Viewing affirmative mentions of gene expression of Trav6-3 (M. musculus) in T cells

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Pereira and Boucontet (2004)TCRT cellOur data suggest that these mechanisms, together with a natural variation affecting the expected frequencies at which rearrangement of different Vgamma gene segments give raise to functional TCRgamma chains, have coevolved to maximize the diversity of the gammadelta TCR repertoire minimizing the risk that a gammadelta T cell will express more than one TCR specificity at the cell surface, despite the fact that multiple TCRgamma rearrangements take place in the same progenitor cell.
Havran and Jameson (2010)TCRT cellsThe murine epidermis contains resident T cells that express a canonical gammadelta TCR.
Kanagawa et al. (1994)TCRT cellsIt has previously been shown that a B cell tumor line derived from MAIDS mouse stimulated a large fraction of unprimed T cells based on TCR V beta chain expression.
Kanagawa et al. (1994)TCRT cellThere are two distinct T cell populations which can be distinguished based on their TCR expression and function in the TCR transgenic mice, one bearing the transgene derived alpha- and beta-chain TCR that is nonreactive to MAIDS superantigen and the other bearing an endogenous alpha- but transgene-derived beta-chain TCR that is reactive to superantigen.
Kanagawa et al. (1994)TCRT cellsUnlike T cells found in noninfected TCR transgenic mice, anergic T cells expanding in virally infected TCR transgenic mice are homogeneous for the TCR phenotype, indicating the presence of a selection of T cells based on their TCR expression.
Serwold et al. (2007)TCRT cellEarly TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes.
Kunjibettu et al. (2001)TCRT cellsConserved transmembrane tyrosine residues of the TCR beta chain are required for TCR expression and function in primary T cells and hybridomas.
Rechtsteiner et al. (2006)TCRT cellPrecursor frequency can compensate for lower TCR expression in T cell competition during priming in vivo.
Xue et al. (2005)TCR geneT cellsRetroviral TCR gene transfer into patient T cells can readily produce populations of antigen-specific lymphocytes after a single round of polyclonal T cell stimulation.
Serreze et al. (2001)TCRT-cellsTo address this issue, we reduced the precursor frequency of autoreactive T-cells in NOD mice through allelic exclusion induced by transgenic expression of an H2-Db class I-restricted T-cell receptor (TCR) specific for a pathologically irrelevant lymphocytic choriomeningitis virus (LCMV) peptide.
Penninger et al. (1991)TCRT cellsT cells express either TCR alpha beta or TCR gamma delta isotypes.
Xue et al. (2004)TCRT cellThe TCR of allogeneic T cells can be introduced into patient T cells to equip them with anti-tumor specificity that may not be present in the autologous T cell repertoire.
Rubinstein et al. (2003)TCRT cellsThe transfer of TCR genes to mature T cells to generate tumor-reactive T cells provides a potential mechanism to overcome these limitations.
Miller (1992)TCRT cellsAlthough there was some evidence of intrathymic deletion of those T cells that expressed the highest density of the H-2Kb-specific TCR, lower density cells were present in the periphery.
Kruisbeek (2001)CD3-TCRT cellA protocol is provided for screening of T cell hybridomas for expression of the CD3-TCR complex by flow cytometry analysis.
Smiley and Grusby (1997)TCRT cellsDual-receptor T cells expressing one self-restricted TCR.
Smiley and Grusby (1997)TCRT-cellDuring thymic development, T cells rearrange and express genes encoding clonotypic T-cell receptors (TCR), and undergo selective events involving interactions between TCR and thymic major histocompatibility complex (MHC) molecules.
Smiley and Grusby (1997)TCRT cellsRecent studies indicate that up to 30% of peripheral T cells may express two TCR, that both TCR on these cells are functional, and that dual-specific T cells can promote autoimmunity.
Smiley and Grusby (1997)TCRT cellsHere we demonstrate that dual-receptor T cells are readily generated in class II-deficient (class II-) mice expressing the class II-restricted AND TCR transgene (TCRtg).
Lin et al. (2007)TCRT cellsOligoclonal expression or oligoclonal trend of some TCR Vbeta subfamilies (Vbeta10, 11 and Vbeta2, 15, 16, 19) was detected in T cells after stimulation with tissue-antigen of NOD/SCID mouse.
