Viewing affirmative mentions of binding in T cells

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Tamma and Coico (2003)IgDIgD-RT cellBased on our previous findings that immunoglobulin D (IgD) receptor (IgD-R) cross-linking with oligomeric IgD (IgD-R-xL) led to T cell activation, we examined the effect of IgD-R-xL on the expression of Fas antigen and apoptosis induction.
Li et al. (1998)CD44CD44T cellChimeric CD4/CD44 molecules associate with CD44 via the transmembrane region and reduce hyaluronan binding in T cell lines.
Li et al. (1998)CD44CD44T cellThus, the transmembrane region of CD44 is required for the association with CD44 molecules in the cell membrane and we propose that the self-association of CD44 molecules occurs on the T cell surface to promote hyaluronan binding.
Anderton et al. (1994)hsp65hsp65T cellTo assess the potential of these hypotheses, we analyzed hsp65 T cell epitopes recognized after immunization of Lewis rats with Mt or hsp65.
Duprez et al. (1992)IL2IL2T lymphocytesIL2 binds to high-affinity IL2 receptors on the surface of T lymphocytes, mediates cell growth, and is internalized.
Hanawa et al. (2002)CD28CD28iT cellsCD28i was found noncovalently associated with CD28 and was tyrosine-phosphorylated/PI3-kinase-complexed following the crosslinking of CD28, and the CD28 costimulatory signal was enhanced in T cells expressing CD28i.
Hanawa et al. (2002)CD28CD28iT cellsThese data demonstrate that CD28i, via noncovalent association with CD28, plays a role as a costimulatory signal amplifier in human T cells.
Sakane and Takada (1989)CD4CD4T cellsRather, the binding of CD4 MoAb to CD4+ T cells interferes with a late event because it is capable of abolishing the proliferative activity of fully activated CD4+ T cells.
Wormley et al. (2000)CD4CD4 proteinT cellsAltogether, our results provide evidence that the CD4 protein on vaginal CD4+ T cells is conformationally distinct compared with its systemic counterpart, either as a result of a unique CD4 mRNA sequence or from a stable interaction of soluble CD4 with the surface of vaginal T cells.
Baroja and Ceuppens (1987)IL-2IL-2T-cellsPrecise measurement of IL-2 production in vitro is hampered by binding of IL-2 to IL-2 receptors on activated T-cells which results in IL-2 consumption.
Marcus et al. (1987)IL-2IL-2T lymphocytesThese data suggest that interference with the binding of IL-2 to the high-affinity IL-2 receptor of activated T lymphocytes plays an important role in the inhibition of Con A-induced proliferation.
Debatin et al. (1990)APO-1APO-1T cellsThe monoclonal antibody anti-APO-1 recognises a 52 kD cell membrane protein (APO-1) on some lymphoid tumour cell lines and on activated T cells.
Horie et al. (2009)PTPN22LypT-cellIn the PTPN22 risk variant (rs2476601), this substitution disrupts an interaction between Lyp and the protein tyrosine kinase, Csk, and may translate biologically to a potential for ‘hyperreactive’ pathogenic T-cell responses [8].
Müller et al. (1993)CD4CD4T cellsSurface Ig levels of CD4+ T cells were closely associated with the CD4 cell number in HIV-infected patients of all stages of disease (r = -0.67, P = 0.00005).
Zhang et al. (1996)CD4CD4T cellThe exocyclic derived from CDR3 (residues 82-89) of human CD4, which specifically associated with CD4 on the T cell surface to create a heteromeric CD4 complex, blocked IL-2 production and antagonized the normal function of the CD4 receptor.
Abromson-Leeman et al. (1995)MBPMBPT cellExperimental autoimmune encephalomyelitis-resistant mice have highly encephalitogenic myelin basic protein (MBP)-specific T cell clones that recognize a MBP peptide with high affinity for MHC class II.
Taylor and Schwarz (2001)OX40OX40T cellsThrough interactions with OX40 ligand, OX40 delivers potent costimulatory signals to T cells.
Torsella et al. (1992)TCGFTCGFT-cellsAn example of biological transduction, analyzed in this report, is the triggering of T-cell proliferation by the binding of T-cell growth factor (TCGF) to specific TCGF-binding sites on responsive T-cells.
