Viewing affirmative mentions of gene expression of IL2 (H. sapiens) in leukocyte

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Zaizov et al. (1986)IL-2leukocytesObserved in all patients was impaired endogenous production of interleukin-2 (IL-2), expression of the IL-2 receptor combined with diminished responses to mitogens, mixed leukocytes reaction (MLR), and natural killer (NK) reactivity.
Lindqvist et al. (1987)IL-2leucocyteA monoclonal antibody inhibiting leucocyte adhesion blocks induction of IL-2 production but not IL-2 receptor expression.
Paetkau et al. (1980)IL2leukocyteUV-irradiated stimulators are also unable to induce the normal production of IL2 which is observed in a mixed leukocyte culture.
Holán et al. (1994)interleukin-2PBLThe production of interleukin-2 (IL-2) by mitogen-stimulated human peripheral blood leukocytes (PBL) was significantly enhanced by a short pretreatment of PBL with direct current (DC) at low intensities.
Holán et al. (1994)IL-2PBLExposure of PBL to DC of 1 mA for more than 10 min resulted in inhibition of IL-2 production which correlated with decreased proliferation capacity of the treated cells.
Hirunpetcharat et al. (1988)IL-2leukocytesAn agar plating technique for detection and enumeration of IL-2 producing cells from human peripheral blood mononuclear leukocytes (PBML) has been developed.
Hirunpetcharat et al. (1988)IL-2PBMLThe development of IL-2 producing cells was optimum when 1 X 10(6) cells/ml PBML were stimulated with 2 micrograms/ml PHA-P for 4 hours, and when 2.5 X 10(5) cells were co-cultured with 6 X 10(6) Con A blasts in soft agar for 5 days.
Hirunpetcharat et al. (1988)IL-2PBMLThe average number of IL-2 producing cells in 10 normal healthy controls were 754 +/- 94 (mean +/- S.E.M.) cells/10(6) PBML.
Hirunpetcharat et al. (1988)IL-2PBMLThis technique is very simple to perform and provides an accurate and straightforward means to enumerate IL-2 producing cells from human PBML in a variety of human immunologic disorders.
Moretta et al. (1981)TCGFPBLQuantitative analysis of the amounts of TCGF produced under optimal conditions indicated that supernatants obtained from spleen cell cultures were approximately five times more active than those derived from peripheral blood leucocytes (PBL).
Irwin et al. (1996)interleukin-2white blood cellsTo determine whether alterations of immune function also occur after even a modest loss of sleep, the effects of early-night partial sleep deprivation on circulating numbers of white blood cells, natural killer (NK) cell number and cytotoxicity, lymphokine-activated killer (LAK) cell number and activity, and stimulated interleukin-2 (IL-2) production were studied in 42 medically and psychiatrically healthy male volunteers.
Bowlin et al. (1989)IL-2leukocyteWe have recently established that swainsonine (SW), an inhibitor of mannosidase II during N-linked glycoprotein processing, augmented mitogen-induced mononuclear leukocyte IL-2 receptor expression and IL-2-induced proliferation.
Holán et al. (1991)interleukin-2leukocytesThe production of interleukin-2 (IL-2) by Concanavalin A (ConA)-stimulated peripheral blood leukocytes (PBL) from normal human donors was enhanced by natural human interferon-alpha (IFN-alpha).
Kaplan (1994)interleukin 2immune cellsThe local production of interleukin 2 (IL-2) by T lymphocytes acts to enhance the immune response by inducing growth and differentiation of a variety of immune cells.
Nelson et al. (1991)IL-2leukocyteMAIN OUTCOME MEASURES: We measured peripheral T lymphocyte human leukocyte antigen locus-DR (HLA-DR) expression and IL-2 receptor expression using monoclonal antibodies and flow cytometry.
Oppenheim and Lotze (1994)Interleukin-2immune cellsInterleukin-2 (IL-2) is a soluble factor produced by T cells that stimulates growth and activity of lymphocytes and other immune cells.
Novitski? et al. (2005)IL-2leukocytesThe paper presents the results of a study of spontaneous and stimulated production of TNF-alpha, INF-gamma, INF-alpha, IL-2 by peripheral mononuclear leukocytes in patients with disseminated destructive drug-resistant pulmonary tuberculosis.
