anti-mu antibody and with 3 different growth factors: interleukin 2, 20-kDa B cell growth factor and 50-kDa B cell growth factor.
Llorente et al. (1990)IL 2B cellsWe analyzed the effects of interleukin 2 (IL 2) and IL 4 isolated and in association on the specific response of human B cells triggered by trinitrophenylated polyacrylamide beads (TNP-PAA).
Mayer et al. (1985)IL 2B cellThus, it appears that IL 2 does have a role in B cell maturation mediated, in part, by IL 2 binding to the IL 2 receptor present on certain B cells.
Vazquez et al. (1986)IL 2B cellThus, the B cell subset responding to the 50-kDa BCGF after anti-mu antibody activation is distinct from that responding to IL 2.
Vazquez et al. (1986)interleukin 2B cellDifferent human B cell subsets respond to interleukin 2 and to a high molecular weight B cell growth factor (BCGF).
De Groot et al. (1990)IL-2B lymphocytesHuman tonsillar B lymphocytes proliferate in vitro after activation with immobilized anti-IgM antibodies in combination with interleukin 2 (IL-2) or interleukin 4 (IL-4).
Hivroz et al. (1989)IL2B lymphocytesSimilarly, upon triggering with anti-mu and IL2, normal tonsillar B lymphocytes also demonstrate an increase of CD23 expression but this was observed only on day 3.
Hashimoto et al. (1986)interleukin 2B cellDissociation of interleukin 2-dependent and -independent B cell proliferation with monoclonal anti-interleukin 2 receptor antibody.
Ralph et al. (1984)IL 2B cellsThese results suggest that IL 2 stimulates B cells via a low-affinity interaction with a receptor different from the Tac receptor identified on T cells, and that the active site on the IL 2 molecule for B cells differs from that for T cell targets.
Mehta et al. (1986)IL 2B cellsBCGF-12 kd receptors on activated B cells have been shown to be distinct form those interacting with IL 2.
Ralph et al. (1984)IL 2B cellIf IL 2 promotes Ig secretion by binding with a low affinity to the B cell BIF receptor, IL 2 and BIF could be homologous proteins.
Boyd et al. (1985)IL 2B cellsAfter activation, B cells express the IL 2 receptor as determined by their reactivity with monoclonal anti-IL 2 receptor antibodies.
Teodorczyk-Injeyan et al. (2010)IL-2B lymphocyteIL- 10 has been shown to increase the affinity of the B cell receptor for IL-2 resulting in a putative improvement of signal transduction and promotion of B lymphocyte activation [24].
Björck et al. (1992)IL-2B cellsNone of the lymphokines were by themselves able to induce aggregation in resting B cells but, when added together with anti-IgM, IL-4 and to a lesser extent IL-2, promoted the formation of large, dense aggregates which were macroscopically visible after 3-4 days in culture.
Panayotides et al. (1986)anti-IL-2B-cellSome human B-cell malignancies have been reported to react with anti-IL-2 receptor antibodies, but no response to IL-2 has been documented in these cases.
Giovarelli et al. (1988)IL-2B cellsThese findings indicate that elevated quantities of IL-2lf may be released in B-CLL particularly due to the B- and T cell interconnections, and that the leukemic B cells appear capable of absorbing IL-2 and of proliferating after costimulation with IL-2.
Nakanishi et al. (1984)IL-2B cellsVery small amounts of [3H]IL-2 (less than 1,000 molecules per cell) bind to activated B cells.
Nakanishi et al. (1984)IL-2B cellsThese results indicate that IL-2 binds to a receptor on appropriately prepared B cells and causes them to differentiate into high rate IgM-synthesizing cells.
Wei et al. (1993)IL-2B cellsIn addition to T cells, NK cells, B cells, and monocytes, we provide new evidence that human polymorphonuclear neutrophils (PMN) can be functionally activated by IL-2 via binding to IL-2R beta expressed on the cell surface.
Kimata and Yoshida (1994)IL-2B cellsGM2 and GM3 each inhibited Ig production, thymidine uptake, and TNF-alpha production by surface IgG1+ (slG1+), sIgG2+, sIgG3+, sIgG4+, and sIgM+ B cells without affecting IL-2 binding or TNF-alpha binding to B cells, but had no such inhibitory effects on sIgA1+ or sIgA2+ B cells.
Ando et al. (1985)interleukin 2B cellsIt is functionally active so that TPA-induced B cells respond to interleukin 2 by increased DNA synthesis.
Ling et al. (1995)IL-2B lymphocytesProduction of IgM, IgG and IgA was induced from human blood B lymphocytes by culturing with a CD40 MoAb and IL-2 for 9 days.
Saberi Hosnijeh et al. (2010)IL2B-cellSubanalyses of B-cell NHL patients showed a significant association with IL2 (P trend = 0.003), tumor necrosis factor-alpha (TNF-alpha; P trend = 0.03), and ICAM (P trend = 0.04) and a borderline association with IL5 (P trend = 0.07) and IFN-gamma (P trend = 0.08).
Jan et al. (2002)IL-2B cellsConcordantly, a marked increase was observed in nuclear factor of activated T cells (NF-AT) DNA binding activity to the IL-2 distal NF-AT site, but not to nuclear factor for immunoglobulin kappa chain in B cells or activator protein 1 motifs.