Sant'Angelo et al. (2001)TCRT cellsMaintenance of TCR clonality in T cells expressing genes for two TCR heterodimers.
Sant'Angelo et al. (2001)TCRT cellT cell receptor (TCR) allelic exclusion is believed to be primarily mediated by suppression of further recombination at the TCR locus after the expression of a functional TCR protein.
Bryson et al. (1991)TCRT cellsTherefore, the development of CsA-induced autoreactive T cells as assessed by V beta TCR expression showed strain variation that did not correlate with the induction of syngeneic GVHD and suggested that other mechanisms may be involved in the development of this autoimmune phenomenon.
Hirsch et al. (1988)TCRT cellHowever, subnormal TCR expression alone could not fully explain the observed T cell dysfunction, inasmuch as a period of time existed after TCR re-expression during which T cells appeared to be anergic to CTL and MLR reactivity.
Stolzer et al. (2005)TCRT cellsAlthough some efforts have been made to direct the antigen specificity of developing T cells by retroviral mediated expression of known TCR, it is not clear if the resultant T cells are fully functional.
Stolzer et al. (2005)TCRT cellsActivated T cells expressing this TCR, which is specific for the Ac1-11 peptide from myelin basic protein presented by I-A(u), cause rapid onset of experimental autoimmune encephalomyelitis (EAE).
Zúñiga-Pflücker and Lenardo (1996)TCRT-cellThe earliest stages of mouse alpha/beta T-cell differentiation occurring before surface expression of the TCR include three important events: proliferation, commitment to the T lineage, and rearrangement and expression of the TCR loci.
Shores et al. (1994)TCRT cellThe zeta chain played a role in thymic development by promoting TCR surface expression, but zeta-mediated signals were not essential because TCRs that contained signaling-deficient zeta chains promoted T cell maturation and transduced signals associated with thymic selection.
Waldner et al. (2000)TCRT cellTo examine the contribution of T cell receptor (TCR) specificity in the induction of EAE, we generated transgenic mice expressing the rearranged TCR genes from an encephalitogenic or a nonencephalitogenic PLP-139-151/I-A(s)-specific T cell clone.
Kanagawa (1989)TCRT cellTo test whether antibodies directed to TCR affect T cell tumor growth in vivo, mice were inoculated intravenously with C6VL tumor cells expressing V beta 6 TCR and then treated intraperitoneally with mAb specific for V beta 6 TCR.
Itohara et al. (1990)TCRT-cellThe TCR expressed by this gamma delta T-cell subset consists of the same V delta 1 chain.
Brodeur et al. (2009)TCRT cellsTCR expression on double-positive (DP) thymocytes is a prerequisite for thymic selection that results in the generation of mature CD4(+) and CD8(+) single-positive T cells.
Dossett et al. (2009)TCRT cellsOne goal of such adoptive therapy is to establish a persistent memory response to prevent recurrence; however, long-term function of transferred TCR-transduced T cells is limited due to reduced expression of the introduced TCR in vivo in quiescent resting T cells.
Dossett et al. (2009)TCRT cellsAdoptive immunotherapy of disseminated leukemia with TCR-transduced, CD8+ T cells expressing a known endogenous TCR.
Dossett et al. (2009)TCRT cellsHowever, by introducing the TCR into a cell with a known endogenous specificity, activation of these T cells by stimulation through the endogenous TCR can be used to increase expression of the introduced TCR, potentially providing a strategy to increase the total number of tumor-reactive T cells in the host and restore more potent antitumor activity.
Asarnow et al. (1989)TCRT cellsMany T cells in the epidermal and intestinal epithelia of mice express TCR composed of gamma/delta heterodimers.
Biron et al. (1987)TCRT cellMurine blast natural killer (NK) cells responding to in vivo stimulation were isolated and characterized as to their expression of the T cell receptor (TCR) variable genes alpha, beta, and gamma and the TCR constant genes T3 delta and T3 epsilon.
Prinz et al. (2002)TCRT-cellExpression of two different TCR alpha chains by one T cell (dual TCR) is discussed as a potential mechanism underlying T-cell mediated autoimmunity.
Komori et al. (1993)TCRT cellsT cells which lacked expression of the transgenic TCR beta chain expressed endogenous TCR beta chains.
