Viewing affirmative mentions of negative regulation of IL2 (H. sapiens) in lymphocytes

Full-text article links are indicated by after the article reference.

Document Target Regulator Anatomy Sentence
Theander et al. (1988)IL-2lymphocytesFurthermore, treatment of phytohemagglutinin-stimulated lymphocytes with AP and ELA resulted in inhibition of binding of intact IL-2 to IL-2 receptors on the stimulated lymphocytes.
Bygbjerg et al. (1987)IL-2lymphocytesPyrimethamine at concentrations above therapeutic levels suppressed the lymphocytes' proliferation, but not their IL-2 production.
Bygbjerg et al. (1987)IL-2lymphocyteThe IL-2 production was suppressed at concentrations twice as high as those required to suppress lymphocyte proliferation.
Arya et al. (1984)TCGF mRNAlymphocytesDexamethasone, a synthetic glucocorticoid, strongly inhibits the synthesis of TCGF mRNA in human normal peripheral blood lymphocytes stimulated in culture with phytohemagglutinin.
Domingo et al. (1985)interleukin-2lymphocyteHuman pregnancy serum inhibits proliferation of T8-depleted cells and their interleukin-2 synthesis in mixed lymphocyte cultures.
Domingo et al. (1985)IL-2lymphocyteA possible mechanism to explain the inhibition of mixed lymphocyte cultures by pregnancy serum could therefore be decrease of cellular proliferation of the T8-depleted subpopulation with a decrease in IL-2 synthesis, implying an inhibition of cytotoxic effector cells.
Froelich et al. (1988)interleukin-2lymphocytesPhytohemagglutinin induced proliferation by aged lymphocytes: reduced expression of high affinity interleukin-2 receptors and interleukin-2 secretion.
Kermani-Arab et al. (1985)interleukin 2lymphocytesMediation of the antiproliferative effect of cyclosporine on human lymphocytes by blockade of interleukin 2 biosynthesis.
Yoshimura and Kahan (1985)IL-2lymphocytesPeripheral blood lymphocytes (PBL) from CsA-Pred treated recipients displayed 40.6% inhibition (1.14 +/- 0.06 U/ml, n = 117, P less than 0.001) of IL-2 production compared with normal individuals (1.93 +/- 0.04 U/ml, n = 164).
Yoshimura and Kahan (1985)IL-2lymphocytesCsA did not inhibit the expression of the IL-2 receptor: 4.15 +/- 11.2% and 63.1 +/- 10.3 of normal lymphocytes and 36.7 +/- 9.8% and 60.4 +/- 12.2% of CsA-treated patient lymphocytes expressed anti-IL-2 receptors after 24 or 48 hr of PHA stimulation, respectively.
Bagasra et al. (1993)interleukin-2lymphocytesThere was a decreased ability of lymphocytes, obtained after alcohol consumption, to produce interleukin-2 and soluble immune response suppressor activity after stimulation with concanavalin A.
Freed et al. (1987)interleukin 2lymphocyteA 50 microM concentration of H2O2 completely blocked the generation of cytotoxic T cells in the mixed lymphocyte culture but did not inhibit the production of interleukin 2.
Carrillo-Vico et al. (2005)IL-2lymphocytesMelatonin exerted these effects by a receptor-mediated action mechanism because both IL-2 and IL-2 receptor expressions significantly decreased when lymphocytes were incubated in the presence of the specific membrane and/or nuclear melatonin receptor antagonists, luzindole, and/or CGP 55644, respectively.
Hu et al. (1990)IL-2lymphocytesThe possible application of PA to the treatment of immune disorders involving deficiency of IL-2 production and/or IL-2 responsiveness of lymphocytes is also considered.
Johann-Liang et al. (1997)IL-2lymphocyteIn those children in whom immunosuppression was evident, decreasing serum IL-2 levels correlated with depletion of CD4+ lymphocytes (r = 0.74), whereas there was an inverse correlation between serum IL-2 levels and CD4+ lymphocyte counts (r = -0.47) in children with no or moderate immunosuppression.
Bagasra et al. (1989)interleukin 2lymphocytesThere was also decreased ability of lymphocytes to produce interleukin 2 and soluble immune response suppressor activity after stimulation with concanavalin A, the former, possibly both, for over 4 days after alcohol ingestion.