Brown et al. (2001)MSP1aMSP1T lymphocytesCD4(+) T lymphocytes from calves immunized with Anaplasma marginale major surface protein 1 (MSP1), a heteromeric complex of MSP1a and MSP1b, preferentially recognize the MSP1a carboxyl terminus that is conserved among strains.
Kondo et al. (1993)IL-2IL-2T cellA monoclonal antibody to the gamma chain, TUGm2, inhibited IL-2 binding to the functional IL-2 receptors and also inhibited IL-4-induced cell growth and the high-affinity binding of IL-4 to the CTLL-2 mouse T cell line.
Hioe et al. (2001)gp120anti-gp120T cellsThe anti-gp120(CD4BD) MAbs complexed with gp120 suppressed gamma interferon production as well as proliferation of gp120-specific CD4 T cells.
Fung-Leung et al. (1994)CD8CD8T cellsThymocytes and most peripheral T cells express CD8 as heterodimers of CD8 alpha and CD8 beta.
Charoonpatrapong et al. (2006)HMGB1HMGB1T-cellsA recent discovery reveals that DCs release the chromatin protein high mobility group box 1 (HMGB1) as a potent immunomodulatory cytokine mediating the interaction between DCs and T-cells, via HMGB1 binding to the membrane receptor for advanced glycation end products (RAGE).
Pfistershammer et al. (2006)FVIIIFVIIIT cellsWe asked the question whether FVIII itself, FVIII complexed with von Willebrand factor (VWF) or thrombin-activated FVIII contain danger signals for human DCs that induce the upregulation of costimulatory molecules or the expression of proinflammatory cytokines necessary for effective activation of CD4(+) T cells.
Mills et al. (1990)IL2RIL2T lymphocytesInteraction of interleukin 2 (IL2) with its high affinity membrane receptor complex (IL2R) is sufficient to induce proliferation of T lymphocytes.
Hammond et al. (1992)CD4CD4T cellsCD4+ CTL were shown to recognize not only the infected cells within these acutely infected cultures but also noninfected CD4+ T cells that had passively taken up gp120 shed from infected cells and/or free virions.
Ye et al. (2004)BAFF-RBAFFT cellWe report that the binding of BAFF to BAFF-R expressed by a subset of primarily CD4(+) T cells costimulates T cell activation and allo-proliferation in vitro and in vivo, and that mice with a mutation in the BAFF-R, or with a targeted deletion of BAFF, show prolonged cardiac allograft survival as compared to wild-type or transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI)(-/-) controls.
Matsuzawa et al. (2002)FasLFasT cellsTaken together with the fact that DN T cells massively express Fas ligand (FasL), this study implied that FasL overexpressed on DN cells may be involved in the accumulation of DN T cells in LN, LN atrophy and wasting syndrome, and that lprcg Fas, which can bind to Fas ligand but not transduce apoptosis signal into cells, may modulate these pathological conditions by interfering with the binding of FasL to Fas.
Li et al. (1994)NF-kappa B1kappa BT cellsOn the basis of Western blotting experiments using antibodies to kappa B/Rel family proteins, the kappa B-binding activity constitutively expressed in T cells from RCC patients is composed mostly of the NF-kappa B1 (p50) subunit.
Fang et al. (1999)HSC70HSC70T-cellHere we showed that HSC70 directly binds to gp46 by co-immunoprecipitation of HSC70 and gp46 from HTLV-I-producing human T-cell lysate.
Veillette et al. (1988)p56lckCD4T lymphocytesThese results suggest that p56lck is functionally and physically associated with CD4/CD8 in normal murine T lymphocytes and support the concept that an independent signal is transduced by the interaction of these surface molecules with major histocompatibility complex determinants.
Strom and Bangs (1982)insulininsulinT cellsTo verify that the insulin effect was due to a stereospecific interaction between insulin and classical, high-affinity insulin receptors, insulin and a series of insulin-like peptides were compared in their ability to bind to alloactivated T cells and amplify the MLR.
Müschen et al. (1998)CD95CD95T lymphocytesTera-2 cells were then more susceptible to CD95 mediated apoptosis but also killed more CD95 receptor bearing Jurkat T lymphocytes via CD95 ligation compared to the control conditions.
Vernal et al. (2006)RANKLCD4T-cellOur study was aimed at associating the levels of RANKL with the CD4(+) T-cell activity present in gingival tissues of chronic periodontitis patients.
