Viewing affirmative mentions of gene expression of IL2 (H. sapiens) in liver

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Conti et al. (1999)IL-2liverBACKGROUND/AIMS: To investigate the respective roles of interleukin-2 (IL-2) and IL-4 during rejection, we evaluated the expression of IL-2, IL-2 receptor and IL-4 in human liver allografts.
He et al. (2000)IL-2 geneliverTo improve the safety and efficiency of human hepatocellular carcinoma (HCC) gene therapy, we explored the use of a liver-specific promoter and a tumor-specific enhancer to achieve regular IL-2 gene expression for treatment of HCC.
He et al. (2000)IL-2 geneliverThe liver-predominant expression pattern of the IL-2 gene was observed in the medium of the transfected cells.
Martinez et al. (1993)IL-2liverIL-2 and IL-5 gene expression in response to alloantigen in liver allograft recipients and in vitro.
Martinez et al. (1993)IL-2liverIL-2 and IL-5 gene expression in response to alloantigen was studied in liver allograft recipients and in an in vitro system.
Kasprzak et al. (2006)IL-2liversInterleukin-2 (IL-2) expression in livers of patients with chronic hepatitis C virus (HCV) infection.
Kasprzak et al. (2006)IL-2liversAs compared to the control material, in livers of both groups of chronic hepatitis C patients augmented expression of IL-2 was demonstrated.
Yoshioka et al. (1984)IL-2liverWe measured the production of and response to IL-2 of peripheral blood T cell subsets from patients with chronic active liver diseases (CALD) and other liver diseases (Others) by the proliferative response of the cells activated with phytohaemogglutin P.
Lai et al. (1989)interleukin 2liverThe observed reduction of interleukin 2 production from activated lymphocytes may be related to the severity of liver impairment, rather than the HBV infection itself.
Hammerich et al. (2011)IL-2liversThe same group also found that in livers of IL-2R?
Duvoux and Samuel (2009)IL2liverSeveral advances have accompanied the increasing number of indications and these excellent results: (a) the development of more specific immunosuppressive drugs to prevent rejection, the incidence of which is currently less than 20%: tacrolimus, mycophenolic acid, anti-IL2 receptor antibodies, mTOR inhibitors, (b) a policy of active recruitment of organs together with surgical innovations (split liver, domino LT, living donor transplantation) contributing to the expansion of the pool of organs, (c) standardization of organ allocation policies, based on the sickest first policy.
Cohen et al. (1991)interleukin 2liverAn improved method for the detection of soluble interleukin 2 receptors in liver transplant recipients by flow cytometry.
He et al. (1999)IL-2liverThis study explores the use of a liver-specific albumin promoter and a tumor-specific alpha-fetoprotein (AFP) enhancer to achieve the regulated expression of the cytokine interleukin-2/interferon alpha2b (IL-2/IFNalpha2b) fused gene for treatment of hepatocellular carcinoma (HCC).
He et al. (1999)IL-2liverThe liver-targeted expression pattern of the IL-2/IFNalpha2b fused gene was observed when this product was tested in the culture medium of the infected cells (IL-2 activity was 850 IU/10(6) cells, IFNalpha activity was 320 IU/10(6) cells).
Kolbeck et al. (1993)IL-2liverLymphocytes infiltrating human liver allograft biopsies were expanded in vitro for 3 to 5 days in recombinant IL-2 and then uniformly quantified and phenotypically characterized.
Yoshimura et al. (2002)IL-2liver[Hepatic arterial infusion of IL-2 and chemotherapy for unresectable liver metastasis from colorectal cancer].
Ueda et al. (2000)IL-2liverThe remaining 11 patients received systemic transfer of LAK cells with IL-2 against metastatic lesions located in organs other than the liver (systemic therapy group).
Bishop et al. (1993)IL-2liverIL-2 mRNA was expressed at barely detectable levels in four of 12 normal livers screened and in 20 of 26 liver allograft specimens with rejection.
Boleslawski et al. (2004)interleukin-2liverBACKGROUND: The aim of this study was to evaluate calcineurin activity and interleukin-2 (IL-2) expression by peripheral blood cells as a means of assessing the immune status of liver transplant recipients.