Cox et al. (1987)interleukin-2lymphocytesThe observed decrease in lymphocyte proliferation hyporesponsiveness to interleukin-2 correlated with the ability of 8-methoxypsoralen to induce a dose-dependent decrease in interleukin-2 receptor expression on phytohemagglutinin-stimulated lymphocytes.
Cox et al. (1988)IL-2lymphocyteAt the suboptimal concentration of PHA, 8-MOP (140 microM) caused a sustained inhibition of lymphocyte proliferation, IL-2 production/accumulation and IL-2 receptor expression.
Roffman et al. (1984)interleukin 2lymphocytesChemical reduction of oxidized human lymphocytes inhibits interleukin 2 production but not induction of interleukin 2 responsiveness.
Dornand et al. (1987)IL 2lymphocyteAmiloride-induced suppression of lymphocyte proliferation: inhibition of IL 2 receptor expression after blockade of early sodium influx.
Slauson et al. (1984)IL-2lymphocyteSerotonin thus produced an inhibition of lectin-stimulated lymphocyte proliferation via a mechanism independent of IL-2 production, and caused a decrease in the expression and distribution of IL-2 receptors on the surface of responder cells.
Chen et al. (1986)IL2PBLIn the elder humans, the IL2 production by PBL decreased progressively as the increase of the age of the donors.
Liu (1992)IL2lymphocytesThe lymphocytes IL2 receptors expression and proliferative response in cancer patients were also significantly decreased.
Liu (1992)IL2lymphocytesOur study suggested that impaired IL2 production and IL2 receptors expression by lymphocytes from lung cancer patients may depress the IL2 dependent anti-tumor reaction in vivo.
Bloemena et al. (1988)IL-2lymphocyteThese findings suggest that pred inhibits IL-2 production and subsequent lymphocyte proliferation at the level of the signal derived from the monocyte.
Rappaport and Dodge (1982)IL-2lymphocytesProstaglandins of the E type specifically inhibited the production of interleukin 2 (IL-2) by normal human lymphocytes, whereas PG synthetase inhibitors such as indomethacin and fentiazac raised IL-2 production above normal levels.
Lambert et al. (1989)IL-2lymphocytesEach of the fluids to be analyzed was pre-incubated with mitogen stimulated human lymphocytes for 48 h and then inhibition of [3H]thymidine incorporation or IL-2 receptor expression was estimated.
Ohmura and Onoue (1990)interleukin 2lymphocytesThe rate of the degradation of interleukin 2 (IL-2) mRNA produced in stimulated human tonsillar lymphocytes was found to be significantly decreased in cells continuously stimulated with a calcium ionophore, A23187, and a phorbol ester, phorbol 12, 13-dibutylate (PDB) as compared with that in unstimulated cells.
Huchet and Grandjon (1988)IL-2lymphocytesPeripheral blood lymphocytes pre-incubated for 1 h with histamine 10(-5)-10(-7) M inhibited the IL-2 synthesis of normal autologous lymphocytes in a co-culture system.
Dornand et al. (1986)IL 2lymphocyteAt concentrations higher than 0.3 microM, ouabain inhibited both lymphocyte proliferation and IL 2 production.
Carlsson et al. (1987)IL-2lymphocyteThe collective data show that the SEA-induced suppression of IL-2 activity in lymphocyte culture medium is not due to a suppression of the IL-2 production but rather depends on depletion of IL-2 due to absorption of IL-2 from the culture medium.
Rigby et al. (1984)IL-2lymphocyteWe conclude that calcitriol is a potent inhibitor of PHA-induced lymphocyte blast transformation and that this effect is mediated, in part, through suppression of IL-2 production.
Calder (1993)interleukin-2lymphocytesUnsaturated fatty acids suppress production of the immunoregulatory cytokine interleukin-2 by lymphocytes in vitro. 4.
Farmer et al. (1986)interleukin 2lymphocytesAdditional studies on the mechanism of action of the plasma inhibitor demonstrated that it functions as a nonlymphotoxic inhibitor of interleukin 2 production by stimulated human lymphocytes, and that this activity is accompanied by suppression of expression of the cell surface receptor for interleukin 2.
Bhalla et al. (1986)IL-2lymphocytesSupernatants from lectin-activated lymphocytes incubated with 1,25-(OH)2D3 had reduced interleukin-2 (IL-2) activity.
