Viewing affirmative mentions of positive regulation in T cells

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Horak et al. (1990)p56lckCD4T-cellIn normal T cells, surface association of CD4 molecules with other CD4 molecules or other T-cell surface proteins, such as the T-cell antigen receptor, stimulates the activity of the p56lck tyrosine kinase, resulting in the phosphorylation of various cellular proteins at tyrosine residues.
Izuhara and Harada (1993)IL-4Interleukin-4T cellInterleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of phosphatidylinositol 3-kinase to the IL-4 receptor in a mouse T cell line, HT2.
Amin et al. (1993)IgD-RIgDT cellsIgD-R can be upregulated on CD4+ T cells in vitro and in vivo by glutaraldehyde-aggregated mutant IgD or by fragments of enzymatically digested IgD molecules possessing either the C delta 1 domain (Fd delta) or the C delta 3 domain (Fc delta).
Martins et al. (2008)Blimp-1IL-2T cellOur data (Figs. 1–2 and Fig. 4), and that of others (12, 19), show that the transient nature of IL-2 production after T cell activation depends on induction of Blimp-1 by IL-2 and subsequent Blimp-1–dependent repression of IL-2 production via repression of Il2 and Fos.
Harashima et al. (2001)CD62ETNFT cellsOutside-to-inside signal through the membrane TNF-alpha induces E-selectin (CD62E) expression on activated human CD4+ T cells.
Jayaraman et al. (1996)IP3RIP3RT cellT cell receptor stimulation triggered a physical association between the nonreceptor protein tyrosine kinase Fyn and the IP3R, which induced tyrosine phosphorylation of the IP3R.
Amin et al. (1993)IgD-RIgDT cellsAlthough an influx of Ca2+ is apparently not involved, a role for intracellular Ca2+ in the upregulation of IgD-R by IgD on T cells is indicated by the susceptibility to inhibition by BAPTA, W7, and FK520.
Burger et al. (2004)TNFCD40LTT cellswas induced by membranes of stimulated T cells in the three types of target cells, whereas CD40LT induced TNF production in IFN?
Martins et al. (2008)Prdm1IL-2T cellUsing these mechanisms Blimp-1 participates in an autoregulatory loop by which IL-2 induces Prdm1 expression and thus represses its own expression after T cell activation, ensuring that the immune response is appropriately controlled.
Lang et al. (1995)TNFTUBagT cellSimilarly, TUBag, but not dephosphorylated TUBag, induced massive TNF production by V gamma 9V delta 2 T cell clones only, which already was significant 20 min after exposure.
Lang et al. (1995)TNFT cellSimilarly, TUBag, but not dephosphorylated TUBag, induced massive TNF production by V gamma 9V delta 2 T cell clones only, which already was significant 20 min after exposure.
Armitage et al. (1993)CD40LCD40LT cellsIn this report CD40L is shown to be stimulatory for human T cells, inducing CD25 (p55 IL-2R) and CD40L expression on resting peripheral blood T cells, enhanced expression of these molecules and CD69 on CD3-activated cells and secretion of interferon-gamma, tumor necrosis factor-alpha and interleukin (IL)-2 from T cells cultured in the presence of a sub-mitogenic concentration of phytohemagglutinin A (PHA).
Yang et al. (2000)surfactant protein AKGFT cellIntratracheal KGF is known to stimulate the expression of surfactant protein A (SP-A), an oxidant-sensitive T cell immunomodulator produced by alveolar type II cells.
Yoshii et al. (1991)IL-2NeurotropinT-cellsTo clarify the mechanism by which Neurotropin restores IL-2 production, its effect on the recruitment of IL-2-producing T-cells from bone marrow cells was examined using syngenic radiation bone marrow chimeras.
Khurana et al. (2007)ItkIL-2T cellIn this study, we show that, in activated human NK cells, the tyrosine kinase IL-2-inducible T cell kinase (Itk), differentially regulates distinct NK-activating receptors.
Burger et al. (2004)TNFCD40LTT cellsThe production of TNF and IL-1beta was induced by membranes of stimulated T cells in the three types of target cells, whereas CD40LT induced TNF production in IFN-gamma-macrophages only.
Burger et al. (2004)TNFCD40LTT cellsThese results demonstrate that CD40L is not required in monocyte activation by direct cellular contact with stimulated T cells, although soluble CD40LT induces the production of TNF in IFN-gamma-macrophages.
Zauli et al. (1995)Bcl-2human immunodeficiency virus type-1 Tat proteinT-cellThe human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells.
Westendorp et al. (1994)interleukin-2TatT cellsHuman immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells.
Nanno et al. (1988)serum CSFT cellsThe amount of serum CSF induced by LC9018 in nude mice and whole-body-X-ray-irradiated mice was similar to that in control mice, but the induction of serum CSF was suppressed by the previous administration of carrageenan, indicating that macrophages, but not T cells, were responsible for serum CSF induction by LC9018.
Nanno et al. (1988)serum CSFLC9018T cellsThe amount of serum CSF induced by LC9018 in nude mice and whole-body-X-ray-irradiated mice was similar to that in control mice, but the induction of serum CSF was suppressed by the previous administration of carrageenan, indicating that macrophages, but not T cells, were responsible for serum CSF induction by LC9018.
Kornbluth (2002)anti-HIV beta-chemokinesCD40LT cellsCD40L contributes to the antiviral mechanisms of the host by inducing anti-HIV beta-chemokines and activating CD8(+) T cells.
Jacques et al. (1986)IL 2recT cellTogether, our results obtained on a monoclonal human T cell population with highly purified rec-IL 2 demonstrate that rec-IL 2 and antigen act in synergy to induce the expression of both high and low affinity membrane IL 2 receptors.
Kim et al. (1990)TGF-betatypeT cellTransactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia.
Hoover et al. (1981)T alphaIgAT cellsT cells with Fc receptors for IgA: induction of T alpha cells in vivo and in vitro by purified IgA.
Bartholomew et al. (1995)CD4T cellsIn order to down-modulate CD4 on resting, normal CD4 T cells there was an absolute requirement for FcR-mediated cross-linking of the anti-CD4 antibody, and only CD4 levels were affected.
Zauli and Gibellini (1996)bcl-2TAtT cellsBlocking experiments performed with anti-Tat neutralizing antibodies revealed that TAt increases bcl-2 expression and prevent lymphoid T cells from apoptosis by acting, at least in part, through an autocrine/paracrine loop.
Pellegrini et al. (1994)heat shock protein 70Cd2T cellWe previously showed in a human T cell line (CEM-C12 cells) that Cd2+ induced gene expression of stress proteins, metallothionein-IIA and heat shock protein 70 in a time- and dose-dependent manner.
LeMaoult et al. (2005)KIR2DL4HLA-GT cellsWe report that ILT2, ILT3, ILT4, and KIR2DL4 expression is up-regulated by HLA-G in antigen-presenting cells, NK cells, and T cells.
Yonetoku et al. (2006)interleukin-2phytohemagglutininT lymphocytesThe former exhibits highly potent and selective CRAC channel inhibitory activity, and the latter inhibited phytohemagglutinin-induced interleukin-2 production by Jurkat T lymphocytes and concanavalin A-induced hepatitis in mice.
Utsunomiya et al. (1997)IFN-gammaGRT cellsThese results suggest that GR may protect mice exposed to a lethal amount of influenza virus through the stimulation of IFN-gamma production by T cells, because T cells have been shown to be producer cells of IFN-gamma stimulated with the compound.
Nomura et al. (2003)IL-2TCRT lymphocytesOur results suggest that muscarinic receptors, perhaps M(1) receptors are involved in the enhancement of TCR-induced IL-2 production and IL-2 receptor expression in human T lymphocytes.
Tohma et al. (1992)ICAM-1anti-CD3 monoclonal antibodyT cellsResting CD4+ T cells were largely ICAM-1 negative, whereas immobilized anti-CD3 monoclonal antibody (mAb) rapidly induced ICAM-1 expression.
Sharma et al. (2006)c-mycNotch1T-cellNotch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc.
Morrissey et al. (1987)IL 2GM-CSFT cellsConsistent with these data was the finding that GM-CSF augmented IL 2 production by splenic T cells in response to suboptimal concentrations of Con A.
Li et al. (2000)Grb3-3TatT-cellAnalysis of HIV-1 gene products indicated that Tat and Nef, both of which have been implicated in modulating T-cell function, can independently induce expression of Grb3-3.
Matthews et al. (2010)IFNPKD2T-cellsNevertheless, the failure of T-cells to express PKD1 allows PKD2 to have a unique non-redundant role in T-cells to mediate TCR-induced production of the essential cytokines IL-2 and IFN?.
Konaka et al. (1981)IL2Rabbit anti-Thy-1 antibodyT cellRabbit anti-Thy-1 antibody bound to T cells induces the appearance of T cell growth factor (interleukin 2, IL2) receptors and the production of IL2.
Kadereit et al. (2000)PKRIFNT cellNegative regulation of CD8+ T cell function by the IFN-induced and double-stranded RNA-activated kinase PKR.
Nishimura and Tanaka (2001)NFIL3TGNFATExpression of dominant negative forms of calcineurin or nuclear factor of activated T cells (NFAT) inhibited the induction of NFIL3/E4BP4 mRNA by TG.
Hammer and Gillis (1986)Tac antigenInterleukin-2T cellInterleukin-2 at concentrations of 100 and 1,000 U/ml stimulated tritiated thymidine incorporation, Tac antigen expression, interferon production, and blast transformation in T cell cultures.
Schallenberg et al. (2010)Foxp3DCsT cellsThis observation, together with the notion that splenic CD8+DEC-205+ DCs induce Foxp3 expression in vitro in initially CD4+Foxp3– T cells without added TGF-?
Kooijman et al. (1996)interleukin-2IGF-IT cellsIGF-I potentiates interleukin-2 production in human peripheral T cells.
Kooijman et al. (1996)interleukin-2IGF-IT cellsWe found that IGF-I augmented the phytohaemagglutinin- and anti-CD3-induced interleukin-2 (IL2) production of human peripheral T cells before they enter the S phase of the cell cycle.
Barbi et al. (2008)CXCR3PI3KgammaT cellsPI3Kgamma (PI3Kgamma) is essential for efficient induction of CXCR3 on activated T cells.
Schoop et al. (2004)PD-L1IFN-gammaT-cellSuppressed T-cell activation by IFN-gamma-induced expression of PD-L1 on renal tubular epithelial cells.
Dunn et al. (2000)TNFalphaBTT cellsThe upregulation of surface TNFalpha by BT has functional consequences, in that, BT-treated T cells exhibit enhanced cytotoxic activity.
Hoffmeyer et al. (2001)Gadd45interleukin-2T cellsGadd45gamma, a family member of the growth arrest and DNA damage-inducible gene family 45 (Gadd45), is strongly induced by interleukin-2 (IL-2) in peripheral T cells.
Haddad et al. (2009)NKIL-12T cellsIn this study, we show that although IL-12 stimulates NK and NK1.1(+) T cells in bulk mouse splenocytes, it does not significantly stimulate purified NK cells, indicating that other cells are required.
Paun et al. (2011)IRF-5TLR 7/9T-cellsWhether IRF-5 expression by T-cells is directly mediated by TLR 7/9 triggering or indirectly induced by Type I IFN, produced by APC following TLR7/9 signaling, is still an open question.
Sakane et al. (1989)interleukin-2phytohemagglutininT-cellSUBJECTS AND METHODS: We used a phytohemagglutinin-induced interleukin-2 (IL-2) activity assay and a spontaneous plaque-forming cell assay to evaluate T-cell and B-cell function, respectively, in 34 clinically healthy family members of six SLE probands.
Desbarats et al. (1996)CD95CD4T cellsFas (CD95) expression and death-mediating function are induced by CD4 cross-linking on CD4+ T cells.
Valentin et al. (2001)VCAM-1TaxT-cellsThese data establish that VCAM-1 induced by Tax on T-cells thus contributes to the immunopathological process triggered by HTLV-1 infection.
McGuire et al. (1993)IL-2 genetaxT cellsThese findings demonstrate that transactivation of IL-2 gene expression by tax is augmented by mechanisms distinct from NF-kappa B and raise the possibility that rex, as well as tax, contributes to the oncogenic capability of HTLV-I by altering the expression of the IL-2 gene in T cells infected with this retrovirus.
Luther et al. (2002)LTalpha1beta2CCL19T cellsCCL19 and CCL21 but not CXCL12 induced LTalpha1beta2 expression on naive CD4 T cells, and treatment of CCL21 transgenic mice with LTbetaR-Fc antagonized development of organized lymphoid structures.
Kravchenco and Furalev (1994)CRFconcanavalin AT-lymphocytesE. coli lipopolysaccharide and concanavalin A can stimulate CRF secretion by B- and T-lymphocytes, respectively, whereas hydrocortisone inhibits the CRF secretion induced by any agent tested.
Deckert et al. (1995)p70zapCD59T cellWe show here that CD59 cross-linking induces a time-dependent activation of p56lck and of p70zap (ZAP-70) in CD3-positive Jurkat cells, leading to the stimulation of the T cell receptor zeta/ZAP-70 signaling cascade and interleukin-2 (IL-2) synthesis.
