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Paradisi et al. (1995)IL-2leukocyteThese findings confirm IL-2 to be in seminal plasma, show increased IL-2 secretion in the infertile group, demonstrate negative correlations of IL-2 levels with main spermiogram parameters, and indicate no correlation with leukocyte count.
Baker et al. (1989)IL-2leukocyteConceivably increased biopterins, induced by IL-2 activation of a leukocyte population, is a cell-mediated consequence not necessarily serving as a signal for the antitumor effect associated with adoptive immunotherapy.
Lindqvist et al. (1987)IL-2leucocyteA monoclonal antibody inhibiting leucocyte adhesion blocks induction of IL-2 production but not IL-2 receptor expression.
Holán et al. (1994)interleukin-2PBLThe production of interleukin-2 (IL-2) by mitogen-stimulated human peripheral blood leukocytes (PBL) was significantly enhanced by a short pretreatment of PBL with direct current (DC) at low intensities.
Grimm et al. (1982)IL-2leukocytesActivation in lectin-free interleukin 2 (IL-2) containing supernatants of peripheral blood mononuclear leukocytes (PBL) from cancer patients or normal individuals resulted in expression of cytotoxicity toward 20 of 21 natural killer (NK)-resistant fresh solid tumor cells tested.
Bowlin et al. (1989)IL-2leukocyteWe have recently established that swainsonine (SW), an inhibitor of mannosidase II during N-linked glycoprotein processing, augmented mitogen-induced mononuclear leukocyte IL-2 receptor expression and IL-2-induced proliferation.
Copperman et al. (2006)IL-2leukocytesThis response consists of statistically significant elevations of leukocytes and IL-2.
Brown et al. (1991)interleukin-2Immune cellImmune cell activation in melioidosis: increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein.
Zatz et al. (1985)IL-2PBLUsing a standard human PBL cell population obtained by leukopheresis and cryopreservation, it should now be possible to establish a reproducible bioassay for the isolation and characterization of one or more components of TF5 with the property of enhancing PHA-induced IL-2 production by human PBL.
Zatz et al. (1985)IL-2PBLOur studies demonstrate that aspirin, an inhibitor of the cyclooxygenase pathway, given in vivo, or added to cultures in vitro, results in two-fold increased IL-2 production by PHA-stimulated PBL.
Peltier et al. (2000)IL-2PBMLStimulation of PBML for 14 hr with ConA resulted in an increase in steady state amounts of interleukin-2 (IL-2) mRNA that was not inhibited by OvUS.
Roche et al. (1988)interleukin 2leukocytesEnhancement of interleukin 2 production by quinolone-treated human mononuclear leukocytes.
Marazuela et al. (1994)interleukin 2leukocyteFollowing lymphocyte stimulation, there was an increase in human leukocyte antigen-DR and interleukin 2 receptor expression in patients with untreated Graves' disease.
Antonen and Krohn (1986)IL-2leucocyteWe studied mitogen- and antigen-induced interleukin 2 (IL-2) production in HTLV-III/LAV infected and non-infected individuals and compared the results with T cell subpopulations, and with mitogen- and antigen-induced DNA synthesis and production of leucocyte migration inhibitory factor (LIF) in order to understand the controversial findings related to IL-2 production in HTLV-III/LAV infection.
Gearing et al. (1989)IL-2leucocytesInterleukin 2 (IL-2) production by leucocytes from all three groups was significantly increased following challenge with FHA or PT.
Barbieri et al. (1995)interleukin-2PBMLThe difference between Jurcat cells and PBML was not dependent on culture conditions, because phytohemagglutinin and interleukin-2 activated PBML, kept in culture, showed the same PA preference as freshly prepared non-activated PBML.
Lifson et al. (1986)IL-2PBMLThe IL-2 induced proliferative response thus appears to be dependent on interactions between different subpopulations of PBML but probably does not simply reflect augmentation by IL-2 of antigen-driven or autoreactive processes.
Irwin et al. (1996)IL-2white blood cellsTo determine whether alterations of immune function also occur after even a modest loss of sleep, the effects of early-night partial sleep deprivation on circulating numbers of white blood cells, natural killer (NK) cell number and cytotoxicity, lymphokine-activated killer (LAK) cell number and activity, and stimulated interleukin-2 (IL-2) production were studied in 42 medically and psychiatrically healthy male volunteers.
Henriksson et al. (1998)interleukin 2leucocyteSurvival in renal cell carcinoma-a randomized evaluation of tamoxifen vs interleukin 2, alpha-interferon (leucocyte) and tamoxifen.
Ihrie and Wood (1985)interleukin 2leukocyteContamination of commercial leukocyte-derived human interleukin 2 with interleukin 1.
Brivio et al. (1993)IL-2immune cellsCONCLUSIONS: The results suggest that a three day course of IL-2 preoperatively is well tolerated, stimulates would repair, neutralizes the lymphocytopenia induced by major operation, and induces immune cells to infiltrate the tumour.
Makonkawkeyoon and Kasinrerk (1989)IL-2PBMLIncorporation of M. leprae for 0, 6 and 12 h in PHA-P and PBML cultures had no inhibitory effect on IL-2 production; however, after 14, 16 and 18 h of M. leprae incorporation, significant inhibitory effects were noted on IL-2 production.
Bowlin et al. (1987)IL-2MNLPolyamine depletion of MNL augmented detectable levels of Con A-induced IL-2 activity.
Petersen et al. (2002)IL-2leukocyteWe have found 72 h of culture optimal for detection of IL-2 and IL-4 produced by human mononuclear cells (MNC) in response to stimulation with phytohaemaglutinin and for detection of IL-2 in human leukocyte antigen (HLA)-mismatched mixed leukocyte culture (MLC).
Brkic et al. (1985)interleukin 2leukocytesPeripheral blood mononuclear leukocytes (cells of marrow donor origin) from 89 patients were collected at various times after allogeneic marrow transplantation, stimulated in vitro by phytohemagglutinin, and assayed for the production of interleukin 2 (IL-2).
Vilcek et al. (1985)IL 2PBLTaken together, the data suggest that endogenously generated IL 2 is a major mediator of IFN-gamma induction in PBL cultures stimulated with antigens or T cell mitogens.
Vervliet and Schandené (1985)IL-2PBLThe PBL cultures of the same seven patients were also defective for IL-2 production after PHA stimulation.
Roche et al. (1988)IL-2MNLSince at these concentrations the PHA-induced proliferative response of MNL was not impaired by quinolones, the increased recovered IL-2 activity was not related to a decreased absorption of IL-2 by activated MNL.
Roche et al. (1988)IL-2MNLIL-2 activity in the supernatants of PHA-stimulated MNL was found to be enhanced by quinolones in a dose- and time-dependent manner.
Roche et al. (1988)IL-2MNLThese data show that quinolones increased IL-2 synthesis by MNL and suggest the potential usefulness of these antibiotics, not only as antimicrobial agents, but also as modulators of immune responses.
Touw et al. (1985)IL 2leukocyteTheir stimulative effect was significantly enhanced when leukocyte-derived IL 2 or pure recombinant IL 2 was supplemented.
Touw et al. (1985)IL 2leukocytesApparently, IL 2 and feeder leukocytes are both required for the induction of colonies in these cases of ALL.
Huenecke et al. (2010)IL-2leukocyteOur data indicate that IL-2 stimulation increases the expression of activating receptors and emphasizes mechanisms beside KIR/human leukocyte antigen.
Levis et al. (1976)lymphokineleucocyteA soluble hapten (dinitrobenzene sulphonic acid (DNBSO3)) and particulate antigens consisting of DNCB, DNFB or DNBSO3 complexed with erythrocytes, all induce a specific blastogenic response and lymphokine production in leucocyte cultures from human subjects topically sensitized to dinitrochlorobenzene (DNCB).
Levis et al. (1976)lymphokineleucocytesThus, several DNP-containing haptens (DNCB, DNFB, DNBSO3) induce specific lymphocyte transformation and lymphokine production when exposed in several different manners to leucocytes from humans sensitized to DNCB.
Rouveix et al. (1987)lymphokineleukocytePenicillin (50 and 100 micrograms/ml) and cephalosporins (50 and 100 micrograms/ml) directly stimulated production of the lymphokine leukocyte aggregating factor (LAgF) by unstimulated lymphocytes and enhanced mitogen-stimulated production of this lymphokine.
Grimm et al. (1982)lymphokinePBLCulture of PBL in IL-2 for 2-3 d was required for the lymphokine activated killers (LAK) to be expressed, and lytic activity toward a variety of NK-resistant fresh and cultured tumor targets developed in parallel.
Goto and Zvaifler (1986)interleukin 2leukocyteCharacterization of the precursors of the NK-like cytotoxic cells generated in the autologous mixed leukocyte reaction and by interleukin 2 activation.
Kimata et al. (1993)interleukin-2leukocyteInduction of interleukin-2 expression was inhibited by anti-CD2 and anti-lymphocyte function-associated antigen 3 (LFA-3) monoclonal antibodies but not anti-human leukocyte antigen-DR, anti-CD4, anti-LFA-1, or anti-intercellular adhesion molecule 1.
Rudnicka et al. (2003)IL-2PBMLPBML from RUT/HLO-positive patients responded significantly less intensively to H. pylori LPS in the presence of IL-2, to IL-2 alone and to H. pylori LPS+IL-2.
Henriksson et al. (1998)IL-2leucocyteThe patients (n = 65) randomized to biotherapy received subcutaneous recombinant IL-2, leucocyte IFN-alpha in a treatment cycle of 42 days, as well as tamoxifen p.o.
Dupere et al. (1990)interleukin-2leukocytesPatterns of cytokines released by peripheral blood leukocytes of normal donors and cancer patients during interleukin-2 activation in vitro.
Guan et al. (1987)lymphokineleucocytesInhibition of migration by gluten derived peptides appears to result from the release of lymphokine by leucocytes specifically from coeliac patients.
Quiroga et al. (1993)interleukin-2leukocyteAmong the leukocyte types evaluated, eosinophilic infiltration was elevated in interleukin-2 quarters over that of PBS controls.
Dozmorov et al. (2007)IL-2immune cellIncluded are early immune cell response (PTCRA, PPIB), immune response via IL-2 (DGKE) and NF-?
Odum et al. (1989)IL-2leukocyteAlloactivated HLA class II-positive T-cell lines induce IL-2 reactivity but lack accessory cell function in mixed leukocyte culture.
Baadsgaard et al. (1988)IL-2leukocytesIn conclusion, UV-EC may activate CD8+ lymphocytes by at least two pathways: (1) UV-EC activation of CD4+2H4+ lymphocytes may induce differentiation/proliferation of CD8+ suppressor cells and (2) UV-EC activation of CD4+ cells may induce IL-2 production, that, in combination with UV-induced epidermal leukocytes, stimulates CD8+ cells.
Ferrante et al. (1998)IL-2immune cellsAg-stimulated IL-2 production and mitogen-stimulated type 1 and type 2 cytokine production by PBMC, as well as expression of Th1- and Th2-associated phenotypical markers, of B7-1, B7-2, and CD95 (Fas) on the surface of immune cells, and the serum concentration of soluble Apo-1/Fas were evaluated in multiple sclerosis (MS) patients with either acute (AMS) or stable (SMS) disease and in healthy controls (HC).
Stassar et al. (1994)IL2leukocytesAfter the fifth and sixth BCG instillations a significant increase in the concentration of cytokines (IL2, IL6, IL8 and TNFa), IgG and IgA antibodies to BCG and the number of leukocytes in urine was observed.
Dupere et al. (1990)IL-2PBLsIn contrast, the cancer patients' PBLs, after 5 days of IL-2 activation in vivo, responded with one of two patterns of production of cytokines.
Sztein et al. (1987)IL-2leukocyteThe in vitro effects of thymosin fraction 5 (TF5) and lithium chloride (LiCl) on the ability of peripheral blood mononuclear cells (PBMC) obtained from 37 normal male donors and 33 male patients with AIDS-related complex (ARC) to respond to alloantigenic stimulation (mixed leukocyte reaction, MLR) and to produce interleukin 2 (IL-2) in response to mitogens were studied.
Bendtzen and Petersen (1982)lymphokineleukocyteThe mechanism of action of the immunosuppressive drug, cyclosporin A (CyA), was analyzed with respect to antigen-induced production of the human lymphokine, leukocyte migration inhibitory factor (LIF).
Gandhi et al. (2010)IL-2immune cellsIn MS, chemokines act as chemoattractants: recruiting immune cells and the proinflammatory cytokines they secrete, such as IL-2, IFN?
Namazi (2005)IL-2immune cellsBased on the immunopathogenesis of psoriasis, this paper introduces three novel, potential treatments for this clinical conundrum: (i) cannabinoids, which exert inhibitory effects on antigen processing and macrophage/T-cell interaction and also on the release of IL-2, TNF-alpha and nitric oxide from immune cells; (ii) loratadine, which is an antihistamine capable of increasing [corrected] the cAMP/cGMP ratio and the production of leukotriene B4; and (iii) allopurinol, which scavenges free radicals, inhibits the production of TNF-alpha, and downregulates the expression of intercellular adhesion molecule-1 and P2X7 receptors on monocytes/macrophages, which are involved in antigen presentation and production of the inflammatory response, respectively.
