| Document |
Target |
Regulator |
Anatomy |
Sentence |
| Wang et al. (2007) | IFN | mAb 7D7 | T lymphocyte | Cross-linking of BTLA with mAb 7D7 suppressed T lymphocyte proliferation, downregulated the expression of T cell activation marker CD25, and inhibited the production of interferon (IFN)-gamma, interleukin (IL)-2, IL-4, and IL-10.
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| Collins et al. (1990) | TCGF | IL-2 | T-cell | Anti-human IL-2 partially blocked the T-cell growth factor (TCGF) activity produced by these hybrids. |
| Gattass et al. (1988) | OKT8 | Jacalin | T cell | Jacalin inhibits the binding of OKT8 (anti-CD8) to both fresh PBMC and jacalin-induced T cell blasts. |
| Swenson et al. (1995) | IgD-R | IgD | T cells | More importantly, monomeric IgD injected 6 to 24 h before a primary Ag injection also inhibits 1) the up-regulation of IgD-R on T cells induced by Ag injection alone, and 2) the generation of IgG memory, as shown in the response to a second dose of Ag injected on day 10. |
| van der Veken et al. (2009) | KIR | KIR | T cells | Although Ag-specific cytolytic activity and cytokine production of KIR(+) T cells can be inhibited by KIR ligation, the effect of KIR on proliferation is unclear. |
| Kondo et al. (1993) | IL-2 | | T cell | A monoclonal antibody to the gamma chain, TUGm2, inhibited IL-2 binding to the functional IL-2 receptors and also inhibited IL-4-induced cell growth and the high-affinity binding of IL-4 to the CTLL-2 mouse T cell line. |
| Gasic et al. (2007) | IL-2 | IL-2 | T-cell | The inhibition of T-cell proliferation in the presence of MEL 174 was followed by a decrease in IL-2 production, which was partly abrogated by exogenous IL-2, a decrease in nitric oxide (NO) production and increased apoptosis. |
| Martins et al. (2008) | IL-2 | Blimp-1 | T cell | Therefore, Blimp-1 attenuates CD4+ T cell proliferation and IL-2 production upon antigen-specific TCR stimulation in vivo (Fig. 5).
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| Martins et al. (2008) | IL-2 | Blimp-1 | T cell | Thus, this study demonstrates that Blimp-1 represses IL-2 production after T cell activation and shows that the molecular mechanism responsible depends, at least in part, on Blimp-1–dependent repression of Il2 and Fos transcription. |
| Souabni et al. (2002) | Notch1 | Pax5 | T cell | Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1.
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| Souabni et al. (2002) | Notch1 | Pax5 | T cell | Pax5 thereby interfered with T lineage commitment and early thymocyte development by repressing the transcription of the T cell specification gene Notch1.
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| Herbeck et al. (2010) | interferon-gamma | PROX1 | T cells | PROX1 is a negative regulator of interferon-gamma expression in T cells and also mitigates the advancement of vascular neoplasms, such as Kaposi sarcoma, a common AIDS-defining malignancy. |
| Yoshida et al. (2008) | CXCR4 | CD63DeltaN | T-cell | We have discovered that an N-terminal deletion mutant of a membrane protein, CD63, (CD63DeltaN) blocks entry of CXCR4-using, T-cell tropic human immunodeficiency virus type 1 (X4 HIV-1) by suppressing CXCR4 surface expression. |
| Georas et al. (1998) | interleukin-4 | Stat6 | T cells | Stat6 inhibits human interleukin-4 promoter activity in T cells.
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| Lendeckel et al. (2000) | GSK-3beta | | T cells | Inhibition of alanyl-aminopeptidase suppresses the activation-dependent induction of glycogen synthase kinase-3beta (GSK-3beta) in human T cells.
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| Thornton et al. (2006) | AP-1 | BATF | T cell | In addition, the unique circumstances of this regulation were exploited to demonstrate that inhibition of AP-1 activity by BATF exerts a direct, and reversible, effect on T cell proliferation in vitro.
