Viewing negative mentions of negative regulation of IL2: interleukin 2 (Homo sapiens)

Full-text article links are indicated by after the article reference.

Document Target Regulator Anatomy Sentence
Borysiewicz et al. (1985)IL-2In early measles infection (up to 48 h) there was no suppression of IL-2 production: in fact measles infected cells spontaneously released low levels of IL-2 in the absence of lectin.
Chandy et al. (1984)Interleukin-2Interleukin-2 production was diminished in the patient but not in the healthy twin.
Gillies et al. (1992)IL2T-cellThe fusion of IL2 to the carboxyl terminus of the immunoglobulin heavy chain did not reduce IL2 activity as measured in a standard proliferation assay using either mouse or human T-cell lines.
Usui (1990)IL-2mononuclear cellsThe production of IL-2 by peripheral blood mononuclear cells (PBM) from patients with renal cell carcinoma was not suppressed, when compared with that in controls.
Zier et al. (1984)IL-2IL-2 synthesis by 6 non-insulin-dependent diabetic subjects (NIDDM) was not decreased (mean +/- SEM, 1.20 +/- 0.04 U/ml).
Bloemena et al. (1988)IL-2However, expression of the biologically active, high-affinity IL-2 receptors was not diminished.
Goebel et al. (2000)IL-2In immunoblots of IL-2R beta- and gamma-chain-immunoprecipitates the tyrosine phosphorylation of both chains by IL-2, but not by IL-15, was attenuated in the presence of Daclizumab.
Reed et al. (1986)IL2PBMCAt concentrations that produced 75-90% suppression of proliferation in PHA-stimulated PBMC cultures, IDS caused no decrease in interleukin 2 (IL2) production (determined by bioassay) or in IL2 receptor expression (determined with anti-Tac antibody).
Kawakami et al. (1988)IL2lymphocytesThese results indicate that WGA inhibits T lymphocyte proliferation by inhibiting the responsiveness of the lymphocytes to IL2 but not by interfering with IL2 production and IL2 receptor expression.
Freed et al. (1991)IL-2The polar maleimides N-hydroxymaleimide (NHM) and 4-maleimidosalicylic acid (M84) did not suppress IL-2 production significantly, even though NHM reacted with more cellular thiols (12%) than did NPM (8%).
Baba et al. (2006)IL-2lymphocyteHowever, aziridine 2 had no effect on the resting lymphocyte proliferation in the absence of mitogens, at any concentration used, reduced Con A-stimulated T lymphocyte proliferation and LPS- stimulated B lymphocyte proliferation in a dose dependent manner and diminished IL-2 and IL-6 production.
Bergeron et al. (1996)interleukin 2lymphocytesAddition of interleukin 2 to prestimulated interleukin 2 receptor positive lymphocytes failed to downregulate the expression of high-affinity interleukin 2 receptor and completely abolished the embryonic fluid-mediated inhibitory effect on [3H]thymidine incorporation.
Ishiyama et al. (1993)IL-2Cyclosporin A (CyA) suppressed in vitro IL-2 production in one patient, but not in the other.
Hassan et al. (1997)IL-2The influence of CsA in reducing but not blocking IL-2 synthesis is discussed.
Kusugami et al. (1991)interleukin-2T cellsMucosal CD8+ T cells and plastic-adherent cells were unable to suppress interleukin-2 activity by autologous or allogeneic CD4+ T cells.
Kusugami et al. (1991)interleukin-2T cellsFinally, supernatants from Crohn's disease and ulcerative colitis cell cultures failed to suppress interleukin-2 production by control CD4+ T cells.
Armant et al. (1995)IL-2The IL-2 protective effect was mediated through the p75 beta chain of the IL-2R, as neutralizing monoclonal antibody (mAb) to the p75 beta chain but not to the p55 alpha chain completely abolished the IL-2 anti-apoptotic activity.
Riesbeck (1999)IL-2Bleomycin, carboplatin, doxorubicin, novobiocin or etoposide, which were included for comparison, did not interfere with IL-2 expression.
