Viewing negative mentions of regulation of IL2: interleukin 2 (Homo sapiens)

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Valtorta et al. (1991)IL-2GHRH 1-44GHRH 1-44 did not affect PHA-induced lymphoproliferation, IL-2 production and IL-2 receptor expression.
Atluru et al. (1990)IL-2HA1004In contrast, HA1004 had no effect on cell proliferation, IL-2 production, or IL-2R expression.
Borth and Teodorescu (1986)IL-2alpha 2MWhile reaction mixtures of native alpha 2M, aprotinin or methylamine-treated alpha 2M and IL-2 had no effect on IL-2 activity when incubated at 37 degrees for 5 h, alpha 2M.t (90 nM, [T]:[alpha 2M] = 0.8) inactivated IL-2 at a rate of one-sixth of that of the free enzyme.
Borth and Teodorescu (1986)IL-2IL-2While reaction mixtures of native alpha 2M, aprotinin or methylamine-treated alpha 2M and IL-2 had no effect on IL-2 activity when incubated at 37 degrees for 5 h, alpha 2M.t (90 nM, [T]:[alpha 2M] = 0.8) inactivated IL-2 at a rate of one-sixth of that of the free enzyme.
Auberger et al. (1989)IL2TLCKConversely, the tryptic-type protease inhibitor, TLCK (N-alpha-p-tosyl-lysine chloromethylketone), which structurally is very similar to TPCK, had no effect on IL2 synthesis.
Dao et al. (1994)IL-2IFN-alphaCTLL-2IFN-alpha alone had no effect on either the IL-2 production or apoptosis of MOLT-16 cells, but significantly increased both the IL-2 production and apoptosis in the MOLT-16 cells after phytohemagglutinin (PHA) stimulation as determined by CTLL-2 assay and by flow cytometric analysis using propidium iodide (PI) staining.
Azogui et al. (1983)IL 2The IL 2 production was not restored or was slightly affected by irradiation early after BMT.
Lomnitzer et al. (1984)IL-2Glutaraldehyde-treated S cells (which retained the ability to absorb IL-2) did not affect the proliferative response or IL-2 production by the R cells, indicating that passive absorption of IL-2 was not entirely responsible for suppression induced by S cells.
Russell et al. (1998)IL-2CTLL-2Neither X-irradiation nor UV-B irradiation of the cultures affected IL-2 produced in the assay or human recombinant IL-2 measured by 3H-TdR incorporation into the IL-2 dependent cell line, CTLL-2.
Gulino et al. (1990)IL-2 geneT cellsPhorbol ester and calcium ionophore did not modulate the expression of the transfected IL-2 gene in NIH-3T3 and HeLa cells, while these agents increased its expression in transfected BFS lymphoma T cells.
Borysiewicz et al. (1985)IL-2lymphocytesSimilarly, IL-2 release was not affected by Herpes simplex virus infection of such cultures, although lymphocytes infected with Sendai or respiratory syncytial viruses produced considerably less IL-2.
Lindqvist et al. (1987)IL-2PBLFACS analysis showed that IL-2 receptor expression was unaffected by antibody 60.3, whereas DNA synthesis of the same P(Bu)2-treated PBL was inhibited.
Roosnek et al. (1985)IL2In contrast, the IL2 production by the Jurkat line was not influenced by addition of thiols.
Matsui et al. (1992)IL-2Cocaine treatment alone had no effects on proliferation, IL-2 production, or Ca2+ mobilization.
Yang et al. (1994)IL-2blast cellsTriptolide also suppressed the expression of IL-2 receptors on PHA induced T-blast cells, but did not alter the production of IL-2 by mouse splenic cells and human tonsil lymphocytes.
Ramarli et al. (1986)IL-2IL2RThis inhibition is restricted to the IL-2 gene (IL2) as transcription of both the IL-2-receptor gene (IL2R) and the Ti beta-chain gene (TCRB) are not affected (human gene designations are in parentheses).
