Viewing affirmative mentions of gene expression of IL2 (H. sapiens) in E2

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Honda and Steinberg (1984)IL-2PGE2The inhibitory effect of PGE2 on the responsiveness of T8+ cells was found to be due to inhibition of T4+-dependent IL-2 production.
Wacholtz et al. (1991)IL2PGE2Moreover, in the presence of IBMX, PGE2 caused a marked inhibition of IL2 production by PHA-stimulated Jurkat cells.
Wacholtz et al. (1991)IL2PGE2The data suggest that the diminished capacity of PGE2 to inhibit IL2 production by Jurkat cells reflects both a diminished capacity of PGE2 to induce increases in cAMP levels in these cells and an increase in the threshold of cAMP required to inhibit Jurkat cells.
Vercammen and Ceuppens (1987)IL-2PGE2Both IL-2 production and the expression of receptors for IL-2 (as detected with the anti-Tac monoclonal antibody) were inhibited by PGE2.
Vercammen and Ceuppens (1987)IL-2PGE2The addition of purified interleukin 1 (IL-1) or recombinant IL-2 to the cultures did not reverse the inhibiting effect of PGE2 on IL-2-receptor expression.
Lardone et al. (2006)IL-2PGE2In our model, when we blocked the melatonin membrane receptor with luzindole, the inhibitory effect of PGE2 on IL-2 production was higher.
Fernández-Cruz et al. (1989)interleukin-2PGE2We tested the effect of PGE2 on the production of interleukin-2 by normal phytohemagglutinin-stimulated peripheral blood lymphocytes (PBL).
Fernández-Cruz et al. (1989)interleukin-2PGE2There was a significant suppression of interleukin-2 production by PGE2 released from AIDS monocytes.
Carrillo-Vico et al. (2003)IL-2PGE2In this model, melatonin counteracts the effects of PGE2 on IL-2 and cAMP production.
Hilkens et al. (1995)IL-2PGE2However, the potent inhibition of IL-2 production by PGE2 seems to be in contrast with the simultaneous up-regulation of IL-4 and IL-5 production, because the induction of these cytokines requires IL-2.
Hilkens et al. (1995)IL-2PGE2To this aim, we examined the effects of PGE2 on the cytokine secretion profiles of a panel of human Th0 clones upon stimulation via different activation pathways, resulting either in high or low IL-2 production.
Hilkens et al. (1995)IL-2PGE2The differential modulation of Th1 and Th2 cytokines by PGE2 was observed only upon modes of stimulation resulting in high IL-2 production.
Hilkens et al. (1995)IL-2PGE2When IL-2 production was low, PGE2 inhibited the secretion of all four cytokines.
Chouaib et al. (1985)interleukin 2PGE2We analyzed the effect of physiologic concentrations of PGE2 on interleukin 2 (IL 2) production, expression of IL 2 receptor (Tac antigen), and expression of the transferrin receptor after in vitro activation with phytohemagglutinin.
Chouaib et al. (1985)IL 2PGE2Because PGE2 is known to increase the intracellular concentration of 3',5' cyclic adenosine monophosphate (cAMP), we investigated the effect of another adenylate cyclase activator, i.e., isoproterenol, as well as the effect of extracellular administration of the cAMP derivative dibutyryl cAMP (dBcAMP) on IL 2 production, Tac antigen expression, and transferrin receptor expression.
Baxevanis et al. (1993)IL-2PGE2RESULTS: PGE2 was found to suppress the production of IL-2 in these cultures.
Mier et al. (1985)IL-2PGE2In contrast to IL-1, IL-2 does not stimulate cultured hypothalamus cells to synthesize PGE2, and, furthermore, IL-2 does not elevate serum C-reactive protein levels.
Rincón et al. (1988)interleukin 2PGE2We have analyzed the effect mediated by prostaglandin E2 (PGE2) and different reagents that increase intracellular cAMP on the expression of the p55 subunit (CD25) of interleukin 2 receptors (IL 2R), on the levels of CD25-specific mRNA and on the expression of high affinity IL 2R.
Hilkens et al. (1995)IL-2PGE2These different modulation patterns were directly related to the IL-2 availability, because (i) neutralizing antibody to IL-2 abrogated the up-regulatory effect of PGE2 on IL-4 and IL-5 secretion in experiments with high endogenous IL-2 levels, (ii) lack of differential cytokine modulation by PGE2 in conditions with low levels of endogenous IL-2 could be restored with exogenous IL-2, and (iii) cell viability was comparable in all conditions.
Fort et al. (1993)IL-2PGE2We therefore also investigated the effect of indomethacin and prostaglandin E2 (PGE2) on IL-2 production.
Fort et al. (1993)IL-2PGE2PGE2 produced a significant reduction in IL-2 production in PSA and in controls.
Miao et al. (1996)IL-2PGE2In addition, the HSP and PGE2 treatment used inhibited the production of the Th1 cytokines IL-2 and IFNg but had a differential modulatory effect on Th2 cytokine production, namely enhancing the production of IL-6 whilst simultaneously impairing the synthesis of IL-4 and IL-10.
