Viewing affirmative mentions of regulation of IL2: interleukin 2 (Homo sapiens)

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Barcellini et al. (1987)IL-2IL-2lymphocytesAnti-T3-induced T cell activation was standardized in human peripheral blood lymphocytes with respect to dose response, time kinetics and effect of exogenous IL-2 on blastogenesis and on IL-2 receptor expression, identified by anti-Tac monoclonal antibody.
Dreno et al. (1989)IL-2skinFrom the knowledge, for some of these antibodies, of the amino-acid regions they recognize on the IL-2 molecule, it is inferred that the skin antigen shares with IL-2 at least two overlapping epitopes located in the 33-54 amino-acid region of IL-2, a region that has been shown to be involved in the binding of IL-2 to the IL-2-receptor (IL-2-R) 55 kD chain.
Reem and Yeh (1985)interleukin 2interleukin 2thymocytesModulation of the expression of interleukin 2 receptors of human thymocytes by recombinant interleukin 2.
Reem and Yeh (1985)interleukin 2interleukin 2thymocytesThe effect of purified recombinant interleukin 2 on the expression of the receptors for interleukin 2 by human thymocytes was examined.
Modiano et al. (1991)interleukin 2Protein kinase CProtein kinase C regulates both production and secretion of interleukin 2.
Fletcher and Goldstein (1987)IL-2thymosin fraction 5Finally, the modulation of IL-2 receptors on human PBL's by thymosin fraction 5 and thymosin alpha 1 suggests that it might be possible to up-regulate IL-2 receptor expression in certain disease states and thus increase the efficacy of IL-2.
Modiano et al. (1997)IL-2immunoglobinT-cellPosttranscriptional regulation of T-cell IL-2 production by human pooled immunoglobin.
Reem and Yeh (1985)IL 2interleukin 2thymocytesThe role of interleukin 2 (IL 2) on the expression of IL 2 receptors and on the synthesis of gamma-interferon (gamma-IFN) by human thymocytes was investigated.
Jakab et al. (1991)IL-2alpha 2-HS-glycoproteinThe effect of the alpha 2-HS-glycoprotein on the mitogen-induced lymphoblastic transformation and IL-2 production.
Jakab et al. (1991)interleukin-2alpha 2-HS-glycoproteinAuthors investigated the in vitro effect of alpha 2-HS-glycoprotein on the lymphoblastic transformation and interleukin-2 production.
Selmaj et al. (1988)interleukin 2myelin basic proteinMultiple sclerosis: effect of myelin basic protein on interleukin 1, interleukin 2 production and interleukin 2 receptor expression in vitro.
Himes et al. (2000)IL-2high-mobility group I(Y) proteinsT cellThe role of high-mobility group I(Y) proteins in expression of IL-2 and T cell proliferation.
Sampedro et al. (2001)IL-2VLDLlymphocyteWe studied the effects of VLDL on lymphocyte activation (IL-2 receptor expression), cell cycle progression, and production of IL-2 and of IL-4 (a proinflammatory and an anti-inflammatory interleukin, respectively) to understand why an atherogenic lipoprotein inhibits cell proliferation.
Rosztóczy et al. (1986)IL-2IFNsOur results indicate that IFNs modulate IL-2 production, which in turn can mediate some of the immunomodulatory effects of IFNs.
Vacca et al. (1990)interleukin 2glucocorticoid hormonesTranscriptional regulation of the interleukin 2 gene by glucocorticoid hormones.
Kogkopoulou et al. (2006)IL-2p38T cellsHere, the role of p38 on interleukin-2 (IL-2) production by human peripheral blood CD4+ T cells was examined.
Boulougouris et al. (1999)IL-2 promoterCD28-dependentPromoter assays revealed CD28-dependent effects on both NF-kappaB and AP-1, but not on NF-AT or the intact IL-2 promoter.
Thulesen et al. (2001)IL-2interleukin-2T cellsIn the present study, we investigated the effects of interleukin-2 (IL-2) and IL-15 on human thymocytes with respect to development of CD8(+) CD56(+) T cells.
Fujino et al. (2000)IL-2muscarinic receptorsT cellPossible intracellular signal pathways of muscarinic receptors to regulate IL-2 production were examined in human T cell line Jurkat cells.
Gerber et al. (1989)interleukin-2T lymphocytesThe influence of interleukin-2, feeder cells, and timing of irradiation on the radiosensitivity of human T lymphocytes assessed by the colony-forming assay.
Inouye et al. (1980)TCGFT cellIn an effort to increase the potency of T cell growth factor (TCGF), several variables were examined for their effects on the production of TCGF.
Chouaib and Fradelizi (1982)interleukin-2[Cellular regulation of human interleukin-2 production].
Chouaib and Fradelizi (1982)IL2Previous studies have also suggested that control of IL2 production is similar in the Human.
Chouaib and Fradelizi (1982)IL2A model for the cellular control of human IL2 production is proposed.
Meuer et al. (1982)IL 2T cellThe human T cell subset(s) responsible for production of interleukin 2 (IL 2) was investigated in the present study.
Weaver et al. (2007)IL-2 geneTranscription of the IL-2 gene is tightly controlled by the combined actions of multiple transcriptional activators.
Williams et al. (1996)IL-2T cellIL-2 production by the human T cell line Jurkat is dependent on a fall in mRNA for c-myc and a rise in mRNA for c-fos.
Sirota et al. (1995)interleukin-2colostrumEffect of human colostrum on interleukin-2 production and natural killer cell activity.
Sirota et al. (1995)interleukin-2bloodThe effect of human colostrum on the production of interleukin-2 (IL-2) and on natural killer (NK) cell activity by peripheral blood mononuclear cells (PBMC) was investigated in 50 healthy women.
Kalashnikova and Pukhal'ski? (1993)interleukin-2lymphocytes[The effect of low doses of dexamethasone on interleukin-2 production by human peripheral blood lymphocytes].
Bygbjerg et al. (1987)interleukin 2lymphocytesEffect of antimalarial drugs on stimulation and interleukin 2 production of human lymphocytes.
Bygbjerg et al. (1987)IL-2lymphocytesEffect of pyrimethamine, an antimalarial antifolate, and of mefloquine, chloroquine, and quinine, which belong to the quinoline group of antimalarials, on proliferation and interleukin 2 (IL-2) production of human lymphocytes was studied in vitro.
Reem et al. (1984)interleukin-2thymocytesRegulation of interleukin-2 synthesis in human thymocytes.
Bruserud and Moen (1984)IL-2B lymphocytesAddition of indomethacin or irradiated EBV-transformed B lymphocytes to the cultures, removal of adherent cells, and 18 h preincubation of the cells before PHA stimulation had an additive enhancing effect on the IL-2 production.
Pahlavani and Richardson (1996)interleukin-2The effect of age on the expression of interleukin-2.
Su et al. (1991)interleukin 2[Effect of diethyldithiocarbamate on interleukin 2 production of patients with oral lichen planus and its clinical therapeutic efficacy].
Goretski? et al. (1989)interleukin-2blood[Modifying effect of the blood serum from patients with soft-tissue sarcomas on interleukin-2 production and activity].
Efrat et al. (1984)IL-2 geneThese findings suggested the involvement of a labile protein repressor in the regulation of human IL-2 gene expression.
Arya et al. (1984)TCGF mRNAT lymphocytesTCGF is produced by a subset of T lymphocytes, and this production is regulated at the TCGF mRNA level.
DeFreitas et al. (1986)interleukin 2T cellsRegulation of interleukin 2 receptors on T cells from multiple sclerosis patients.
Gulino et al. (1990)IL-2T cellsInterleukin-2 (IL-2) gene expression is tightly controlled and generally limited to antigenic stimulation of T cells.
Venkataraman and Westerman (1990)IL-2MNCsThe effects of radiation on the kinetics of Interleukin-2 (IL-2) production and utilization by mononuclear cells (MNCs) were studied.
Smith and Pruett (1989)IL-2Therefore, the recently reported circadian variations in T helper to T suppressor ratios do not seem to significantly affect mitogen-induced IL-2 production.
Sasagawa et al. (2006)IL-2Modulation of IL-2 production by submaximally stimulated Jurkat cells was determined in response to treatment with extracts prepared from dried aerial parts of Echinacea purpurea.
Cadée et al. (2002)rhIL-2In contrast with non-degradable dex-MA hydrogels, degradable dex-lactate-HEMA gels with comparable network characteristics (degree of methacrylate substitution and initial water content) showed an almost zero-order, degradation controlled release of rhIL-2 in a time period of 5-15 days.
Li and Weir (1990)IL-2This inhibition is likely mediated through a reduction in both IL-2 production and IL-2 responsiveness.
Toossi et al. (1989)interleukin 2large granular lymphocytesRegulation of human T-cell production of interleukin 2 by Leu 11 (CD16) positive large granular lymphocytes.
Borysiewicz et al. (1985)IL-2cytotoxic T cellThe immunosuppressive effects of measles virus on T cell function--failure to affect IL-2 release or cytotoxic T cell activity in vitro.
Voss et al. (1989)IL-2PBLThese changes in serum IL-2 receptor levels accompany changes in lytic activity of circulating PBL on Daudi target cells.
Aoki et al. (1997)IL-2AECIL-2 regulation differs fundamentally between AEC and Jurkat T cells.
Vervliet and Schandené (1985)IL-2phytohaemagglutininbloodThe effect of phytohaemagglutinin (PHA) and/or phorbol myristic acetate (PMA) on human interferon-gamma (HuIFN-gamma) and interleukin 2 (IL-2) production was measured in peripheral blood leucocytes (PBL) from multiple sclerosis (MS) patients.
Calder et al. (1987)IL-2Effects of cyclosporin A on expression of IL-2 and IL-2 receptors in normal and multiple sclerosis patients.
Freedman et al. (1992)IL-2bloodEvidence for voltage modulation of IL-2 production in mitogen-stimulated human peripheral blood lymphocytes.
Pelassy et al. (1991)interleukin-2T cellEffects of the serine analogues isoserine and serinol on interleukin-2 synthesis and phospholipid metabolism in a human T cell line Jurkat.
Ketzinel and Kaempfer (1999)IL-2Human IL-2 gene expression is regulated by cell-mediated suppression.
Jacques et al. (1986)interleukin 2cytotoxic T lymphocyteRegulation of interleukin 2 receptor expression on a human cytotoxic T lymphocyte clone, synergism between alloantigenic stimulation and interleukin 2.
Ulmer and Flad (1982)Il-2This population appears to participate in the regulation of Il-2 production.
Carrillo-Vico et al. (2005)interleukin-2/interleukin-2lymphocyteHuman lymphocyte-synthesized melatonin is involved in the regulation of the interleukin-2/interleukin-2 receptor system.
Carrillo-Vico et al. (2005)IL-2Moreover, we demonstrated that this endogenous melatonin interfered with the exogenous melatonin effect on IL-2 production.
Hu et al. (1990)IL-2lymphocytesThe possible application of PA to the treatment of immune disorders involving deficiency of IL-2 production and/or IL-2 responsiveness of lymphocytes is also considered.
Tsudo et al. (1983)TCGF receptorT cellsThese results indicate that regulation of Tac antigen-TCGF receptor is different between normal and malignant T cells, suggesting that failure of down-regulation of Tac antigen on leukemic cells by anti-Tac antibody may play an important role in the malignant proliferation of ATL cells.
Meuer et al. (1984)IL-2Perhaps more importantly, the findings demonstrate that antigen-induced proliferation is mediated through an autocrine pathway involving endogenous IL-2 production, release, and subsequent binding to IL-2 receptors.
Weir et al. (1991)IL-2CTLL-2ENO also potently inhibited both IL-2 production (measured by ELISA) and IL-2 responsiveness (measured by CTLL-2 response to IL-2) in a concentration-dependent manner, yet did not inhibit acquisition of IL-2 receptors.
Walther et al. (1999)interleukin-2T lymphocytesRecent work with the random positioning machine, a new instrument to simulate conditions similar to microgravity, indicate that there are direct gravitational effects on the genetic expression of interleukin-2 and of its receptor in T lymphocytes.
Fernandez et al. (1995)IL-2Does thalidomide affect IL-2 response and production?
Wacholtz et al. (1991)IL2T cellsCharacterization of the 3',5'-cyclic adenosine monophosphate-mediated regulation of IL2 production by T cells and Jurkat cells.
Wacholtz et al. (1991)IL2The effect of cyclic AMP-elevating agents on mitogen-stimulated IL2 production was examined.
Wacholtz et al. (1991)IL2T cellsThus, these observations indicate that IL2 production by both peripheral T cells and Jurkat cells can be modulated by cAMP-elevating agents.
Chen et al. (1994)IL-2immune systemIt is suggested that GSH may exert its effects on the immune system via the regulation of IL-2 synthesis.
Ketzinel et al. (1991)interleukin-2suppressor T lymphocytesRegulation of human interleukin-2 and interferon-gamma gene expression by suppressor T lymphocytes.
Efrat and Kaempfer (1984)IL-2lymphocytesThe regulation of human interleukin 2 (IL-2) mRNA production in induced normal lymphocytes was studied by following the expression of isolated mRNA in microinjected oocytes of Xenopus laevis.
Efrat and Kaempfer (1984)IL-2The net result is the generation of a relatively short wave of IL-2 mRNA activity, demonstrating the tight control of IL-2 gene expression.
Fujita et al. (1986)interleukin-2T lymphocytesRegulation of human interleukin-2 gene: functional DNA sequences in the 5' flanking region for the gene expression in activated T lymphocytes.
Yang et al. (1994)interleukin-2lymphocyteLymphocytes were incubated with a suboptimal dose of Con A or PHA in the presence or absence of varying doses of triptolide to assess the effect of triptolide on lymphocyte proliferation, interleukin-2 (IL-2) production and IL-2 receptor expression.
Yang et al. (1994)IL-2T-lymphocyteTaken together, these results suggest that triptolide inhibits T-lymphocyte proliferation mainly by affecting IL-2 receptor expression rather than IL-2 production.
Tsang et al. (1986)interleukin-2PBMCThe effects of Isoprinosine (ISO) on interleukin-2 (IL-2) production by human peripheral blood mononuclear cells (PBMC) were investigated.
Müller-Quernheim et al. (1986)IL 2T cellsThe sarcoid lung T cells, however, did not express the IL 2 gene constitutively; when placed in culture with no stimulation and evaluated after 24 hr, they demonstrated down regulation of the amounts of IL 2 mRNA transcripts, despite the fact that they were capable of re-expressing the IL 2 gene and releasing more IL 2 in response to added activation signals.
Liu and Rosenberg (2003)IL-2T-cellHere they report that this growth of IL-2 transductants depended on restimulation of the T-cell receptor complex and appeared to be regulated at the transcriptional level of the transduced IL-2 gene.
Barcellini et al. (1988)IL-2In vivo immunopotentiating activity of thymopentin in aging humans: modulation of IL-2 receptor expression.
Hemler et al. (1984)interleukin 2T cellsAntigenic stimulation regulates the level of expression of interleukin 2 receptor on human T cells.
Modiano et al. (1991)IL2The inhibition of PKC affected the expression of IL2 receptors by these cells differently; it had little effect on gene expression or on the membrane-bound form of the receptor, but it decreased soluble receptors in the supernatants by 50-80%.
Arya and Gallo (1985)TCGFNo evidence was obtained suggesting abnormal regulation of the TCGF or of the IFN-gamma gene consequent to HTLV-III infection.
Wiranowska-Stewart and Hadden (1986)interleukin-2Effects of isoprinosine and NPT 15392 on interleukin-2 (IL-2) production.
Dornand et al. (1987)IL 2We have studied the mechanism whereby amiloride inhibits the blastogenesis by measuring their effect on: 1) IL 2 production, 2) acquisition of IL 2 responsiveness and induction of IL 2 receptors, 3) IL 2-induced proliferation.
Briggs et al. (1999)interleukin-2mononuclear cellsTo evaluate molecular mechanisms that might account for the heterogeneity in the in vitro responsiveness of individual subjects' peripheral blood mononuclear cells (PBMC) to immunosuppressive drugs, the authors quantitated in normal human cells the suppressive effects of the glucocorticoids prednisolone and methylprednisolone and of cyclosporine on interleukin-2 (IL-2) mRNA expression and IL-2 production, as well as the stimulatory effect of these drugs on IkappaBalpha mRNA expression.
Holán et al. (1994)interleukin-2T cellEffects of direct current on T cell activity: modulation of interleukin-2 production.
Holán et al. (1994)IL-2MOLT-13DC had similar enhancing and inhibitory effects on IL-2 production by the mitogen-stimulated human leukemia T cell line MOLT-13.
Gaffen and Liu (2004)IL-2Here we present a broad overview of IL-2 history, functional activities, biological sources, regulation and applications to disease treatment.
Trzonkowski et al. (2001)Interleukin 2bloodThe aim of this study was to look at the possible changes in the blood levels of Interleukin 2 (IL2) during the sexual cycle in generally healthy, young, regularly menstruating women.
Rossi et al. (1988)IL2However, IL2 secretion increased in the BM cells from B-CLL patients after addition of indomethacin or prior irradiation, in a similar way to that observed in PB and BM of normal controls, suggesting an apparent normal control of the IL2 production in BM from B-CLL patients.
Matesanz et al. (2000)IL-2 geneT lymphocytesTherefore, we investigated the regulation of allelic expression of the IL-2 gene in non-genetically manipulated human T lymphocytes by following natural allelic polymorphisms.
Matesanz et al. (2000)IL-2T cellsThis allowed the study by single-cell PCR of the regulation of the human IL-2 allelic expression in heterozygous CD4(+) T cells, which was found to be tightly controlled monoallelically.
Rezai et al. (1990)IL-2Histamine blocks interleukin 2 (IL-2) gene expression and regulates IL-2 receptor expression.
Rezai et al. (1990)IL-2In addition, histamine seems to exert immunomodulating effects on IL-2 receptor expression, particularly in those individuals with AIDS-KS.
Fukushima et al. (1987)interleukin 2CTLLTo study the mechanisms that regulate the activity of interleukin 2 (IL 2) and possibly limit its activity, we have examined normal human serum for its ability to inhibit IL 2-mediated proliferation of a cloned IL 2-dependent cytotoxic T lymphocyte line (CTLL).