Mazingue et al. (1987)IL-2IL-2 production was not altered by SDIF but utilization of IL-2 was decreased, suggesting that SDIF blocked cells before or in the early s phase.
Podevin et al. (2001)IL2lymphocyteIn addition to mixed lymphocyte reaction (MLR) inhibition, chenodeoxycholate (CDC) inhibit ConA-induced IL2 production without any effect on IL2 R expression.
Slauson et al. (1984)IL-2The cellular production of IL-2 was not affected by serotonin, as supernatants of treated cultures contained essentially the same IL-2 titers as did control cultures.
Anikeeva et al. (1991)IL-2Deletion of 3'-flanking region on did not affect the IL-2 expression.
Gmünder et al. (1990)IL-2 mRNAT cellAs in cultures of splenic T cells, GSH depletion had no substantial effect on the induction of IL-2 mRNA and TCGF production in several mitogenically stimulated T cell clones.
Ishizaka et al. (1992)IL-2large granular lymphocytesCultured cell viability, IL-2 receptor-beta expression on large granular lymphocytes (LGL), the percentage of IL-2 receptor-beta positive LGLs and cell proliferation were not affected by oxygen-limited conditions.
Schneemilch et al. (2005)IL-2bloodFentanyl, sufentanil, sevoflurane and nitrous oxide did not affect PHA-induced IL-2 and sIL-2 receptor release by human peripheral blood mononuclear cells.
Nath et al. (1984)IL-2Non-adherent cell supernatants and MoF from tuberculoid and healthy individuals had little effect on IL-2 production.
Shimizu et al. (1988)interleukin-2T cellsIn contrast, surfactant had no effect on pokeweed-mitogen (PWM, T cell-dependent B lymphocyte mitogen)-induced DNA synthesis or on interleukin-2 (IL-2) receptor expression on T cells activated with PHA, Con A or PWM.
Malec et al. (1989)IL-2Epinephrine did not affect spontaneous IL-2 receptor expression and it significantly inhibited PHA-induced IL-2 receptor expression and IL-2 generation at 30 min. following injection.
Creemers et al. (1986)IL-2T cellsWe conclude that a defect in IL-2 production is associated with human T-cell lymphotropic virus III infection, but that the expression of the IL-2 receptor on T cells is not greatly affected.
Wilkinson and Euhus (2001)interleukin-2Cyclosporin A does not affect adenoviral-mediated transgene expression of interleukin-2.
Wilkinson and Euhus (2001)IL-2The immunosuppressive drug CsA is known to block native IL-2 transcription but has no affect on the adenoviral-mediated IL-2 or lac-Z transgene.
Sidell and Ramsdell (1988)IL-2PBLIn contrast to these effects on thymocytes, peripheral blood lymphocyte (PBL) proliferative responses were unaffected by RA treatment and, correspondingly, RA affected neither IL-2 receptor expression on PBL blasts nor the growth of these cells.
Maxwell et al. (1993)IL-2lymphocyteSince IL-2 production and lymphocyte proliferation in response to Con A were normal in the patient group and were not altered by treatment, the reduction in TNF levels seemed not to be a general inhibitory effect.
Tao et al. (1991)IL-2monocytesT2 did not affect IL-2 receptor expression by T cells, IL-1 production by monocytes, or the capacity of monocytes to present antigen.
Gelfand et al. (1986)IL2In parallel the drug prevents the lectin-induced increase in concentration of [Ca2+]i and interleukin 2 (IL2) secretion; IL2 receptor expression is unaffected.
Liang et al. (1986)IL-2Although substitution of serine for cysteine 125 did not affect IL-2 activity, deletion of cysteine 125 or deletion of amino acids in the vicinity of this cysteine yielded mutant proteins with little, if any, activity.
Draeger et al. (1986)IL-2Thus, in this group of SLE patients no abnormalities in IL-2 production or response could be demonstrated.
Santoli and Zurier (1989)IL-2Incubation of cells in the presence of oleic, stearic, and palmitic acids, which are not PG precursors, did not affect mitogen-induced IL-2 production.
McElhaney et al. (1992)IL2Subgroup analysis of the elderly group revealed that previous influenza vaccination in 1989 did not significantly affect IL2 levels measured in the present study.
Jordan et al. (1989)IL-2However, IL-2 receptor (IL-2R) expression and mRNA accumulation in stimulated PBMC was not affected by 1,25-D3.
Nokta et al. (1993)IL-2PAPPAP did not affect IL-2 production or IL2 receptor expression and had an inhibitory effect on mitogenic responses.
Yamamoto et al. (1986)IL2 mRNAlymphocytesAddition of alpha-methylornithine and methylglyoxal bis (guanyl hydrazone), which inhibit polyamine synthesis, did not affect the induction of IL2 mRNA in the lymphocytes stimulated with PHA and TPA, indicating that polyamine synthesis is not necessary for IL2 mRNA induction.
Stolc and Krause (1987)IL-2heartThe moderate episodes of heart transplant rejection did not affect the IL-2 receptor levels in comparison to transplant recipients without the rejection episodes.
Nakamura et al. (1991)IL-2macrophagesIn contrast, CD4+ T cells revealed no significant IL-2 responsiveness in the absence of macrophages.
Eisenstein et al. (1988)interleukin-2Antithyroid drugs and triiodothyronine had no effect on interleukin-2 production in vitro.
Kucharz et al. (1988)IL-2T-cellsLithium did not influence the expression of IL-2 receptors on T-cells.
Bessler et al. (2002)IL-2No change in IL-2 levels was observed.
Aihara et al. (1999)IL-2ISO, which reduced Con A-induced secretion of IL-2 in a dose-dependent manner, had no effect on Candida-induced secretion of IL-2.
Bruserud and Lundin (1987)IL-2Heparin had no effect on PHA-stimulated proliferation, IL-2 production or expression of IL-2 receptors.
Kucharz and Sierakowski (1990)interleukin 2T cellsIsoniazid did not affect the expression of interleukin 2-receptors on the surface of T cells, except a slight decrease in cells exposed to high levels of the drug.
Rump et al. (1993)IL-2Serum levels of soluble IL-2 receptors were unaffected by the therapy.
McCarthy et al. (1990)IL 2Concentrations of IL 2 increased 7-fold in DFMO-treated, PHA-stimulated PBMC cultures, compared with untreated cells; whereas IL 2 receptor expression as measured by the anti-Tac monoclonal antibody was not affected by the inhibition of ODC.
Wolf and Hall (1987)IL-2mononuclear cellsIL-2 production by peripheral blood mononuclear cells from 17 other patients with RA was similar to controls and was not affected by F5.
Middleton et al. (2002)interleukin-2Histamine dihydrochloride administered 10 minutes prior to injection of interleukin-2 also had no effect on interleukin-2 kinetics.
Wu et al. (1996)interleukin 2No significant changes in mitogenic response or interleukin 2 production were found after ALA diets.
Alfonzo et al. (2003)IL-2However, the levels of specific IL-2 produced did not change during therapy, and no specific IL-2 was detected during the follow-up period.
Fujimoto et al. (1986)IL 2lymphocyteCCA at 50 micrograms/ml, which was not toxic to cells, blocked AMLR, IL 1 production and immunoglobulin production (IgM and IgG) significantly, while CCA at the same dose did not affect IL 2 production and lymphocyte mitogenic responses to Staphylococcus aureus Cowan I(SAC) and pokeweed mitogen(PWM).
Samelson et al. (1983)IL 2Lectin-induced IL 2 release was not affected by these antibodies.