Menard et al. (1999)GADanti-GAD AbT cellWe suggest that the anti-GAD Ab will bind to the GAD antigen, or perhaps bind to the epitope presented in association with APC-MHC and prevent T cell recognition, thereby delaying disease onset.
Tian et al. (2000)ICAM-5ICAM-5T cellsThe soluble first domain of ICAM-5 inhibited the binding of T cells to immobilized ICAM-5 at concentrations of 50 nM and higher.
Castro et al. (2002)CD2CD5T lymphocytesCD2 physically associates with CD5 in rat T lymphocytes with the involvement of both extracellular and intracellular domains.
Castro et al. (2002)CD2CD5T lymphocytesThe fact that both the extracellular and the cytoplasmic domains of CD2 interact with CD5 suggests a specific and tight association between the two molecules, possibly relevant for the fine-tuning of signal transduction in T lymphocytes.
Bingaman et al. (2000)CD40LCD40T cellsUpon activation, T cells express CD40L, a member of the TNF cytokine superfamily, which serves as a ligand for CD40 on antigen presenting cells, including dendritic cells, B cells, and macrophages.
Saperstein et al. (1992)IL-1IL-1T lymphocyteCompared with freely moving controls, rats given intermittent electric shock to the tail for 40 min exhibited a fall in T lymphocyte proliferation and natural killer (NK) cell cytotoxicity of 33% and 38%, respectively; however, when pretreated with icv human IL-1 monoclonal antibody, which significantly crossreacts with rat IL-1, the decrement was attenuated to 14.6% and 15%, respectively.
Davis et al. (1990)CD4FabT-cellCrystallization of a soluble form of the rat T-cell surface glycoprotein CD4 complexed with Fab from the W3/25 monoclonal antibody.
Peattie et al. (1994)FKBP12FK506T lymphocytesWhen bound to FK506, FKBP12 forms an inhibitory complex with calcineurin and interferes with signal transduction in activated T lymphocytes.
Peters et al. (2009)CD154CD40T cellCD40:CD154 interactions mediate T-dependent B cell responses and efficient T cell priming.
Maddon et al. (1988)CD4class II MHC moleculesT cellThe T cell surface molecule CD4 interacts with class II MHC molecules on the surface of target cells as well as with the envelope glycoprotein of human immunodeficiency virus (HIV).
Maddon et al. (1988)CD4envelopeT cellThe T cell surface molecule CD4 interacts with class II MHC molecules on the surface of target cells as well as with the envelope glycoprotein of human immunodeficiency virus (HIV).
Jäger et al. (2002)NY-ESO-1CD8T cellNY-ESO-1 serum antibody is associated with detectable NY-ESO-1-specific CD8+ T cell reactivity.
Koch et al. (2005)CD1dglycolipid alpha-galactosylceramideT cellsThe glycolipid alpha-galactosylceramide binds with high affinity to CD1d and stimulates natural killer T cells.
Korman et al. (2005)CTLA4B7-2T-cellsEngagement of CTLA4 by the ligands B7-1 and B7-2 imparts a negative signal to T-cells and results in alteration of T-cell activity and selection.
Iguchi-Manaka et al. (2008)DNAM-1LFA-1T cellsDNAM-1 also associates with LFA-1 in activated T cells, for which the protein kinase C–induced serine phosphorylation in the cytoplasmic domain of DNAM-1 is responsible (8), and is involved in an LFA-1–mediated costimulatory signal for naive T cell differentiation and proliferation (9).
Gründemann et al. (2010)KLRG1cadherin familyT-cellThe killer cell lectin-like receptor G1 (KLRG1) is expressed by NK and T-cell subsets and recognizes members of the classical cadherin family.
Keler et al. (2003)CTLA-4B7 costimulatory moleculesT cellThe immune modulatory molecule CTLA-4 (CD152), through interactions with the B7 costimulatory molecules, has been shown to be a negative regulator of T cell activation in various murine model systems.
Ma et al. (2004)CEACEA-FcT cellsThe A3B3 CEA component of the CEA-Fc bound to anti-CEA monoclonal antibody MN-14, as well as to the single-chain Fv (sFv) derived from this antibody that was expressed in the IgTCR on the surface of designer T cells.
Karanikas et al. (2008)Foxp3NFATT cellsIn particular, under the light of recent findings revealing the physical interaction of Foxp3 with the nuclear factor of activated T cells (NFAT), it appears that at least with respect to its nuclear localization, Foxp3 plays a pivotal role in the formation of nuclear complexes that are important to regulate the transcription of several target genes [16], that confer to Tregs their suppressive function [17].
