| Document |
Target |
Regulator |
Anatomy |
Sentence |
| Zhao et al. (1998) | TPO | thrombopoietin | T lymphocyte | The aim of this study was to evaluate the effect of thrombopoietin (TPO) on T lymphocyte in Balb/c mice delivered hTPO cDNA with plasmid vector. |
| Mouly et al. (2007) | CD4 | CD4 silencer | T-cells | Collectively, our results suggest that beyond its well-characterized function in T-cells, the CD4 silencer also regulates CD4 gene expression in human lymphoid non-T-cells.
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| Breit et al. (1996) | IL-4 | IL-4 | T cell | The role of interleukin-4 (IL-4) in the induction of IL-4 in mouse T cells is well established, but conflicting results have been reported with anti-CD3-primed human T cells and T cell clones. |
| Welte et al. (1984) | Tac antigen | Interleukin 2 | T lymphocytes | Interleukin 2 regulates the expression of Tac antigen on peripheral blood T lymphocytes.
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| Xu et al. (2010) | IL-17 | C5a | T cells | Complement C5a regulates IL-17 by affecting the crosstalk between DC and gammadelta T cells in CLP-induced sepsis.
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| Zauli et al. (1995) | Bcl-2 | Tat | T-cell | In this report, we investigated the effect of either endogenous or exogenous Tat on Bcl-2 proto-oncogene expression and cell survival in Jurkat T-cell lines and primary peripheral blood mononuclear cells. |
| Ostrand-Rosenberg et al. (1986) | 402AX teratocarcinoma MHC class I antigen | Lyt | T cells | 402AX teratocarcinoma MHC class I antigen expression is regulated in vivo by Lyt 1, Lyt 2, and L3T4 expressing splenic T cells.
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| Gerrard et al. (1988) | class II histocompatibility antigens | IFN-gamma | T cell | Modulation of class I and class II histocompatibility antigens on human T cell lines by IFN-gamma.
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| Gerrard et al. (1988) | class II histocompatibility Ag | IFN-gamma | T cell | Thus, although IFN-gamma can bind to human T cell lines and enhance class I histocompatibility Ag on these cells, IFN-gamma alone does not appear to regulate expression of class II histocompatibility Ag on T cell lines.
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| Satoh et al. (2007) | lymphoid enhancer factor | Nemo-like kinase | T-cell | We previously reported that Nemo-like kinase (NLK) negatively regulates Wnt signaling via the phosphorylation of T-cell factor/lymphoid enhancer factor. |
| Soos et al. (2001) | MHC | CIITA | T-cell | CIITA may be a key target to modulate MHC class II expression, which could augment immunogenicity, Ag presentation, and CD4(+) T-cell activation in MG therapy.
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| Ekman et al. (1993) | CRH | phytohemagglutinin | T-lymphocyte | We studied the effects of phytohemagglutinin (PHA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) on the biosynthesis of CRH in human T-lymphocyte cell cultures. |
| Yip-Schneider et al. (1993) | c-myc | interleukin-7 | T cells | Characterization of interleukin-7-induced changes in tyrosine phosphorylation and c-myc gene expression in normal human T cells.
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| Bell et al. (2007) | TLR10 | FOXP3 | T cell | Transcriptional control of TLR10 by FOXP3 was determined through luciferase reporter assays in Jurkat T cell lines. |
| Sanchez-Merino et al. (2005) | CD8 | | T cell | Mother-to-child transmission of CD8+ T cell escape variants may particularly affect CD8+ T cell recognition of infant HIV-1 epitopes. |
| Barbi et al. (2008) | CXCR3 | PI3Kgamma | T cells | Levels of CXCR3 and T-bet mRNA were significantly lower in PI3Kgamma inhibitor-treated T cells, indicating that PI3Kgamma may control CXCR3 expression in part through induction of T-bet. |
| Modiano et al. (1997) | IL-2 | immunoglobin | T-cell | Posttranscriptional regulation of T-cell IL-2 production by human pooled immunoglobin.