Maizel et al. (1983)B-cell growth factorB-cellThe ability of the cell population to specifically absorb the B-cell growth factor was dependent upon the time of stimulation with the anti-IgM.
Ambrus et al. (1991)IL-2B cellIn the present study, we demonstrate that stimulation of B cells which have already been activated by Staphylococcus aureus Cowan I (Sac), with high molecular weight B cell growth factor (HMW-BCGF) or low molecular weight B cell growth factor (LMW-BCGF), but not IL-2, IL-4, or interferon-gamma, is associated with an increase in intracellular calcium, which is modest compared to that seen with anti-Ig (approximately 100 nM vs approximately 400 nM).
Park et al. (2004)IL-2B cellsBecause GC-B cells have the signal-transducing components (IL-2/15Rbetagamma), but not a receptor for binding of soluble IL-15 (IL-15Ralpha), IL-15 signaling is possibly transduced by transpresentation from FDCs to GC-B cells via cell-cell contact.
Schultze et al. (2001)interleukin 2B cellsA pilot study of combined immunotherapy with autologous adoptive tumour-specific T-cell transfer, vaccination with CD40-activated malignant B cells and interleukin 2.
Zlotnik et al. (1983)IL 2B cellThe T cell hybridoma FS7-20, produced by the fusion of normal B10.BR T cells to the AKR thymoma BW5147, was found when stimulated with concanavalin A (Con A) to produce the lymphokines: interleukin 2 (IL 2), interferon-gamma (IFN gamma), macrophage-activating factor (MAF), Ia induction factor IaIF), and the B cell helper factor interleukin X (IL X).
Kotani et al. (1988)IL-2B cellsThe helper factors are different from IL-2, and act on both resting (small) and activated (large) B cells.
Tosato et al. (1988)B cell growth factorB cellIn addition, an antiserum to IFN-beta that recognizes both IFN-beta 1 and IFN-beta 2 completely neutralizes the B cell growth factor activity of activated monocyte supernatants.
Kimata and Lindley (1994)IL-2B cellsIL-8 had no effect in binding of IL-4, IL-2 or TNF-alpha by B cells, however, it enhanced TNF-alpha production by B cells.
Shields et al. (1992)B cell growth factorB cellFreshly prepared Epstein-Barr virus-transformed B lymphoblastoid cell lines derived from five different donors were tested for their responses to recombinant human interleukin-4 and to low molecular weight B cell growth factor.
Muraguchi et al. (1986)B cell-specific growth factorB cellThis paper demonstrates that B cell lines, as well as normal activated B cells generate and respond to B cell-specific growth factor(s) (BCGF).
Allouche et al. (1989)IL-2B cellWe found that both fresh leukemic cells obtained from patients, and cells from established leukemic lines of T cells, B cell, and myeloid origin constitutively expressed a p70 IL-2-binding protein on their surface, as detected by affinity cross-linking of radioiodinated IL-2.
Goedert et al. (2000)IL-2B cellsThe same effects of CD40L were observed when B cells were stimulated by a combination of IL-2 and IL-4 and this inhibition could not be abrogated by increasing the amounts of IL-4.
Corrales et al. (1996)IL-2B cellsIn addition, a strong correlation between both the absolute levels of B cells binding to exogenous IL-2 and IL-6 and the absolute number of CD5+ B cells in hyperthyroid GD patients (LR = 0.798, p < 0.001; LR = 0.569, p < 0.01, respectively) was observed.
Corrales et al. (1996)IL-2B cellsThese results suggest that CD5+ B cells in GD are partly regulated by thyroid hormone serum levels as well as by IL-2 and IL-6 binding to B cells.
Cairns et al. (1988)B cell growth factorB cellThis molecule has identity both with B cell-derived B cell growth factor and with an IgE-binding factor.
Nariuchi et al. (1986)B-cell growth factor IIB-cellThe activity was indicated not to be due to interleukin 2, B-cell growth factor I, B-cell growth factor II, or interferon.
Hornung et al. (1993)IL-2B lymphocytesAfter 48 hr in culture, S. aureus bacteria upregulated significantly the binding of phycoerythrin-conjugated IL-2 and IL-6, respectively, by purified B lymphocytes, indicating generation and/or upregulation of receptors for these cytokines.
Garlisi and Mastro (1992)lymphokineB-cellsInterleukin-2 (IL-2) is a lymphokine which, upon binding to its receptor, leads to the proliferation and differentiation of T-cells (helper, suppressor, and cytotoxic) and B-cells.
Ruff et al. (1994)interleukin-2B cellsIn 72 h cultures of normal peripheral and tonsillar B cells, cross-linking surface immunoglobulin in the presence of interleukin-2 or interleukin-4 led to formation of clusters in vitro together with an increase in cell size and a slight up-regulation of CD11c, as determined by flow cytometry.
Rollins et al. (1988)interleukin 2B-cellWe present here structural and regulatory features of the JE gene and its product that link it to a family of cytokines, including macrophage colony-stimulating factor, interferon alpha, interleukin 6 (also known as interferon beta 2, B-cell-stimulatory factor 2, 26-kDa protein, and hybridoma/plasmacytoma growth factor), and interleukin 2.