Ghyka et al. (1992)IL-2leukocytePatients with classical European Kaposi's sarcoma were treated by intra- and peritumoral injections of human alpha leukocyte interferon (IFN) (12 cases) or, alternatively, with IFN and naturally synthesized IL-2 (8 cases).
Sonnenfeld et al. (1996)interleukin-2leukocytesThe first experiment determined the ability of leukocytes to produce interleukin-1 and to express interleukin-2 receptors.
Jacobson et al. (1988)interleukin 2leukocyteThere were increased numbers of large CD3-positive cells that also expressed histocompatibility leukocyte Class II (DR) and interleukin 2-receptor molecules.
Vie et al. (1985)IL-2PBLWe have studied the lectin-induced production of Interleukin II (IL-2) by peripheral blood leucocytes (PBL) obtained from recipients of kidney grafts.
Vie et al. (1985)IL-2PBLAfter grafting and during the first year the IL-2 levels produced by PBL from recipients with well functioning grafts are very low (p less than 0.001).
Ariel et al. (1998)IL-2immune cellsThus, the migrating immune cells, the cytokines, and the ECM can create a functional relationship in which both inflammation-inducing signals and inhibitory molecules of immune responses can coexist; the enzymatic products of IL-2 may serve as natural feedback inhibitors of inflammation.
Makonkawkeyoon and Kasinrerk (1989)IL-2PBMLAll three M. leprae preparations had suppressive activity on IL-2 production when peripheral blood mononuclear leucocytes (PBML) were stimulated with the mitogens PHA-P or Con A in a dose response.
Makonkawkeyoon and Kasinrerk (1989)IL-2PBMLM. leprae also had suppressive activity on IL-2 production when PBML were stimulated with the specific antigen, PPD.
Makonkawkeyoon and Kasinrerk (1989)IL-2PBMLIncorporation of M. leprae for 0, 6 and 12 h in PHA-P and PBML cultures had no inhibitory effect on IL-2 production; however, after 14, 16 and 18 h of M. leprae incorporation, significant inhibitory effects were noted on IL-2 production.
Bergeron et al. (1996)interleukin 2leukocyteRegulation of leukocyte interleukin 2 and interleukin 2 receptor gene expression by rabbit blastocoelic fluid.
Bergeron et al. (1996)interleukin 2immune cellNevertheless, inhibition of interleukin 2 and interleukin 2 receptor expression by embryonic fluid restrains immune cell activity and therefore can be implicated in the survival of the fetal semi-allograft.
Petersen et al. (2002)IL-2leukocyteWe have found 72 h of culture optimal for detection of IL-2 and IL-4 produced by human mononuclear cells (MNC) in response to stimulation with phytohaemaglutinin and for detection of IL-2 in human leukocyte antigen (HLA)-mismatched mixed leukocyte culture (MLC).
Mohagheghpour et al. (1985)interleukin 2leukocytesTo investigate the basis of the immune defect in LL patients, we studied the ability of patient mononuclear leukocytes to produce interleukin 1 (IL 1) and interleukin 2 (IL 2) upon stimulation with M. leprae, and determined the ability of exogenous IL 1 and IL 2 to reconstitute the LL patient response to this antigen in vitro.
Brkic et al. (1985)IL-2leukocytesPeripheral blood mononuclear leukocytes (cells of marrow donor origin) from 89 patients were collected at various times after allogeneic marrow transplantation, stimulated in vitro by phytohemagglutinin, and assayed for the production of interleukin 2 (IL-2).
Zatz et al. (1985)IL-2PBLThymosin fraction 5 (TF5) enhances interleukin-2 (IL-2) production by human peripheral blood mononuclear leukocytes (PBL) when cocultured in the presence of phytohemagglutinin (PHA).
Zatz et al. (1985)IL-2PBLUsing a standard human PBL cell population obtained by leukopheresis and cryopreservation, it should now be possible to establish a reproducible bioassay for the isolation and characterization of one or more components of TF5 with the property of enhancing PHA-induced IL-2 production by human PBL.
Bowlin et al. (1987)IL-2MNLIn this regard, we have examined the effect of polyamine depletion on interleukin 2 (IL-2) production, receptor expression, and responsiveness in Con A stimulated mononuclear leukocytes (MNL).
Zatz et al. (1985)interleukin-2PBLRecent studies have shown that thymosin fraction 5 (TF5) enhances production of interleukin-2 (IL-2) by phytohemagglutinin (PHA)-stimulated normal human peripheral blood mononuclear leukocytes (PBL).