Najjam et al. (1998)IL-2Overall our data suggest that the binding of human IL-2 to heparin and heparan sulfate does not interfere with IL-2/IL-2 receptor interactions.
Kuroiwa et al. (1994)IL-2Depressed IL-2 production in active UC was not reversed by the addition of anti-CD3 monoclonal antibody plus phorbol myristate acetate (PMA), but was largely reversed by adding calcium ionophore plus PMA.
Micha?kiewicz et al. (1989)IL-2interleukin 2The suppressor effect was not reversed by interleukin 2 (IL-2) added to the culture medium.
Tadmori et al. (1994)IL-2IL-10B-cellInvestigation of the effect of IL-10 on cytokine synthesis revealed that when B-cell lines were used as stimulators of MLR, IL-10 suppressed IFN-gamma and IL-2 synthesis but was unable to suppress TNF-alpha production.
Bárcena et al. (1991)IL-2IL-4thymocytesIn contrast to peripheral lymphocytes, IL-4 does not down-regulate the expression of the IL-2 receptor light chain on thymocytes.
Burns et al. (1996)IL-2PBMCIL-2 production by PBMC in response to Daudi cells was also decreased by depletion of CD4+ T cells, but not by depletion of CD8+ or gammadelta T cells.
Stopeck et al. (1998)IL-2IL-2 secretion by tumor cells persisted for at least 30 days post-transfection and was unaffected by freeze thawing or irradiation to 8000 rads.
Smith et al. (1983)IL 2The neutralization of cellular proliferation was specific for IL 2-reactive cells, coincided with an inhibition of IL 2 receptor binding, could be completely overcome by affinity-purified IL 2 and was species-specific; human and murine IL 2 were neutralized, whereas rat IL 2 activity remained unaffected.
Mekori et al. (1989)IL-2Reserpine also interfered with the mitogen-induced IL-2 production by these cells, but the IL-2 receptor expression, as measured by immunofluorescence, was unaffected.
Hess et al. (1997)interleukin-2proximalSMX-HA at immunosuppressive concentrations also failed to interfere with interleukin-2 mRNA transcription and interleukin-2 protein production, which suggests that signaling events proximal to cytokine production are not affected by the metabolite.
Fleischmann et al. (1989)interleukin-2No loss of recombinant interleukin-2 activity occurred during heating in serum-free media.
Gmünder et al. (1990)IL-2T cellModerate intracellular GSH levels, however, are apparently not inhibitory for IL-2 production, since intracellular GSH depletion by cysteine starvation or by graded concentrations of DL-buthionine sulfoximine (BSO) had virtually no effect on IL-2-specific mRNA expression and the production of T cell growth factor (TCGF).
June et al. (1989)IL-2 geneT-cellIn contrast, IL-2 gene expression and T-cell proliferation induced by CD28 MoAb plus PMA were unaffected by cyclosporine.
Liu et al. (2006)IL-2IL-2 was significantly decreased by morphine and fentanyl but not by tramadol in vitro.
Kabuki et al. (1990)IL2lymphocytesSaibokuto also suppressed the induced IL2 responsiveness of lymphocytes from the same patients on stimulation wit PPD, but not with Con A.
Gelfand et al. (1986)IL2In parallel the drug prevents the lectin-induced increase in concentration of [Ca2+]i and interleukin 2 (IL2) secretion; IL2 receptor expression is unaffected.
Mookerjee and Pauly (1989)IL-2monocytesThe mitogenic effect of IL-2 pulsed monocytes can not be suppressed by inclusion of anti-Tac antibody in the pulsing medium although the same concentration of the antibody suppresses the effect if present throughout culture.
Bernsen et al. (1999)IL-2The main differences are systemic therapy and surgical removal of the primary tumour in case of human cancer patients, whereas these treatment modalities are not used in IL-2 treated veterinary cancer cases.
Klingemann et al. (1993)IL-2Starting values for LTC-IC in patient marrow samples were markedly reduced to approximately 7% of normal values, but as in normal cultures, did not decrease further in culture with or without IL-2.
Baroja and Ceuppens (1987)IL-2No decline of IL-2 concentrations beyond 18-24 h of culture was observed, indicating that anti-Tac effectively blocked IL-2 consumption.
Miyawaki et al. (1982)TCGFT cellsIn contrast, absorption of TCGF by PHA-induced blasts was not significantly reduced even when they were pretreated with other monoclonal antibodies (anti-Ia, OKT9, or OKT10) with specificity for antigens expressed on activated T cells.
Seymour et al. (1985)IL-2There appeared to be no relationship between IL-2 production and BRA and the severity of the disease as assessed by loss of attachment.
Fernandez et al. (1995)IL-2No inhibitory effect on the IL-2 production by thalidomide could be detected at any of the drug concentrations tested (5-30 micrograms/mL), whereas 10 to 100 ng/mL of cyclosporine inhibited the IL-2 production by 95 to 100%.
Mochizuki et al. (1997)IL-2UV-5 cells were not suppressed in IL-2 medium.
Swisher et al. (1991)IL-2lymphocyteThe in vivo effect of IL-2 on tumor-associated lymphocyte activity was assessed in the resected specimens by immunohistochemistry and compared with observations in 45 patients who did not receive IL-2.
Calder and Newsholme (1992)interleukin-2lymphocyteHowever, stearate did not decrease the interleukin-2 concentration but did inhibit lymphocyte proliferation.
Dornand et al. (1986)IL 2Our data revealed that at concentrations lower than 0.2 microM, IL 2 accumulation was not reduced in ouabain-treated cultures, even when cell proliferation was completely inhibited (0.1-0.2 microM ouabain).
Nokta and Pollard (1989)IL-2The differential effect of IL-2 was independent of IL-2 receptor expression.
Hall et al. (1991)HrIL-2However, HrIL-2 nephrotoxicity in vitro was unaffected by addition of dexamethasone to cultures and LLC-PK.1 cells were found to be resistant to the anti-proliferative effects of TNF-a.
Vercammen and Ceuppens (1987)IL-2PGE2The addition of purified interleukin 1 (IL-1) or recombinant IL-2 to the cultures did not reverse the inhibiting effect of PGE2 on IL-2-receptor expression.
Lewis et al. (1993)IL-2These concentrations are below those at which IL-2 mRNA synthesis was shown to be unaffected.
Katzen et al. (1985)IL 2T cellsThe failure of IL 2 secretion was not caused by down-regulation of IL 2 production by IL 2 itself, because the addition of IL 2 to cultures of T cells stimulated with PHA in the presence of monocytes did not interfere with IL 2 production.
Butler et al. (1983)IL-2B cellPrevious experiments using various culture-derived supernatants in a human system were unable to separate the activities of B cell growth factor (BCGF) and interleukin 2 (IL-2) by immunochemical means.
Redondo et al. (1987)IL-2Although levamisole did not replace IL-2 and had no effect at saturating IL-2 concentrations, it reduced by 2- to 4-fold the dose of IL-2 required to give 50% of the maximal DNA synthesis, the optimal concentration of levamisole being between 1 to 3 X 10(-4) M.
Mantovani et al. (1988)IL-2PBMCWe found no significant defect in the IL-2 receptor expression by PBMC of cancer patients.
Noma et al. (1989)IL-2T cellsOvalbumin (OVA)-induced IL-2 responsiveness of lymphocytes from patients with hen-egg allergy was not suppressed by the supernatant from Df-stimulated T cells, indicating the antigenic specificity of the effect.
Bosco et al. (1997)IL-2-inducedmonocyteEngagement of CD14 by specific mAbs resulted in the selective and dose-dependent suppression of IL-2-induced, but not of IFN-gamma-induced, monocyte tumoricidal activity.
Santoli et al. (1990)IL-2T cellDihomogamma linoleic acid (DGLA), AA, and their metabolites (PGE1 and PGE2, respectively) strongly inhibited short- and long-term growth of IL-2-dependent T cell cultures; EPA was much less inhibitory and its product, PGE3, failed to suppress IL-2 responses.