Flament et al. (1996)deltaCD48T cellsTo further assess the role of CD48 in the interaction of human gamma/delta T cells with their specific target, we generated two series of alloreactive clones, L and K.
Huang et al. (1994)TCRbacterial enterotoxinsT cellsDeletion of mature peripheral T cells may result from TCR ligation by bacterial enterotoxins, endogenous provirus-encoded superantigens, and peptide antigens.
Horie et al. (2009)PTPN22protein tyrosine kinaseT-cellIn the PTPN22 risk variant (rs2476601), this substitution disrupts an interaction between Lyp and the protein tyrosine kinase, Csk, and may translate biologically to a potential for ‘hyperreactive’ pathogenic T-cell responses [8].
Crapper and Schrader (1986)PSFserum proteinsT cellsGel filtration under non-dissociating conditions indicated that the PSF in the serum had an apparent molecular weight of 34,000, a figure identical with that of PSF generated from activated T cells in vitro, indicating that PSF was not bound by serum proteins.
Kakoulidou et al. (2007)CD152CD80T-cellHuman Soluble CD80 is generated by alternative splicing, and recombinant soluble CD80 binds to CD28 and CD152 influencing T-cell activation.
Tsudo et al. (1983)TCGF receptorAnti-Tac monoclonal antibodyT-cellAnti-Tac monoclonal antibody, which blocks the membrane binding and action of human T-cell growth factor (TCGF), is strongly proposed to recognize TCGF receptor.
Shi et al. (2002)Sle1lprT cellsIn this study, we show that the epistatic interaction of Sle1 (in particular, Sle1/Sle1) with FAS(lpr) leads to massive lymphosplenomegaly (with elevated numbers of activated CD4 T cells, CD4(-)CD8(-) double negative (DN) T cells, and B1a cells), high levels of IgG and IgM antinuclear (including anti-ssDNA, anti-dsDNA, and anti-histone/DNA), and antiglomerular autoantibodies, histological, and clinical evidence of glomerulonephritis, and >80% mortality by 5-6 mo of age.
Zhu et al. (2006)CD58CD2T cellThe combination of T cell activation and CD2 ligation to CD58 decreased the laterally mobile fraction of the ligated CD2.
Pfistershammer et al. (2006)von Willebrand factorFVIIIT cellsWe asked the question whether FVIII itself, FVIII complexed with von Willebrand factor (VWF) or thrombin-activated FVIII contain danger signals for human DCs that induce the upregulation of costimulatory molecules or the expression of proinflammatory cytokines necessary for effective activation of CD4(+) T cells.
Pfistershammer et al. (2006)VWFFVIIIT cellsOur results indicate that neither FVIII, thrombin-activated FVIII, VWF nor a complex of FVIII and VWF modulate the maturation of human DCs or their capacity to stimulate autologous or allogeneic T cells.
Yao et al. (2000)FasLFasT-cellsFasL, a cell-surface molecule on activated T-cells interacts with its receptor, Fas, to induce apoptosis in target cells.
Wang et al. (2009)OX40Lmonoclonal antibody 1E7T cellsCross-linking of OX40L with monoclonal antibody 1E7 markedly promoted T cell proliferation and activation and enhanced cytokine production, demonstrating that OX40L transmitted a signal to T cells.
Park et al. (2006)Chk2cellT-cellHuman T-cell leukemia virus type 1 Tax attenuates gamma-irradiation-induced apoptosis through physical interaction with Chk2.
Bartholomew et al. (1995)CD4FcRT cellsIn order to down-modulate CD4 on resting, normal CD4 T cells there was an absolute requirement for FcR-mediated cross-linking of the anti-CD4 antibody, and only CD4 levels were affected.
DeBenedette et al. (1997)B7-2CD28T cellThe interaction of the T cell surface protein CD28 with its ligand, B7-1 or B7-2, provides a critical costimulatory signal for T cell activation.
Molina et al. (1992)LckCD8 T-cell surface glycoproteinsT-cellLck associates specifically with the cytoplasmic domains of both CD4 and CD8 T-cell surface glycoproteins and interacts with the beta-chain of the interleukin-2 receptor, which implicates Lck activity in signal transduction during thymocyte ontogeny and activation of mature T cells.