Sánchez et al. (1993)IL-2liverIn contrast, no expression of IL-2R alpha or IL-2 transcripts was found in fetal liver cells, whereas transcription of the IL-4 gene was detected in a small fetal liver cell subset.
Napoli et al. (1994)IL-2liversMETHODS: Cytokine mRNA expression for interleukin (IL) 1 beta, IL-2, IL-6, IL-8, transforming growth factor beta, interferon gamma, and tumor necrosis factor alpha was examined by semiquantitative polymerase chain reaction in 25 human cirrhotic livers and 13 controls.
Zhang et al. (2008)interleukin-2liver[Effects of Jinlong Capsule on expressions of interleukin-2 and soluble interleukin-2 receptor in patients with primary liver cancer after transarterial chemoembolization therapy].
Bird et al. (1989)lymphokineliverTo investigate whether disordered immune function, as shown by abnormalities in lymphokine production, is present in alcoholic liver disease, interleukin-1 and interleukin-2 activity were assayed in a group of patients with acute alcoholic hepatitis in the absence of underlying cirrhosis, and a group of patients with inactive alcoholic cirrhosis.
Jonsson et al. (2000)IL-2liverIL-4 and IL-12 were not detected and IL-2 was only faintly detected in the liver-derived CD4+ population.
Hoshino et al. (1999)IL-2liverUtilizing IFN-gamma knockout (-/-) mice as a model system, IL-2-activated liver NK and T cells expressed 10-fold more IL-13 and IL-5 mRNA and protein than normal controls following IL-2 treatment in vitro.
Agarwal et al. (1999)IL-2liverCONCLUSIONS: The higher levels of TNF-alpha and IL-2 in the pus aspirate compared to blood pre treatment, supports the role of locally released cytokines in the target organ i.e. liver in amoebiasis.
Zhang et al. (2008)IL-2liverThe levels of IL-2 and sIL-2R can be considered as the valuable parameters for evaluating the effects on primary liver cancer, and Jinlong Capsule is helpful for the patients with primary liver cancer.
Shinkai et al. (2006)IL2liverThe aim of this study was to characterize the inflammation in BA by quantifying lymphocyte density and expression of TH1 cytokines such as IL2 and tumor necrosis factor alpha (TNF-alpha) in liver biopsies using qrt-PCR.
Kelly et al. (2004)IL-2liverIL-2 was detected in normal liver (median 4700 pg/100 mg protein).
Franco et al. (1990)IL2liverThirty T cell clones were generated from T cell blasts, infiltrating the liver of autoimmune chronic active hepatitis (CAH) patients, stimulated with autologous hepatocytes expressing class II major histocompatibility complex (MHC) molecules and interleukin 2 (IL2).
Dharancy et al. (2007)IL-2liverRESULTS: IL-2 transcript levels were significantly higher in severe than in mild HCV in both liver graft recipients and nontransplanted patients.
Tashiro et al. (2000)IL-2liverCONCLUSIONS: The prolongation of survival of IL-10 cDNA transferred liver allografts might be due to inhibition of the early phase of alloimmune-response by over expression of IL-10, despite the expression of IL-2 and interferon-gamma.
Sennikov et al. (2001)IL-2liverIt was revealed that the cell population enriched with erythroid progenitors, isolated from human fetal liver, can produce IL-1 beta, IL-2, IL-4, IL-6.
Das et al. (2008)IL-2liverThis impairment of IL-2 production would be expected to limit T cell clonal expansion potential, particularly within the liver, where CD4 help is restricted (24).
Tashiro et al. (2000)IL-2liverIn gene-transduced long-term surviving liver allografts, IL-10 was expressed, and the expression of IL-4 was also up-regulated on posttransplant day 3, despite the expression of Th1 cytokines (IL-2 and interferon-gamma), although in rejected liver allografts, IL-2 and interferon-gamma were expressed without expression of IL-4 and IL-10.
Wyler (1991)lymphokineliversA novel lymphokine that is mitogenic for fibroblasts and is produced by CD4+ lymphocytes in the granuloma has been found in infected livers.