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| Otomo et al. (2001) | CD4 | RIB 5/2 | T cells | Monoclonal anti-rat CD4 antibody, RIB 5/2, has been shown to modulate the CD4 glycoprotein without eliminating recipient T cells. |
| Lemasson et al. (1997) | p56lck | rex genes | T cells | To understand the mechanism of p56lck protein downregulation observed in human T cells infected by human T-cell leukemia virus type 1 (HTLV-1), we have investigated the ability of the 3' end of the HTLV-1 genome as well as that of the tax and rex genes to modulate p56lck protein expression and p56lck mRNA synthesis. |
| Lemasson et al. (1997) | p56lck | tax | T cells | To understand the mechanism of p56lck protein downregulation observed in human T cells infected by human T-cell leukemia virus type 1 (HTLV-1), we have investigated the ability of the 3' end of the HTLV-1 genome as well as that of the tax and rex genes to modulate p56lck protein expression and p56lck mRNA synthesis. |
| Seckinger et al. (1994) | myc | Interleukin-7 | T cells | Interleukin-7 regulates c-myc expression in murine T cells and thymocytes: a role for tyrosine kinase(s) and calcium mobilization.
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| Metcalfe (2005) | LIF | axotrophin | T lymphocyte | This approach has revealed unexpected patterns of gene activity in tolerance and most notably that a novel stem cell gene, axotrophin, regulates T lymphocyte responsiveness both in terms of proliferation and in release of leukaemia inhibitory factor (LIF). |
| Kantarci et al. (2005) | CCR5 | Delta32 | T cell | CCR5*Delta32 has a dose effect on CCR5 expression in the CNS, but is neither necessary for development of MS, nor CD3+ T cell recruitment into the CNS. |
| Chan et al. (1994) | cell | CD7 | T cell | Together, our results suggest that CD7 is associated with tyrosine kinase activity and that this tyrosine kinase activity correlates with the ability of CD7 to regulate T cell integrin functional activity.
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| Merrell et al. (1997) | Ig | TFE3 | T lymphocytes | To understand the role of TFE3 in Ig expression and lymphoid development, we used embryonic stem (ES) cell-mediated gene targeting and RAG2-/- blastocyst complementation to generate mice which lack TFE3 in their B and T lymphocytes. |
| Toungouz et al. (1996) | IFN-gamma | IVIg | T cell | The aim of the present work is to investigate the influence of IVIg on IFN-gamma production occurring during MLR and its subsequent impact on T cell proliferation and tumor necrosis factor (TNF)-alpha secretion. |
| Monticelli and Rao (2002) | IL-4 | NFAT family members | NFAT | We have taken a positive approach to the question of whether these two NFAT family members differentially regulate IL-4 gene transcription. |
| Himes et al. (2000) | IL-2 | high-mobility group I(Y) proteins | T cell | The role of high-mobility group I(Y) proteins in expression of IL-2 and T cell proliferation.
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| Wang et al. (2007) | SKAP-55 | ADAP | T cells | ADAP controls SKAP-55 expression such that ADAP(-/-) T cells are also deficient in SKAP-55 expression. |
| Kayagaki et al. (1999) | TRAIL | Type | T cells | Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs.
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| Kayagaki et al. (1999) | TRAIL | IFNs | T cells | Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs.
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| Reem and Yeh (1984) | gamma interferon | Interleukin 2 | T lymphocytes | Interleukin 2 regulates expression of its receptor and synthesis of gamma interferon by human T lymphocytes.
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| Reem and Yeh (1984) | gamma interferon | Interleukin 2 | T lymphocytes | Interleukin 2 (IL-2) has an important role in the regulation of the expression of IL-2 receptors and the synthesis of gamma interferon (IFN-gamma) by T lymphocytes. |
| Ernst et al. (1988) | IgA | anti-suppressor circuit | T cells | A novel mechanism for the selection of isotype-specific antibody responses: the role of intestinal T cells in the regulation of IgA synthesis by the anti-suppressor circuit.
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| Liang et al. (2003) | T-cell | JNK | NFAT | A mechanism underlying this effect was suggested by the observation that JNK directly regulated nuclear factor of activated T-cell (NFAT) activation in culture and in transgenic mice containing an NFAT-dependent luciferase reporter. |
| Morandi et al. (2010) | chemokine receptor | HLA-G | T cells | The effect of sHLA-G on chemokine receptor expression was lower on resting T cells (not shown).
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| Kuo and Jan (2009) | antigen-specific antibody | silibinin | T-cell | The effect of silibinin on antigen-specific antibody production and T-cell cytokine expression was investigated. |
| Sánchez-Valdepeńas et al. (2007) | NF-kappaB | zeta | T cells | Differential regulation of p65 and c-Rel NF-kappaB transactivating activity by Cot, protein kinase C zeta and NIK protein kinases in CD3/CD28 activated T cells.
