Viewing negative mentions of positive regulation in T cells

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Welte et al. (1984)IL-2IL-2T cellOKT3 monoclonal antibody at low, nonmitogenic concentrations (25 pg/ml) or IL-2 alone at optimal concentrations (20 U/ml) did not induce IL-2 receptor expression, as measured by Tac antibody or by T cell proliferation.
Wacholtz et al. (1991)IL2lectinT cellsOther cyclic adenosine monophosphate (cAMP) elevating agents (forskolin, isoproterenol, and the cAMP analogue, dibutyryl cAMP) also inhibited lectin-stimulated IL2 production by T cells, but could not inhibit IL2 production by Jurkat cells.
Lo et al. (2008)NFATPML-VINFATThere was a selective requirement of PML isoform in NFAT activation: PML-I and PML-VI, but not PML-IV, increased NFAT transactivation.
Gerrard et al. (1988)Ia AgIFN-gammaT cellHowever, we have observed that IFN-gamma did not induce the expression of Ia Ag on Ia- human T cell lines.
Ariumi and Trono (2006)HIV-1 late geneT-cellNotably, ATM overexpression did not stimulate the HIV-1 late gene expression within the context of Rev-independent constructs or the Rex-dependent production of capsid from human T-cell leukemia virus type 1 proviral constructs.
Autieri et al. (2000)AIF-1 proteininterleukin-1betaT-cellAIF-1 protein is not expressed in quiescent cultured human VSMCs but is induced in cells challenged with various inflammatory cytokines, primarily by interferon-gamma, interleukin-1beta, and T-cell-conditioned media.
Peola et al. (1996)CD73CD38T cellsCD73 was not induced by other agents that activate T cells and CD73 was the only GPI-anchored molecule up-regulated by CD38 ligation out of six analyzed.
Lacoste et al. (1990)HIV LTRTNF-alphaT cellsTNF-alpha was able to increase expression of the HIV LTR in T cells, but in monocytic cells, TNF-alpha did not induce the HIV LTR above a constitutive level of activity.
Ito et al. (2009)IL-17IL-1betaT cellsFurthermore, IL-17 production by gamma/delta T cells was induced by IL-1beta plus IL-23 independently of T cell receptor.
Suzuki and Cooper (1985)transferrinIL 2T cellsIn addition, IL 2 enhanced the expression of transferrin receptors by activated T cells but did not have a similar effect on activated B cells.
Smyth et al. (1990)IL-2IL-6T cellsThe costimulatory effect of IL-6 did not appear to involve the IL-2/IL-2R pathway in as much as IL-6 did not induce IL-2 production or detectably increase IL-2R surface expression in T cells.
Morris et al. (1982)IFNPhytohemagglutininT-cellPhytohemagglutinin, a T-cell mitogen, did not stimulate IFN production in these lines.
Suemura et al. (1986)Fc epsilonIgET cellsPHA-conditioned medium plus IgE did not induce Fc epsilon R expression on T cells.
Ohba et al. (2009)STIM1T cellsEndothelin-1 (ET-1) treatment for 48h enhanced TRPC1 expression, SOCE, and nuclear factor of activated T cells activation without upregulating STIM1.
Butcher et al. (1990)TacIL-4T cellsIL-4 could not promote Tac expression on high-density T cells prepared from the same tissue source.
Splawski and Lipsky (1987)IgAT cellMitogen-stimulated T cell supernatants increased IgA secretion of the hybridoma cells but did not cause synergistic stimulation of the cells in the presence of PC-Sepharose.
Ludgate (2002)TSHRT cellsApproximately 20% of mice develop thyroid-stimulating antibodies (TSAB) and increased thyroxine levels but no thyroiditis; (2) transfer of TSHR primed T cells to naive syngeneic recipients.
Kong et al. (1995)CD45T cellsMoreover, the CD45+ T cells had an abnormal regulation of CD45 expression level, as they could not increase their CD45 expression level after in vitro allogeneic stimulation.