Parhar et al. (1989)IL-2T lymphocyteWe have earlier shown that first trimester human decidual cells and decidual macrophages suppress T lymphocyte alloreactivity in an MHC-unrestricted manner by secreting PGE2, which blocks the generation of IL-2 receptors (IL-2R) and production of IL-2 by lymphocytes but does not interfere with the interaction between IL-2 and IL-2R or the lytic function of CTL, once generated.
Laurent et al. (1986)IL2T cellsThese findings showed that IL2 receptor expression is not restricted to activated T cells, and raise the question of the possible role of IL2 in the regulation of malignant B cell clone expansion.
Geiselhart et al. (1997)IL-2The effect of p-BQ appeared to be specific for IL-2 production, since de novo induction of the IL-2 receptor alpha-chain (CD25) and ICAM-1 (CD54) and upregulation of LFA-1 alpha/beta (CD11a and CD18) were unaffected.
Belosevic and Nacy (1990)IL-2In this cooperative interaction of cytokines, IL-2 can be replaced with any of several mAb directed against the beta chain of the IL-2 receptor, but not by antibodies to a number of other cell receptors or antigens.
Szamel et al. (1993)IL-2While interleukin-2 (IL-2) synthesis and cellular proliferation were completely inhibited by 200 ng/ml CsA in BMA 030- or BMA 031-stimulated cells, expression of high-affinity IL-2 receptors was not influenced by the immunosuppressive drug.
Cohen and Munro (1984)TCGFThey do not impede either the function or production of TCGF in the secondary culture but we are unable to detect a non-specific suppressor factor made by these cells.
Attal et al. (1995)IL-2We conclude that, in ALL, early allogeneic BMT after the BFM induction regimen is an effective consolidation treatment and that IL-2 does not decrease the high relapse rate observed after autologous BMT.
Shah et al. (1991)IL-2Our results suggested that the secretion of inhibitory factors could not explain the IL-2 defect.
Williams et al. (1995)IL-2PKCT cellsData is presented, using the potent and selective PKC inhibitor Ro 31-8425 and transient expression of a constitutively active ras mutant, which clearly shows that PKC is not downstream of p21ras in the induction of NF-AT and AP-1 transcriptional activity and in the expression of IL-2 in human Jurkat T cells.
Müller et al. (1993)IL-2Although the expression of high affinity IL-2 receptors (IL-2R) (p75) was unaffected, exogenously added IL-2 failed to restore proliferation.
Szamel et al. (1995)IL-2T-cellIn human peripheral blood lymphocytes stimulated via the T-cell antigen receptor/CD3 complex IL-2 synthesis and cellular proliferation were effectively inhibited by a concentration of ouabain as low as 50 nM, whilst the expression of high affinity IL-2 receptors was not influenced.
Jonasch et al. (2008)IL-2Disease progressors who had not yet received IL-2 began IL-2 treatment, and progressors who had already received IL-2 came off study.
Müller-Steinhardt et al. (2009)IL-2Notably, 3/11 and 2/11 individuals had unaffected IL-2 and IL-4 mRNA expression after 4h incubation with SRL, respectively.
Hayward et al. (1988)IL-2T cellsProliferative responses by T cells from newborn cord blood stimulated with PHA or CD3 were reduced following infection with live (but not killed) herpes simplex virus in vitro although activation (measured by calcium flux) and IL-2 production were unaffected.
Gately et al. (1991)IL-2This effect of IL-12 was independent of IL-2 because it was not blocked by antibodies to either IL-2 or IL-2R.
Linker-Israeli and Casteel (1988)IL-2PBMSF PBM suppressed production of IL-2, but not proliferative responses to this lymphokine.
Haq et al. (1995)interleukin-2bloodN. sativa did not, however, enhance or suppress interleukin-2 secretion by mitogen activated peripheral blood mononuclear cells.
Gately et al. (1992)IL-2LAK cellsActivation of LAK cells by IL-12 appeared to be independent of IL-2 since it was not inhibited by neutralizing anti-human IL-2.