Sugimura et al. (1989)interleukin 2T lymphocytesA cytokine, lymphocyte blastogenesis inhibitory factor (LBIF), arrests mitogen-stimulated T lymphocytes at early G1 phase with no influence on interleukin 2 production and interleukin 2 receptor light chain expression.
Makonkawkeyoon and Kasinrerk (1989)IL-2PBMLIncorporation of M. leprae for 0, 6 and 12 h in PHA-P and PBML cultures had no inhibitory effect on IL-2 production; however, after 14, 16 and 18 h of M. leprae incorporation, significant inhibitory effects were noted on IL-2 production.
Keicho et al. (1993)interleukin-2lymphocytesEM had a suppressive effect on the proliferative response of human lymphocytes stimulated with mitogens and antigens, while EM had no effect on concanavalin A (Con A)-induced interleukin-2 (IL-2) production or IL-2R alpha (CD25) expression.
Kozenitzky et al. (1992)IL-2lymphocytesFollowing treatment IL-2 production, free IL-2 receptor (IL-2R), the ability of lymphocytes to induce a local graft-versus-host reaction (GVHR) and the ability of separated CD4 cells to induce help were tested. 8-Methoxypsoralen alone did not significantly affect either cell proliferation or IL-2 production or functional activity.
Bloehr et al. (1992)interleukin 2PBMCT3 had no effect on the release of interleukin 2 by PBMC.
Weinberg (2001)Interleukin-2Interleukin-2 (IL-2) and IL-10 production was not affected by HU.
Dupont (1987)interleukin 2lymphocytesDespite its significant antiproliferative action, 6-mercaptopurine does not affect interleukin 2 production nor Ia antigen induction on lymphocytes after stimulation with phytohemagglutinin.
Yukioka et al. (1987)IL-2SMNCAlthough DFMO did not affect the production of IL-2 or the expression of high-affinity IL-2 receptor, IL-2-dependent proliferation of SMNC was inhibited by DFMO, and the inhibition was reversed by exogenous putrescine.
Kogkopoulou et al. (2006)IL-2T cellsIn contrast, IL-2 levels were not affected significantly when strong stimulation was provided to T cells.
June et al. (1987)IL-2 mRNACyclosporine was found not to affect the accumulation of IL-2 mRNA after CD28 plus PMA stimulation, although there was no detectable IL-2 mRNA after stimulation by CD3 in the presence of the drug.
Lomnitzer (1988)interleukin-2Isoprinosine had no effect on the expression of receptors for interleukin-2.
Ritzenthaler et al. (2005)interleukin-2plasmaTreatment did not affect milk fat, protein, or lactose concentrations, immune indices (e.g., plasma T-helper cells and interleukin-2), or measured risk factors for CVD (e.g., plasma triacylglyceride and cholesterol).
Ohno et al. (1988)IL-2IFNIn contrast, the addition of IFN-gamma to the PHA-stimulated cultures markedly enhanced IL-2 production, while IFN-gamma per se had no effect on IL-2 production in the absence of PHA.
Yücesoy et al. (1997)IL-2Our findings suggest that chronic lead and cadmium exposure in humans resulted in significant suppression of the serum IL-1beta level, but did not alter IL-2 and TNF-alpha levels.
Eisenstein et al. (1994)IL-2ThyroidThyroid hormone or antithyroid drugs had no effect on IL-2 production in vitro.
Beharka et al. (2001)IL-2IEL's ability to proliferate and produce IL-2 was not affected by subject age.
Komada et al. (1996)IL-2Chelation of calcium 12 hr after Con A stimulation decreased IL-2R expression, but had no effect on IL-2 production.
Lederman et al. (1995)interleukin-2mononuclear cellsProcysteine did not affect the production of interleukin-2 by peripheral blood mononuclear cells of healthy HIV-seronegative subjects, as measured by bioassay but it decreased the density of cell-surface interleukin-2 receptors detected by flow cytometry after stimulation with phytohemagglutinin (PHA).