Zatz et al. (1985)IL-2PBLOur studies demonstrate that aspirin, an inhibitor of the cyclooxygenase pathway, given in vivo, or added to cultures in vitro, results in two-fold increased IL-2 production by PHA-stimulated PBL.
Zatz et al. (1985)IL-2PBLAn inhibitor of the lipoxygenase pathway, 15-hydroxyeicosatetraenoic acid, did not significantly change IL-2 production by PBL or influence the enhancement by TF5.
Clerici et al. (1997)IL-2leukocyteThe following parameters were analyzed: 1) HPV infection of the cervix and other sites of the lower genital tract by colposcopic, cytologic, and histologic examinations; 2) HPV typing; 3) in vitro production of IL-2 by PBMCs in response to stimulation with soluble antigen (influenza [FLU] antigen) or to cell-associated human leukocyte antigen (HLA) alloantigen; and 4) in vitro production of the type 1 cytokines IL-2 and IFN gamma and of the type 2 cytokines IL-4 and IL-10 by PBMCs in response to mitogen stimulation.
Vervliet and Schandené (1985)IL-2PBLThe effect of phytohaemagglutinin (PHA) and/or phorbol myristic acetate (PMA) on human interferon-gamma (HuIFN-gamma) and interleukin 2 (IL-2) production was measured in peripheral blood leucocytes (PBL) from multiple sclerosis (MS) patients.
Vervliet and Schandené (1985)IL-2PBLThe PBL cultures of the same seven patients were also defective for IL-2 production after PHA stimulation.
Roche et al. (1988)interleukin 2leukocytesEnhancement of interleukin 2 production by quinolone-treated human mononuclear leukocytes.
Roche et al. (1988)IL-2immune cellsSince the production of interleukin-2 (IL-2) is known to be involved in the proliferation of immune cells, we investigated the effects of three quinolones: ciprofloxacin (Cip), ofloxacin (Ofl) and pefloxacin (Pef) on IL-2 production in vitro by phytohemagglutinin (PHA)-stimulated human MNL.
Roche et al. (1988)IL-2MNLThese data show that quinolones increased IL-2 synthesis by MNL and suggest the potential usefulness of these antibiotics, not only as antimicrobial agents, but also as modulators of immune responses.
Kermani-Arab et al. (1984)interleukin-2leukocytesDeficiency of interleukin-2 production and interleukin-2 receptor expression on peripheral blood leukocytes after phytohemagglutinin stimulation in pemphigus.
Dendrou and Wicker (2008)IL-2immune cellGenetic variation in these regions may promote T1D susceptibility by influencing transcription and/or splicing and, hence, IL-2 and IL-2RA/CD25 expression at the protein level in different immune cell subsets; thus, there is a need to establish links between the genetic variation and immune cell phenotypes and functions in humans, which can be further investigated and validated in mouse models.
Raghu et al. (1996)interleukin-2leukocytesWe found that the treatment of phytohemagglutinin (PHA)-stimulated peripheral blood leukocytes (PBL) with these mAbs resulted in a significant reduction of interleukin-2 (IL-2) levels in the culture.
Grimm et al. (1982)IL-2PBLCulture of PBL in IL-2 for 2-3 d was required for the lymphokine activated killers (LAK) to be expressed, and lytic activity toward a variety of NK-resistant fresh and cultured tumor targets developed in parallel.
Grimm et al. (1982)IL-2leukocytesActivation in lectin-free interleukin 2 (IL-2) containing supernatants of peripheral blood mononuclear leukocytes (PBL) from cancer patients or normal individuals resulted in expression of cytotoxicity toward 20 of 21 natural killer (NK)-resistant fresh solid tumor cells tested.
Ishii et al. (1987)IL-2-dependentleucocytesWe have investigated rapid and marked phosphorylation of cellular proteins induced by interleukin 2 (IL-2) in both phytohaemagglutinin-stimulated normal peripheral blood leucocytes, and IL-2-dependent or -independent human T-cell lines bearing human T-cell leukaemia (lymphotropic) virus type I.
Ghyka et al. (1991)IL-2leukocytePatients with classical European Kaposi's sarcoma have been treated by intra- and peritumoral injections of human alpha-leukocyte interferon (IFN) (12 cases) or alternatively with IFN and naturally synthetized IL-2 (8 cases).