Nagel et al. (1988)IL2lymphocytesThe results suggest that decreased expression of both IL2 and IL2R mRNA contributes to the low synthesis of IL2 and membrane IL2R, respectively, and is partially responsible for the diminished proliferative activity observed in lymphocytes from the elderly.
Noma et al. (1990)IL2lymphocytesThe induction of OVA-specific IL2 responsiveness in patient lymphocytes was markedly suppressed on the addition of culture supernatant from OVA-stimulated normal T cells, but Df-specific IL2 responsiveness of the lymphocytes from Df-sensitized patients with bronchial asthma was not suppressed by the same supernatant.
Noma et al. (1990)IL2lymphocytesThe patient lymphocytes whose IL2 responsiveness was suppressed with the supernatant from normal lymphocytes still expressed Tac antigen.
Tadmori et al. (1986)IL 2lymphocyteAntibody 9.6, added during the first 4 hr after lymphocyte stimulation, markedly inhibited IL 2 mRNA accumulation induced by low but synergistic combination of PHA (5 micrograms/ml) and TPA (1.0 ng/ml).
Oh et al. (1993)interleukin 2lymphocyteConcomitant with the inhibition of lymphocyte activation and interleukin 2 (IL-2) production, transcription of the IL-2 message is also reduced in a time-dependent manner.
Stein et al. (1999)IL-2lymphocytesA major effect of CSA is to decrease interleukin-2 (IL-2) production; however, measurement of this effect in isolated lymphocytes as a marker of response to CSA has been problematic.
Li et al. (1992)IL-2lymphocyteCompared with preoperative levels, IL-2 production and IL-2 receptor expression were significantly reduced on postoperative day 4, and the reduction was consistent with the suppression of lymphocyte proliferative response to phytohemagglutinin.
Hinoshita et al. (1990)interleukin 2lymphocytesDecreased production and responsiveness of interleukin 2 in lymphocytes of patients with nephrotic syndrome.
Hinoshita et al. (1990)IL-2lymphocytesThe IL-2 production was also significantly decreased in lymphocytes from patients with membranous nephropathy.
Langhoff (1989)IL-2lymphocytesThese results suggested that a deficient production of IL-2 may be part of; (i) the decreased transformation response (ii) and the increased sensitivity in vitro to glucocorticoids of lymphocytes from hemodialyzed patients.
Abraham et al. (1988)IL-2lymphocyteThese findings suggest that although hemorrhagic serum produces a marked decrease in IL-2 generation, the suppressive effects of hemorrhagic serum on mitogen-induced lymphocyte proliferation are not due to this decrease in IL-2 production.
Berezhnaia et al. (1987)IL-2PBLMean IL-2 production by PBL in 19 patients was significantly diminished as compared with the control.
Langhoff et al. (1986)IL-2lymphocytesThus, it is suggested that a deficient production of IL-2 may partly explain the reduced lymphocyte response of uremic lymphocytes in vitro.
Teodorczyk-Injeyan et al. (1989)interleukin-2lymphocytesThis serum demonstrated a strong suppressive activity, inhibiting expression of cellular interleukin-2 receptor and proliferative responses of normal human lymphocytes to alloantigen and exogenous interleukin-2 by 60% to 90%.
Santoli and Zurier (1989)IL-2lymphocyteTaken together, these data indicate that essential fatty acids inhibit IL-2 production directly without conversion into their cyclo-oxygenase pathway products, and suggest that human lymphocyte function may be altered profoundly by small changes in their fatty acid profile.
Guilloux et al. (1994)IL-2TILStimulation of TIL clones by allogeneic melanoma lines sharing the appropriate HLA-peptide complexes revealed that defective IL-2 production seemed to be a constant feature for some clones, while it was, for other clones, dependent on the antigen-presenting tumor cells.
de Faucal et al. (1984)IL2lymphocytesImpaired IL2 production by lymphocytes of patients with systemic lupus erythematosus.
Yamamoto et al. (1986)IL2 mRNAlymphocytesProstaglandin E2, which is known to elevate intracellular cAMP level, also inhibited IL2 mRNA induction in the lymphocytes stimulated with PHA and TPA.
Valtorta et al. (1991)IL-2lymphocyteLow concentrations of GHRH 1-29 increased phytoemoagglutinin (PHA)-induced lymphoproliferation, while high concentrations inhibited lymphocyte response, interleukin-2 (IL-2) secretion and IL-2 receptor expression on activated cells.
Beckner and Farrar (1987)IL 2lymphocyteAlthough the stimulation of adenylate cyclase by activators of the enzyme was evident in lymphocyte membrane preparations, the inhibitory effect of IL 2 was observed only if cells were pretreated with IL 2 and the membranes activated with Ca++ and ATP.
Shiratsuchi et al. (1987)IL-2PBLThe addition of recombinant IL-2 also had a restorative effect (up regulation) in vitro on the partly impaired PPD-induced IL-2 receptor expression by PBL from the patients with advanced, refractory tuberculosis.
Sfikakis et al. (1996)interleukin-2lymphocytesDownregulation of interleukin-2 and apha-chain interleukin-2 receptor biosynthesis by cisplatin in human peripheral lymphocytes.
Lomnitzer et al. (1983)interleukin 2lymphocytesHC-treated adherent cells produced less interleukin 1 (IL-1) than control cells, and interleukin 2 (IL-2) production by HC-treated lymphocytes was also reduced.
Sadick et al. (1984)interleukin 2lymphocyteThereafter interleukin 2 production rapidly decreased, whereas the lymphocyte proliferative response declined more slowly.
Lardone et al. (2006)IL-2lymphocytesA previous study showed that exogenous melatonin is able to counteract the decrease in IL-2 production caused by prostaglandin E2 (PGE2) in human lymphocytes via its membrane receptor.
Miossec et al. (1987)IL-2lymphocytesIn the presence of RA SF, normal lymphocytes showed not only a decreased response to exogenous IL-2, but also a decreased production of IL-2.
Ye et al. (2001)interleukin-2lymphocytesOBJECTIVE: To investigate the growth inhibition of interleukin-2 receptor (IL-2R) gene-transduced peripheral blood lymphocytes (PBLs) on human ovarian cancer cells.
Ranjan et al. (2004)IL-2lymphocytesCONCLUSION: Curcumin has profound immunosuppressive effects mediated via inhibition of IL-2 synthesis, mitogen, and IL-2 induced activation of human lymphocytes.
Murray et al. (1986)interleukin-2lymphocytesIn vitro inhibition of interleukin-2 production by peripheral blood lymphocytes from stage III melanoma patients by prostaglandin E2: enhancement of lymphocyte proliferation by exogenous interleukin-2 plus indomethacin.
Perl et al. (1986)IL-2lymphocytesThese data suggest that depressed LDCC and Con A-induced blastogenesis of patients with active SLE may not be related to impaired IL-2 production but rather to an inherent dysfunction of the effector lymphocytes, including their unresponsiveness to IL-2.
Tanaka and Tsujimura (2002)IL-2lymphocytesCyclosporin is a non-cytotoxic immunomodulating drug which inhibits NF-AT-dependent IL-2 transcription in lymphocytes.
Zeitz et al. (1989)IL-2lymphocytesHigh mitogen-stimulated IL-2 production of lamina propria lymphocytes was only partially inhibited in CsA-treated animals.
McCarthy et al. (1990)interleukin 2lymphocyteInhibition of polyamine synthesis suppresses human lymphocyte proliferation without decreasing cytokine production or interleukin 2 receptor expression.
Noma et al. (1989)IL-2lymphocytesPatients' lymphocytes whose IL-2 responsiveness was decreased still expressed Tac antigen (low-affinity IL-2 receptors) but, in contrast to the patients' original lymphocytes, did not absorb or respond to IL-2, suggesting the loss of high-affinity IL-2 receptors (p55/p75) from these cells.
Karlsson and Nässberger (1991)interleukin-2lymphocytesFK506 lacks the ability to inhibit expression of interleukin-2 receptor beta-chain on human lymphocytes.
Filaci et al. (1997)interleukin 2lymphocyteS-adenosil-L-methionine did not affect lymphocyte proliferation while it reduced interleukin 2 secretion upon phytohemagglutinin and pokeweed stimulation and interferon-gamma secretion upon all stimuli tested.
Dong et al. (1991)interleukin-2lymphocyteInhibition of interleukin-2 production and lymphocyte responsiveness by the cell activation inhibitor, CI-959.
Dong et al. (1991)IL-2lymphocytesCI-959 (5-methoxy-3-(1-methylethoxy)-N-1H-tetrazol-5-yl-benzo [b]-thiophene-2-carboxamide), an antiallergy compound, blocked release of IL-2 from Con A stimulated rat splenocytes and human lymphocytes with respective IC50s of 19.1 and 23.1 microM.