Oka et al. (2001)SHP1T cellSHP1 expression could not be induced in either of two NK/T cell lines by phorbol ester, suggesting that genetic impairment or modification with methylation of SHP1 DNA could be one of the critical events in the pathogenesis of NK/T lymphoma.
Löhr et al. (1990)asialoglycoprotein receptorT cellsThe response of T cells to the human hepatic asialoglycoprotein receptor did not require the lectinlike activity of the asialoglycoprotein receptor.
Vercelli et al. (1989)IgET cellFurthermore, alloreactive T cell clones which are unable to engage the B cell MHC Class II molecules fail to induce IgE synthesis in spite of their ability to secrete IL-4.
Kojima et al. (1999)parathyroid hormone-related proteinT-cellSerum levels of parathyroid hormone-related protein are not elevated in patients with T-cell prolymphocytic leukemia.
Tsang et al. (1986)IL-2T cellHowever, no augmentation of IL-2 production was observed when cultures of HUT-78 cells, a human leukemic T cell line, were treated with ISO.
Holán et al. (1994)IL-2T cellIn two additional T cell lines tested, MOLT-16 and H-9, DC did not enhance mitogen-stimulated IL-2 production, but suppressed it when applied at 1 mA for more than 10 min.
Bix et al. (1998)IL-4T cellsHere, we show that this bias arises not from an increase in the amount of IL-4 produced per cell, but rather from an increase in the proportion of CD4(+) T cells that commit to IL-4 expression.
Yoshie et al. (2002)CCR4T-cellInducible expression of HTLV-1 transcriptional activator tax in a human T-cell line Jurkat did not, however, up-regulate CCR4 mRNA.
Sandalova et al. (2004)BimT cellsPeptides that failed to induce Bim expression, failed to induce apoptosis in specific T cells, whereas partially agonistic ligands, which trigger death receptor-independent activation-induced cell death (AICD), induced Bim, but were inefficient in up-regulating Bcl-X(L).
Debets et al. (1988)TNF-alphaT cellsIn the absence of proliferating T cells the mitogens did not induce secretion of TNF-alpha by monocytes.
Laberge et al. (1996)IL-16T cellsSerotonin induced secretion of IL-16 from CD8+, not CD4+, T cells which did not require the de novo protein synthesis.
Bassetti et al. (2009)Bcl-3T cellsThis property was intrinsic to the T cells over-expressing the Bcl-3 and did not require Bcl-3 expression by other cells such as antigen-presenting cells.
Li et al. (2006)CKLF1T lymphocytesIn order to determine the expression profile of CKLF1 in activated T lymphocytes, we first employed a PCR-based method on human blood fractions cDNA panels and found that CKLF1 was upregulated in activated CD4+ and CD8+ cells, with no obvious changes in CD19+ cells.
Lyck et al. (2003)ICAM-1T cellsSurprisingly, tyrosine phosphorylation of endothelial ICAM-1 was not necessary for TEM of T cells or for Rho guanosine triphosphatase (RhoGTPase) activation.
Xia et al. (2010)BTLAT cellsHowever, BTLA expression did not increase in CD8+ T cells after HSV-1 infection (Figure 1C).
Ng et al. (2009)CD8T cellAlthough current inactivated vaccines are unable to induce heterosubtypic CD8(+) T cell immunity, we have shown that lipopeptides are particularly efficient in this regard.
Bensussan et al. (1984)IL-2T-cellWe find that Te-Ti triggering of suppressor clones (T8AC6, T8AC7 or T8RW) does not result in IL-2 production or T-cell proliferation and in contrast to inducer clones, also leads to a transient IL-2 unresponsive state.
Mullin et al. (2006)PKDT cellsHowever, the data show that activation of Rho is neither sufficient nor essential for PKD activation in T cells.
Ford et al. (1999)CD154T cellsHowever, CD154 message stability was only modestly increased in T cells coactivated with anti-CD3 and anti-CD28 at 5 h and not increased by costimulation at 24 h.
