Viewing affirmative mentions of gene expression of IL2 (H. sapiens) in blood

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Duchateau et al. (1985)interleukin 2bloodPeripheral human blood lymphocytes from healthy blood donors were investigated in vitro to observe the influence of different doses of thymopentin on nonstimulated proliferation, candidin-stimulated proliferation, and phytohemagglutinin (PHA)-induced interleukin 2 (IL2) production.
Ghoneum et al. (1987)interleukin-2bloodWe have developed a simple culture assay system for measuring the in vitro effects of a chemical carcinogen, 3-methylcholanthrene (MCA), on certain activities of human peripheral blood lymphocytes: blastogenesis, cell-mediated cytotoxicity by natural killer cells, interleukin-2 production, lymphotoxin release and percent T-cell subpopulations.
Sirota et al. (1995)interleukin-2bloodThe effect of human colostrum on the production of interleukin-2 (IL-2) and on natural killer (NK) cell activity by peripheral blood mononuclear cells (PBMC) was investigated in 50 healthy women.
Goretski? et al. (1989)interleukin-2blood[Modifying effect of the blood serum from patients with soft-tissue sarcomas on interleukin-2 production and activity].
Goretski? et al. (1989)Interleukin-2bloodInterleukin-2 (IL-2) production by lymphocytes of a peripheral blood (LPB) in patients with soft tissue sarcomas is considerably lower in comparison with that in donors.
Goretski? et al. (1989)IL-2LPBAutological serum had either suppressive or stimulative effect on LPB IL-2 production in the observed patients.
Lyte (1988)interleukin-2bloodIn vitro production of interleukin-2 by lymphocytes in whole blood and isolated culture.
Lyte (1988)IL-2bloodLymphocytes in whole blood culture produced significantly greater amounts of IL-2 on a per cell basis than did Ficoll-Hypaque purified lymphocytes.
Lyte (1988)IL-2bloodFurthermore, the majority of IL-2 produced by lymphocytes in whole blood culture was shown by freeze-thaw lysis to be intracellularly located, while the majority of IL-2 produced by purified lymphocytes was detected extracellularly.
Lyte (1988)IL-2bloodThe addition of 2-mercaptoethanol (2-ME) resulted in enhanced extracellular production of IL-2 in whole blood and Ficoll-Hypaque cultures.
Saito et al. (1988)IL-2bloodIL-2 production by PHA-stimulated human lymphocytes in umbilical blood was studied ontogenetically.
Jantscheff et al. (1999)IL-2bloodTests detecting a single Vero-IL2 cell against a background of 10(5) non-transfected cells were not able to demonstrate significant expression of exogenous IL-2 (i.e. the transgene or transgene-carrying cells) in tumor biopsies or blood at different times.
Freedman et al. (1992)IL-2bloodEvidence for voltage modulation of IL-2 production in mitogen-stimulated human peripheral blood lymphocytes.
Wacholtz et al. (1991)IL2bloodProstaglandin E2 (PGE2) inhibited IL2 production by human peripheral blood T cells stimulated with PHA.
Bentel and Atkinson (1988)interleukin 2bloodSurprisingly, and in marked contrast to our previously documented severe depression of interleukin 2 production by transplant recipients' peripheral blood mononuclear cells, the mitogen-induced production of the cytokine that induces procoagulant activity production (macrophage procoagulant inducing factor, MPIF) was also normal in the majority of patients when assayed using the responsive myelomonocytic cell line RC-2A.
Rose et al. (1991)interleukin 2bloodThese cells were morphologically identical in appearance to malignant cells found in peripheral blood and infiltrating the dermis, expressed the OKT4/Leu3 phenotype and the receptor for interleukin 2, and, by analogy to gene rearrangement studies on leukemic blood cells, were monoclonal in origin.
Cantrell and Smith (1983)IL-2bloodTo assess the potential role of IL-2 receptor levels in determining the rate and magnitude of T cell proliferation, the expression of IL-2 receptors by lectin-stimulated human peripheral blood T cells was examined and correlated with T cell growth.
Lister et al. (1995)interleukin 2bloodOverall toxicity associated with early posttransplant transfer of A-NK cells and interleukin 2 did not differ from that observed with peripheral blood stem cell transplantation alone in comparable patients.
Bîrsan et al. (2004)IL-2bloodFrom these samples, plasma concentrations of A-285 were measured by liquid chromatography/mass spectrometry (LC/MS), and intracellular T-cell production of the cytokines IL-2, IFN-gamma, and TNF-alpha was quantified by flow cytometry using a mitogen-stimulated whole blood assay.
Briggs et al. (1999)IL-2bloodEffects of glucocorticoids and cyclosporine on IL-2 and I kappa B alpha mRNA expression in human peripheral blood mononuclear cells.
Shah et al. (1991)IL-2bloodOur results demonstrated that the IL-2 expanded cells evidenced the immunoregulatory defect for IL-2 synthesis that we had initially defined using virgin T cells from peripheral blood.
Lai et al. (1989)interleukin 2bloodMitogen-stimulated cellular interleukin 2 (IL2) receptor expression, soluble interleukin 2 receptor release, and interleukin 2 production, were studied in peripheral blood mononuclear cells cultured for 24 h.
Hirunpetcharat et al. (1988)IL-2bloodAgar plating technique for enumeration of IL-2 producing cells in human peripheral blood mononuclear leukocytes.
Moretti et al. (1992)IL-2bloodThe precursor frequency of cell capable of producing IL-2 per ml/blood is estimated from the minimum X2 regression of the function of non-responding wells plotted as logarithmic function of the number of PBMC added per well.
Weir et al. (1991)IL-2bloodVerapamil or cyclosporine alone inhibited IL-2 production of PHA- and phorbol ester-stimulated peripheral blood mononuclear cells--however, no additive effect was seen when the two drugs were both added to culture, probably because of the very potent inhibition by cyclosporine alone.
Smith et al. (1989)IL-2bloodThis inhibitor inhibits the mitogenic response of normal peripheral blood mononuclear cells and seems to be primarily due to impaired IL-2 production.
Venkataraman (1992)interleukin-2bloodCryopreservation-induced enhancement of interleukin-2 production in human peripheral blood mononuclear cells.
Uchiyama et al. (1985)interleukin-2bloodWe studied the expression of the interleukin-2 (IL-2) receptor and the proliferative response to exogenous IL-2 of peripheral blood leukemic cells from patients with adult T cell leukemia (ATL) in order to see whether IL-2 receptor expressed on ATL cells is different from normal IL-2 receptor and whether it plays a role in the neoplastic growth in ATL.
Uchiyama et al. (1985)IL-2bloodPeripheral blood leukemic cells from 42 patients with ATL examined expressed IL-2 receptors that were detected by anti-Tac monoclonal antibody when examined immediately after the separation of cells or after the culture for 24 or 48 h.
Cooley et al. (1989)interleukin 2bloodPrevious studies have shown that interleukin 2 (IL2) production by peripheral blood mononuclear cells (PBMC) is severely impaired post allogeneic bone marrow transplantation, whereas production of interferon-gamma (IFN-gamma) is at most marginally depressed.
Chen et al. (1995)interleukin-2bloodHuman interleukin-2 expression level was 5.71IU/ml for NIH3T3, 6IU/ml for both 2. 2. 15 and peripheral blood mononuclear cells after infection with pseudoviral particles with 8 of multiplicity of infection (M.
Giordano et al. (1988)IL-2RSbloodOur aim was to investigate serum IL-2RS levels in 35 newly diagnosed Type 1 diabetic patients, in 25 age-matched healthy blood donors and in five patients with Hodgkin's disease.
Fairfax and Borzy (1988)IL-2bloodTo analyze the elements of the interleukin 2 (IL-2) system in newborns, the proliferative responsiveness to, production of, and expression of cell surface receptors for IL-2 were quantitated in cord blood mononuclear cells (CBMC) from 25 normal, full-term newborns and were compared to results in peripheral blood mononuclear cells (PBMC) from 15 juveniles and 28 adults in order to examine the IL-2 system as a function of age.
Bossé et al. (1996)interleukin-2bloodGene expression of interleukin-2 in purified human peripheral blood eosinophils.
Tamori et al. (1989)IL-2bloodThe effect of 1 alpha, 25-dihydroxyvitamin D3 (1 alpha, 25(OH)2D3) on the expression of interleukin-2 (IL-2) receptor in activated T lymphocytes was examined. 1 alpha, 25(OH)2D3 enhanced the expression of IL-2 receptor (p55, Tac peptide) in phytohemagglutinin (PHA)-stimulated (3 days) human peripheral blood mononuclear cells (PBM) only in the presence of IL-2 without affecting the proliferation of the cells.
Bernier et al. (1989)interleukin-2bloodRadio-immunological study of the regulation of interleukin-2 production in peripheral blood mononuclear cell cultures from normal subjects and rheumatoid arthritis patients.
Baxevanis et al. (1990)interleukin-2bloodEnhancement of human T lymphocyte function by prothymosin alpha: increased production of interleukin-2 and expression of interleukin-2 receptors in normal human peripheral blood T lymphocytes.
Baxevanis et al. (1990)interleukin-2bloodThe in vitro incubation of phytohemagglutinin (PHA)- or alloantigen-stimulated peripheral blood T cells with prothymosin alpha (ProT alpha) resulted in a marked and reproducible increase in the production of interleukin-2 (IL-2).
Tompkins et al. (1990)IL-2bloodIn vitro inhibition of IL-2 biosynthesis in activated human peripheral blood mononuclear cells by a trauma-induced glycopeptide.
Teodorczyk-Injeyan et al. (2008)IL-2bloodThe former were used for studies of the in vitro production of IL-2, while systemic (in vivo) levels of IL-2 production were determined in sera derived from non-heparinized blood samples.
Teodorczyk-Injeyan et al. (2008)IL-2bloodThe in vitro studies were carried out to investigate if the capacity for an inducer-related IL-2 production by peripheral blood mononuclear cells (PBMCs) isolated from heparinized blood samples was altered as a result of SMT.
D'Andrea et al. (1986)interleukin-2bloodPeripheral blood mononuclear cells (cells of donor marrow origin) from nine patients were collected serially at 3-month intervals during the first year post transplant and evaluated for proliferation and lymphokine (gamma interferon and interleukin-2) production in vitro.
Uchiyama et al. (1984)IL-2bloodPeripheral blood leukemic cells from 35 patients with ATL expressed IL-2 receptors which were detected by anti-Tac monoclonal antibody when examined immediately after the separation of cells or after culture for 24 or 48 hr.
Fleischer (1981)cell growth factorbloodInduction of T cell growth factor synthesis in human peripheral blood lymphocytes by staphylococcal protein A.
Alexander et al. (1993)IL2bloodIn contrast to the lack of proliferative activity, stimulation of T-TIL or peripheral blood lymphocytes with phytohemagglutinin or anti-CD3 resulted in comparable levels of both IL2 and gamma-interferon mRNA and protein expression.
Schaecher et al. (2001)IL-2bloodThe effects of calpain inhibition upon IL-2 and CD25 expression in human peripheral blood mononuclear cells.
Kusunoki and Hayashi (2008)interleukin-2bloodCONCLUSIONS: Significant immunological alterations noted include: (i) attrition of T-cell functions, as reductions in mitogen-dependent proliferation and interleukin-2 (IL-2) production; (ii) decrease in helper T-cell populations; and (iii) increase in blood inflammatory cytokine levels.
Utsugisawa et al. (2003)interleukin-2bloodWe compared the early effects of FK506 on clinical severity, interleukin-2 (IL-2) production by phytohemagglutinin-stimulated peripheral blood mononuclear cells (PBMs), and serum levels of acetylcholine receptor antibodies between myasthenia gravis (MG) patients with elevated (>1250 pg/ml, n = 9) or normal (<1250 pg/mL, n = 10) levels of PBM IL-2 production.
Stein et al. (1999)interleukin-2bloodInhibition of stimulated interleukin-2 production in whole blood: a practical measure of cyclosporine effect.
Stein et al. (1999)IL-2bloodMETHODS: CSA inhibition of phytohemagglutinin-P (PHA)-stimulated IL-2 production, measured by ELISA, was studied ex vivo in whole blood drawn before, and after subjects received 4 mg/kg oral CSA.
Stein et al. (1999)IL-2bloodIn vitro, 32.5-1200 microg/L CSA also inhibited PHA-stimulated IL-2 production in whole blood in a dose-dependent fashion with a similar IC(50) (approximately 300-400 microg/L) ex vivo and in vitro.
Chung et al. (1994)interleukin-2bloodSK&F 96365 also inhibits [3H]-thymidine incorporation and interleukin-2 (IL-2) synthesis in peripheral blood lymphocytes. 3.
Yukioka et al. (1988)interleukin-2bloodVitamin D compounds suppress the production of interleukin-2 (IL-2) by peripheral blood mononuclear cells (PBMCs) stimulated with phytohemagglutinin in a dose-dependent manner.
Shiohara et al. (1987)interleukin-2bloodWe studied production of interleukin-2 (IL-2) and IL-2 inhibitor from peripheral blood of patients with palmoplantar pustulosis (PPP).
Akiyoshi et al. (1985)IL-2bloodThe capacity of peripheral blood mononuclear cells (PBM) to produce interleukin-2 (IL-2) was studied serially before and following operation in patients undergoing various surgical procedures.
Agostini et al. (1985)interleukin-2bloodImpaired production of interleukin-2 in peripheral blood of patients with sarcoidosis.
Flamand et al. (1995)interleukin-2bloodOur data demonstrate that infection of peripheral blood mononuclear cells (PBMC) by HHV-6 results in suppression of T-lymphocyte functions, as evidenced by reduced interleukin-2 (IL-2) synthesis and cellular proliferation.
Smith (1991)IL-2bloodIt is based on: 1) IL-2 given to human volunteers can cause all the symptoms of schizophrenia; 2) GI lymphocytes in nonhuman primates produce much more IL-2 and IL-2R when stimulated than peripheral blood lymphocytes; 3) the GI tract is the largest lymphoid 'organ' in the body.
Eisenstein et al. (1988)Interleukin-2bloodInterleukin-2 production by mitogen-induced peripheral blood mononuclears was markedly low in 24 of 29 patients when compared to controls.
Meloni et al. (2002)IL2bloodImmunological studies were carried out prior to the last IL2 cycle and showed high levels of CD3-positive T cells expressing the IL2 receptor alpha chain (CD25), both in the peripheral blood and in the bone marrow.
Qiu (1992)IL-2bloodThe capacity of IL-2 production of peripheral blood lymphocyte (PBL) were determined in 54 patients with pneumonia in acute stage (23 cases of 20-57 years old and 31 cases over 60 years old) and 33 cases in convalescent stage. 20 elderly COPD in remission patients and 59 healthy control (32 aged 20-55 and 27 over 60) were determined also.
Fang and Bi (1989)IL-2bloodIt was found that, though the activity of IL-2 produced by peripheral blood mononuclear cells from these patients became much lower, the activity of IL-2 produced by draining lymph node mononuclear cells from the same donors showed no decline, in contrast to non-malignant patients and healthy controls.
Cathcart et al. (1987)IL-2bloodNone of the peripheral blood T-cells from IPF patients were actively producing IL-2 in vitro without further stimulation, providing evidence against constitutive production in vivo.
Härtel et al. (2004)interleukin-2bloodPrevious investigations have demonstrated the occurrence of tacrolimus-resistant production of interleukin-2 (IL-2) in vitro, which may explain in part why rejection episodes are still a frequent problem despite attainment of therapeutic blood concentrations and HLA matching.
Härtel et al. (2004)IL-2 mRNAbloodWhole-blood samples from 3 of 11 healthy individuals demonstrated marked suppression of IL-2 mRNA expression (>50%) when tacrolimus was administered in vitro.
Härtel et al. (2004)IL-2 mRNAbloodWhen CsA was added to whole-blood cultures, the influence on IL-2 mRNA expression was comparable to that of tacrolimus in 9 of 11 individuals.
Härtel et al. (2004)IL-2 mRNAbloodCONCLUSIONS: Our results suggest an individual degree of calcineurin inhibitor sensitivity of activated whole-blood lymphocytes based on IL-2 mRNA expression.
Hayashi et al. (1993)interleukin 2bloodExpression of lymphokine genes including interleukin 2 (IL-2), interleukin 3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon gamma (IFN-g), tumor necrosis factor (TNF) and lymphotoxin (LT) were sequentially monitored in peripheral blood mononuclear cells by Northern blot analysis after stimulation with phytohemagglutinin (PHA).
Chou et al. (2009)interleukin-2bloodA new synthetic compound, 2-OH, enhances interleukin-2 and interferon-gamma gene expression in human peripheral blood mononuclear cells.
Selmaj et al. (1988)IL-2bloodThe production of interleukin 1 (IL-1) and interleukin 2 (IL-2) by peripheral blood mononuclear cells (PBMC) stimulated with human myelin basic protein (MBP) was assessed in vitro in multiple sclerosis (MS) patients in relapse, patients with other neurological diseases (OND) and healthy subjects.
Zeitz et al. (1989)IL-2bloodCsA treatment inhibited the primary antibody response to LGV, inhibited peripheral blood lymphocyte mitogen-induced proliferation and IL-2 production, and inhibited LGV-specific proliferation of peripheral blood lymphocytes.
Fujino et al. (1997)interleukin-2bloodStimulatory roles of muscarinic acetylcholine receptors on T cell antigen receptor/CD3 complex-mediated interleukin-2 production in human peripheral blood lymphocytes.
Viora and Camponeschi (1995)interleukin-2bloodThe in vitro effect of single or combined doses of zidovudine (AZT) and dideoxycytidine (ddC) on the production and utilization of interleukin-2 (IL-2) by normal human peripheral blood mononuclear cells (PBMC) was evaluated by measuring IL-2 concentrations in supernatants from PHA-stimulated PBMC cultures.
Nouri and Panayi (1987)IL-2bloodWe show that in the peripheral blood IL-2 production was similar in RA and controls (3.7 vs 3.0 U/ml, respectively).
Bubeník et al. (1988)interleukin 2bloodThe production of interleukin 2 (IL-2) by phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC) from 21 patients with transitional cell carcinoma of the urinary bladder (BTCC) and 16 control blood donors was measured with a solid phase enzyme immunoassay based on the dual antibody immunometric sandwich principle.
Hirano et al. (2000)interleukin 2bloodPeripheral blood mononuclear cell resistance to cyclosporine was correlated with ability of the cells to express interleukin 2 and interleukin 2R.
Karttunen et al. (1985)Interleukin 2bloodInterleukin 2 production in whole blood culture: a rapid test of immunity to Francisella tularensis.
Karttunen et al. (1985)interleukin 2bloodWhole blood culturing is an easy method for producing interleukin 2.
Lauta (2003)IL-2bloodSerum levels of IL-6, sIL-6R, sIL-2R, and the expression of membrane-bound IL-2 receptors, both on bone marrow plasma cells and on peripheral blood mononuclear cells, are correlated with disease activity and disease stage.