Zajonc et al. (2005)CD1dalpha-glactosyl ceramide headgroupT cellThe 3'-sulfated galactose headgroup is highly exposed for presentation to the T cell receptor and projects up and away from the binding pocket due to its beta linkage, compared with the more intimate binding of the alpha-glactosyl ceramide headgroup to CD1d.
Mazurov et al. (2007)CD82cellT cellThe inner loop of tetraspanins CD82 and CD81 mediates interactions with human T cell lymphotrophic virus type 1 Gag protein.
Chen et al. (2010)PD-1MAb 9H1T cellCross-linking of PD-1 with MAb 9H1 markedly blocked PD-1 negative signal and promoted T cell proliferation.
Liu et al. (2009)Gal-3CD7T lymphocytesGalectin-3 (Gal-3) is strongly induced in cultured human T lymphotropic virus-1-infected T lymphocytes, and may cause apoptosis through interaction with CD7.
Nie et al. (2005)L2aSATB1T cellsStudies have suggested that binding of the SATB1 protein to L2a, a matrix association region located 4.5 kb 5' to the mouse CD8alpha gene, positively affects CD8 expression in T cells.
Hunter et al. (2000)FYBSH2 domainT cellsStimulation of T cells via the alpha4beta1 integrin enhances the association of tyrosine phosphorylated SLAP-130/FYB with the SH2 domain of the src tyrosine kinase p59fyn.
Nagaki et al. (1994)SEBclass II major histocompatibility complex proteinsT cellsBACKGROUND/AIMS: Staphylococcal enterotoxin B (SEB) acts as a superantigen binding to class II major histocompatibility complex proteins, and this complex stimulates T cells.
Asprodites et al. (2008)TLR2TLR1T cellsWe report that the ligation of the TLR1/2 heterodimer on OT-1 cytotoxic T-lymphocytes (CTL) but not TLR2(-/-)OT-1 T cells increased cytolytic activity in vitro and in vivo.
Mukherjee et al. (2005)MUC1lckT cellsMUC1 (CD227) interacts with lck tyrosine kinase in Jurkat lymphoma cells and normal T cells.
Mukherjee et al. (2005)SrcMUC1T cellUsing the Jurkat T cell lymphoma cell line and normal human T cells, we demonstrate that MUC1 is not only expressed in these cells but is also phosphorylated upon T cell receptor (TCR) ligation and associates with the Src-related T cell tyrosine kinase, p56lck.
Wiese et al. (1996)Tipp56lckT cellWe have previously shown that in H. saimiri transformed cells a viral gene product termed tyrosine kinase interacting protein (Tip) associates with the T cell-specific tyrosine kinase p56lck and becomes phosphorylated by the enzyme on tyrosine residues.
Mills et al. (1990)interleukin 2affinity membrane receptor complexT lymphocytesInteraction of interleukin 2 (IL2) with its high affinity membrane receptor complex (IL2R) is sufficient to induce proliferation of T lymphocytes.
Zhang et al. (1997)CD4human immunodeficiency virus type 1 envelopeT lymphocytesSynthetic CD4 exocyclics inhibit binding of human immunodeficiency virus type 1 envelope to CD4 and virus replication in T lymphocytes.
Barber et al. (1989)p56lckCD8T-cellIn this study, we reveal that the human CD8 antigen is also associated with the T-cell-specific protein-tyrosine kinase (p56lck).
Dembic et al. (1998)CD4class II MHC moleculesT cellsCD4 contributes to antigen recognition of T cells by binding to class II MHC molecules.
Karlsson et al. (2005)Cia5Eae2T cellInvestigation of the CD4/CD8 T cell ratio in mice from the partially advanced intercross shows that this trait is linked to one of the Eae2 subloci through interactions with Eae3/Cia5.
Karlsson et al. (2005)Eae2Eae3T cellInvestigation of the CD4/CD8 T cell ratio in mice from the partially advanced intercross shows that this trait is linked to one of the Eae2 subloci through interactions with Eae3/Cia5.
Blank et al. (2005)PD-1PD-L1T cellsInteraction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy.
Dao et al. (2003)TCRMHC class II beta-chainT cellAlthough structural studies have suggested that this TCR site interacts with the MHC class II beta-chain, the avidity of this TCR for its ligand and the function of the T cell can be reconstituted by a point mutation in the bound antigenic peptide.
Cavallo et al. (1997)beta-cateninHMG box DNA-binding proteinsT-cellIt is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates.