Viewing affirmative mentions of positive regulation of IL2: interleukin 2 (Homo sapiens)

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Reem et al. (1985)IL-2IL-2thymocytesIL-2 also upregulates the expression of high-affinity IL-2 receptors on activated thymocytes.
Capelli et al. (1999)IL-2IL-2The immunocytochemical study revealed that IL-2 induces the expression of the IL-2 receptor on human glioblastoma cells.
Kasahara et al. (1989)IL2IL1In contrast to the IL2 and IFN-gamma gene activation, IL2 receptor (Tac/p55 antigen) expression was induced directly by IL1 itself as with PMA in this subclone.
Kasahara et al. (1989)IL2IL1Taken collectively, these experiments support the notion that IL1 does not trigger IL2 gene activation per se, but amplifies the preactivated lymphokine genes initiated by PMA and ionomycin, whereas IL1 can activate the IL2 receptor gene without any other known signal requirements.
Or et al. (1992)IL-2IL-2These results on the protein level were confirmed at the mRNA level as well and demonstrated that only PDB and IL-2 could induce IL-2 mRNA and PDB and IL-4 enhanced IL-4 mRNA.
Bryl et al. (1999)interleukin 2erythropoietinblood cellRecombinant human erythropoietin stimulates production of interleukin 2 by whole blood cell cultures of hemodialysis patients.
Bryl et al. (1999)IL-2rhEPOblood cellAddition of rhEPO in vitro to the whole blood cell cultures of the HD patients before implementation of erythropoietin confirmed that rhEPO is able to directly stimulate IL-2 production.
Duchateau et al. (1985)interleukin 2phytohemagglutininlymphocyteIn vitro influence of thymopentin on proliferative responses and phytohemagglutinin-induced interleukin 2 production in normal human lymphocyte cultures.
Kruger et al. (1984)interleukin-2OKT3lymphocytesWe studied the ability of phytohemagglutinin (PHA) and two anti-T-cell monoclonal antibodies, OKT3 and Pan T2, to induce interleukin-2 (IL2) production and proliferation in peripheral blood lymphocytes (PBL) from 14 patients with combined varied immunodeficiency (CVI).
Kruger et al. (1984)interleukin-2Pan T2lymphocytesWe studied the ability of phytohemagglutinin (PHA) and two anti-T-cell monoclonal antibodies, OKT3 and Pan T2, to induce interleukin-2 (IL2) production and proliferation in peripheral blood lymphocytes (PBL) from 14 patients with combined varied immunodeficiency (CVI).
Kruger et al. (1984)interleukin-2phytohemagglutininlymphocytesWe studied the ability of phytohemagglutinin (PHA) and two anti-T-cell monoclonal antibodies, OKT3 and Pan T2, to induce interleukin-2 (IL2) production and proliferation in peripheral blood lymphocytes (PBL) from 14 patients with combined varied immunodeficiency (CVI).
Westendorp et al. (1994)interleukin-2TatT cellsHuman immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells.
Bartz et al. (1995)interleukin 2phytohemagglutininlymphocytesOne CsA analog with antiviral activity costimulated the phytohemagglutinin-induced production of interleukin 2 by human lymphocytes.
Jacques et al. (1986)IL 2recT cellTogether, our results obtained on a monoclonal human T cell population with highly purified rec-IL 2 demonstrate that rec-IL 2 and antigen act in synergy to induce the expression of both high and low affinity membrane IL 2 receptors.
Vacca et al. (1994)IL-2 promotertatWe observed that tat increased the IL-2 promoter transcriptional activity in response to phorbol ester and ionomycin.
Barcellini et al. (1988)IL-2ThymopentinThymopentin was able to increase IL-2 production and IL-2 receptor expression, as assessed on PHA-activated blasts by percentage of Tac-positive cells and response to exogenous IL-2.
Wiranowska-Stewart and Hadden (1986)IL-2phytohemagglutininTwo purine immunoenhancing drugs, isoprinosine and NPT 15392, were evaluated as inducers of IL-2 or enhancers of IL-2 induction by phytohemagglutinin (PHA).
Nomura et al. (2003)IL-2phytohemagglutininPretreatment with oxotremorine-M (Oxo-M) caused the increase in phytohemagglutinin-induced IL-2 production.