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| Davis et al. (1988) | DAF | phosphatidylinositol-specific phospholipase C | T cell | T cell mitogenesis is largely dependent on the phosphatidylinositol-linked form of DAF, because removal of DAF by a phosphatidylinositol-specific phospholipase C eliminates anti-DAF-induced T cell proliferation. |
| Nishimura and Tanaka (2001) | NFIL3 | | NFAT | Expression of dominant negative forms of calcineurin or nuclear factor of activated T cells (NFAT) inhibited the induction of NFIL3/E4BP4 mRNA by TG. |
| Zhang et al. (2004) | CD4 | HNPs | T cells | Here we show that HNPs may inhibit T cells by downregulating CD4 expression, a molecule of critical importance for T cell's interaction with the target cell. |
| Barbi et al. (2008) | CXCR3 | | T cells | Inhibition of PI3Kinases using wortmannin and LY294002 or blockade of PI3Kgamma activity using a selective inhibitor or PI3Kgamma siRNA suppressed induction of CXCR3 on T cells following activation. |
| Defrance et al. (1989) | CD5 | interleukin (IL) 4 | T cells | In this study, it is demonstrated that interleukin (IL) 4 down-regulates the surface expression of CD5 on tonsil B cells and B-CLL cells, but not on T cells. |
| Makrigiannakis et al. (2001) | FasL | antalarmin | T lymphocytes | We found that antalarmin, a CRH receptor type 1 antagonist, decreased FasL expression and promoted apoptosis of activated T lymphocytes, an effect which was potentiated by CRH and inhibited by antalarmin. |
| Bettelli et al. (2005) | NFAT | Foxp3 | T cell | Foxp3 has already been associated with the generation of CD4(+)CD25+ regulatory T cells; our data additionally demonstrate that Foxp3 suppresses the effector functions of T helper cells by directly inhibiting the activity of two key transcription factors, NFAT and NF-kappa B, which are essential for cytokine gene expression and T cell functions.
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| Lillehoj and Shevach (1985) | IL-2 | CsA | T cells | In contrast, CsA blocked acquisition of responsiveness of resting T cells to IL-2, inhibited IL-2 production, and also inhibited IL-2 receptor expression at 48 hrs but not at 24 hrs following mitogen stimulation. |
| Joncourt et al. (1985) | 125I-insulin | | T cells | The specific binding of 125I-insulin and 3H-dexamethasone to phytohemagglutinin-(PHA)-stimulated T cells was found to decrease with age. |
| Omoto et al. (2004) | nef | STYLE encoding siRNA | T cells | To evaluate whether the STYLE encoding siRNA could inhibit the expression of the nef gene in cultured human T cells, pYM2.2 was transfected into each of the STYLE-infected Jurkat T cells (m.o.i. = ca. 0.1). |
| Schmidt et al. (1990) | interleukin-2 | Cyclosporin A (CsA) | T-cell | Cyclosporin A (CsA) is thought to exert its immunosuppressive effects by inhibiting the expression of a distinct set of lymphokine genes which are induced upon T-cell activation, among them the gene coding for interleukin-2. |
| Broxmeyer et al. (1983) | granulocyte-macrophage colony-stimulating factors | transferrin | T lymphocytes | Purified human transferrin, when saturated with iron or zinc, decreased the production of granulocyte-macrophage colony-stimulating factors (GM-CSF) by human T lymphocytes that had been stimulated by phytohemagglutin or concanavalin-A. |
| Williamson et al. (2006) | gp120 | | T cells | CONCLUSION: We have demonstrated clear evidence of high-affinity binding of EGCG to the CD4 molecule with a Kd of approximately 10 nmol/L and inhibition of gp120 binding to human CD4+ T cells.
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| Mi et al. (2003) | interleukin (IL)-2 | TRAIL | T-cells | TRAIL inhibits the proliferation of NOD diabetogenic T-cells by suppressing interleukin (IL)-2 production and cell cycle progression, and this inhibition can be rescued in the presence of exogenous IL-2. cDNA array and Western blot analyses indicate that TRAIL upregulates the expression of the cdk inhibitor p27(kip1). |
| Fox et al. (1994) | interleukin 2 | cell | T cell | Inhibition of interleukin 2 production and alteration of interleukin 2 mRNA processing by human T-T cell hybridoma-derived suppressor factors.
