Viewing affirmative mentions of IL2 (H. sapiens)-mediated positive regulation of IL2 (H. sapiens)

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Capelli et al. (1999)IL-2IL-2The immunocytochemical study revealed that IL-2 induces the expression of the IL-2 receptor on human glioblastoma cells.
Or et al. (1992)IL-2IL-2These results on the protein level were confirmed at the mRNA level as well and demonstrated that only PDB and IL-2 could induce IL-2 mRNA and PDB and IL-4 enhanced IL-4 mRNA.
Depper et al. (1985)IL-2Interleukin 2Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene.
Welte et al. (1987)IL-2IL-2However, the upregulation of IL-2 receptor expression by exogenous IL-2 was found to be comparable to normal controls when tested as early as 3 weeks post-SBA-E-BMT.
Taylor et al. (1986)IL 2IL 2IL 2 does not appear to induce IL 2 receptors on cells previously lacking this molecule.
Rocha-Zavaleta et al. (2004)Interleukin-2IL-2Interleukin-2 (IL-2) receptor-betagamma signalling is activated by c-Kit in the absence of IL-2, or by exogenous IL-2 via JAK3/STAT5 in human papillomavirus-associated cervical cancer.
Reed et al. (1985)IL 2interleukin 2Monoclonal antibody OKT11A inhibits and recombinant interleukin 2 (IL 2) augments expression of IL 2 receptors at a pretranslational level.
Thibault et al. (1991)IL-2IL-2In the presence of STPM, IL-2 secretion and the expression of protein P55 (IL-2R P55) from its receptor were examined in two models of PBMC proliferation: induced by PHA in 3-day-old cultures, and induced by IL-2 in 6-day-old cultures.
Wiranowska-Stewart and Hadden (1986)IL-2IL-2Two purine immunoenhancing drugs, isoprinosine and NPT 15392, were evaluated as inducers of IL-2 or enhancers of IL-2 induction by phytohemagglutinin (PHA).
Bartlett et al. (1998)IL-2IL-2Relatively low-dose IL-2 delivered by subcutaneous or intravenous routes may provide an important complement to antiretroviral therapy to increase absolute CD4 cells with the potential for less toxicity than with higher IL-2 doses.
Kenney et al. (1986)IL-2interleukin-2Those test systems detect covalent and non-covalent aggregates, degradation products, and inappropriately oxidized forms of human interleukin-2 all of which contribute to an overall loss of IL-2 biological activity.
Roifman et al. (1985)IL-2interleukin 2Due to its purity and potential availability in large amounts, human recombinant interleukin 2 (IL-2) expressed in Escherichia coli is an important source of IL-2 for experimentation and possible therapy.
Mills et al. (1990)IL2IL2Similar concentrations of suramin were required to inhibit binding of 125I-labeled IL2, IL2-induced tyrosine phosphorylation, and IL2-induced proliferation, suggesting that these processes may be linked.
Mire-Sluis et al. (1987)IL-2IL-2These data strongly suggest that stimulation of IL-2 receptors by IL-2 was not required for the completion of the first round of mitosis.
Hayashi et al. (2002)IL-2IL2-3A1We stably immobilized human IL-2 to collagen by covalently binding it to the N-terminus of human type III collagen (3A1) as IL2-3A1 chimeric protein using recombinant technology.
Tamori et al. (1989)interleukin-2interleukin-21 alpha, 25-dihydroxyvitamin D3 enhances the up-regulation of interleukin-2 receptor (p55) by interleukin-2.
Akiyoshi et al. (1988)IL 2IL 2The production of interleukin 2 (IL 2) and the ability to induce cytotoxic cells after activation with IL 2 (LAK) were therefore examined.
Ruby et al. (1990)IL-2IL-2The virus used to immunize one of the monkeys additionally expressed the human IL-2 gene, which encoded human IL-2 (VV-gp160-IL-2).
Tsunoda et al. (1991)IL-2IL-2IL-2 was essential to induce the synergistic effect of IL-2 and IFN-gamma to cytotoxic activity.
Depper et al. (1985)IL-2IL-2-inducedThe IL-2-induced increase in IL-2 receptor number is maximal within 12 hr, requires new RNA and protein synthesis, and is mediated by an interaction of ligand with the high-affinity receptors for IL-2.