Noma et al. (1990)IL2lymphocytesThe induction of OVA-specific IL2 responsiveness in patient lymphocytes was markedly suppressed on the addition of culture supernatant from OVA-stimulated normal T cells, but Df-specific IL2 responsiveness of the lymphocytes from Df-sensitized patients with bronchial asthma was not suppressed by the same supernatant.
Mapara et al. (1993)IL-2-dependentOne informative BCLL, however, with a similar pattern of APO-1-antigen expression, did not show SAC plus IL-2-dependent bcl-2 down-regulation.
Corrêa-Sales et al. (1997)IL-2lymphocyteIn contrast, mitogen-induced lymphocyte proliferation and IL-2 secretion are not depressed.
Li et al. (1987)lymphokineleukocyteWe have shown that hydrocortisone in physiological concentrations can inhibit the production of leukocyte migration inhibition factor (LMIF), but does not diminish the action of this lymphokine.
Mårlind et al. (2008)F16-IL2The administration of doxorubicin either before (8 days, 24 h, or 2 h) or simultaneously with the injection of F16-IL2 did not decrease the accumulation of immunocytokine in the tumor as measured by quantitative biodistribution analysis.
Kretowski et al. (1999)IL-2In the previous studies increased, decreased and unchanged IL-2 levels in patients with recent onset of insulin-dependent diabetes mellitus (IDDM) were found.
Kasid et al. (1990)IL-2TNFIn conjunction with IL-2, cytokines such as IFN-alpha, IFN-gamma, or TNF did not interfere with IL-2 induction of TNF and LT mRNA.
Rowland et al. (1999)IL-2MOLT-4To verify that thalidomide was acting selectively to down-regulate TNF-alpha, IL-2 production by MOLT-4 cells was also measured and found to be unaffected by the drug.
Bessler et al. (2005)IL-2Atorvastatin did not affect IL-1beta, but suppressed IL-1ra, IL-2 and IFNgamma production.
Anderson and Teuber (2010)IL-2However, immunomodulatory effects are present, including an inhibition of cellular proliferation despite no decrease in IL-4 or IL-2.
McDermott et al. (1998)IL-2The coadministration of s(CHO) IL-1R produced no apparent reduction in IL-2 clinical toxicity manifested by either the ability to administer more IL-2 than anticipated or a reduction in the toxicity associated with a given amount of IL-2.
Hirte et al. (1992)IL-2TNF-alphaTNF-alpha alone did not generate significant LAK activity, but in the presence of suboptimal concentrations of IL-2 (10 and 100 units/ml), TNF-alpha significantly boosted the generation of LAK, but was unable to significantly reverse AF-mediated suppression of the IL-2 response (even at 1000 units/ml).
Tovar et al. (2002)IL-2immune systemHowever, IL-2 production and mRNA expression from stimulated lymphocytes were unaffected by supplementation, probably because the deficiency was not severe enough to affect the immune system.
Gorse and Kopp (1987)interleukin-2Vincristine and vinblastine treatment of the cells did not reduce interferon or interleukin-2 yields.
Thies et al. (2001)interleukin-2lymphocyteWe conclude that a moderate level GLA or EPA but not of other (n-6) or (n-3) PUFA can decrease lymphocyte proliferation but not production of interleukin-2 or interferon-gamma.
Koulova et al. (2005)IL-2The combination of recombinant IL-2 and GM-CSF administered in the designed schedule and doses was not effective in patients with metastatic RCC and may even interfere with the therapeutic potential of moderate-dose IL-2 and increase its adverse events.
Park et al. (2000)IL-2monocytesPHA-stimulated proliferation and IL-2 production of nonadherent monocytes in females was not significantly reduced.
Lalmanach-Girard et al. (1992)IL-2lymphocytesFurthermore, IL-2 production and IL-2 receptor expression by activated lymphocytes were markedly decreased in the presence of STPM proteins compared to the native membrane but remained unaffected in the presence of STPM lipids.