Bacon et al. (1995)STATIL-12T-cellIn this report we demonstrate that IL-12 induces tyrosine phosphorylation of a recently identified STAT family member, STAT4, and show that STAT4 expression is regulated by T-cell activation.
Rochman and Leonard (2008)STAT5TSLPT cellsWe now demonstrate that CD8(+) T cells express TSLPR and that TSLP activates both STAT5 and Akt and induces Bcl-2 in these cells.
Lee et al. (2004)IgGCjLPST-cellsThe increased sensitivity to CjLPS and the induction of IgG anti-GM1 by CjLPS but not control LPS are consistent with a mechanism of B-cell activation that involves both the LPS and the antigen-specific surface Ig receptors, with possible participation of T-cells.
Sternberg and Mabbott (1996)nitric oxide synthaseinterferon-gammaT cellNitric oxide-mediated suppression of T cell responses during Trypanosoma brucei infection: soluble trypanosome products and interferon-gamma are synergistic inducers of nitric oxide synthase.
Joh et al. (1997)CD8alphaCD8betaT cellsSince it has been reported that CD8alpha can be induced in mature CD4+ T cells by cell activation, but not CD8beta, we studied whether ATL cells which express CD8alpha may also express CD8beta.
Kumaki et al. (1996)IL-15interferon-gammaT cellRESULTS: Both non-transformed and SV-40 transformed human fetal RPE cells express IL-15, a T cell growth factor which has similar biological activities to IL-2, and the expression of IL-15 is enhanced by interferon-gamma (IFN-gamma) or tumor necrosis factor-alpha (TNF-alpha) stimulation.
Kumaki et al. (1996)IL-15TNF-alphaT cellRESULTS: Both non-transformed and SV-40 transformed human fetal RPE cells express IL-15, a T cell growth factor which has similar biological activities to IL-2, and the expression of IL-15 is enhanced by interferon-gamma (IFN-gamma) or tumor necrosis factor-alpha (TNF-alpha) stimulation.
Kumaki et al. (1996)IL-15IFNT cellRESULTS: Both non-transformed and SV-40 transformed human fetal RPE cells express IL-15, a T cell growth factor which has similar biological activities to IL-2, and the expression of IL-15 is enhanced by interferon-gamma (IFN-gamma) or tumor necrosis factor-alpha (TNF-alpha) stimulation.
Todryk et al. (2001)CD40CD154T-cellAn integral and necessary part of a T-cell immune response involves triggering of CD40 on antigen-presenting cells (APC) by its ligand, CD154, on responding T helper (Th) cells.
Kanda (1999)IL-10GD1aT cellsThese results suggest that GD1a and GM3 may induce IL-10 production in T cells by regulating the PTK-dependent signaling pathway.
Duan et al. (2010)FasL67LRT cellsCONCLUSIONS: Based on these results, we conclude that 67LR induces FasL expression and cytotoxicity against Fas-sensitive Jurkat T cells in human cholangiocarcinoma cells through the phosphorylation of c-Myc on Ser-62 and the subsequent activation of the FasL promoter through the ERK pathway.
Kirkiles-Smith et al. (2000)MHCTNFT cellThere was a strong correlation among pig skin xenograft damage, human T cell infiltration, and the TNF-induced up-regulation of swine MHC class I and class II molecules, VCAM-1, and, in particular, the de novo expression of porcine E-selectin.
Oyaizu et al. (1991)interleukin-6Human immunodeficiency virus type 1 envelope glycoproteinsT-cellHuman immunodeficiency virus type 1 envelope glycoproteins gp120 and gp160 induce interleukin-6 production in CD4+ T-cell clones.
Oyaizu et al. (1991)IL-6envelopeT cellsIn addition, we have shown that the envelope glycoproteins act directly on CD4(+)-cloned T cells to induce IL-6 production in the absence of monocytes.
Holmes et al. (2007)HIV-1 geneFoxP3T cellsFoxP3 enhances HIV-1 gene expression by modulating NFkappaB occupancy at the long terminal repeat in human T cells.
Rivas-Caicedo et al. (2009)Jak3CCL21T lymphocytesIn this context, our group has recently reported that CCL19 and CCL21 induce Jak3 phosphorylation in T lymphocytes [14].