Gastl et al. (1984)IL-2lymphocyteSince addition of exogeneous IL-2 significantly enhanced the patients' lymphocyte proliferation in response to Con A, a defective IL-2 production was assumed to be at the origin of the impaired mitogenic response in chronic schistosomiasis.
Ruscetti et al. (1980)TCGFlymphocyteRemoval of PHA 12 h after incubation had no effect on lymphocyte transformation but decreased TCGF release by 90%.
Musatti et al. (1987)IL-2lymphocytesEnhanced prostaglandin synthesis was one of the factors causing impairment of the proliferative response and the diminished IL-2 production in lymphocytes from patients with lymphoma. 5.
Abraham et al. (1986)IL-2lymphocyteInjury impairs cell-mediated immune function by depressing mitogen-induced lymphocyte proliferation and decreasing interleukin-2 (IL-2) production.
Goodyear et al. (1996)IL-2lymphocyteIL-2 receptors, a marker for lymphocyte activation, were decreased during the acute phase of eczema herpeticum, and for 1 month thereafter.
Kierszenbaum and Sztein (1992)interleukin-2lymphocytesTrypanosoma cruzi suppresses the expression of the p75 chain of interleukin-2 receptors on the surface of activated helper and cytotoxic human lymphocytes.
Karlsson et al. (1991)interleukin-2lymphocytesThe immunosuppressive agent FK506 inhibits in vitro expression of membrane-bound and soluble interleukin-2 receptors on resting but not on activated human lymphocytes.
Toder et al. (1991)IL 2lymphocytesThis effect is followed by decrease of IL 2 production in spleen; increase of MAC 1-positive cells at placenta; amplification of suppressive activity of local and systemic lymphocytes and by reverse of embryotoxic effect of maternal serum.
Kierszenbaum et al. (1989)interleukin 2lymphocytesHere, Felipe Kierszenbaum and colleagues discuss the ability of the pathogenic protozoan Trypanosoma cruzi to suppress the expression of interleukin 2 receptors by human lymphocytes.
Walker et al. (1983)IL 2lymphocyteThese findings strongly suggest that PGE2 primarily exerts its inhibitory effect on lymphocyte proliferation through an inhibition of IL 2 production.
Sugimura et al. (1989)IL2lymphocyteTaken together, these results suggest that there might be a control system of T cell proliferation distinct from the previously reported mechanisms, such as the inhibition of IL2 production or the inhibition of IL2R light chain (CD25) expression, and that LBIF might be an important molecule in the regulation of normal lymphocyte proliferation.
Nihlmark and Lindqvist (1989)IL-2lymphocytesAlthough IL-2 receptor analysis performed on the stimulated and antitubular-treated lymphocytes showed a 2-fold decrease in high-affinity and a 100-fold decrease in low-affinity IL-2 receptor expression, a proliferative response to externally added rIL-2 was noticed.
Elliott et al. (1987)IL-2lymphocyteDiminished lymphocyte reactivity has been recently shown in these patients to be linked to deficiencies in interleukin-2 (IL-2) production.
Coventry et al. (1996)IL-2TILThe mechanism for apparent inhibition of IL-2 production and IL-2R expression in the presence of IL-2 mRNA is currently unclear; however, this may explain the relative anergic state of native TIL.
Dohi et al. (1991)IL-2PBLThese findings suggest that defective IL-2 production and IL-2 responsiveness of PBL in patients with MCNS contribute to the pathogenesis of MCNS.
Kozenitzky et al. (1992)IL-2lymphocyteIn the present study, the addition of AS101 and PMA serve to restore the impaired IL-2 production, T- and T-helper lymphocyte functional activity, but not the IL-2R release.
Sakharova et al. (2005)interleukin-2lymphocytesThe higher viability of mycobacteria and the increase in the drug resistance have been shown to be associated with the decreased activity of lymphocytes and the suppressed production of interleukin-2, which suggests a decrease in the activity of type 1 T helper cells and a significant increase in the synthesis of tuberculosis antibodies with the lower serum concentrations of circulating immune complexes.
Vanrenterghem (1997)interleukin-2lymphocyteBoth tacrolimus and CsA interfere with the early stage of lymphocyte proliferation by blocking interleukin-2 synthesis.