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| Liang et al. (2003) | ERK1 | YopH | T-cell | We show that YopH severely decreases the T-cell receptor-induced cellular tyrosine phosphorylation, ERK1/2 activity, and interleukin-2 transcriptional activity. |
| Ferguson and Kupper (1993) | FN | | T cells | These peptides blocked the interaction of the integrins VLA-4 and VLA-5 with fibronectin (FN), and our results suggested that by preventing the interaction of T cell integrins with FN, we successfully prevented the migration of T cells to sites of antigenic challenge. |
| Kwon et al. (2008) | SIRT1 | Tat | T cells | We find that the viral transactivator Tat promotes hyperactivation of T cells by blocking the nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase SIRT1. |
| Tomita et al. (2007) | HIF-1alpha | LY294002 | T-cell | The PI3K inhibitor LY294002 suppressed HIF-1alpha protein expression, HIF-1 DNA-binding and HIF-1 transcriptional activity in HTLV-1-infected T-cell lines. |
| Ma et al. (2010) | NKG2D | major histocompatibility complex class I-related chain A protein | T cells | The soluble major histocompatibility complex class I-related chain A protein reduced NKG2D expression on natural killer and T cells from patients with prolactinoma and non-secreting pituitary adenoma.
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| Moreau and Chauvin (2010) | cysteine proteases | cystatin | T cells | A cystatin produced by H. contortus and N. brasiliensis modulates the antigen presentation to T cells by inhibiting cysteine proteases of antigen presenting cells, involved in the processing of the antigen [30, 31].
2.3. |
| Veillette et al. (2009) | Src | LYP | T-cell | PEP/LYP is a potent inhibitor of T-cell activation, principally by suppressing the activity of Src family protein tyrosine kinases (PTKs). |
| Berberich-Siebelt et al. (2006) | Myc | C/EBPbeta | T cells | By binding to the c-myc promoter(s), C/EBPbeta represses c-Myc expression and, therefore, arrests T cells in the G1 phase of the cell cycle. |
| Alon et al. (2005) | talin | | T cells | A mutation of the alpha4 tail that disrupts paxillin binding, alpha4(Y991A), reduced talin association to the alpha4beta1 heterodimer, impaired integrin anchorage to the cytoskeleton, and suppressed alpha4beta1-dependent capture and adhesion strengthening of Jurkat T cells to VCAM-1 under shear stress. |
| Tsunetsugu-Yokota et al. (2002) | CD40L | | T cells | In contrast, blocking the CD58/CD2 but not the CD40/CD40L interaction reduced production of IFN-gamma without affecting the maturation of CD8+ T cells. |
| Matsumura et al. (1995) | CTLA4 | | T cells | CTLA4Ig is a recombinant soluble protein that binds with high affinity to rat B7/BB1 and other surface molecules on APCs, subsequently blocking the binding of B7/BB1 to CD28/CTLA4 on T cells. |
| Reed et al. (1988) | p53 | CsA | T cell | Comparisons of the actions of CsA on gene expression in a cloned murine T cell (L2), stimulated with concanavalin A or IL-2, demonstrated that CsA specifically blocked the accumulation of mRNAs for the c-myc and p53 protooncogenes when induced by Con A, but not when induced by IL-2. |
| Elliott and Palfree (1984) | Ia glycoproteins | | T cells | T cell receptor/Ia interactions were directly studied by inhibition of H-2k vesicle binding by T cells with partially purified Ia glycoproteins. |
| Tsudo et al. (1982) | Ia-like antigen | anti-Tac antibody | T cells | In the mixed lymphocyte culture, the expression of Ia-like antigen on allo-activated T cells was also inhibited by anti-Tac antibody, although the antibody does not recognize Ia-like antigen. |
| Longmire et al. (1978) | Fc receptors | antigen-antibody complexes | T lymphocytes | The target cells appear to be T lymphocytes; the effector cells bear Fc receptors that are inhibited by antigen-antibody complexes. |
| Guo et al. (2004) | cell | Cdx1 | T-cell | In order to elucidate further the molecular mechanisms underlying this phenomenon, we first hypothesized that Cdx1 or Cdx2 expression reduces colon cancer cell proliferation by inhibiting beta-catenin/T-cell factor (TCF) transcriptional activity. |
| Lundquist et al. (2002) | CD4 | Nef | T cells | These results demonstrate that CD4 downregulation by Nef plays a crucial role in HIV-1 replication in activated T cells and underscore the potential for the development of therapies targeting this conserved activity of Nef.