Pucci et al. (1998)IL-2 mRNAT cellsWe found that the IL-2 mRNA level in T cells from young but not from old mice increased up to 6- to 10-fold by addition of cycloheximide (CHX) while the stability of IL-2 mRNA is not affected.
Muthukumar et al. (2004)IL-7T-cellThese data suggest that during pathogenic SIV infection with high viral replication, elevated IL-7 levels are unable to recover T-cell homeostasis, thereby leading to disease progression.
Chao et al. (2007)CD25T lymphocytesDecreased expression of CD25 on decidual activated T lymphocytes is not mediated by reduced CD25 messenger ribonucleic acid.
Bremer et al. (2009)PrPT-cellsThere was no significant increase of PrP on CD19+ B-cells, CD3+ T-cells, or CD11b+/CD11c+ monocytes in immunized vs. non-immunized mice.
Elhofy et al. (2009)CCR6T cellsCCR6 expression was not required by T cells to induce EAE.
Liu and Whisler (1998)TNF-alphaT cellsResults show that exposure of resting T cells to micromolar concentrations of H2O2 did not induce TNF-alpha protein production or transcriptional activation of the TNF-alpha promoter.
Mor et al. (2008)Foxp3T cellExcept for H-Ras transduction with shRNA, each inhibitory mode increased expression of Foxp3 and nuclear factor of activated T cell proteins, and surface expression of CD25.
Ohta et al. (1983)IgET-cellEnhancement was also dependent on the presence of PWM; T-cell irradiation did not enhance IgE synthesis in unstimulated cultures.
Bhardwaj et al. (1989)IL-1T cellsSupernatants from cocultures of monocytes and T cells or several recombinant cytokines induced little or no IL-1.
Saryan et al. (1983)IgET cellsIn contrast, supernatants of normal T cells failed to induce IgE synthesis.
Larsen (1990)IL-2T cellsSequential stimulation with PDBu and ionomycin failed to induce IL-2 production, IL-2R expression, and consequently proliferation of the T cells, indicating that T-cell activation requires simultaneous activation of protein kinase C (PKC) and elevation of cytosolic calcium.
Koide and Steinman (1987)IL-1T cellsSeveral other stimuli did not induce IL-1 in cultured macrophages, including phorbol 12-myristate 13-acetate, gamma-interferon, Con A, macrophage colony-stimulating factor, IL-3, cachectin, and activated T cells.
Mu et al. (1999)PgpT cellsThus, human T cells do not markedly up-regulate their expression of functional Pgp molecules as detected by mAb 4E3 following activation, suggesting that Pgp does not play a major role in IL-2 secretion by activated T cells.
Eggena et al. (2005)CD4T cellThe presence of coinfection was associated with increased CD4(+) T cell activation but, interestingly, not with increased CD8(+) T cell activation.
Erben et al. (1998)CD4T-lymphocytesFlow cytometric analysis of peripheral blood lymphocytes revealed that, except for a transient increase in CD4 positive T-lymphocytes in OVX rats relative to SHAM animals at 1 week post-surgery, the number of CD5, CD4, or CD8 positive lymphocytes or the mean fluorescence per cell for these antigens in OVX rats remained unchanged throughout the study.
Li et al. (2000)PKRT cellsPriming of T cells with IFN does not restore PKR activation.
Li et al. (2000)PKRT cellsTreatment of T cells with proteasome inhibitors or incubation of PKR immunoprecipitates with phosphatase inhibitors does not restore PKR activation.
Le et al. (1986)IFN-gammaIL 2T lymphocyteNeither IL 1 nor IL 2 alone induced IFN-gamma production in purified T lymphocyte cultures.
Torelli et al. (1985)c-mybT-lymphocyteThe increase in c-myb expression was not due to a particular T-lymphocyte subset, as shown by in situ hybridization assays.
Ahmadzadeh et al. (2007)FOXP3T cellsIn the absence of IL-2, antigen stimulation resulted in T-cell activation and acquisition of effector function without induction of FOXP3, indicating that acquisition of effector function is independent of induction of FOXP3 expression in CD8 T cells.