Kawakami et al. (1989)IL-2IL-2IL-4 also inhibited several phenomena induced by IL-2 such as cell proliferation, augmentation of NK activity, increase of Leu-19+ cells, and expression of IL-2R(p55) on either CD3+ or Leu-19+ cells.
Schiller et al. (1993)IL-2IL-2Patients were randomized to receive either IL-2 alone for course 1, followed by IL-2/IFN-alpha for course 2, or IL-2/IFN-alpha in course 1, followed by IL-2 alone.
Atluru et al. (1993)IL-2IL-2A-63162 inhibited PBMC proliferation stimulated by phytohemagglutinin (PHA) and phorbol myristate acetate (PMA) plus A23187, IL-2 receptor expression stimulated by PHA, and IL-2 or IL-6 synthesis induced by PHA plus PMA or PMA plus A23187.
Hank et al. (1999)IL-2IL-2In patients receiving comparable IUs of the two preparations, HLR IL-2 induced the release of more soluble IL-2 receptor alpha into the serum than Chiron IL-2.
Asao et al. (1990)IL-2IL-2Interleukin 2 (IL-2)-induced tyrosine phosphorylation of IL-2 receptor p75.
Shenker et al. (1994)IL-2IL-2-inducedLTX inhibited the IL-2-induced expression of both CD69 and the IL-2 receptor.
Krishnaraj and Bhooma (1996)IL2IL2IL2-induced interferon gamma secretion.
Evans et al. (1992)IL-2IL-2We found that PHA did not stimulate RB phosphorylation within 10 h of treatment, but IL-2 could effectively stimulate RB phosphorylation within 2 h, and this approached a maximum within 8-10 h of IL-2 treatment.
Yang et al. (1990)IL-2IL-2Studies of cytokine receptor expression indicated that OKT3 plus IL-2 plus TNF caused an earlier up-regulation of the IL-2 receptor beta chain (Tac) and higher TNF receptor expression by day 6 compared to 100 units/ml IL-2 alone.
Granelli-Piperno et al. (1986)IL-2IL-2Exogenous IL-2 had little (IFN) or no (IL-2) effect on lymphokine mRNAs, but significantly increased c-myc, IL-2-R and heat shock protein mRNAs.
Tanaka et al. (1988)IL-2IL-2Novel IL-2-binding molecules (p70 and p75) mediating internalization and degradation of IL-2 were examined by employing a human B lymphoblastoid line, SKW6-4 cells.
Reem and Yeh (1985)IL 2IL 2Addition of IL 2 to these cultures further augmented the expression of IL 2 receptors and gamma-IFN synthesis and resulted in the optimal expression of IL 2 receptors and maximal gamma-IFN synthesis.
Aiello et al. (1986)IL-2IL-2Although IL-2 could play a role in facilitating the expression of IL-2 receptors, its effectiveness to do so depended on the presence of IL-1.
Kanakura et al. (1993)IL-2IL-2The action of IL-2 is known to be mediated through binding to a specific IL-2 receptor (IL-2R) which comprises at least two distinct proteins: IL-2R alpha (p55) and IL-2R beta (p70-75).
Hémar and Dautry-Varsat (1990)IL2IL2IL2 can transiently increase the expression of this gene.
Caggiari et al. (2001)IL-2Interleukin-2BACKGROUND: Interleukin-2 (IL-2) has been used successfully to increase CD4 cell counts in patients who are human immunodeficiency virus (HIV) positive.
John et al. (1996)interleukin-2IL-2Expression of the human interleukin-2 (IL-2) receptor alpha chain gene is potently upregulated by its own ligand, IL-2.
Franklin et al. (1996)IL-2IL-2Stimulation of the human interleukin-2 (IL-2)-dependent cell line, Kit225, with IL-2 resulted in the rapid activation of microtubule-associated protein-2 kinase (MAPK), as demonstrated by the tyrosine phosphorylation of p42erk2, the reduced mobility of MAPK in SDS-PAGE gels, and the increased ability of lysates from these cells to phosphorylate myelin basic protein.