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| Mark et al. (1998) | IL-2 | | T lymphocytes | Specifically, blockade of either CD80 or CD86 in ovalbumin-sensitized and challenged mice resulted in reduced expression of IL-2Ralpha (CD25) on CD4+ T lymphocytes, decreased airway eosinophilia, lower serum IgE production and diminished AHR. |
| Bohlen et al. (2000) | major histocompatibility complex antigens | IL-10 | T cells | IL-10 inhibits secretion of IL-2 and interferon (IFN)gamma by T cells and downregulates major histocompatibility complex antigens. |
| Vito et al. (1996) | Fas | ALG-3 | T-cell | ALG-3, a truncated mouse homologue of the chromosome 1 familial Alzheimer's disease gene PS2, rescues T hybridoma 3DO cells from T-cell receptor-induced apoptosis by inhibiting Fas ligand induction and Fas signaling. |
| Telfer et al. (2004) | CD4 | Runx1 | T cells | Runx1 is able to repress CD4 in CD4/CD8 double-positive thymocytes, but not in mature splenic T cells. |
| Weiske and Huber (2006) | T-cell factor | Hint1 | T-cell | In this respect, we have recently shown that Hint1, by interaction with Pontin and Reptin, inhibits T-cell factor/beta-catenin-mediated transcription of Wnt target genes. |
| Ladner et al. (2005) | Lyp | | T-cell | One function of Lyp is downregulation of T-cell signaling through its interaction with the negative regulatory kinase C-terminal Src tyrosine kinase (Csk). |
| Matsui (1996) | IL-2R | STI | T cells | The flow cytometric analysis of IL-2 receptor (IL-2R) expression on T cells showed that STI specifically suppressed the expression of IL-2R beta and IL-2R gamma. |
| Mori et al. (1997) | IL-5 | GC | T-cell | Our results showing that GC suppressed IL-5 production by human CD4+ T cells activated by two distinct stimuli, TCR and IL-2R stimulation, underscore the efficacy of GC in the treatment of allergic diseases via suppression of T-cell IL-5 synthesis.
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| Kumar et al. (2006) | AHR | IFN-gamma | T cells | Treatment with anti-IFN-gamma decreases the number of IFN-gamma-producing CD4+ T cells in both wild-type and gene-targeted mice, providing a possible explanation for the ability of anti-IFN-gamma to inhibit AHR in the setting of chronic challenge. |
| Carucci et al. (2000) | CD86 | Calcitonin gene-related peptide | T cell | Calcitonin gene-related peptide decreases expression of HLA-DR and CD86 by human dendritic cells and dampens dendritic cell-driven T cell-proliferative responses via the type I calcitonin gene-related peptide receptor.
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| Salvador et al. (2005) | p38 | Gadd45alpha | T cell | Thus, constitutive activation of T cell p38 through the alternative pathway is prevented by Gadd45alpha, the absence of which results in p38 activation, T cell hyperproliferation and autoimmunity.
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| Sander et al. (2006) | NFATc1 | Peroxisome proliferator-activated receptor gamma | T cells | Peroxisome proliferator-activated receptor gamma (PPARgamma) inhibits NFATc1 activity in T cells and cardiomyocytes, but it is not known if PPARgamma controls NFATc1 function in endothelial cells. |
| Hintzen et al. (1994) | CD27 | CD27L | T cell | Down-regulation of CD27 from the T cell surface by recombinant CD27L was shown to be at least partially caused by release of soluble CD27. |
| Mamane et al. (2002) | cyclin B1 | IRF-4-mediated | T cells | Furthermore, IRF-4-mediated repression of cyclin B1 led to a significant decrease in CDC2 kinase activity in HTLV-1 infected T cells. |
| Elliott et al. (1992) | interleukin-2 | GSF | T-cells | GSF also inhibits production of interleukin-2 (IL-2) by mitogen activated human T-cells. |
| Smyth et al. (1991) | PFP mRNA | TGF-beta | T cells | TGF-beta also inhibited the rapid activation-induced expression of PFP mRNA and cytotoxic potential in resting T cells, thereby indicating that the effect of TGF-beta was independent of T cell proliferation. |
| Smyth et al. (1991) | PFP | TGF-beta | T cell | Therefore, TGF-beta may be an important general regulator of CD8+ T cell cytotoxic function, in particular by suppressing expression of PFP, a major cytolytic protein implicated in the lytic function of cytotoxic lymphocytes.