Zhang et al. (1995)IL-2liversOn day 6 after induction of 11%-12% TBSA full-thickness burn, the animals were sacrificed, and proliferation and IL-2 production of splenic lymphocytes, LPO levels of the plasma, livers and spleens were measured.
Tsai et al. (1996)IL-2liversIL-2 and IFN-gamma could be amplified, whereas IL-4 was virtually undetectable in the livers from the two patients with PBC.
Magrin et al. (1989)interleukin-2liverThe behaviour of the immune system during liver damage caused by chronic hepatitis delta virus (HDV) infection was evaluated by assessing, in 16 patients with HBsAg+ chronic liver disease and HDV superinfection (15 HBeAg-, 1 HBeAg+), phytohaemagglutinin (PHA)-induced interleukin-2 synthesis and interleukin-2 receptor expression, PHA and staphylococcal enterotoxin B (SEB)-induced gamma-interferon synthesis and, in some cases, the presence of hepatitis B virus DNA (HBV-DNA) within peripheral blood mononuclear cells (PBMC).
Morshed et al. (1993)IL-2liverInterferon-gamma, interleukin (IL)-2 and IL-2 receptor expressions in hepatitis C virus-infected liver.
Moldawer et al. (1988)IL-2liverTo evaluate their potential role, food intake and liver and plasma protein synthesis were determined in both endotoxin-sensitive C57Bl/6j mice and endotoxin-resistant C3H/HeJ mice given either crude secretory products of Staphylococcus albus-stimulated human blood monocytes or murine recombinant IL-1-alpha, human recombinant IL-1-alpha or -beta, human recombinant tumor necrosis factor-alpha, or human IL-2.
Ciuffreda et al. (2008)IL-2liverIn contrast, HCV-specific T-cell responses had an effector profile in HIV/HCV co-infected individuals and liver transplant recipients with absence of single IL-2-producing HCV-specific CD4+ and dual IL-2/IFN-gamma-producing CD8+ T cells.
Kawarabayashi et al. (2000)IL-2liverIn addition to a flow cytometric analysis, liver MNC and PBMC were cultured with the immobilized anti-CD3 Ab, IL-2, or a combination of IL-2 and IL-12 and their IFN-gamma production and the antitumor cytotoxicity were assessed.
Sari et al. (2001)IL-2liverMATERIAL AND METHODS: We determined serum and ascites fluid TNF-alpha, IL-1beta, IL-6, IL-8, and soluble IL-2 receptor levels in 14 patients with congestive heart failure (group 1) and in 15 patients with chronic liver disease (group 2).
Van de Water et al. (1995)lymphokineliverAdditionally, lymphokine analysis of interleukin (IL) 2/IL-4/interferon gamma production from individual liver-derived autoantigen-specific T cell clones suggests that both T helper cell Th1- and Th2-like clones are present in the liver.
Saadoun et al. (2004)IL-2liverUsing intracellular staining and flow cytometry, we assessed the ability of freshly isolated liver T cells from these biopsies to produce IFN-gamma, TNF-alpha, IL-2, IL-4, and IL-10 in response to stimulation with PMA and ionomycin.
Mizoguchi et al. (1987)lymphokineliverA novel lymphokine, which we have designated as cholestatic factor (CF), was produced from peripheral blood lymphocytes of patients with drug-induced allergic intrahepatic cholestasis by stimulation with a causative drug in the presence of the liver soluble fraction containing liver-specific lipoprotein (LSP).
Mizoguchi et al. (1986)lymphokineliverA novel lymphokine, which we have designated as the cholestatic factor (CF). was produced from peripheral blood lymphocytes of patients with drug-induced allergic intrahepatic cholestasis by stimulation with a causative drug in the presence of the liver soluble fraction containing liver-specific lipoprotein (LSP).
Gujar and Michalak (2009)IL-2liverFurthermore, immediately after exposure to a liver-nonpathogenic dose of WHV, lymphocytes acquired a heightened capacity to proliferate in response to mitogenic stimuli and displayed augmented expression of alpha interferon, interleukin-12 (IL-12), and IL-2, but not tumor necrosis factor alpha.
Bozkaya et al. (2000)IL-2liverRESULTS: Apart from group 1 patients, all patients groups had higher IL-2 levels compared to controls suggesting that IL-2 production is increased when liver disease becomes active in HBeAg-positive phase of HBV infection.
Canivet et al. (2008)IL-2liverThe aim of this study was to assess T-cell function, i.e., intralymphocyte cytokine expression (IL-2 and TNF-alpha), T-cell activation [i.e., transferrin receptor (CD71) and interleukin (IL)-2 alpha-chain (CD25) expression], and T-cell proliferation using a flow-cytometry whole-blood assay in patients waiting for a liver transplantation (n=49).
Yamaguchi et al. (1988)interleukin 2liverIncreased serum soluble interleukin 2 receptor levels in patients with viral liver diseases.
Bozkaya et al. (2000)IL-2liverWe aimed to determine the serum levels of IL-2, IL-10 and TNF-alpha in patients with chronic hepatitis B and to correlate these findings with the activity of liver disease, HBeAg/anti-HBe status and replication level of the virus.
Zekry et al. (2002)IL-2liverIntrahepatic messenger RNA expression of T helper cell subtype 1 (TH1) cytokines interleukin-2 (IL-2), interferon-gamma, and tumor necrosis factor-alpha and TH2 cytokines IL-4 and IL-10 was measured by real-time polymerase chain reaction system using TaqMan probes in 53 liver specimens from six groups of patients.
García-Monzón et al. (1990)interleukin-2liverIn the present study, the expression of different activation antigens have been investigated, such as the interleukin-2 and the transferrin receptors and a recently described T-cell activation molecule termed "activation-inducer molecule" on the different lymphocyte subsets of both peripheral blood and liver-infiltrating lymphocytes from patients with virus-induced chronic active hepatitis.
Tilg et al. (1990)interleukin 2liverThe study objective was first to investigate serum levels of tumor necrosis factor alpha, interleukin 1 beta, interferon gamma, interferon alpha, interleukin 2, beta-2-microglobulin (B2M), and urinary neopterin in patients after orthotopic liver transplantation; and second to relate their levels to clinical complications.
Fukuda et al. (1995)IL-2liverThe expression of IL-2, IL-4 and interferon-gamma (IFN-gamma) mRNA using liver biopsies at different phases of acute exacerbation of chronic hepatitis B.
Fukuda et al. (1995)IL-2liverTo investigate the hypothesis that Th1 phenotype cytokines are associated with the increasing activity of hepatitis and Th2 phenotype cytokines with decreasing activity in the liver of chronic viral hepatitis, expressions of the mRNA of the cytokines IL-2, IFN-gamma and IL-4 in the liver of 23 patients with chronic hepatitis B were investigated by reverse transcription polymerase chain reaction.
Sarobe et al. (1996)interleukin-2liverMETHODS: We used thirty-six 15-mer synthetic peptides from hepatitis C virus E1 protein (genotype 1a) in a sensitive interleukin-2 production assay in two groups of controls (healthy seronegative individuals and patients with liver diseases unrelated to hepatitis C virus), and three groups of patients with chronic hepatitis C: nine patients who cleared the virus after interferon treatment (group 1), nine patients who failed to respond to the therapy (group 2) and nine previously untreated patients (group 3).
Fuji et al. (1987)interleukin 2liverWhile concanavalin A-stimulated and recombinant interleukin 2-stimulated production of interferon-gamma in patients with chronic active hepatitis and liver cirrhosis was significantly decreased when compared with that of controls (518 +/- 189 and 729 +/- 195 units per ml, mean +/- S.D.), there was also a lot of overlap.
Melby et al. (2001)IL-2liverUncontrolled parasite replication in the hamster liver, spleen, and bone marrow occurred despite a strong Th1-like cytokine (IL-2, IFN-gamma, and TNF/lymphotoxin) response in these organs, suggesting impairment of macrophage effector function.
Nossal (1984)non-lymphokineliverJust to start an argument, I will speculate that IL-3 will not be involved here, but rather that we must search for non-T-cell-derived (non-lymphokine) factors produced by specialized cells (not macrophages) in the foetal liver or the bone marrow.