Lindsten et al. (1993)CTLA-4 mRNAT cellsCTLA-4 mRNA expression can be induced on quiescent T cells via phorbol ester-mediated activation of protein kinase C but not with calcium ionophore treatment alone.
Moore et al. (2008)CD4CD4The proportion with no increase in CD4 count from baseline did not differ between those with suppressed or unsuppressed VLs at 6, 18, and 24 months after ART initiation.
Moore et al. (2008)CD4CD4No increase in CD4 cell counts at 6 months had a sensitivity of 0.04 [95% confidence interval (CI) 0.00 to 0.10] and a positive predictive value of 0.03 (95% CI 0.00 to 0.09) for identifying individuals with VL>or=500 copies per milliliter at 6 months.
Peola et al. (1996)CD73T cellsCD73 was not induced by other agents that activate T cells and CD73 was the only GPI-anchored molecule up-regulated by CD38 ligation out of six analyzed.
Pingel et al. (1999)IL-4T cellsSuch altered ligands failed to activate IL-4 production from transgenic LACK-specific T cells or following injection into BALB/c mice.
Kumar et al. (1998)JNKT cellTransfection of a T cell line, H9 cells with the HIV-tat gene also resulted in an activation of JNK that was not further increased by treatment of cells with exogenous HIV-tat protein.
Scholzen et al. (2009)Foxp3T cellsFoxp3 expression in CD4 T cells was not induced when purified T cells as opposed to whole PBMCs were co-cultured with iRBCs, demonstrating that induction of Foxp3+ CD4 T cells is not due to a direct interaction of T cells with iRBCs but dependent on other cells present in the co-culture system (Figure 5A).
Scholzen et al. (2009)CD25hiFoxp3hiT cellsreduced the proportion of induced CD25hiFoxp3hi, but not CD25hiFoxp3int CD4 T cells down to 50.8+/?
Gribaudo et al. (1990)2-5A synthetaseIFN-gammaT cellsIn contrast IFN-gamma was capable of increasing 2-5A synthetase activity only in fibroblasts, but not in T cells.
Gribaudo et al. (1990)2-5A synthetase geneIFN-gammaT cellsNuclear run-on assays revealed that the 2-5A synthetase gene in T cells is not transcriptionally activated by IFN-gamma.
Moll et al. (1994)CD7T cellsCell activation in vitro did not induce CD7 expression in negative T cells but increased CD7 expression in CD7-positive cells.
Xystrakis et al. (2006)IL-10T cellsDexamethasone does not enhance secretion of IL-10 by their CD4+ T cells.
Pyatt et al. (1996)NF-kappa BT cellsPb did not activate NF-kappa B in 4 different T cell lines, suggesting that lymphoid cell lines may not be reliable surrogates for the study of transcriptional activation in human T cells.
Adolf (1984)IFNT-cellIFN production was enhanced by the diterpene tumor promoters, TPA and mezerein, but not by classical T-cell mitogens.
McCullagh et al. (2004)NFATNFATNFAT activity is decreased by denervation in slow muscles and is increased by electrostimulation of denervated muscles with a tonic low-frequency impulse pattern, mimicking the firing pattern of slow motor neurons, but not with a phasic high-frequency pattern typical of fast motor neurons.
Novak and Rothenberg (1990)interleukin 2T cellscAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells.
Kaufman et al. (2004)PSAT-cellsAlthough no significant increases in anti-PSA antibody titers were detected, 46% of patients demonstrated an increase in PSA-reactive T-cells.
Barthlott et al. (2005)CD25T cellsAs a consequence of competition for IL-2, CD25+ CD4+ T cells further up-regulate the IL-2R alpha chain (CD25), a process that is strictly dependent on IL-2, whereas responder T cells fail to up-regulate CD25.
Giannoni et al. (2008)CD40T cellsThe results showed that CD40 expression on T cells is not necessary for preventing viral reactivation.
Meuer and Meyer zum Büschenfelde (1986)IL 2T lymphocytesIn contrast, presensitized T lymphocytes do not require IL 1 for IL 2 production.