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| Chan et al. (1993) | Lck | | T cell | The biological relevance of CD8 alpha-Lck association in T cell development was tested with transgenic mice generated to express a CD8 alpha molecule with two amino acid substitutions in its cytoplasmic domain, which abolishes the association of CD8 alpha with Lck. |
| Wang et al. (2008) | interferon-gamma | Prospero-related homeobox protein | T cells | Repression of interferon-gamma expression in T cells by Prospero-related homeobox protein.
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| Cramer and Frelinger (2001) | major histocompatibility antigens | Nef | T cells | Nef downregulates CD4 and major histocompatibility antigens on the surface of HIV-infected T cells. |
| Nguyen et al. (2009) | GAP-43 | NFAT-3 | NFAT | Finally, we observe that NFAT-3 is required to repress the physiological expression of GAP-43 and other pro-axon outgrowth genes in specific developmental windows in the mouse brain. |
| Dhanasekaran et al. (2003) | hCD81 | | T cells | Peptide 1 is able to block the binding interaction of recombinant HCV-E2 (rHCV-E2) to hCD81 expressed on Molt-4 T cells at high concentrations (3.5 mM), a low affinity that we attributed to the random coil structure in water.
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| Yang et al. (2007) | CCR5 | PNA CCR5 | T cells | The PNA CCR5 blocked the expression of CCR5 in spleen CD3+ T cells. |
| Cockfield et al. (1993) | IFN-gamma mRNA | anti-IFN-gamma mAb | T cell | The inhibition of IFN-gamma mRNA expression by the anti-IFN-gamma mAb occurred in both T cell-deficient athymic nude mice and their normal controls, suggesting that the autoamplification of IFN-gamma mRNA in vivo is T cell independent. |
| Genestier et al. (1999) | Myc | TGF-beta1 | T cell | In parallel, TGF-beta1 inhibited c-Myc expression in T cell hybridomas, and ectopic expression of a chimeric molecule composed of c-Myc and the steroid binding domain of the estrogen receptor (Myc-ER) blocked both the inhibition of FasL and the decrease of AICD induced by TGF-beta1, providing that 4-hydroxytamoxifen was present. |
| Yoshida et al. (2008) | CXCR4 | CD63 | T-cell | We have discovered that an N-terminal deletion mutant of a membrane protein, CD63, (CD63DeltaN) blocks entry of CXCR4-using, T-cell tropic human immunodeficiency virus type 1 (X4 HIV-1) by suppressing CXCR4 surface expression. |
| McCaughan et al. (1994) | glutathione S-transferase P | | T cell | The effect of inhibition of glutathione S-transferase P on the growth of the Jurkat human T cell line.