Panelli et al. (2004)IL-2immune cellsIn addition IL-2 induced activation of cytolytic mechanisms and a massive production of chemo-attractants that could secondarily recruit other immune cells.
Ovsyannikova et al. (2006)interleukin 2leukocyteHuman leukocyte antigen and interleukin 2, 10 and 12p40 cytokine responses to measles: is there evidence of the HLA effect?
Gamliel et al. (1990)interleukin 2leukocyteIn addition to inducing proliferation of HCL cells, BCGF enhanced the expression of interleukin 2 receptors (CD25; T-activated cell antigen) with no change in the expression of class I and class II human leukocyte antigen.
Marazuela et al. (1994)interleukin 2leukocyteFollowing lymphocyte stimulation, there was an increase in human leukocyte antigen-DR and interleukin 2 receptor expression in patients with untreated Graves' disease.
Belldegrun et al. (1993)IL-2PBLIL-2 producers could stimulate growth and cytotoxicity of naive (i.e., freshly isolated, uncultured) and activated PBL.
Rosztóczy et al. (1989)interleukin-2leukocytesEffects of phorbol myristate acetate on interleukin-2 and accompanying interferon production of human leukocytes induced by heat-inactivated Staphylococcus aureus.
Antonen and Krohn (1986)IL-2leucocyteWe studied mitogen- and antigen-induced interleukin 2 (IL-2) production in HTLV-III/LAV infected and non-infected individuals and compared the results with T cell subpopulations, and with mitogen- and antigen-induced DNA synthesis and production of leucocyte migration inhibitory factor (LIF) in order to understand the controversial findings related to IL-2 production in HTLV-III/LAV infection.
Simbirtsev et al. (1993)IL-2leukocytesHuman recombinant IL-1 beta injected intraperitoneally into CBA mice dose-dependently induced leukocytosis, stimulated phagocytosis and reduced tetrazolium nitroblue by peritoneal leukocytes, colony formation by bone marrow cells, enhanced Con A and IL-2-induced proliferation and IL-2 production in thymocytes and splenocytes.
Rouveix et al. (1987)lymphokineleukocytePenicillin (50 and 100 micrograms/ml) and cephalosporins (50 and 100 micrograms/ml) directly stimulated production of the lymphokine leukocyte aggregating factor (LAgF) by unstimulated lymphocytes and enhanced mitogen-stimulated production of this lymphokine.
Takamura (1990)IL-2MNLsThe enhancing effect of some B cell-line cells was found to be related to the IL-2 production from the MNLs, but not related to the IFN, TNF, and LT production.
Lezama-Dávila et al. (1998)IL-2leucocyteTo better understand the immunological pathways controlling outcome of the human disease, we analysed the pattern of tumour necrosis factor (TNF) and interleukin-2 (IL-2), both of which were present in the sera of humans with active or healed chiclero's ulcer, in relation to the development of delayed-type hypersensitivity (DTH) responses and leucocyte counts in peripheral blood.
Coluzzi et al. (2004)IL-2leucocyteThe production of interferon-gamma (IFN-gamma) and interleukin-2 (IL-2), evaluated by intracellular cytokine analysis, and the frequencies of class I and II human leucocyte antigen (HLA) alleles were studied in comparison with healthy human subjects.
Konno et al. (1994)Interleukin-2leukocytesInterleukin-2, interleukin-3, interleukin-4 and interleukin-5 production from peripheral blood leukocytes was strongly suppressed when the cells were cultured in the presence of these agents.
Faist et al. (1993)IL-2leukocytesThe influence of major trauma on the regulatory levels of interleukin-1 (IL-1) and IL-2 in human mononuclear leukocytes.
Brown et al. (1991)interleukin-2Immune cellImmune cell activation in melioidosis: increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein.
Clark and Longo (1988)IL-2immune cellsApproaches aimed at activating specific antitumor immune cells include the use of IL-2-expanded infiltrating lymphocytes from tumors, exposure of peripheral blood cells cultured in IL-2 to tumor cells to hopefully expand those with a specific antitumor response, and the use of tumor cell vaccines in conjunction with IL-2.
Gearing et al. (1989)IL-2leucocytesInterleukin 2 (IL-2) production by leucocytes from all three groups was significantly increased following challenge with FHA or PT.