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| Xue et al. (2007) | IL-7Ralpha | Ets-family | T cells | GA binding protein (GABP) is a ubiquitously expressed Ets-family transcription factor that critically regulates the expression of the interleukin-7 receptor alpha chain (IL-7Ralpha) in T cells, whereas it is dispensable for IL-7Ralpha expression in fetal liver B cells. |
| Medeiros et al. (2005) | integrins | PKC | T cell | The functional activity of integrins is dynamically regulated by T cell receptor stimulation and by protein kinase C (PKC). |
| Medeiros et al. (2005) | integrins | protein kinase C | T cell | The functional activity of integrins is dynamically regulated by T cell receptor stimulation and by protein kinase C (PKC). |
| Fischer et al. (2004) | CXCL12 | ITK | T cells | ITK regulates the ability of CXCL12/SDF-1alpha to induce T cell migration as overexpression of wild-type ITK-enhanced migration, and T cells lacking ITK exhibit reduced migration as well as adhesion in response to CXCL12/SDF-1alpha. |
| Pierdominici et al. (2002) | beta-chemokines | MIP | T-cell | The effect of highly active antiretroviral therapy (HAART) on the expression of CCR5 and CXCR4 HIV coreceptors and the production of the beta-chemokines regulated upon activation, normal T-cell expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1alpha, and MIP-1beta has been investigated in 30 HIV-1-infected individuals during 12-36 months of therapy. |
| van Oirschot et al. (2001) | kip1 | Protein kinase A | T cell | Protein kinase A regulates expression of p27(kip1) and cyclin D3 to suppress proliferation of leukemic T cell lines.
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| Straube and Herrmann (2001) | CD8beta | rat gammadelta | T cells | Differential modulation of CD8beta by rat gammadelta and alphabeta T cells after activation.
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| Brunner et al. (2000) | Fas ligand | c-Myc | T cells | Expression of Fas ligand in activated T cells is regulated by c-Myc.
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| Paulsen et al. (1995) | gluten antigens | | T-cell | Here we report studies on the influence of aa substitutions in the DQ beta 1*0201 chain on DQ2-restricted T-cell recognition of gluten antigens. |
| Dubois et al. (1995) | annexin II | annexin V | T cells | In vivo and in vitro phosphorylation of annexin II in T cells: potential regulation by annexin V.
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| Egerton et al. (1992) | ezrin | protein tyrosine phosphatases | T cell | We also observed no increases in ezrin tyrosine phosphorylation in TCR-stimulated Jurkat T cells, unless the cells were pretreated with protein tyrosine phosphatase inhibitors, suggesting that T cell ezrin tyrosine phosphorylation is tightly controlled by protein tyrosine phosphatases. |
| Ho et al. (1991) | cell | GATA-3 | T cell | Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.
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| Hivroz-Burgaud et al. (1991) | NF-AT | TcR | T cells | Data are presented that indicate that either the [Ca2+]i or PKC signal generated via the TcR/CD3 complex would not alone induce NF-AT expression, and that the TcR/CD3 complex probably regulates NF-AT expression because of its ability to regulate multiple intracellular signals in T cells, and not via any single biochemical event. |
| Nakanishi et al. (1988) | Ig | T cell replacing factor | T cell | Both B151-T cell replacing factor 1 and IL-5 regulate Ig secretion and IL-2 receptor expression on a cloned B lymphoma line.
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| Tsudo et al. (1982) | Tac antigen | anti-Tac monoclonal antibody | T cells | Modulation of Tac antigen on activated human T cells by anti-Tac monoclonal antibody.
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| Palacios (1981) | MLR | HLA-DR antigens | T lymphocytes | Since resting T cells cells do not respond to IL-1 or produce IL-2, it is concluded that HLA-DR antigens of the stimulator cells participate in the production of IL-2 in AMLR and MLR by enabling the IL-2 producer T lymphocytes to respond to IL-1. |
| Shi et al. (2007) | CD4 | beta-arrestin 1 | T cell | Critical regulation of CD4+ T cell survival and autoimmunity by beta-arrestin 1.
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| Kashiwakura et al. (1999) | interferon gamma | Txk | T lymphocytes | Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes.
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| Broxmeyer and Platzer (1984) | I-A | Lactoferrin | T lymphocytes | Lactoferrin acts on I-A and I-E/C antigen+ subpopulations of mouse peritoneal macrophages in the absence of T lymphocytes and other cell types to inhibit production of granulocyte-macrophage colony stimulatory factors in vitro.