Komori et al. (1993)TCRT cellsThus, deletion of the transgenic TCR can occur in a high proportion of T cells, which allows rearrangement and expression of endogenous TCR beta chains.
Coccoris et al. (2005)TCRT cellBecause the T cell receptor is the single specificity-determining molecule in T cell function, adoptive transfer of TCR genes into patient T cells may be used as an alternative approach for the transfer of tumor-specific T cell immunity.
Rivera et al. (2003)TCRT cellsThe reconstituted, host-derived lymphoid compartments contained normal functional cell populations as determined by the presence of T cells expressing all 16 common TCR Vbeta families, and the presence of all antibody isotypes in the serum.
Williams et al. (1998)TCRT cellsIn vivo expression of a TCR antagonist: T cells escape central tolerance but are antagonized in the periphery.
McCaughtry et al. (2008)TCRT cellWe used the HY(cd4) model, where T cell receptor for antigen (TCR) expression is appropriately timed and a ubiquitous self-antigen drives clonal deletion in male mice.
Wasserman and Evavold (2008)TCRT cellsPrevious studies have found that a 95% reduction in TCR expression does not adversely affect response to foreign Ags, indicating that T cells have an excess of TCR for Ag recognition.
Wasserman and Evavold (2008)TCRT cellsThus, reduction of TCR expression may provide a potential therapy for self-reactive T cells involved in autoimmune diseases through the induction of anergy.
Corthay et al. (1998)TCR repertoireT cellTCR sequencing indicated that each of the five T cell epitopes selected its own TCR repertoire.
Blichfeldt et al. (1996)TCRT cellsA considerable fraction of T cells express two distinct T cell receptors (TCR), mainly due to expression of two TCR alpha chains.
Blichfeldt et al. (1996)TCRT cellsWe tested this hypothesis in a transgenic TCR model in which most T cells express different amounts of the transgene-encoded TCR, due to expression of endogenous TCR alpha chains.
Blichfeldt et al. (1996)TCRT cellsCytosolic Ca2+ mobilization in single T cells from these clones elicited by lambda2(315) peptide-pulsed, I-Ed-expressing antigen-presenting cells, correlated linearly with the relative transgene-encoded TCR expression.
Kobzdej et al. (1997)TCRT cellMice with transgenic T cell receptor (TCR) recognizing H-Y male antigen developed spontaneous lymphomas originated from immature thymocytes, with the surface expression of transgenic TCR and CD4/CD8 co-receptors.
Birkholz et al. (2010)TCRT cellsWe measured antigen presentation with specific autologous CD4(+) T cells, generated by TCR-RNA transfection.
Vetrone et al. (2009)TCRT cellsWe identified a specific subpopulation of cells expressing the Vbeta8.1/8.2 TCR that is predominant among TCR-beta+ T cells.
Zwicker et al. (2009)TCRT cellsIn this model, individuals with the RIPTAg transgene develop insulinoma; those expressing a transgenic TCR (8.3-TCR) recognizing the islet-specific glucose 6 phosphatase catalytic subunit-related protein (IGRP) harbor a peripheral immune system dominated by diabetogenic CD8(+) T cells.
Bosco et al. (2006)TCRT cellsTo address whether CD4+CD25+ T cells express two TCR alpha chains, we have carried out four-colour flow cytometry using combinations of the available anti-Valpha reagents in mice where one allele of the TCRA locus had been inactivated.
Chistiakov (2005)TcRT cellsFor example, in the CBA/J mouse immunized with human Tg, clonally expressed T cells were shown to primarily express the murine TcR V?
Felli et al. (2005)TCRT-cellWe previously showed that overexpression of pT alpha/pre-TCR and constitutive activation of NF-kappa B characterize the T-cell leukemia/lymphoma developing in Notch3-IC transgenic mice.
Reséndiz-Albor et al. (2005)TCRT lymphocytesIn contrast, in the SI most T lymphocytes were CD4+ expressing TCR-alpha beta+, although a higher proportion expressed TCR-gamma delta+ than in the LI.
Finger et al. (2005)TCRT cellsExpansion of CD4 T cells expressing a highly restricted TCR structure specific for a single parasite epitope correlates with high pathology in murine schistosomiasis.
Finger et al. (2005)TCRT cellsOur findings suggest that exacerbated schistosome egg-induced immunopathology can be driven by T cells expressing a highly restricted TCR structure specific for a single parasite epitope.
Harrow and Ortiz (2005)TCRT cellThe molecular mechanisms ensuring the ordered expression of TCR genes are critical for proper T cell development.
Chamoto et al. (2004)TCRT-cellHere, we have developed an efficient protocol for preparing mouse antigen-specific Th1 cells from nonspecifically activated Th cells after retroviral transfer of T-cell receptor (TCR)-alpha and TCR-beta genes.
Braciak et al. (2003)TCRT cellsImmunization of B10.PL mice with a recombinant adenovirus expressing the TCR Vbeta8.2 chain (Ad5E1 mVbeta8.2), resulted in induction of regulatory type 1 CD4 T cells, directed against the framework region 3 determinant within the B5 peptide (aa 76-101) of the Vbeta8.2 chain.
Capone et al. (2003)TCRT lymphocytesDespite the forced expression of the human CD1d-restricted TCR in C alpha(-/-) mice, staining with mCD1d-alpha-GalCer tetramers reveals that the absolute numbers of peripheral CD1d-dependent T lymphocytes increase at most by 2-fold.
Ercolini et al. (2003)TCRT cellThis 10-mer was recognized by all tumor-specific FVB/N T cells generated regardless of the TCR Vbeta region expressed by the T cell or the method of vaccination used, establishing it as the immunodominant MHC class I epitope in neu.
Lee et al. (2003)TCRT cellsDevelopment of T cells expressing an altered TCR complex.
Lee et al. (2003)TCRT cellsNormal mouse T cells may express alternative TCR complexes containing the FcepsilonR gamma chain (FcRgamma) rather than the zeta homodimer that is present in conventional TCR complexes.
Tahara et al. (2003)TCRT cellsThese findings suggest that it is possible to reconstitute functional tumor-specific CD8(+) T cells by transfer of TCR alphabeta-chain genes derived from TIL, and that such T cells might be useful as cytotoxic effector cells or as a vehicle for delivering therapeutic agents.
Chen et al. (2002)TCRT cellThe findings in the present study indicate that, in mice implanted with a specific SAGT, the level of expansion of the SAGT-reactive CD4(+) T cell fractions varies widely depending on the TCR Vbeta elements expressed and that the reactive CD4(+) T cells acquire a capacity to raise a memory response.
Launois et al. (2002)TCRT cellsIn this work we show that Leishmania homolog of mammalian RACK1-reactive CD4(+) T cells also expressing the V beta 4-V alpha 8 TCR chains are the source of the early IL-4 response to L. major in resistant mice given anti-IL-12 or -IFN-gamma Abs only at the onset of infection.
Sivinski et al. (2002)TCRT cellsWe confirmed that a CD8(+) effector cell was required to eliminate MUC1-expressing Panc02 tumors, and demonstrated that T cells expressing TCR-alpha/beta and co-stimulation through CD28 and CD40:CD40L interactions played critical roles during the initiation of the anti-Panc02.MUC1 immune response.
Rajagopalan et al. (2002)TCRT cellsHowever, SEB-induced in vivo expansion of CD8(+) T cells expressing TCR Vbeta8 family in DQ8.Ii(-/-) mice was comparable with that of DQ8.Ii(+/+) mice.
Granucci et al. (2001)TCRT cellsHere we show that T cells expressing high density of anti-IgG2ab TCR were positively selected in the thymus with a higher efficiency in animals expressing IgG2ab, reached peripheral lymphoid organs and negatively controlled IgG2ab serum levels.
Meyer et al. (2001)TCRT cellsIn myelin basic protein (MBP)-specific TCR-transgenic (Tg) mice, peripheral T cells express the Valpha2.3/Vbeta8.2-Tg TCR, demonstrate vigorous proliferative responses to MBP in vitro, and can exhibit experimental autoimmune encephalomyelitis (EAE) within 5 days of pertussis toxin injection.
Exley et al. (2001)TCRT cellsA subset of CD161 (NK1) T cells express an invariant Valpha14Jalpha281 TCR-alpha chain (Valpha(invt) T cells) and produce Th2 and Th1 cytokines rapidly in response to CD1d, but their physiological function(s) remain unclear.
Fahlén et al. (2000)TCRT cellsT cells expressing forbidden TCR V(beta) chains were found both in the thymus and periphery of transgenic mice, while non-transgenic littermates had successfully deleted these T cell subsets.
Jordan et al. (2000)TCRT cellsSurprisingly, S1-specific CD4(+) T cells were not substantially deleted in TS1xHA28 mice; indeed, lymph node cells expressing the S1-specific TCR were as abundant in TS1xHA28 mice as in TS1 mice.
Fu et al. (2000)TCRT-cellT595B1 expressed CD3, T-cell receptor (TCR)beta, TCR-Vbeta2, CD4, CD25, CD45RB, CD44, LFA-1, and ICAM-1 molecules on its cell surface and showed MHC class II I-E(k)-restricted tumor antigen-specific proliferation.
Doncarli et al. (1999)TCRT cellA recurrent valpha17/vbeta10 TCR-expressing T cell clone is involved in the pathogenicity of collagen-induced arthritis in DBA/1 mice.
Lin et al. (1999)TCRT cellAs a model of negative selection of gammadelta T cells, we have used G8 gammadelta-T cell transgenic mice, which express a gammadelta TCR that recognizes the nonpolymorphic MHC class I TL(b) molecule.
Chiu et al. (1999)TCRT cellTo explore the role of M3 expression and peptide supply in positive and negative selection, we generated transgenic mice expressing an M3-restricted TCR-alpha/beta from a CD8(+) T cell hybridoma (D7) specific for a listerial peptide (LemA).
Nguyen et al. (1999)TCRT lymphocytesActivated T lymphocytes generated expressed TCR alpha/beta+ with a predominant CD8+ population after 12 stimulations (98.54% CD8+ vs. 0.18% CD4+).
Sakamoto et al. (1999)TCRT cellsBACKGROUND: In mice, natural killer (NK) T cells are specialized subsets of T cells that express an invariate T cell receptor (TCR) alpha chain and NK markers.
Buggiano et al. (1999)TCRT-cellMMTV encodes a superantigen (SAg) that has the property of stimulating T-cell populations expressing a particular variable region of the T-cell receptor (TCR) beta chain (Vbeta) and needs to be presented in the context of major histocompatibility complex (MHC) class II molecules.
Sleckman et al. (1998)TCRT cellThe generation of a productive "in-frame" T cell receptor beta (TCR beta), immunoglobulin (Ig) heavy (H) or Ig light (L) chain variable region gene can result in the cessation of rearrangement of the alternate allele, a process referred to as allelic exclusion.
Sleckman et al. (1998)TCRT cellsAssembly of TCR alpha and TCR gamma chain variable region genes exhibit allelic inclusion and alphabeta and gammadelta T cells can express two TCR alpha or TCR gamma chains, respectively.
Spada et al. (1998)TCRT cellA conserved subset of mature circulating T cells in humans expresses an invariant Valpha24-JalphaQ T cell receptor (TCR)-alpha chain rearrangement and several natural killer (NK) locus-encoded C-type lectins.
Wilson and MacDonald (1998)TCRT cellsT cells belong to two distinct lineages expressing either alpha beta or gamma delta TCR.
Dieli et al. (1997)TCRT cellWe have recently demonstrated a remarkable selection of in vitro cultivated, TNP-specific polyclonal T cell lines for the expression of a TCR beta chain encoded by the V beta 8.2 gene.
Utsunomiya et al. (1997)TCRT cellAnti-type 2 T cells, CD4+, CD28+, TCR alpha/beta +, IFN-gamma-producing T cell, are able to counteract the activity of BA2T cells which have been shown to be key cells in the increased susceptibility of thermally injured mice to these infections.
O'Reilly et al. (1997)TCRT cellFrom an analysis of bcl-2 transgenic mice expressing a TCR transgene or bearing a mutation in the scid or rag-1 gene we conclude that Bcl-2 inhibits proliferation only of T cell progenitors that are activated via the pre-TCR, not those stimulated via c-Kit and the IL-7 receptor.
Blazar et al. (1996)TCRT-cellAlthough T-cell receptor (TCR) alpha/beta expressing cells have a well-known role in graft-versus-host disease (GVHD) generation, the role of TCR gamma/delta expressing cells in this process has remained unclear.