Viewing affirmative mentions of gene expression of IL2: interleukin 2 (Homo sapiens)

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Abdullah et al. (1991)IL2fibroblastsInterleukin 2 (IL2), an immune modulator produced by T lymphocytes, was tested in vitro for its effects on human diploid fibroblasts.
Gerber et al. (1989)IL2lymphocytesThe shape of the survival curve and the radiosensitivity was shown to depend upon the ability of lymphocytes to produce IL2: the survival curve for lymphocytes that were the most competent producers of IL2 is the closest to linearity; the lymphocytes that were poor producers show biphasic survival curves.
Duprez et al. (1988)interleukin 2T cellWe have described a human tumor T cell line, IARC 301, which constitutively expresses high affinity interleukin 2 (IL2) receptors, and showed that after binding to its receptors, IL2 is endocytosed and degraded.
Kahle et al. (1981)IL 2In addition, cloning efficiencies were acceptable (over 30%) when IL 2 produced spontaneously from the leukaemic cell Jurkat (M-N) was used.
Bödeker et al. (1981)lymphokine interleukin-2lymphocytesHuman spleen cells or peripheral blood lymphocytes (PBL) were stimulated with the T-cell mitogens concanavalin A or phytohemagglutinin to produce the lymphokine interleukin-2 (IL-2).
Foa et al. (1992)IL2 geneThese considerations have led to the belief that more sophisticated technologies aimed at introducing the IL2 gene into the neoplastic cells may potentially overcome some of the limitations coupled to the in vivo infusion of high doses of IL2.
Azogui et al. (1983)IL 2bone marrowInhibiton of IL 2 production after human allogeneic bone marrow transplantation.
Azogui et al. (1983)IL 2The aim of the present work was to study the helper function by measuring the production of interleukin 2 (IL 2).
Azogui et al. (1983)IL 2A consecutive series of 34 patients was tested for IL 2 production after BMT.
Azogui et al. (1983)IL 2The mechanism of this low IL 2 production was investigated.
Azogui et al. (1983)IL 2lymphocytesIrradiation of patients' lymphocytes in vitro with low dose gamma-rays partially restored the IL 2 production after 6 mo of evolution.
Azogui et al. (1983)IL 2The IL 2 production was not restored or was slightly affected by irradiation early after BMT.
Azogui et al. (1983)IL 2These results suggest that the lack of immune reconstitution after BMT may be caused by the lack of IL 2-producing cells and/or the increased activity of suppressor cells of the helper function.
Morgano et al. (1990)IL2lymphocyteDecreased lymphocyte blastogenesis, IL2 production and NK activity following nifedipine administration to healthy humans.
Lorberboum-Galski et al. (1990)IL2T cellsTo produce a molecule that will kill activated T cells as well as lymphomas and leukemias expressing interleukin 2 (IL2) receptors, we have created a recombinant chimeric protein in which IL2 is attached in peptide linkage to a truncated mutant form of Pseudomonas exotoxin (PE) (Lorberboum-Galski, H., FitzGerald, D.J.P., Chandhary, V.K., Adhya, S., and Pastan, I. (1988) Proc.
Lorberboum-Galski et al. (1990)IL2T cellsOur results indicate that IL2-PE664Glu should be evaluated as an immunosuppressive agent for the treatment of human immune disorders in which activated T cells expressing the IL2 receptor are prominent.
Hamai et al. (1997)interleukin-2vasculaturePathogenetic implication of interleukin-2 expressed in preeclamptic decidual tissues: a possible mechanism of deranged vasculature of the placenta associated with preeclampsia.
Hamai et al. (1997)IL-2placentaPROBLEM: The purpose of this study is to clarify whether IL-2 expressed in the decidua in preeclampsia affects the angiogenesis of the placenta.
Hamai et al. (1997)Interleukin-2vasculatureCONCLUSIONS: Interleukin-2 (IL-2) expressed in preeclamptic decidua might reduce the angiogenic substances arising from trophoblasts by inducing LAK-cells from decidual lymphocytes, which might be relevant to deranged vasculature of the placenta, a characteristic histology in preeclampsia.