Nomura et al. (2003)IL-2TCRT lymphocytesOur results suggest that muscarinic receptors, perhaps M(1) receptors are involved in the enhancement of TCR-induced IL-2 production and IL-2 receptor expression in human T lymphocytes.
Holán et al. (1991)interleukin-2IFN-alphaleukocytesThe production of interleukin-2 (IL-2) by Concanavalin A (ConA)-stimulated peripheral blood leukocytes (PBL) from normal human donors was enhanced by natural human interferon-alpha (IFN-alpha).
Holán et al. (1991)IL-2IFN-alphaThe ability of IFN-alpha to increase IL-2 production was abrogated by the treatment of IFN-alpha preparations with specific anti-IFN-alpha antibody, and the induced IL-2 activity was completely inhibited by monoclonal antibody against human IL-2.
Freed et al. (1989)IL-25-10 microM cytochalasin BIn contrast, 5-10 microM cytochalasin B (CB) inhibited ER formation, agglutination, Tac expression and DNA synthesis, but augmented IL-2 production by three- to ten-fold.
Freed et al. (1989)IL-2CBIn contrast, 5-10 microM cytochalasin B (CB) inhibited ER formation, agglutination, Tac expression and DNA synthesis, but augmented IL-2 production by three- to ten-fold.
Konaka et al. (1981)IL2Rabbit anti-Thy-1 antibodyT cellRabbit anti-Thy-1 antibody bound to T cells induces the appearance of T cell growth factor (interleukin 2, IL2) receptors and the production of IL2.
Noma et al. (1990)IL2OvalbuminlymphocytesOvalbumin-specific induction of IL2 responsiveness in lymphocytes from patients with hen egg allergy and its regulation by the culture supernatant of normal lymphocytes.
Kooijman et al. (1996)interleukin-2IGF-IT cellsIGF-I potentiates interleukin-2 production in human peripheral T cells.
Kooijman et al. (1996)interleukin-2IGF-IT cellsWe found that IGF-I augmented the phytohaemagglutinin- and anti-CD3-induced interleukin-2 (IL2) production of human peripheral T cells before they enter the S phase of the cell cycle.
Roosnek et al. (1987)IL2mouse monoclonal antibodymonocytesIn contrast, CLB-T3/4.2a, a mouse monoclonal antibody of the same isotype with a high avidity (much greater than OKT3) for the CD3 complex, induces IL2 receptor expression and IL2 responsiveness only at very low concentrations (less than 5 ng/ml), yet in the presence of monocytes this antibody induces proliferation within a similar dose range as WT32.
Sakane et al. (1989)interleukin-2phytohemagglutininT-cellSUBJECTS AND METHODS: We used a phytohemagglutinin-induced interleukin-2 (IL-2) activity assay and a spontaneous plaque-forming cell assay to evaluate T-cell and B-cell function, respectively, in 34 clinically healthy family members of six SLE probands.
McGuire et al. (1993)IL-2 generex proteinsIn the present studies, the ability of the tax and rex proteins to transactivate IL-2 gene expression has been reinvestigated.
McGuire et al. (1993)IL-2 genetaxIn the present studies, the ability of the tax and rex proteins to transactivate IL-2 gene expression has been reinvestigated.
McGuire et al. (1993)IL-2 genetaxConsistent with this hypothesis is the observation that tax-mediated activation of IL-2 gene expression is resistant to the immunosuppressive affects of cyclosporin A, a property postulated for the CD28RC binding complex.
McGuire et al. (1993)IL-2taxUnexpectedly, this tax-mediated up-regulation of IL-2 expression is synergized by the presence of the rex protein.
McGuire et al. (1993)IL-2 genetaxT cellsThese findings demonstrate that transactivation of IL-2 gene expression by tax is augmented by mechanisms distinct from NF-kappa B and raise the possibility that rex, as well as tax, contributes to the oncogenic capability of HTLV-I by altering the expression of the IL-2 gene in T cells infected with this retrovirus.
Yamamoto et al. (1986)IL2PhytohemagglutininlymphocytesPhytohemagglutinin (PHA) and a tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) act synergistically to induce interleukin 2 (IL2) mRNA in human lymphocytes in vitro.
Purvis et al. (1992)IL-2PMASublines derived from the high-level Tat transfectants with reduced Tat activity showed normalization of PHA/PMA-induced IL-2 expression.
Knoring et al. (2003)IL-2phytohemagglutininmature T lymphocytesAfter termination of a course of glutoxim therapy, there was an increase in the baseline low values of lymphocytic proliferative activity, in the count of mature T lymphocytes, and in the production of IL-2 induced by phytohemagglutinin.
Aihara et al. (1999)IL-2Con ACon A induced secretion of IL-2 in each of the three groups.
Depper et al. (1985)IL-2Interleukin 2Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene.
Goto et al. (2008)interleukin-2phytohemagglutininT-cellDifferent effects of all-trans-retinoic acid on phorbol ester-stimulated and phytohemagglutinin-stimulated interleukin-2 expression in human T-cell lymphoma HUT-78 cells.
Flescher et al. (1989)IL-2PHAmonocytesPre-incubation with spermidine, but not any of three diamines tested, suppresses PHA-stimulated IL-2 production and this effect requires monocytes.
Roosnek et al. (1987)IL-2lectinmononuclear cellsWe have studied lectin-induced interleukin-2 (IL-2) production and proliferation of peripheral blood mononuclear cells from patients who had undergone a successful allogeneic bone marrow transplantation.
Reem and Yeh (1985)IL 2Con AthymocyteCon A induced the expression of IL 2 receptors by a moderate number of the thymocyte population and induced the synthesis of low amounts of gamma-IFN.
Klein et al. (1983)IL2IL1MonocytesMonocytes, IL1, or PMA are known to be crucial requirements for IL2 production by PHA-stimulated T cells.
Welte et al. (1987)IL-2IL-2However, the upregulation of IL-2 receptor expression by exogenous IL-2 was found to be comparable to normal controls when tested as early as 3 weeks post-SBA-E-BMT.
Engedal et al. (2004)IL-2RART lymphocytesTogether, these results suggest that retinoic acid inhibits spontaneous apoptosis of activated T lymphocytes through a RAR-dependent increase in IL-2 production.
Atluru et al. (1993)IL-2PHAA-63162 inhibited PBMC proliferation stimulated by phytohemagglutinin (PHA) and phorbol myristate acetate (PMA) plus A23187, IL-2 receptor expression stimulated by PHA, and IL-2 or IL-6 synthesis induced by PHA plus PMA or PMA plus A23187.
Dao et al. (1993)IL-2tumor necrosis factor-alphaMOLT-14In addition, the IL-2 production by PHA-stimulated MOLT-13 and MOLT-14 cells was also augmented by human natural tumor necrosis factor-alpha (TNF-alpha) in a dose-dependent manner but was inhibited by IFN-alpha even at low concentrations (10 IU/ml).
Dao et al. (1993)IL-2TNF-alphaMOLT-14In addition, the IL-2 production by PHA-stimulated MOLT-13 and MOLT-14 cells was also augmented by human natural tumor necrosis factor-alpha (TNF-alpha) in a dose-dependent manner but was inhibited by IFN-alpha even at low concentrations (10 IU/ml).
Dao et al. (1993)IL-2TNF-alphaMOLT-14These results suggest that (1) the addition of IFN-gamma has a direct effect on PHA-stimulated MOLT-13 and MOLT-14, resulting in an augmentation of IL-2 production; (2) phenotypically different T cell lines vary in their susceptibility to IFN-alpha and IFN-gamma regulation; and (3) the augmentation of IL-2 production by TNF-alpha appears to have no correlation with phenotypically different T cell clones.
Vie et al. (1985)IL-2lectinPBLWe have studied the lectin-induced production of Interleukin II (IL-2) by peripheral blood leucocytes (PBL) obtained from recipients of kidney grafts.
Kaufmann et al. (1985)IL-2antigenWe have found that antigen/lectin alone can trigger the cytolytic potential of the hybridomas and induce IL-2 secretion.
Ott et al. (1997)IL-2TatIL-2 superinduction by Tat occurred at the transcriptional level, was mediated by the CD28-responsive element in the IL-2 promoter, and was exclusively dependent on the 29 amino acids encoded by the second exon of Tat.
Ott et al. (1997)IL-2IL-2 superinduction by Tat occurred at the transcriptional level, was mediated by the CD28-responsive element in the IL-2 promoter, and was exclusively dependent on the 29 amino acids encoded by the second exon of Tat.
Taylor et al. (1986)IL 2IL 2IL 2 does not appear to induce IL 2 receptors on cells previously lacking this molecule.
Borzy et al. (1989)interleukin-2PhytohemagglutininPhytohemagglutinin-induced interleukin-2 production and cell surface interleukin-2 receptor expression improved posttransplant, with normal production values observed by 8 months posttransplant.
Hamagashira (1993)IL-2IL-2TILThe IL-2 receptor expression of PBL-T, TIL and LNC was also activated with low-dose CBE and IL-2.
Hamagashira (1993)IL-2IL-2cytotoxic T cellsThe results suggested that low-dose CBE and IL-2 augment the IL-2 receptor expression of T lymphocytes, thereby the proliferation of the antigen specific cytotoxic T cells.
June et al. (1989)IL-2CD28The present studies examined whether CD28 augments IL-2 expression by a unique pathway or merely acts at a point common to CD3-induced proliferation but distal to the effects of cyclosporine.
Kusugami et al. (1991)interleukin-2phytohemagglutininInduction of interleukin-2 by different stimuli (phorbol ester, phytohemagglutinin, or anti-CD3 monoclonal antibody) before or after incubation under basal conditions ("resting") failed to normalize the capacity to generate interleukin-2 by Crohn's disease and ulcerative colitis cells.
Kusugami et al. (1991)interleukin-2anti-CD3 monoclonal antibodyInduction of interleukin-2 by different stimuli (phorbol ester, phytohemagglutinin, or anti-CD3 monoclonal antibody) before or after incubation under basal conditions ("resting") failed to normalize the capacity to generate interleukin-2 by Crohn's disease and ulcerative colitis cells.
Rambaldi et al. (1987)interleukin 2Interferon-gammamonocytesInterferon-gamma induces expression of the interleukin 2 receptor gene in human monocytes.
Combe et al. (1987)IL-2phytohemagglutininbloodDecreased phytohemagglutinin (PHA) stimulated IL-2 production by lymphocytes was observed in rheumatoid peripheral blood (5.3 +/- 10.9 units/ml) and SF (3.8 +/- 5.2 units/ml) compared to peripheral blood from 12 normal donors (18.1 +/- 15.4 units/ml) and SF from 5 patients with other rheumatic diseases (11.9 +/- 10.9 units/ml).
Kang et al. (1987)interleukin 2HSB.2 C5B2T cellBGEF also enhanced IL-1-induced production of interleukin 2 (IL-2) by both thymocytes and a human T cell clone, HSB.2 C5B2.
Chen and Chen (2001)interleukin-2PhytohemagglutininT lymphocytesPhytohemagglutinin (PHA) is a mitogen for T lymphocytes and can stimulate the increased production of episomes as well as the release of eDNA, interleukin-2, and other factors.
Adunyah et al. (1997)IL-2IL-15We report that IL-15 induces tyr phosphorylation of the p75IL-2R beta and p64IL-2R gamma subunits and Shc.
Bowlin et al. (1987)IL-2Con AMNLPolyamine depletion of MNL augmented detectable levels of Con A-induced IL-2 activity.
Komada et al. (1996)interleukin 2Con ACon A induced both interleukin 2 receptor (IL-2R) expression and interleukin 2 (IL-2) production.
Murakawa and Sakane (1988)interleukin-2phytohemagglutininDeficient phytohemagglutinin-induced interleukin-2 activity in patients with inactive systemic lupus erythematosus is correctable by the addition of phorbol myristate acetate.
Rocha-Zavaleta et al. (2004)Interleukin-2IL-2Interleukin-2 (IL-2) receptor-betagamma signalling is activated by c-Kit in the absence of IL-2, or by exogenous IL-2 via JAK3/STAT5 in human papillomavirus-associated cervical cancer.
Lotz et al. (1986)IL-2IL-1Exogenous IL-1 also enhanced IL-2 release.
Chen and Chen (2001)interleukin-2PHAT lymphocytesPhytohemagglutinin (PHA) is a mitogen for T lymphocytes and can stimulate the increased production of episomes as well as the release of eDNA, interleukin-2, and other factors.
Dao et al. (1994)interleukin-2interferon-alphaT cellsWe have previously shown that interferon-alpha (IFN-alpha) augments interleukin-2 (IL-2) production in mitogen-activated but not unstimulated T cells (1).
Azogui et al. (1983)IL 2lymphocytesIrradiation of patients' lymphocytes in vitro with low dose gamma-rays partially restored the IL 2 production after 6 mo of evolution.
Mossalayi et al. (1986)IL2PBLThe same dose of Imuthiol also stimulated IL2 production by human PBL.
Duchateau et al. (1985)IL2On the contrary, preincubation with different concentrations of thymopentin influenced PHA-induced IL2 production.
Duchateau et al. (1985)IL2A significant increase in the IL2 level was observed in the supernatant of the cultures if 1,000 ng/ml of thymopentin was used in the preculture period.
Meuer et al. (1982)IL 2T cellMitogen stimulation led to secretion of equivalent amounts of IL 2 from both the major T cell subsets; in contrast, after allogeneic activation, IL 2 was produced predominantly from the T4+ subset.
Silveira-Lacerda et al. (2010)IL-2lymphocytesFor the first time, we show that, at low concentration (10-100 microg L(-1)), the cis-[RuCl(2)(NH(3))(4)]Cl compound induces peripheral blood lymphocytes proliferation and also stimulates them to IL-2 production.
Bartlett et al. (1998)IL-2A dose-response relationship favored increasing IL-2 doses, and subcutaneous delivery offered greater increases than intravenous administration.
Bauer et al. (1995)IL-2RESULTS: Interleukin-2 dose modifications were based on tolerance and toxicity, such that 46% of these patients received a 50% increase in IL-2 dose during the second week, and 81% of those receiving the elevated dose continued receiving this dose level during the third week of treatment.
Sirota et al. (1995)IL-2colostrumAt concentrations as low as 0.5%, human colostrum stimulated IL-2 production; at a higher concentration (10%), IL-2 secretion was inhibited.
Sirota et al. (1995)IL-2colostrumThe stimulation of IL-2 production induced by human colostrum might compensate for its inhibitory effect on NK cell activity.
Uchiyama et al. (1993)interleukin 2Transfection of interleukin 2 gene into human melanoma cells augments cellular immune response.
Uchiyama et al. (1993)IL-2IL-2 gene was transfected into three human melanoma cell lines; secretion of IL-2 from stable transfected cells was confirmed by enzyme-linked immunosorbent assay.
Kalashnikova and Pukhal'ski? (1993)interleukin-2lymphocytesDose-dependent modifying of mitogen-induced interleukin-2 (IL-2) release by human peripheral blood lymphocytes (PBL) treated with dexamethasone (Dx) was demonstrated.
Watson et al. (1991)IL-2NK cellsThe increase in the percentage of cells with markers of NK cells and in expression of IL-2 receptors was dose dependent.
Smith and Roberts-Thomson (1989)IL-2synovial fluidPeripheral blood and synovial fluid (SF) mononuclear cells from 30 patients with rheumatoid arthritis (RA) were hyporesponsive to mitogenic stimulation with plant lectins and CD3 antibodies, due to depressed interleukin 2 (IL-2) production and IL-2 receptor upregulation.
Smith and Roberts-Thomson (1989)IL-2mononuclear cellsIn contrast, in the seronegative arthritis patient group only SF mononuclear cells were hyporesponsive to mitogenic stimulation and there were no significant differences in IL-2 production or IL-2 receptor upregulation as compared with control subjects.
Smith and Roberts-Thomson (1989)IL-2mononuclear cellsNo significant correlations were observed between IL-2 inhibitor levels and mitogenic responses, IL-2 production and IL-2 receptor upregulation on peripheral blood and SF mononuclear cells but an inverse correlation was noted between SF mitogenic responses and the expression of selected activation markers.
Warrington (1988)IL-2At high cell densities, IL-2 production was decreased in SLE but remained enhanced in RA.
Warrington (1988)IL-2The possibility is discussed that a local hyper-production of IL-2 could induce disturbances of the immune response, resulting in the breaking of normal tolerance.