Lederman et al. (1995)interleukin-2mononuclear cellsProcysteine does not affect interleukin-2 production but inhibits interleukin-2 receptor expression in PHA-stimulated peripheral blood mononuclear cells.
Swift et al. (1988)IL 2The immunosuppressive drug cyclosporin A inhibited IL 2 release without altering induction of IL 2 receptors or phosphorylation of the Mr 70,000 protein.
Donati et al. (1992)IL-2It was observed that a single session of in vitro dialysis did not induce production of interleukin-2 (IL-2) and did not alter the expression of IL-2 receptor (IL-2R) on the cytoplasmic membrane and the secretion of soluble IL-2R, whereas it induced transcription of mRNA for IL-2R.
Chouaib et al. (1985)IL 2This was associated with a similar degree of inhibition of IL 2 production while the expression of IL 2 receptor was not affected.
Teodorczyk-Injeyan et al. (2008)IL-2No significant alterations in serum-associated IL-2 levels were observed in any of the study groups.
Dröge et al. (1985)interleukin 2The same concentration of L-ornithine had no effect on the production of the lymphokines interleukin 2 (IL 2) and gamma-interferon (IFN-gamma).
Beilin et al. (2007)IL-2The production of IL-2 did not change from that of the preoperation samples.
Pullman and Doe (1992)IL-2LPMCIn mucosa from cancer-bearing colons the amount of IL-2 produced by LPMC was unaffected by the invasiveness of the colon cancer.
Szekeres-Bartho et al. (1989)IL-2The inhibitory material, on the other hand, did not affect either production or function of IL-2.
Batten et al. (1999)IL-2T cellsIn contrast, addition of B7-1 transfectants to T cells/PAEC had no effect either on T cell proliferation, IL-2 production, or CsA resistance.
Szamel et al. (1997)IL-2lymphocytesThe expression of high affinity IL-2 receptors was completely inhibited by cholera toxin, while IL-2 synthesis and secretion were not influenced in BMA 031-stimulated human lymphocytes.
Figueroa et al. (1993)IL-2No concomitant changes in soluble or membrane receptor expression or IL-2 production were observed.
Stepkowski (2000)IL-2cytotoxic T lymphocytesThe agent 15-deoxyspergualin moderately inhibits both mitogen-stimulated T-cell proliferation and the generation of cytotoxic T lymphocytes (CTLs) but does not affect the production of interleukin 2 (IL-2).
Chae et al. (1988)interleukin-2Although natural and recombinant IFN-alpha significantly inhibited these proliferative responses, they did not affect interleukin-2 (IL-2) production in these cultures, suggesting that they inhibit proliferation by a mechanism that does not involve inhibition of IL-2 production. rIFN-gamma did not affect the generation of specific cytotoxicity in MLC, although it was significantly enhanced by natural IFN-alpha and rIFN-alpha 2.
Poulton et al. (1988)IL-2This suggests that regulation of the IL-2 receptor is not responsible for the reduction in the number of cells that proceed to proliferation.
Heslan et al. (1991)IL-2IL-2Since a sensitive IL-2 ELISA failed to exhibit any significant antigenic presence of IL-2 in the IEF fractions with the highest VPF activity, we conclude that VPF activity of the concentrated supernatants is not related to IL-2 nor to a biologically inactive form of IL-2.
Marcinkiewicz et al. (1996)IL-2macrophageFurthermore, NG-monomethyl-L-arginine monoacetate, a specific inhibitor of NO release had no effect on IL-2 release, while indomethacin, which blocked prostaglandin synthesis, largely abrogated the suppressor activity of both macrophage populations.
Katagiri et al. (1990)IL-2CCA had no significant effect on IL-2 receptor expression, an early G1 event, but did inhibit transferrin receptor expression, a late G1 event.
el-Farrash et al. (1995)IL-2IL-2The cell line (EMF) was initially IL-2 dependent and then became IL-2 independent after gradual withdrawal of the IL-2.