Nishio et al. (1994)IL-2IL-2These results suggested that IL-2 increased tyrosine phosphorylation and the affinity to IL-2R beta of the 56-kDa proteins in NK-rich cells.
Kirken et al. (1997)IL2IL2Interestingly, IL2-induced serine phosphorylation of Stat5a differed quantitatively and temporally from that of Stat5b with Stat5a serine phosphorylation leveling off after 10 min and the more pronounced Stat5b response continuing to rise for at least 60 min of IL2 stimulation.
Williams et al. (1988)IL-2 geneIL-2 geneTwo regions within the human IL-2 gene promoter are important for inducible IL-2 expression.
Busse et al. (2010)IL-2IL-2-inducedWe show how the IL-2-induced upregulation of high-affinity IL-2 receptors (IL-2R) establishes a positive feedback loop of IL-2 signaling.
Long and Buckner (2008)IL-2IL-2The cytokines IL-2 and IL-7, but not IL-4, increased initial activation induced FOXP3 expression, increased proliferation and sustained expression of FOXP3(+) cells throughout the culture.
Collins et al. (1999)IL-2IL-2-inducedNo significant differences between cell lines were observed in IL-2 receptor chain (alpha, beta, or gamma(c)) expression, in IL-2-mediated proliferation, or in IL-2-induced phosphorylated forms of Stat3, Stat5, Jak1, or Jak3.
Ruscetti (1983-1984)TCGFTCGFThe only requirement for these colony-forming cells to form secondary colonies in replating experiments is exogenous TCGF- The need for adherent cells in primary colony formation can be substantially replaced by interleukin 1, a factor which is produced by adherent cells and functions by amplifying TCGF production.
Baine et al. (1995)IL-2IL-2Formation of the NFAT-1 transcriptional complex on the IL-2 promoter is essential for IL-2 transcription.
Brams et al. (1993)IL-2-inducedIL-2-inducedIL-4 reduced the IL-2-induced immunoglobulin production.
Liu et al. (1992)IL-2IL-2The induction response of mRNA due to IL-2 stimulation is probably mediated by the IL-2 receptor p75 chain since its mRNA was upregulated by IL-2 with a kinetics comparable to that associated with an increase of perforin mRNA.
Sodhi and Basu (1992)lymphokineIL-2As reported earlier, the IL-2 induced lymphokine activated killer (LAK) activity is significantly up-regulated in the presence of cisplatin/FK-565.
Ascherman et al. (1997)IL-2Interleukin-2Interleukin-2 (IL-2)-mediated induction of the IL-2 receptor alpha chain gene.
Migone et al. (1998)IL-2Interleukin 2Interleukin 2 (IL-2) rapidly induces tyrosine phosphorylation of intracellular substrates, including the IL-2 receptor beta chain (IL-2Rbeta), Janus kinase 1 (Jak1), Jak3, signal transducer/activator of transcription proteins, and Shc, but the mechanism underlying dephosphorylation of these proteins is not known.
Vaillant et al. (1993)IL-2IL-2IL-2 depression was induced by IL-2 concentrations of 10(5) units/ml, and tau-IFN effects were measured for concentrations of 100 mu/ml.
Tsuda and Takatsuki (1985)IL-2IL-2Our studies revealed that transferrin receptors do not always appear after IL-2 receptor expression, IL-2 up-regulates the expression of IL-2 receptor but not of transferrin receptor, and IL-2 can initiate DNA synthesis without altering transferrin receptor expression.
Ostensen and Førre (1988)Il-2Il-2It was shown that TNF alpha induced Il-2 receptor expression on CD16(+) cells alone and even more in combination with Il-2.
Plaisance et al. (1993)IL-2IL-2IL-2 is also active on IL-2 alpha+beta+gamma- cell lines since it decreases ICAM-1 and HLA class-II expression at the surface of JUSO cells.
Lin et al. (1997)IL-2IL-2NK activity against K562 cells was deficient in HIV+ patients compared to controls and could be enhanced by IL-2, IL-12, or IL-15, with the combinations of IL-2 + IL-12 and IL-12 + IL-15 producing more cytotoxicity than individual cytokines.
Candotti et al. (1997)interleukin-2IL-2Abnormalities in tyrosine phosphorylation of JAK3 in response to interleukin-2 (IL-2) and IL-4 were present in all patients.
Musso et al. (1992)IL-2-inducedIL-2-inducedBy using mAb alpha-IL-1 beta we showed that IL-2-induced IL-6 production is not mediated by the autocrine stimulation of IL-1 beta elicited by IL-2.
Peest et al. (1995)IL-2IL-2IL-2 therapy induced endogenous IL-2 production and elevated soluble IL-2 receptor serum concentrations.
Kehrl et al. (1986)IL-2IL-2TGF-beta inhibited IL-2-induced upregulation of the IL-2 and transferrin receptors.
Brunetti et al. (2002)IL-2IL-2IL-10 synergized with Dex in inhibiting IL-2 production and increased Dex inhibitory effect on the expression of the IL-2 receptor alpha chain, which is up-regulated by CD3 stimulation and IL-2.
Li et al. (2009)IL2IL2Both 15d-PGJ2 (Figure 4A) and rosiglitazone (Figure 4B) suppressed IL2-induced phosphorylation of STAT5 in V?
Piau et al. (1989)interleukin 2interleukin 2Thus, we propose that interleukin 2 enhances tyrosine phosphorylation by stimulating a tyrosine kinase activity.
Cerwenka et al. (1994)IL-2IL-2However, cells activated in the presence of TGF-beta 1 proliferated vigorously in secondary cultures and produced highly elevated amounts of IL-2 (12 +/- 3-fold enhancement of IL-2 production in response to CD2 plus CD28 stimulation compared with control cells, mean +/- SEM; n = 10).
Kotlán et al. (1988)IL-2IL-2Thus, IL-2 and HLA-DR expression increased on PBL 2 and 3 days after antigen exposure and paralleled elevations of IFN-gamma, neopterin, and beta 2 microglobulin levels.
Sawami et al. (1992)IL-2IL-2Addition of IL-2 also increased mRNA levels for c-fos, c-myc, IL-2 receptor alpha, and IL-2 receptor beta chain.
Sauce et al. (2002)IL-2IL-2Replacing the initial CD3/IL-2 activation by CD3/CD28/IL-2 partially restored the anti-EBV response of GMCs by reducing the initial activation-induced cell death and enhancing the proliferation of EBV-tetramer(+) cells.
Flieger et al. (2007)IL-2-induced-ADCCinterleukin-2Therefore, we investigated with a flowcytometric cytotoxicity assay the effect of several immunomodulatory drugs on antibody dependent cellular cytotoxicity (ADCC), interleukin-2 (IL-2) induced cytotoxicity and IL-2-induced-ADCC.
Casey et al. (2010)IL-2IL-2After staining with 10 µl allophycocyanin-conjugated IL-2-specific detection antibody, 10 µl FITC-conjugated IFN-?
Karanth et al. (1992)IL-2IL-2The addition of 0.187, 3.75, 15, or 60 microM DA to IL-2-induced PRL release.
Karanth et al. (1993)interleukin 2interleukin 2Role of nitric oxide in interleukin 2-induced corticotropin-releasing factor release from incubated hypothalami.
vanderSpek et al. (1996)DAB389 IL-2DAB389 IL-2The resultant fusion toxin, DAB389 IL-2(T439P), was 300-fold less cytotoxic than wild type DAB389 IL-2, partially as the result of a 100-fold decrease in binding affinity for the high affinity form of the IL-2 receptor.
Yu et al. (1996)IL-2IL-2Although IL-2 and IFN-alpha activated STAT1 alpha and STAT5, IL-2 predominantly activated STAT5, while IFN-alpha predominantly activated STAT1 alpha.
Cacciola et al. (1992)IL-2IL-2This could indicate that the B leukemic cells release sIL-2R which in turn, for its potential capacity of binding circulating IL-2, could contribute to the abnormal immunoregulation which characterizes B-CLL.
Moon et al. (2011)IL-2interleukin 2Gene expression was significantly induced for tumor protein p53 (p53), cyclin-dependent kinase inhibitor 1C (p57 Kip2), breast cancer Type 2 early onset (BRCA2), cAMP responsive element binding protein 2 (ATF-2), interleukin 2 (IL-2), heat shock 27 KD protein (hsp27), and CYP19 (aromatase).