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| McCaughan et al. (1994) | GSTP | | T cell | To investigate the possible role of glutathione S-transferase P (GSTP) in carcinogenesis and cell proliferation, ethacrynic acid (EA) was used to inhibit GSTP in the human Jurkat T cell line. |
| DeKoter et al. (2007) | PU.1 | | T cell | However, reduction of PU.1 concentration is required for normal development of megakaryocyte-erythroid progenitors, B cell progenitors, and T cell progenitors. |
| Agrawal et al. (1998) | MUC1 | | T-cell | After removal of the mitogenic stimulus from the T-cell cultures, MUC1 expression is downregulated. |
| Wu and Perlman (1999) | RAG1 | | T-cell | Mice deficient in recombinase-activating gene function (RAG1(-/-)), defective in B- and T-cell maturation, become persistently infected with MHV but do not develop demyelination. |
| Shalitin et al. (1998) | hpr | | T-cell | To determine whether the haptoglobin related protein (hpr) affects the growth of an established T-cell leukemia cell line, an Hpr antisense expression vector that specifically reduces hpr production was constructed. |
| Hafner et al. (2003) | EphB6 | | T-cells | More recently, an important role of EphB6 signalling in T-cells has been described, suggesting possibly deleterious immunologic effects of a loss of EphB6 in cancer progression. |
| Mourtada-Maarabouni et al. (2008) | GAS5 | | T-cells | Consistent with this, downregulation of endogenous GAS5 inhibits apoptosis and maintains a more rapid cell cycle, indicating that GAS5 expression is both necessary and sufficient for normal growth arrest in T-cell lines as well as human peripheral blood T-cells. |
| Aerts-Toegaert et al. (2007) | CD83 | | T cell | Down-regulation of CD83 expression on human DC through RNA interference (RNAi) results in a less potent induction of allogeneic T cell proliferation, reduced IFN-gamma secretion by established T cells and decreased capacity in the priming of functional tumor antigen-specific CD8+ T lymphocytes. |
| Whisler et al. (1986) | CRP | | T cells | Other results indicated that CRP inhibition of colony formation during the AMLR was associated with considerable reductions in the proliferation of autoreactive T cells. |
| Moroi et al. (1991) | p56lck | | T cell | Immunoblot analysis with MOL 171 showed the accumulation of 60 kD form of Lck protein, p60lck, and the decrease of p56lck in human T cell leukemia virus type I (HTLV-I)-transformed T cell lines. |
| Moroi et al. (1991) | p56lck | | T cells | The appearance of p60lck with the decrease of p56lck in normal T lymphocytes after stimulation suggested the origin of p60lck in HTLV-I-transformed T cells.
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| D'Aquila et al. (1998) | CCR5 | | T cell | These data indicate that CCR5/delta(ccr5) heterozygosity, which decreases cell-surface levels of CCR5 available to serve as an HIV-1 entry coreceptor, is a selective pressure for evolution of T cell line-tropic viruses that use an alternative coreceptor.
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| Etemad-Moghadam et al. (2002) | CD4 | | T lymphocytes | We investigated the basis for the depletion of CD4(+) T lymphocytes in a SHIV-macaque model. |
| Casazza et al. (2001) | CD8 | | T-cell | After an undetectable viral load was achieved, a slower decrease in HIV-specific CD8(+) T-cell response was observed that was well described by first-order kinetics. |
| Casazza et al. (2001) | CD8 | | T-cell | These data suggest that HAART quickly starts to restore CD8(+) T-cell responses to other chronic viral infections and leads to a slow decrease in HIV-specific CD8(+) T-cell response in HIV-infected patients. |
| Casazza et al. (2001) | CD8 | | T-cell | The slow decrease in the rate of CD8(+) T-cell response and rapid increase in response to recurrent viral replication suggest that the decrease in CD8(+) T-cell response observed represents a normal memory response to withdrawal of antigen.
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| Fieger et al. (2005) | S1P1 | | T cells | Inhibition of S1P1 tyrosine sulfation or sulfatase removal of S1P1 sulfate in mouse CD4 T cells suppresses immune functional effects of S1P. |
| Lechner et al. (1996) | CD95 | | T cell | Under long-term culture conditions T cell lines derived from both young and old individuals progressively lost the capacity to decrease the expression of CD95 at the end of their activation cycle and an increasing susceptibility to activation-driven programmed cell death was noted. |
| Hurwitz et al. (2003) | CTLA-4 | | T cell | Androgen ablation (AA) may induce prostate tumour/tissue-specific T cell mediated inflammation and, as such, a phase II trial is currently in progress to ascertain whether CTLA-4 blockade can enhance AA-induced treatment responses in patients with advanced prostate cancer. |
| Chouaib and Fradelizi (1982) | IL2 | | T lymphocytes | We have observed that a complete depletion of adherent monocytes abrogates IL2 production by T lymphocytes. |
| Chouaib and Fradelizi (1982) | IL2 | | T cell | These results suggest that activation of a radiosensitive T cell by monokines is required for the inhibition of IL2 production. |
| Dutartre and Pascal (1991) | IL2 | | T cell | Lymphocyte proliferation and IL2 production in response to a T cell mitogen are greatly diminished during the whole life of the animals, on the contrary B cell proliferation in the presence of lipopolysaccharide is not modified. |
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