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| Kogkopoulou et al. (2006) | IL-2 | p38 | T cells | Here, the role of p38 on interleukin-2 (IL-2) production by human peripheral blood CD4+ T cells was examined. |
| Okamura et al. (1998) | TCRalpha | LEF-1 | T cell | Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1.
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| Okamura et al. (1998) | TCRalpha | LEF-1 | T cell | Lymphoid enhancer factor 1 (LEF-1) and T cell factor 1 (TCF-1) are closely related transcription factors that are both expressed during murine T cell differentiation and that regulate the T cell receptor alpha (TCRalpha) enhancer in transfection assays. |
| Fowlkes and Robey (2002) | Notch1 | Notch1 | T cell | A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development.
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| Oestreich et al. (2008) | PD-1 | NFATc1 | T cell | NFATc1 regulates PD-1 expression upon T cell activation.
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| Wu et al. (2005) | GATA-3 | CpG oligodeoxynucleotide | T cells | AIM: To investigate effects of CpG oligodeoxynucleotide (CpG ODN) on the mRNA expression of transcription factors GATA binding protein 3 (GATA-3) and T-box expressed in T cells (T-bet) in asthmatic mice.
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| Dokter et al. (1992) | Interleukin-4 | IL-4 | T cells | Interleukin-4 (IL-4) receptor expression on human T cells is affected by different intracellular signaling pathways and by IL-4 at transcriptional and posttranscriptional level.
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| Kobielak et al. (2001) | cell | LEF-1 | T-cell | Lymphoid enhancer-binding factor-1 (LEF-1), a member of the high mobility group (HMG) family of proteins, regulates expression of T-cell receptor-alpha gene and is one of the key regulatory molecules in the epithelial-mesenchymal interactions during embryonic development. |
| Rouas et al. (2009) | FOXP3 | miR-31 | T cells | Using lentiviral transduction of fresh cord blood T cells, we demonstrated that miR-31 and miR-21 had an effect on FOXP3 expression levels. |
| Chung and Schlichter (1997) | Kv1.3 | PKC | T lymphocytes | Because PKC activation (as well as increased intracellular Ca2+) is required for T-cell proliferation, we have studied the regulation of Kv1.3 current by PKC in normal (nontransformed) human T lymphocytes. |
| Mittelstadt and Ashwell (1999) | FasL | Egr-3 | T cells | Thus, Egr-2, in addition to Egr-3, regulates FasL expression in activated normal T cells, and Egr-2 is likely to play a direct role in aberrant fasL up-regulation in lpr/lpr and gld/gld CD4(-)CD8(-) T cells.
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| Daynes and Araneo (1989) | IL4 | glucocorticoid (GCS) hormones | T cell | Here we provide compelling evidence that production of the murine T cell growth factors interleukin (IL) 2 and IL4 are differentially regulated by glucocorticoid (GCS) hormones. |
| Maruyama et al. (2007) | IFN | Txk | T lymphocytes | However, how Txk regulates interferon (IFN)-gamma gene transcription in human T lymphocytes was not fully elucidated. |
| Hildebrandt et al. (2008) | TNFalpha | IL-13 | T cell | In vitro studies further demonstrate that both exogenous and T cell-derived IL-13 can regulate TNFalpha production by macrophages following lipopolysaccharide stimulation. |
| Sander et al. (2006) | NFATc1 | PPARgamma | T cells | Peroxisome proliferator-activated receptor gamma (PPARgamma) inhibits NFATc1 activity in T cells and cardiomyocytes, but it is not known if PPARgamma controls NFATc1 function in endothelial cells. |
| Prontera et al. (1996) | metalloprotease | IL-4 | T-cell | Here we have evaluated the effects of a T-cell cytokine interleukin-4 (IL-4) on the expression and activity of a metalloprotease, stromelysin, and its tissue inhibitor (TIMP-1) in human skin fibroblasts. |
| Singh et al. (2007) | Fas | TCDD | T cells | We investigated the regulation of Fas or FasL promoter by TCDD in EL4 T cells using luciferase reporter constructs. |
| Yu et al. (2008) | CCR7 | SOCS1 | T cells | SOCS1 regulates CCR7 expression and migration of CD4+ T cells into peripheral tissues.
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| Carmo et al. (1999) | CD5 | CD2 | T cells | CD2 and CD3 associate independently with CD5 and differentially regulate signaling through CD5 in Jurkat T cells.
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| Yu et al. (1998) | STAT6 | IL-13 | T cell | These findings show that IL-13 and IL-4 have the ability to regulate NK and T cell activation and that IL-13 is a potent regulator of STAT6 and JAK3 in these cell types.
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| Li et al. (2010) | Bim | Interleukin-7 | T-cell | Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival.
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| Möttönen et al. (2000) | CD154 | IL-15 | T cells | As interleukin (IL)-15 is a potent activator of synovial T cells we wanted to study whether IL-15 also regulated the expression of CD154 on these T cells. |
| Hontecillas and Bassaganya-Riera (2007) | CD4 | PPAR-gamma | T cell | Peroxisome proliferator-activated receptor (PPAR) gamma activation has been implicated in the prevention of immunoinflammatory disorders; however, the mechanisms of regulation of effector and regulatory CD4+ T cell functions by endogenously activated PPAR-gamma remain unclear. |
| Lu et al. (2009) | CD4 | TSLP | T cell | These results demonstrate that IL-7 and TSLP use different mechanisms to regulate human CD4(+) T cell homeostasis.
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| Marie-Cardine et al. (1999) | NF-AT | SIT | T cell | However, binding of SHP2 to SIT is not required for inhibition of NF-AT induction, suggesting that SIT not only regulates NF-AT activity but also controls NF-AT unrelated pathways of T cell activation involving SHP2.
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| Thulesen et al. (2001) | IL-2 | interleukin-2 | T cells | In the present study, we investigated the effects of interleukin-2 (IL-2) and IL-15 on human thymocytes with respect to development of CD8(+) CD56(+) T cells. |
| Bordon et al. (2009) | IL-17A | D6 | T cells | Thus, D6 can contribute to the development of colitis by regulating IL-17A secretion by gammadelta T cells in the inflamed colon.
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| Tylaska et al. (2002) | MCP-1 | Ccr2 | T cell | Ccr2 regulates the level of MCP-1/CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen.
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| Richard et al. (2005) | PTHrP | ETS | T-cell | Our data demonstrate that transcriptional regulation of PTHrP in ATLL cells can be controlled by T-cell receptor signaling and the ETS and MAPK ERK pathway in a Tax-independent manner.
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| Fujino et al. (2000) | IL-2 | muscarinic receptors | T cell | Possible intracellular signal pathways of muscarinic receptors to regulate IL-2 production were examined in human T cell line Jurkat cells. |
| Gerber et al. (1989) | interleukin-2 | | T lymphocytes | The influence of interleukin-2, feeder cells, and timing of irradiation on the radiosensitivity of human T lymphocytes assessed by the colony-forming assay.
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| Steen et al. (1993) | hypoxanthine phosphoribosyltransferase | | T-cell | The phenotypic effects of mutation in the hypoxanthine phosphoribosyltransferase (hprt) gene on hprt enzyme activity and hprt mRNA levels were studied in 6-thioguanine (TG) resistant human T-cell clones with various types of hprt mutation. |
| Motoya et al. (1997) | ICAM-1 | | T-cell | In order to investigate the factors that influence the induction of ICAM-1 molecules, Northern blot analysis to measure the expression level of ICAM-1 mRNAs and Southern blot hybridization to analyze the integration of human T-cell-leukemia virus type 1 (HTLV-1) provirus were done. |
| Inouye et al. (1980) | TCGF | | T cell | In an effort to increase the potency of T cell growth factor (TCGF), several variables were examined for their effects on the production of TCGF. |
| Yoshizawa et al. (1998) | MBP | | T-cell | Studies of the MBP-directed response of these mice suggest that endogenous MBP expression is directly responsible for EAE resistance in BALB/c mice, by quantitatively affecting expression of the T-cell repertoire. |
| Boschelli (2009) | PKCTheta | | T cell | PKCTheta, first identified in 1992, is a key enzyme in the regulation of T cell activation and survival. |
| Lechner et al. (1996) | CD95 | | T cells | Regulation of CD95 (APO-1) expression and the induction of apoptosis in human T cells: changes in old age.
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| Clerici (1995) | CD4 | | T lymphocytes | Thus, HIV infection is characterised by quantitative and qualitative defects affecting CD4 T lymphocytes. |
| Kalish et al. (2000) | CD4 | | T cell | Several studies of patients infected with human immunodeficiency virus (HIV) type 1 have suggested that women have lower plasma HIV-1 RNA levels than men, even when controlling for CD4 T cell levels. |
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