Jensen et al. (2009)IL-2-basedimmune cellsCONCLUSION: Intratumoral FOXP3-positive regulatory immune cells significantly increased during IL-2-based immunotherapy, and high numbers of on-treatment FOXP3-positive cells were correlated with poor prognosis in patients with metastatic renal cell carcinoma.
Almawi et al. (1991)IL-2 geneleukocytesBy Northern blot analysis now we demonstrate that antiproliferative concentrations of dexamethasone and 6 alpha-methylprednisolone block mitogen-induced IL-2 gene expression in human peripheral blood mononuclear leukocytes in a concentration-dependent fashion.
Rafiee et al. (2004)lymphokineleukocytesCsA prevents the activation of lymphokine genes essential for T cell proliferation by disrupting calcium-dependent signal transduction pathways in leukocytes [1].
Janele et al. (2006)IL-2leukocytesIn this study on peripheral blood leukocytes of healthy male subjects, we scrutinized the influence of prior sex hormones (for 24 h) with and without later addition of cortisol (for another 24 h) on stimulated secretion of TNF, IL-2, IL-4, IL-6, IL-10, and interferon-gamma (IFN-gamma).
Makonkawkeyoon et al. (1990)IL-2PBMLWhen PBML from leprosy patients were stimulated with concanavalin-A (ConA) for IL-2 production, there were no differences in the IL-2 levels in treated BL/LL, untreated BL/LL, treated BT/TT, and untreated BT/TT patients compared to normal controls.
Kami?ska et al. (1999)IL-2PBLMonitoring the cytokine production ability of PBL during IFN-gamma therapy revealed an increase in IL-2, IFN-gamma and TNF-alpha titers produced upon in vitro induction after 2 weeks of treatment (6 injections of rIFN-gamma).
Sauder et al. (1988)IL-2leukocyteETAF/IL-1 has a multiplicity of divergent biological effects: enhancement of thymocyte proliferation, stimulation of cells in the hypothalamus to mediate fever, leukocyte chemotaxis, stimulation of hepatic synthesis of acute-phase proteins, augmentation of IL-2 production and keratinocyte proliferation.
Kami?ska et al. (1999)IL-2leukocytesThe patient was monitored for serum IFN, TNF, IL-2 activities and for the ability of peripheral blood leukocytes (PBL) to produce IFN-alpha/beta, IFN-gamma, IL-2 and TNF-alpha after in vitro induction.
Funaro et al. (1994)interleukin-2leukocyteStimulation of T cells via CD44 requires leukocyte-function-associated antigen interactions and interleukin-2 production.
Maes et al. (1991)IL-2leukocytesHowever, we were unable to detect any significant relationships between DPP IV on the one hand, and mitogen-induced blast transformation, soluble IL-2 receptor accumulation in PHA culture supernatant, total number of leukocytes and lymphocytes, T lymphocytes, CD4+ and CD25+ cells, on the other.
Castés et al. (1999)IL-2leukocytesPSI resulted in a significant increase of NK cells, an augmented expression of the T-cell receptor for IL-2, and a significant decrease of leukocytes with low affinity receptors for IgE.
Antin and Ferrara (1992)IL-2leukocyteWe suggest that acute GVHD after marrow transplantation reflects (1) host injury due to the conditioning regimen followed by the production of inflammatory cytokines; (2) stimulation of mature donor T cells in the milieu of increased cell surface expression of leukocyte adhesion molecules and HLA molecules, followed by the autocrine production of IL-2; and, finally, (3) recruitment and activation of additional mononuclear effector cells from donor marrow progenitors, which produce additional inflammatory cytokines, thus sustaining the response.
Dillner et al. (1987)lymphokineleukocyteTen synthetic peptides containing 18-22 residues deduced from the amino-acid sequences of the EBV-encoded latent-infection-associated membrane protein (LMP) and the 2 principal nuclear antigens, EBNA-1 and EBNA-2, were tested for their ability to induce lymphokine release from sensitized T-cells of EBV-seropositive donors, as measured by the leukocyte migration inhibition assay (LMI).
Mathur and Kremer (1993)interleukin-2leukocyteAlveolar macrophages from patients with sarcoidosis have been observed to release high levels of tumor necrosis factor-alpha and interleukin-2 and to exhibit enhanced expression of leukocyte function antigen 1 and intercellular adhesion molecule 1.