Cheong et al. (2003)IL2Our model system is recombinant parvovirus MVM expressing human IL2, but the method should be adaptable to other vectors expressing transgenes that are secreted and for which antibodies are available.
Mossalayi et al. (1986)IL2PBLThe same dose of Imuthiol also stimulated IL2 production by human PBL.
Gillis et al. (1981)TCGFT cellCultures from old donors produced less T cell growth factor (TCGF) and incorporated less tritiated thymidine (3H-Tdr) than did similar cultures from young donors in the presence of either mitogen.
Gillis et al. (1981)TCGFT cellTCGF production or responsiveness was not associated with the presence of "suppressor" activity in elderly T cell preparations.
Inouye et al. (1980)TCGFT lymphocytesTCGF production for cloning and growth of functional human T lymphocytes.
Inouye et al. (1980)TCGFT cellIn an effort to increase the potency of T cell growth factor (TCGF), several variables were examined for their effects on the production of TCGF.
De la Hera et al. (1987)IL2mature T cellsMitogenic membrane ligands have been shown to activate interleukin 2 (IL2) production only in mature T cells, IL2 constitutive secretion having not yet been demonstrated.
De la Hera et al. (1987)IL2thymocytesHere we have isolated a population of T11+3-4-6-8- human thymocytes and CD7+/T11-3-4-6-8- prothymocytes which produce and consume IL2 upon phytohemagglutinin triggering.
Duchateau et al. (1985)interleukin 2lymphocyteIn vitro influence of thymopentin on proliferative responses and phytohemagglutinin-induced interleukin 2 production in normal human lymphocyte cultures.
Duchateau et al. (1985)interleukin 2bloodPeripheral human blood lymphocytes from healthy blood donors were investigated in vitro to observe the influence of different doses of thymopentin on nonstimulated proliferation, candidin-stimulated proliferation, and phytohemagglutinin (PHA)-induced interleukin 2 (IL2) production.
Duchateau et al. (1985)IL2No IL2 production was observed in the unstimulated cultures, even in the presence of thymopentin.
Duchateau et al. (1985)IL2On the contrary, preincubation with different concentrations of thymopentin influenced PHA-induced IL2 production.
Kaplan et al. (1988)IL-2MLA-144 produces IL-2 constitutively; however, it did not possess membrane-associated epitopes.
Kaplan et al. (1988)IL-2T cellsAlthough it is possible that the epitopes seen were present on a distinct molecule independent of secreted IL-2, the distribution on a variety of T cells and regulation via cellular activation suggest that the surface expression of IL-2 epitopes is in some way related to the soluble lymphokine.
Andersson and Sander (1989)IL-2lymphocytesA new intracytoplasmic immunofluorescence staining technique to detect and quantify human interleukin-2 (IL-2)-producing lymphocytes is described.
Andersson and Sander (1989)IL-2mononuclear cellsBlood mononuclear cells (MNC) were cultured and stimulated by mitogenic anti-CD3 antibody to produce IL-2.
Andersson and Sander (1989)IL-2Only 1% of the cells produced IL-2, but each IL-2 stained cell was very bright, indicating a low capacity of anti-CD3 antibody to induce IL-2 production rather than an insensitivity of our detection system.
Stern et al. (1984)IL-2The availability of homogeneous IL-2 will allow accurate biological studies of its activity free from the contamination of the numerous lymphokine species that are known to be co-produced with IL-2 during the induction procedure.
Altman et al. (1984)interleukin 2Antibodies of predetermined specificity against chemically synthesized peptides of human interleukin 2.
Chouaib and Fradelizi (1982)interleukin-2[Cellular regulation of human interleukin-2 production].
Chouaib and Fradelizi (1982)IL2T lymphocytesThe mechanism of IL2 production by T lymphocytes has been clearly established in Mice.