Chouaib et al. (1984)IL 2PGE2No detectable killing of IL 2-producing cells by PGE2-induced suppressors was observed.
Baxevanis et al. (1993)IL-2PGE2Removal of monocytes from PBMC restored to almost normal levels the deficient NK and LAK cell activity in patients with breast cancer and was also associated with a normalization in the levels of PGE2 and IL-2.
Faist et al. (1987)IL-2PGE2Prostaglandin E2 (PGE2)-dependent suppression of interleukin alpha (IL-2) production in patients with major trauma.
Faist et al. (1987)IL-2PGE2Cell cultures were assayed for proliferative responses to PHA, IL-2 synthesis, PGE2 production, gamma-interferon levels, and phenotyping studies.
Faist et al. (1987)IL-2PGE2These data suggest that the suppression of IL-2 synthesis post trauma is caused mainly by two factors: the excessive PGE2 output of inhibitory monocytes and inadequate function in immature and/or blocked lymphocytes.
Chouaib et al. (1987)interleukin 2PGE2Reconstitution of calcium mobilization in the presence of PGE2 by the calcium ionophore A23187 results in a partial restoration of both interleukin 2 (IL2) production and cell proliferation and has no effect on the inhibition of transferrin receptor expression.
Chouaib et al. (1987)IL2PGE2These data also indicate that the down regulation of transferrin receptor by PGE2 is proximal to protein kinase C activation and is not associated with decreased expression of the functional IL2 receptor.
Bastin et al. (1990)interleukin 2PGE2Our results show that PGE2 and cholera toxin inhibit, in a dose-related manner, the phytohemagglutinin (PHA)-dependent production of interleukin 2 by these cells.
Quintiliani et al. (1995)lymphokinePGE2No differences were found in the NK cytotoxic activity, lymphokine synthesis, serum levels, and production of PGE2 between transfused and untransfused patients.
Bodor (2006)IL-2PGE2We conclude that ICER is a critical component of Treg-mediated inhibitory function that affects transcriptional attenuation of IL-2 production in T cells and that HIV-1 subverts this mechanism via PGE2 and/or Tat-mediated induction of ICER.
Langhoff et al. (1991)interleukin-2PGE2Similarly, production of interleukin-2 was significantly reduced in patient groups as compared to control subjects, but there was no relationship between production of PGE2 and responses to PHA or production of interleukin-2.
Bartik et al. (1993)interleukin 2PGE2The results also showed that PGE2 was a much more effective inhibitor of anti-CD3 mAb-induced interleukin 2 synthesis by T cells than was ISO.
Elliott et al. (1993)IL-2PGE2The results demonstrate that concentrations of DEX and PGE2 which individually do not significantly suppress IL-2 synthesis act together to inhibit the synthesis of IL-2 synergistically. 5.
Elliott et al. (1993)IL-2PGE2Additionally, PGE2 and DEX did not affect expression of the IL-2 receptor (IL-2R), as measured by upregulation of the alpha chain, on anti-CD3 mAb stimulated T cells. 6.
Gardner et al. (1991)IL-2PGE2IL-1 beta was present in 65 of 94 (less than 20 to 419 pg/ml, TNF alpha in 54 of 75 (less than 10 to 73 pg/ml), stromelysin in 18 of 23 (less than 1.0 to 56 ng/ml), IL-2 in 7 of 23 (0.1 to 1.3 ng/ml) and PGE2 in 9 of 10 fluids (0.03 to 0.49 ng/ml).
Daculsi et al. (1993)IL-2PGE2Addition of PGE2 inhibits IL-2 production and has no effect on IFN production.
Baxevanis et al. (1994)IL-2PGE2In patients who had major surgery, a decrease in IL-2 levels and increases in IL-1 beta, TNF-alpha, IL-6, and PGE2 levels were observed up to 9 days after the operation compared to those of the preoperative values.
Namazi (2004)IL-2PGE2PGE2 decreases the production of IL-1, IL-2, IFN-gamma and TNF-alpha and proliferation of TH1 cells and increases the production of IL-4, leading to suppression of the type 1 immune response.
Mary et al. (1989)Interleukin 2PGE2Interleukin 2 production by activated Jurkat T cells is markedly decreased by prostaglandin E2 (PGE2).
Mary et al. (1989)interleukin 2PGE2The inhibition of both pp21 and pp23 phosphorylation and interleukin 2 synthesis by PGE2 can be largely reversed by the cAMP-dependent protein kinase inhibitor, N-[2-(methylamino)-ethyl-1]-5-isoquinoline sulfonamide.
Chattopadhyay et al. (2009)IL2RgammacPGE2Indeed, tumor-shed PGE2 down-regulates IL2Rgammac expression, reduces phosphorylation as well as activation of Janus kinase 3 (Jak-3)/signal transducer and activator of transcription 5 (Stat-5) and decreases Bcl-2/Bax ratio thereby leading to activation of intrinsic apoptotic pathway.
Su et al. (2008)lymphokinePGE2MATERIALS AND METHODS: To test this hypothesis, the effect of adenosine and PGE2 on the cytotoxic activity and cytokine production of lymphokine activated killer (LAK) cells was investigated.