Kremer et al. (2007)IL-10SDF-1T cellsWe further show that SDF-1 primarily costimulates IL-10 secretion by a diverse population of CD45RA(-) ("memory") phenotype T cells that includes cells expressing the presumed regulatory T cell marker, Foxp3.
Overwijk et al. (2006)IFN-gammaIL-23T cellsAlthough IL-23 specifically increased IFN-gamma production by tumor-specific T cells, IFN-gamma itself was not a primary mediator of the vaccine adjuvant effect.
Goto et al. (2008)interleukin-2phytohemagglutininT-cellDifferent effects of all-trans-retinoic acid on phorbol ester-stimulated and phytohemagglutinin-stimulated interleukin-2 expression in human T-cell lymphoma HUT-78 cells.
Kim et al. (2004)XCL1TatT lymphocytesTaken together, these results demonstrate that Tat directly trans-activated XCL1 expression and suggest potential roles of Tat-induced XCL1 expression in the CNS infiltration of T lymphocytes during HIV-1 infection and subsequent HIV-1-induced neurological diseases.
Adachi et al. (1994)LC-PTPIL-2T cellsInduction of protein-tyrosine phosphatase LC-PTP by IL-2 in human T cells.
Adachi et al. (1994)LC-PTPIL-2T cellHere, we demonstrate the rapid activation of a leukocyte tyrosine phosphatase LC-PTP (HePTP) gene expression by IL-2 in an IL-2 dependent human T cell ILT-Mat.
Smyth et al. (1990)cellIL-2T cellThe induction of T cell PFP mRNA by IL-2/IL-6 was extremely rapid and increases in both PFP mRNA expression and cytotoxic potential were IL-6 dose dependent.
Miele et al. (1991)2-5A synthetaseIFNT-cellThis method, used to assay 2-5A synthetase induction by IFN-alpha in human T-cell H9 and CEM-CM3 lines, should be applicable for routine analysis of clinical specimens.
Bartlett and Noelle (1987)I-EIL-4T cellDetection of I-E induced by both purified IL-4 and a T cell-derived supernatant was highly reproducible and sensitive using this method.
Jiang et al. (2007)IL-1NGFT cellNGF could markedly promote LPS-induced expression of HLA-DR, CD40, CD80, CD83, CD86, CCR7, secretion of IL-12p40 and proinflammatory cytokines IL-1, IL-6, TNF-alpha, and the T cell-stimulating capacity of MoDCs, indicating that NGF can promote LPS-induced DC maturation.
Stevens and Yu-Lee (1994)interferon regulatory factor-1PRLT lymphocytesThe interferon regulatory factor-1 (IRF-1) gene is both an immediate-early G1 phase gene and an S phase gene inducible by PRL in rat Nb2 T lymphocytes.
Schatten et al. (1984)Ts1S1509aT cellWe demonstrated previously that S1509a-induced Ts1, TsF1, and Ts2 specifically suppress in vivo Ly1+2- T cell-dependent responses to S1509a and that Ts1 suppress in vivo Ly-1+2- T cell-mediated proliferative responses to S1509a.
Pichler et al. (2008)4-1BBTaxT cellsTax was sufficient to induce the expression of the endogenous 4-1BB gene in uninfected T cells, and it strongly activated (45-fold) the 4-1BB promoter via a single NF-kappaB site.
Farley et al. (2006)CCL5FasLT cellAdditionally, in the presence of caspase inhibitors, but not in their absence, FasL triggered the accumulation of CCL5/RANTES (regulated on activation normal T cell expressed and secreted) mRNA.
Reed et al. (1985)mycIL2T cellsTaken together, these data provide evidence that (i) c-myc gene expression can be regulated by at least two distinct pathways in T lymphocytes, only one of which is sensitive to cyclosporine A, and (ii) the accumulation of c-myc mRNA can be induced in T cells by IL2 during the G1 phase of the cell cycle.
Takeuchi et al. (2011)Cyp26b1RAT cellsIn the present study, we found that Cyp26b1 is expressed in antigen-experienced T cells from gut-related lymphoid organs, and that RA induced Cyp26b1 expression in naïve T cells upon activation (Fig. 1 & 2).
Liang et al. (2007)protein kinase CT cellsFurthermore, Wnt5a overexpression increases apoptosis in T cells in vitro and increases protein kinase C (PKC) and calmodulin-dependent kinase II (CamKII) activity while inhibiting beta-catenin expression and activity.
Daftarian et al. (1996)IL-10tumor necrosis factor-alphaT cellsIL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-alpha.