Chouaib and Fradelizi (1982)IL2Previous studies have also suggested that control of IL2 production is similar in the Human.
Chouaib and Fradelizi (1982)IL2T lymphocytesWe have observed that a complete depletion of adherent monocytes abrogates IL2 production by T lymphocytes.
Chouaib and Fradelizi (1982)IL2monocytesOn the other hands in humane inhibition of IL2 production was also mediated by an excess of monocytes.
Chouaib and Fradelizi (1982)IL2T cellThese results suggest that activation of a radiosensitive T cell by monokines is required for the inhibition of IL2 production.
Chouaib and Fradelizi (1982)IL2A model for the cellular control of human IL2 production is proposed.
Ghoneum et al. (1987)interleukin-2bloodWe have developed a simple culture assay system for measuring the in vitro effects of a chemical carcinogen, 3-methylcholanthrene (MCA), on certain activities of human peripheral blood lymphocytes: blastogenesis, cell-mediated cytotoxicity by natural killer cells, interleukin-2 production, lymphotoxin release and percent T-cell subpopulations.
Ghoneum et al. (1987)Interleukin-2Interleukin-2 and lymphotoxin production were decreased by 64% and 38%, respectively.
Ghoneum et al. (1987)interleukin-2natural killer cellWe conclude that MCA exerts an inhibitory effect on T-cell functional activity such as interleukin-2 and lymphotoxin production which correlate with a suppression of blastogenesis and natural killer cell activity.
Zissel et al. (1996)IL-2T cellAccessory function allows antigen-presenting cells to produce sufficient secondary signals for optimum T cell proliferation and interleukin-2 (IL-2) production.
Cossarizza et al. (1989)IL-2lymphocytesExtremely low frequency pulsed electromagnetic fields increase interleukin-2 (IL-2) utilization and IL-2 receptor expression in mitogen-stimulated human lymphocytes from old subjects.
Cossarizza et al. (1989)interleukin-2lymphocytesThe effects of the exposure of mitogen-stimulated human lymphocytes from aged subjects to low-frequency pulsed electromagnetic fields (PEMFs) were studied by measuring the production of interleukin-2 (IL-2) and the expression of IL-2 receptor.
Meuer et al. (1982)IL 2T lymphocytesCellular origin of interleukin 2 (IL 2) in man: evidence for stimulus-restricted IL 2 production by T4+ and T8+ T lymphocytes.
Meuer et al. (1982)IL 2T cellThe human T cell subset(s) responsible for production of interleukin 2 (IL 2) was investigated in the present study.
Meuer et al. (1982)IL 2T cellMitogen stimulation led to secretion of equivalent amounts of IL 2 from both the major T cell subsets; in contrast, after allogeneic activation, IL 2 was produced predominantly from the T4+ subset.
Meuer et al. (1982)IL 2T cellThe stimulus dependency of IL 2 production suggests that the individual functional repertoires of T4+ and T8+ T cell subsets may be linked to unique surface receptors and/or interaction molecules involved in cell triggering rather than a restricted capacity to produce lymphokine.
Elfenbein et al. (1984)interleukin-2mononuclear cellsWe found that interleukin-2 production, upon optimal stimulation, was impaired for mononuclear cells of most recipients early after marrow transplant.
Elfenbein et al. (1984)interleukin-2There appear to be defects in both interleukin-2 production and interleukin-2 responsiveness in this system early after marrow transplant.
Ryll et al. (1990)interleukin-2Production of recombinant human interleukin-2 with BHK cells in a hollow fibre and a stirred tank reactor with protein-free medium.
Ryll et al. (1990)IL-2For the production of recombinant human interleukin-2 (IL-2) two different culture processes, a 1-2 liter homogeneous stirred bubble-free aerated system and a dense cell hollow fibre bioreactor were compared.
Ryll et al. (1990)IL-2In the stirred culture 0.75 mg IL-2 were produced with 1 l of perfused medium at a maximum cell number of 3 X 10(10).
Silveira-Lacerda et al. (2010)interleukin-2PBMCResults also showed that cis-[RuCl(2)(NH(3))(4)]Cl presents a dual role on PBMC stimulating proliferation and interleukin-2 (IL-2) production at low concentration and inducing cytotoxicity, inability to proliferate, and inhibiting IL-2 production at high concentration.
Silveira-Lacerda et al. (2010)IL-2lymphocytesFor the first time, we show that, at low concentration (10-100 microg L(-1)), the cis-[RuCl(2)(NH(3))(4)]Cl compound induces peripheral blood lymphocytes proliferation and also stimulates them to IL-2 production.
Zhao et al. (2008)IL-2colonWe have further analyzed the ability of rNDV/IL2 to express IL-2 in several human tumor cell lines, including the human breast carcinoma cell line MCF-7, the human colon-adenocarcinoma cell line HT29, and human Jurkat cell line.
Zhao et al. (2008)IL-2bodyIL-2 expressed by tumor cells infected with rNDV/IL-2 was stable up till 16 days, at body temperature, and with biological activity.
Zhao et al. (2008)IL-2Expression kinetics indicated that the expression level of IL-2 was already high at 24 h after infection and reached the highest level at 48 h after infection.
Weaver et al. (2007)IL-2T cellsThe cytokine interleukin-2 (IL-2) is produced by T cells when they recognize a foreign antigen.
Katsiari and Tsokos (2006)IL-2T cellsT cells from patients with SLE produce decreased amounts of interleukin-2 (IL-2), a central cytokine in the regulation of the immune response.
Petrov and Lijnen (2000)IL-2PBMCTo evaluate the role of interleukin-2 (IL-2) in the inhibition of the proliferation of human peripheral blood mononuclear cells (PBMC) by calcium channel blockade, the effect of nifedipine, which blocks the L-type calcium channel on the proliferation, the IL-2 expression and the IL-2 production in human PBMC, was compared with the effect of mibefradil, which blocks both L- and T-type calcium channels with a more selective blockade of T-type channels.
Petrov and Lijnen (2000)IL-2T-cellIL-2 receptor expression in the cells was monitored using antiactivated T-cell antigen (Tac) antibody, and the IL-2 production in the cell supernatants of the cultures was determined by an enzyme amplified sensitive immunoassay.
Petrov and Lijnen (2000)IL-2The normal expression of IL-2 receptors was preserved while the IL-2 production was blocked in the presence of nifedipine or mibefradil.
Frydecka et al. (1999)Interleukin 2Interleukin 2 (IL-2), a pleiotropic cytokine which plays a central role in immune response, has been introduced in several clinical trials in patients with hematological malignancies after BMT or PBSCT to increase immunocompetence of these patients and eradicate residual malignant cells.
Williams et al. (1996)IL-2T cellDGLA suppresses T cell activation and production of interleukin-2 (IL-2).
Williams et al. (1996)IL-2T cellIL-2 production by the human T cell line Jurkat is dependent on a fall in mRNA for c-myc and a rise in mRNA for c-fos.
Nishimura et al. (1996)IL-2lymphocytesTo clarify whether seronegative, HTLV-I related neurological disease may exist, we have developed a method that measures the production of interleukin-2 (IL-2) from HTLV-I synthetic peptide-stimulated peripheral blood lymphocytes (PBL) of HTLV-I infected persons.
Sirota et al. (1995)interleukin-2natural killer cellEffect of human colostrum on interleukin-2 production and natural killer cell activity.
Sirota et al. (1995)interleukin-2bloodThe effect of human colostrum on the production of interleukin-2 (IL-2) and on natural killer (NK) cell activity by peripheral blood mononuclear cells (PBMC) was investigated in 50 healthy women.
Sirota et al. (1995)IL-2colostrumAt concentrations as low as 0.5%, human colostrum stimulated IL-2 production; at a higher concentration (10%), IL-2 secretion was inhibited.