Yio and Mayer (1997)lckgp180T cellFurther characterization of gp180 revealed the following. 1) The protein migrated between 150 and 180 kDa in SDS-polyacrylamide gel electrophoresis and could be resolved by Western blot using mAb B9 or mAb L12. 2) The molecule has two forms, an apically sorted glycosylphosphatidylinositol-anchored form and a basolateral transmembrane form. 3) gp180 is heavily N-glycosylated, since N-glycanase treatment results in a >50% reduction in size. 4) Purified gp180 can bind to peripheral blood T cells and activate p56(lck). 5) gp180 can activate p56(lck) in 3G8 (a murine T cell hybridoma transfected with human CD8alpha cDNA) but not in 3G4 (CD4 transfectant), suggesting that gp180 binds to CD8.
Bäumler et al. (1996)CD95T cellsCD95 expression in HIV-1+ children is not restricted to previously activated CD45RO+ T cells but is also increased on freshly isolated naive CD45RA+ T cells.
Arbogast et al. (1999)Cdk6T cellsThe reduced Cdk6 activity was not attributable to a low level of the protein since a 24-h activation resulted in a comparable expression of the kinase in T cells from young and old individuals.
Corthay (2009)Foxp3T cellsIt has been reported that naïve, CD25-negative mouse CD4+ T cells do not upregulate Foxp3 when activated [48, 50, 60].
Tan et al. (2006)IL-17AT cellsIn spleen-derived T cells, gamma irradiation induces significant murine IL-17A expression in vivo but not in vitro.
Clagett et al. (1980)immunoglobulin MT cellsThere was no requirement for T cells in the deoxyribonucleic acid synthesis, proliferactive, immunoglobulin M (IgM), or IgG responses.
Tekstra et al. (2001)MCP-1T cellThese results suggest that T cell proliferation alone is not sufficient for MCP-1 production and that stimulation of the APC during the process of antigen presentation results in MCP-1 production.
Verma-Gandhu et al. (2007)beta-endorphinT cellsIn vitro, T helper (Th) type 1 and type 2 cytokine stimulation of CD4+ T cells or isolation of T cells from in vivo Th-polarized mice did not increase T cell release of beta-endorphin or the induction of beta-endorphin expression in the myenteric plexus.
Mustelin (1987)ODCT lymphocytesMitogenic monoclonal antibodies against the T3 molecule and mitogenic lectins induce a rapid (within 5 min) protein synthesis-independent activation of ornithine decarboxylase (ODC) in human T lymphocytes.
Matsuzaki et al. (1986)IL-2T-cellThis process was not a consequence of nonspecific IL-2 gene activation, which occurs in cells persistently infected with reovirus, because reovirus infection did not activate IL-2 secretion in T-cell hybridomas with other antigenic specificities.
Pae et al. (2003)HO-1T cellsOur further studies showed that CD28 signal alone was enough to induce HO-1 expression and CD3 signal, of which signal alone did not induce HO-1 expression, was required at least for full HO-1 expression in both CD25(-) and CD25(+) subsets of human CD4(+) T cells.
Probst et al. (1993)ReAT-cellAnalysis of the T-cell response to this protein showed that it contains several T-cell epitopes, one of which cross-reacts with other enterobacteria not able to induce ReA.
Welte et al. (1987)IL-2T cellsThe IL-2 production could be enhanced by coculture with host PBMC frozen before transplant but not by stimulation with mitogenic amounts of OKT3 antibody, thus suggesting an in vivo activation of donor T cells or their precursors by host tissue.
Garofalo et al. (2002)Zap-70T cellTherefore, T cell activation does not promote a redistribution of glycosphingolipid-enriched microdomains but induces Zap-70 translocation in selective membrane domains in which Zap-70 may interact with GM3.
Hara and Fu (1985)IL-2T cellsTPA induced a low level of IL-2 receptor expression in monocyte-depleted T cells, without inducing IL-2 secretion.